Articles
<![CDATA[Comparing the Effect of Repetitive Transcranial Magnetic Stimulation Therapy and Aerobic Exercise as an Add-on Therapy on the Cognitive Function of Patients with Depression ]]>
<![CDATA[Ikhwan Muhammad]]>;
<![CDATA[Hening Laswati Putra]]>;
<![CDATA[Martha Kurnia Kusumawardani]]>;
<![CDATA[Agustina Konginan]]>;
<![CDATA[Fazia]]>
<![CDATA[ Surabaya Physical Medicine and Rehabilitation Journal Vol. 5 No. 2 (2023): SPMRJ, AUGUST 2023 ]]>
Publisher : <![CDATA[Faculty of Medicine, Universitas Airlangga ]]>
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DOI: 10.20473/spmrj.v5i2.25367
<![CDATA[Background: Cognitive disturbances are a major cause of disability in depression. The antidepressant medication effectively improves cognitive function. However, its adverse effect limits its use, so add-on treatment is needed to support its effectiveness. Aim: This study aims to compare the efficacy of aerobic exercise and repetitive transcranial magnetic stimulation (rTMS) as an add-on treatment for improving cognitive function. Material and Methods: Twenty-seven patients with first episodes of moderate and severe depression were recruited from the outpatient psychiatry clinic to join this randomized controlled trial. Participants were allocated to three groups: antidepressant only, antidepressant with add-on aerobic exercise, and antidepressant with add-on rTMS therapy. All participants received 2 weeks of intervention. Cognitive functions were assessed using Montreal Cognitive Assessment (MOCA). Results: No differences were found in baseline characteristic data between groups. Total MOCA score increased after intervention in a group with no add-on treatment (p=0.007), with add-on aerobic exercise (p=0.011), and with add-on rTMS therapy (p=0.017). Hence, there was no between-group difference (p=0.222). The MOCA subtest analysis revealed between-group differences in changes in delayed recall subtest score (p=0.01). The group with add-on rTMS therapy improved better than the group with antidepressants only (p=0.005). Conclusion: The addition of rTMS therapy resulted in better improved delayed recall function than the addition of aerobic exercise or without any add-on treatment. This finding supports the application of rTMS therapy as an add-on treatment to improve the cognitive function of patients with depression.]]>
<![CDATA[Metabolite Profiling of the Environmental-Controlled Growth of Marsilea crenata Presl. and Its In Vitro and In Silico Antineuroinflammatory Properties ]]>
<![CDATA[Burhan Ma'arif]]>;
<![CDATA[Faisal Akhmal Muslikh]]>;
<![CDATA[Dilla Amalia]]>;
<![CDATA[Anisah Mahardiani]]>;
<![CDATA[Luthfi Achmad Muchlasi]]>;
<![CDATA[Pramudita Riwanti]]>;
<![CDATA[Maximus Markus Taek]]>;
<![CDATA[Hening Laswati]]>;
<![CDATA[Mangestuti Agil]]>
<![CDATA[ Borneo Journal of Pharmacy Vol. 5 No. 3 (2022): Borneo Journal of Pharmacy ]]>
Publisher : <![CDATA[Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya ]]>
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DOI: 10.33084/bjop.v5i3.3262
<![CDATA[This study was aimed to evaluate the metabolite contents and antineuroinflammatory potential of Marsilea crenata Presl. grown under a controlled environmental condition. The antineuroinflammatory test has been carried out in vitro using ethanolic extract of M. crenata leaves on HMC3 microglia cells. An in silico approach was applied to predict the active compounds of the extract. The HMC3 microglia cells were induced with IFNγ to create prolonged inflammatory conditions and then treated with 96% ethanolic extract of the M. crenata leaves of 62.5, 125, and 250 μg/mL. The expression of MHC II was analyzed using the ICC method with the CLSM instrument. Metabolites of the extract were profiled using UPLC-QToF-MS/MS instrument and MassLynx 4.1 software. In silico evaluation was conducted with molecular docking on 3OLS protein using PyRx 0.8 software, and physicochemical properties of the compounds were analyzed using SwissADME webtool. The ethanolic extract of M. crenata leaves could reduce the MHC II expression in HMC3 microglia cells in all concentrations with the values 97.458, 139.574, and 82.128 AU. The result of metabolite profiling found 79 compounds in the extract. In silico evaluation showed that 19 compounds gave agonist interaction toward 3OLS, and three met all parameters of physicochemical analysis. The ethanolic extract of the environmental-controlled growth of M. crenata leaves antineuroinflammatory activity on HMC3 microglia cells. The extract was predicted to contain some phytoestrogen compounds which act as 3OLS agonists.]]>
<![CDATA[Uji Sitotoksistas Ekstrak Etanol 96% Daun Semanggi (Marsilea crenata Presl.) pada Sel hFOB 1.19 dengan Metode Microtetrazolium (MTT) Assay ]]>
<![CDATA[Burhan Ma'arif]]>;
<![CDATA[Nabila Rosa]]>;
<![CDATA[Meilina Ratna Dianti]]>;
<![CDATA[Alif Firman Firdausy]]>;
<![CDATA[Hening Laswati]]>;
<![CDATA[Mangestuti Agil]]>
<![CDATA[ FARMASIS: Jurnal Sains Farmasi Vol 1 No 1 (2020): Farmasis : Jurnal Sains Farmasi ]]>
Publisher : <![CDATA[Universitas PGRI Adi Buana, Surabaya ]]>
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<![CDATA[Semanggi (Marsilea crenata Presl.) merupakan salah satu tanaman yang telah dimanfaatkan oleh masyarakat Indonesia, khususnya Jawa Timur, sebagai bahan makanan selama beberapa dekade. Marsilea crenata Presl. mengandung senyawa fitoestrogen memiliki struktur dan fungsi mirip estrogen dalam tubuh. Tujuan penelitian melakukan uji sitotoksisitas dan menentukan nilai IC50 dari ekstrak etanol 96 persen daun Marsilea crenata Presl. terhadap sel hFOB 1.19. Metode yang digunakan adalah microtetrazolium (MTT) assay dengan microplate reader. Sel dikultur pada microplate-96 well dan diberikan ekstrak dengan variasi dosis 62,5 ppm; 125 ppm; 250 ppm; 500 ppm; 1000 ppm; 2000 ppm dan 4000 ppm, kemudian ditambahkan reagen MTT 100μL, diinkubasi selama 2-4 jam dan ditambahkan SDS 10 persen sebagai stopper. Pembacaan hasil menggunakan microplate reader. Hasil dari pembacaan tersebut digunakan sebagai perhitungan nilai IC50 yang dapat menunjukkan tingkat sitotoksisitas ektrak etanol 96 persen Marsilea crenata Presl. Nilai IC50 yang didapatkan sebesar 2074,965 μg/ml. Berdasarkan hasil tersebut ekstrak etanol 96 persen Marsilea crenata Presl. dapat dikatakan aman dan tidak bersifat sitotoksik jika dikembangkan menjadi bahan obat.]]>
<![CDATA[Efek Neuroprotektif Fraksi Air Daun Semanggi (Marsilea crenata Presl.) secara In Vitro ]]>
<![CDATA[Burhan Ma'arif]]>;
<![CDATA[Muslim, Menara]]>;
<![CDATA[Riyanti, Anisa Eka]]>;
<![CDATA[Guhir, Abdul Malik]]>;
<![CDATA[Amalia, Dilla]]>;
<![CDATA[Saidah, Nisfatul Lailatus]]>;
<![CDATA[Anggraini, Wirda]]>;
<![CDATA[Atmaja, Ria Ramadhani Dwi]]>;
<![CDATA[Laswati, Hening]]>;
<![CDATA[Agil, Mangestuti]]>
<![CDATA[ FARMASIS: Jurnal Sains Farmasi Vol 2 No 1 (2021): Farmasis : Jurnal Sains Farmasi ]]>
Publisher : <![CDATA[Universitas PGRI Adi Buana, Surabaya ]]>
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DOI: 10.36456/farmasis.v2i1.3537
<![CDATA[Background: Estrogen deficiency can trigger several diseases, one of which is neurodegenerative. Neurodegenerative begins with neuroinflammation, which triggers the activation of microglia cells resulting in a pro-inflammatory activity. Potential and relatively safe therapy to use to overcome it is by using phytoestrogen compounds. Marsilea crenata Presl. is a plant that contains phytoestrogens. Objective: The purpose of this study was to analyze the neuroprotective effect of the water fraction of Marsilea crenata Presl. leaves which was shown by inhibition of neuroinflammation and marked by increased levels of MHC II against HMC3 microglia cells. Methods: IFN-γ is induced into HMC3 microglia cells for 24 hours to cause inflammatory conditions. Marsilea crenata Presl. leaves water fraction was given at a dose of 62,5; 125; and 250 µg / ml. Analysis of the neuroprotective effect of HMC3 microglia cells using the ICC method with the aid of the CLSM instrument. Results: The results of this study indicate that the water fraction of Marsilea crenata Presl. leaves can reduce MHC II expression at concentrations of 125 and 250 μg / ml with values of 465,748 and 460,884 AU at p less than 0,005. Conclusion: This study concludes that the water fraction of Marsilea crenata Presl. has neuroprotective activity shown at doses of 125 and 250 μg/ml which can reduce MHC II expression in HMC3 microglia cells induced by IFN-γ. The ED50 value which has a neuroprotective effect is at a dose of 0,582 μg/ml. ]]>
<![CDATA[Metabolite Profiling of 96% Ethanol Extract from Marsilea crenata Presl. Leaves Using UPLC-QToF-MS/MS and Anti-Neuroinflammatory Predicition Activity with Molecular Docking ]]>
<![CDATA[Burhan Ma’arif]]>;
<![CDATA[Denis]]>;
<![CDATA[Arief Suryadinata]]>;
<![CDATA[Artabah]]>;
<![CDATA[Hening Laswati]]>;
<![CDATA[Mangestuti Agil]]>
<![CDATA[ Journal of Tropical Pharmacy and Chemistry Vol. 4 No. 6 (2019): J. Trop. Pharm. Chem. ]]>
Publisher : <![CDATA[Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia ]]>
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DOI: 10.25026/jtpc.v4i6.213
<![CDATA[Phytoestrogen is a group of compounds that can replace the estrogen function in the body. One of its roles was as anti-neuroinflammatory by inhibiting the microglia M1 polarity activation. Marsilea crenata Presl. is a plant that suspected to contain phytoestrogens. The aim of this research was to determine the metabolite profile of 96% ethanol extract of M. crenata using UPLC-QToF-MS/MS, and prediction the anti-neuroinflammatory activity of compounds with molecular docking. The 100 ppm of 96% ethanol extract in DCM and methanol were injected 5 µl each into the UPLC-QToF-MS/MS, and then analyzed by Masslynx 4.1 software to determine the compounds. The result of metabolite profiling shows a total 59 compounds in both DCM and methanol. Molecular docking was done with Autodock 4.2.6. After being analyzed, there are 3 compounds that are predicted to have activities similar to 17?-estradiol, they are prochlorperazine, 12-Aminododecanoic acid, and 1-methyl-2-[(4-methylpiperazin-1-yl)methyl]benzimidaol-5-amine hydrochloride. The results showed that the three compounds were predicted to be phytoestrogen compounds from M. crenata leaves, which have potential as anti-neuroinflammatory.]]>
<![CDATA[Efek Penghambatan Ekspresi ER? Bebas oleh Fraksi n-Butanol Daun Semanggi (Marsilea crenata Presl.) pada Sel hFOB 1.19: Inhibitory Effect of Free-ER? Expression by n-Butanol Fraction of Semanggi (Marsilea crenata Presl.) Leaves on hFOB 1.19 Cells ]]>
<![CDATA[Burhan Ma’arif]]>;
<![CDATA[Agnis Pondineka Ria Aditama]]>;
<![CDATA[Faisal Akhmal Muslikh]]>;
<![CDATA[Dewi Perwito Sari]]>;
<![CDATA[Ira Purbosari]]>;
<![CDATA[Hening Laswati]]>;
<![CDATA[Mangestuti Agil]]>
<![CDATA[ Jurnal Sains dan Kesehatan Vol. 3 No. 4 (2021): J. Sains Kes. ]]>
Publisher : <![CDATA[Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia ]]>
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DOI: 10.25026/jsk.v3i4.635
<![CDATA[Wanita pascamenopause dapat menyebabkan berbagai macam masalah kesehatan, diantaranya adalah osteoporosis yang diakibatkan karena gangguan produksi hormon estrogen dalam tubuh. Salah satu alternatif yang muncul dan berpotensi untuk menggantikan hormon estrogen adalah fitoestrogen. Daun M. crenata diketahui mengandung senyawa fitoestrogen. Tujuan dari penelitian ini adalah untuk mengetahui fraksi n-Butanol daun M. crenata dalam meningkatkan aktivitas osteoblas pada proses pembentukan tulang terhadap sel hFOB 1.19. Penelitian ini menggunakan metode ICC dengan bantuan instrumen CLSM. Penelitian ini dilakukan dengan pemberian fraksi n-Butanol dengan varian konsentrasi62,5; 125; dan 250 ppm, serta pemberian genistein sebagai kontrol positif pada sel hFOB 1.19. Hasil dari penelitian ini menunjukkan bahwa fraksi n-Butanol daun M. crenata memiliki kandungan senyawa estrogenik sebagai agen untuk meningkatkan aktivitas osteoblas melalui penurunan ekspresi ER? bebas sel hFOB 1.19 dan konsentrasi 62,5 ppm sebagai konsentrasi optimal dengan nilai ekspresi 594.108 AU.]]>
<![CDATA[Normal Walking Speed According to Age and Gender in Preliminary Students in Surabaya ]]>
<![CDATA[Ananda, Naoval Diza]]>;
<![CDATA[Laswati, Hening]]>;
<![CDATA[Rejeki, Purwo Sri]]>;
<![CDATA[Suyoko, Andri]]>
<![CDATA[ Surabaya Physical Medicine and Rehabilitation Journal Vol. 4 No. 1 (2022): SPMRJ, FEBRUARY 2022 ]]>
Publisher : <![CDATA[Faculty of Medicine, Universitas Airlangga ]]>
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DOI: 10.20473/spmrj.v4i1.24186
<![CDATA[Background: Studies on walking have been developed recently because the speed of walking plays an important role in making predictions related to physical health. However, studies of walking speed in children are still relatively few even though the need for such data is quite high considering that walking speed can be used as a parameter to measure physicalhealth.Aim: The purpose of this study is to know the difference in walking speed based on age and gender in elementary school students.Methods: This study used an analytic observational study with a cross-sectional approach. All samples are students from Mojo VI State Elementary School Surabaya aged 7 to 12 years who meet the inclusion criteria using 10-meter walk test. The variable studied was walking speed. Method of sampling was conducted at Mojo VI State Elementary School Surabaya. Walking speed analysis was carried out by using the Kruskal-Wallis test for walking speed based on age and an unpaired T test for walking speed based on gender.Results: This research included 170 subjects that are 90 males and 80 males. Based on age, seven years old students have anaveragewalkingspeedof(1.30±0.21)m/s, eightyearsold students with(1.23±of0.18)m/s, nine yearsold students with (1.24 ± 0.17) m/s, ten years old students with (1.24 ± 0.19) m/s. eleven years old students with (1.31 ± 0.22) m/s, and twelve years old students with (1.27 ± 0.20) m/s. Based on gender, the average walking speed obtained in male was (1.26 ± 0.19) m/s, while the average walking speed obtained in female was (1.26 ± 0,20)m/s.Conclusion: There is no difference in the speed of walking based on age (p=0.440) at the age of 7 to 12 years and in both genders (p=0.910).]]>
<![CDATA[Life quality among elderly with obesity in outpatient clinic, dr. Soetomo hospital, surabaya ]]>
<![CDATA[Kurniawati, Patricia Maria]]>;
<![CDATA[Laswati, Hening Laswati]]>
<![CDATA[ Folia Medica Indonesiana Vol. 53, No. 3 ]]>
Publisher : <![CDATA[Folia Medica Indonesiana ]]>
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<![CDATA[Obesity is one of the chronic diseases that may have significant impact and affect the quality of life, especially in elderly who already have multidimensional problems. This study aimed to provide information about the influence of obesity in elderly on every component of his quality of life by using the SF-36 quality of life. This study was conducted on 105 patients in outpatient Medical Rehabilitation, Geriatrics and Diabetes at Dr. Soetomo Hospital, Surabaya. Patients aged 60-75 years, consisting of 62 men and 43 women. The number of patients with obesity was 49 persons (46.7%) with an average body mass index (BMI) of 27.16 kg / m2. Whereas, non-obese patients were 56 persons (53.3%) with an average BMI of 21.23 kg/m2. In conclusion, there was no significant difference in the SF-36 life quality of obesity and non-obesity groups after being analyzed using t-test.]]>
<![CDATA[The effects of physical exercises on c-reactive protein in patients with post ischemic stroke ]]>
<![CDATA[Laswati, Hening]]>;
<![CDATA[Andriana, Meisy]]>;
<![CDATA[Subadi, Imam]]>;
<![CDATA[Yuanita, Ida]]>
<![CDATA[ Folia Medica Indonesiana Vol. 52, No. 3 ]]>
Publisher : <![CDATA[Folia Medica Indonesiana ]]>
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<![CDATA[Several studies have recently highlighted the important role of physical exercise in regulation inflammatory status, but there is relatively little known about markers of inflammation levels after physical exercise in post ischemic stroke patients. The aims of this study to provide the effects of physical exercise using Partial Body-Weight Supported Treadmill Training –Audio Cues (PBWSTT-AC) and Traditional method on the level of inflammatory markers C-Reactive Protein (CRP). This study using pretest-postest control group design, 14 post ischemic stroke patients were randomized and allocate to two groups: Group1 (control group) received traditional walking exercise and group 2 received PBWSTT-AC. The walking exercise study were conducted for 20 minute 3 times a week for 12 sessions (4 weeks). Before and after 12 session of exercises, the serum levels of CRP were determined using immunoserology. All statistical test were carried out using SPSS 17 and statistical significance was set at p<0.05 for all analysis. The CRP levels between group were compared using Student t test or Mann-Whitney test. From multiple comparisons statistic result, no significant difference between groups (p=0.898), that seem in this study the levels of CRP of poststroke patients is not influenced by the Traditional training and PBWSTT-AC. The conclusion of this study that both traditional method and PBWTT-AC in 4 weeks exercise training seem have no effect on CRP levels.]]>
<![CDATA[Mobilisasi Dini di Intensive Care Unit (ICU): Tinjauan Pustaka ]]>
<![CDATA[Dian Marta Sari]]>;
<![CDATA[Siti Chandra Widjanantie]]>;
<![CDATA[Dewi Poerwandari]]>;
<![CDATA[Anitta Florence Stans Paulus]]>;
<![CDATA[Deddy Tedjasukmana]]>;
<![CDATA[Nury Nusdwinuringtyas]]>;
<![CDATA[Anita Ratnawati]]>;
<![CDATA[Hening Laswati Putra]]>
<![CDATA[ Majalah Kedokteran Indonesia Vol 72 No 1 (2022): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo ]]>
Publisher : <![CDATA[PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI) ]]>
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DOI: 10.47830/jinma-vol.72.1-2022-315
<![CDATA[Patients in the intensive care unit (ICU) usually have muscle weakness problems that are not related to their primary diseases when admitted ICU. This problem may become a clinical syndrome that we called ICU-Acquired Weakness (ICU-AW). There is currently no specific treatment for ICU-AW, therefore preventing patients from ICU-AW by controlling associated risk factors such as immobility, becoming a critical approach. Early mobilization (EM) has many benefits in the ICU setting for patients with or without mechanical ventilation. Besides that, the realization of EM needs consider the safety criteria and the barriers to their application. Thus, there are guidelines for the realization of EM to give the best outcomes while minimalizing the adverse events.]]>
