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All Journal HAYATI Journal of Biosciences Jurnal Dedikasi Farmasains : Jurnal Farmasi dan Ilmu Kesehatan EKSAKTA: Journal of Sciences and Data Analysis El-Hayah : Jurnal Biologi Pharmaciana: Jurnal Kefarmasian Journal of Biomedicine and Translational Research Jurnal Kesehatan Masyarakat (JKM) CENDEKIA UTAMA Jurnal Ilmiah Biosaintropis (Bioscience-Tropic) Journal of Islamic Pharmacy Jurnal Farmasi Sains dan Komunitas AKSIOLOGIYA : Jurnal Pengabdian Kepada Masyarakat Jurnal Biologi Tropis Majalah Farmaseutik SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Eksakta : Berkala Ilmiah Bidang MIPA Medical Technology and Public Health Journal Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Jurnal Penelitian Farmasi dan Herbal Jurnal Kesehatan Tambusai Nusantara Hasana Journal Jurnal EduHealth AJAD : Jurnal Pengabdian kepada Masyarakat Borneo Journal of Pharmacy
Ahmad Shobrun Jamil
Universitas Muhammadiyah Malang
Agriculture, Biological Sciences & Forestry Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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ANALISIS KETERKAITAN NETWORK PHAMACOLOGY SENYAWA METABOLIT SEKUNDER Abrus precatorius L. SECARA IN SILICO Khoirunnisa, Azka; Jamil, Ahmad Shobrun; Muchlisin, M. Artabah
Jurnal Penelitian Farmasi Dan Herbal Vol 6 No 2 (2024): Jurnal Penelitian Farmasi & Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v6i2.1686

Abstract

Cancer remains a global health challenge, prompting extensive research efforts worldwide. Lung cancer, the second most diagnosed cancer, presents a particularly grim survival rate. In Indonesia, cancer incidence ranks significantly, with millions affected and hundreds of thousands succumbing to the disease annually. Traditional medicine persists as a preferred option among many, perceived as safer and more affordable. Abrus precatorius L., an ancient medicinal plant, holds promise in this regard, with a rich history of use and a diverse range of pharmacological activities, including anti-cancer properties. Employing in silico modeling and network pharmacology, this study explores the interaction between Abrus precatorius L. compounds and various proteins associated with cancer. Through bioinformatics tools and databases, 27 bioactive compounds are identified and their physicochemical properties assessed, ensuring adherence to pharmacological guidelines. The study predicts potential protein targets for Abrus precatorius L. compounds, revealing interactions with 453 proteins, including those implicated in cancer pathways. Further analysis using StringDB and DISEASES database establishes protein-protein interaction networks, highlighting key proteins like EGFR and TERT, pivotal in multiple cancer types. The study validates the compounds' adherence to Lipinski's Rule of Five, indicating their potential for pharmacological activity and oral absorption. False Discovery Rate (FDR) analysis confirms significant associations between Abrus precatorius L. compounds and various cancers, further underscoring their therapeutic potential. In conclusion, Abrus precatorius L. compounds, particularly targeting EGFR and TERT proteins, emerge as promising candidates for cancer treatment. Their diverse pharmacological activities and interactions with key cancer-related proteins pave the way for further exploration and development of these compounds as alternative medicinal agents. In vitro and in vivo studies are warranted to validate their efficacy, particularly in addressing the complexities of different cancer types. Ultimately, this research offers valuable insights into leveraging natural compounds for combating cancer, addressing a critical need in global healthcare.
Network Pharmacology Analysis of Secondary Metabolites of Ciplukan (Physalis angulata L.) Against Lung Cancer Khoirunnisa, Azka; Jamil, Ahmad Shobrun; Muchlisin, Muhammad Artabah
Majalah Farmaseutik Vol 20, No 2 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v20i2.96275

Abstract

Lung cancer is the most common and high-risk type of cancer. Ciplukan (Physalis angulata L.) has antibacterial, anti-inflammatory, and anticancer activities, as well as cytotoxic ability and inhibits cancer cell growth. Research that discusses the molecular cellular mechanism of P. angulata's potential as an anti-lung cancer has not been widely informed, especially on the network pharmacology aspect of this plant's active compounds. This study reveals the prediction of the molecular mechanism of active compounds of P. angulata as anti-lung cancer using several tools including: Compound database retrieval with Knapsack and PubChem. Absorption Distribution Metabolism and Excretion (ADME) screening with SwissADME. Target protein identification with Gene Card, SwissTargetPrediction and Venny Diagram. Network pharmacology construction with String-DB and Cytoscape. Network pharmacology analysis using Gene Ontology (GO), and Cellular Component and Molecular Function. Based on the results of the analysis of P. angulata protein potential based on Maximal Clique Centrality (MCC) on CytoHubba in Cytoscape application, it shows that the Protein-protein Interaction (PPI) network has 10 main targets, namely ERBB2, KRAS, TP53, PTEN, CDKN2A, NRAS, PIK3CA, BRAF, NF1, and EGFR which interact with each other to regulate cell growth, differentiation, and survival. The results of this study can be concluded that the secondary metabolite compounds of P. angulata have the potential to control and alternative for lung cancer therapy.
ANALISIS POTENSIAL Alpinia galanga MENGGUNAKAN JEJARING FARMAKOLOGI MELALUI ANALISIS PENGAYAAN GENE ONTOLOGY DAN KEGG (KYTO ENCYCLOPEDIA OF GENE AND GENOMES) SEBAGAI ANTIDIABETES Fath, Dwi Hanif Muluqul; Muchlisin, Muhammad Artabah; Jamil, Ahmad Shobrun
Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Vol 9 No 1 (2024): Pharma Xplore : Jurnal Sains dan Ilmu Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jpx.v9i1.6627

Abstract

Alpinia galanga L., is a family of Zingiberaceae that has been used traditionally in various medicinal practices due to its therapeutic properties. With this, this research aims to identify the potential content of Alpinia galanga metabolite compounds as one of the potential alternative therapies in cases of diabetes mellitus and several other disorders. In this study, in silico methods were used, namely pharmacological networks and also Gene Ontology and KEEG pathway enrichment analysis which revealed 28 metabolite compounds that have links to plants and diseases to be studied and also revealed the enrichment of key molecular functions such as catalytic activity, protein kinase activity, and small molecule binding, indicating their regulatory and catalytic properties. In addition, KEGG (Kyto Encyclopedia of Genes and Genomes) pathway analysis highlighted its involvement in signaling pathways associated with glucose homeostasis, cancer, and hormone response. Examination of cellular component terms revealed the subcellular localization and potential interactions of A. galanga compounds in cellular compartments such as the cytoplasm, plasma membrane, and cell periphery. The results showed that out of 28 metabolite compounds, 1 metabolite compounds in A. galanga, namely 1'S-1'- acetosxychavicol, have the potential for treatment in diabetes mellitus cases and show the diverse pharmacological properties of A. galanga, which has implications for its potential in the development of new therapies targeting various diseases and disorders.
PEMANFAATAN SENYAWA METABOLIT SEKUNDER KAWISTA (Limonia acidissima) UNTUK PENGELOLAAN DIABETES: TINJAUAN ANALISIS JEJARING FARMAKOLOGI Hentu, Dina Siti Rahma M.; Muchlisin, M. Artabah; Jamil, Ahmad Shobrun; Astuti, Engrid Juni; Rafikayanti, Agustin
Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Vol 9 No 1 (2024): Pharma Xplore : Jurnal Sains dan Ilmu Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jpx.v9i1.6964

Abstract

This study aims to explore the potential of secondary metabolite compounds from the kawista plant (Limonia acidissima) as antidiabetic agents through an in silico approach. We utilized pharmacological network analysis and analysis of the most important proteins to identify potential protein targets and signaling pathways involved in diabetes regulation. The analysis revealed that secondary metabolite compounds from kawista have the potential to affect various crucial aspects of glucose and lipid metabolism in the body, including through interactions with key proteins such as AKT1. These findings provide new insights into the development of additional therapies for diabetes treatment, and demonstrate the potential of in silico methods in accelerating the discovery and development of new drugs.
Expression of Immunoglobulin M (IgM) and Immunoglobulin G (IgG) in Normal Wistar Rat Post-Cheral® Administration Asyhari, Firda Nuri; Zulfatim, Heni Sukma; Putri, Nenis Try Melani; Dliyauddin, Moh; Jamil, Ahmad Shobrun; Soewondo, Aris; Natsir, Muhammad Halim; Ibrahim, Mansur; Rahayu, Sri; Djati, Muhammad Sasmito; Rifa’i, Muhaimin
HAYATI Journal of Biosciences Vol. 31 No. 5 (2024): September 2024
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.31.5.1030-1036

Abstract

Maintaining immunoglobulin levels in the body is important to protect the body from exposure to pathogens. One effort can be made by consuming herbs containing immunomodulatory compounds, such as Cheral®, which includes a combination of herbs Phyllanthus niruri and Curcuma longa. This research aims to determine the expression of immunoglobulin M (IgM) and immunoglobulin G (IgG) following the administration of Cheral® to Wistar rats. The study was conducted in vivo, utilizing 24 healthy male Wistar rats for a 90-day treatment period. The research was divided into four treatment groups, including a control group and three dosage groups: Dose 1 (156.25 mg/kg BW), Dose 2 (312.5 mg/kg BW), and Dose 3 (468.75 mg/kg BW). IgM and IgG were isolated from the spleen and analyzed using flow cytometry. Flow cytometry data were analyzed using SPSS with a one-way ANOVA and post hoc test (p-value <0.05). The analysis showed that the relative number of IgM-producing cells in the control group was significantly higher than in the treatment groups, with a difference of 44.40%. In contrast, the relative number of IgG-producing cells in Dose 3 was significantly lower than all other treatment groups, showing a decrease of 29.21%. Overall, the expression of IgG and IgM did not differ substantially across all treatments. The lower IgG and IgM profiles compared to the control group indicate Cheral®'s ability to prevent infections and maintain the immune system of the rats throughout the treatment period.
Potential Activity Of Secondary Metabolites Of Kawista (Limonia Acidissima) As Neurodegenerative Diseases : A Network Pharmacology Approaches Dina Siti Rahma M. Hentu; Muchlisin, M. Artabah; Jamil, Ahmad Shobrun; Astuti, Engrid Juni; Rafikayanti, Agustin
Jurnal EduHealth Vol. 15 No. 02 (2024): Jurnal eduHealt, Edition April - June , 2024
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Kawista (Limonia acidissima) is a tropical plant traditionally used in South and Southeast Asian medicine, and its known for its rich nutritional profile and bioactive compounds. This study explores the therapeutic potential of kawista for neurodegenerative diseases. This study aims to investigate the potential of kawista in managing neurodegenerative through a pharmacological network approach. Proteins that can interact with secondary metabolites of kawista were predicted using SwissTargetPrediction, proteins related to neurodegenerative were obtained from GeneCards. The intersecting results were analyzed using STRING with GO (Gene Ontology) and KEGG (Kyoto Encyclopedia of Genes and Genomes) enrichment methods. From 47 secondary metabolites of kawista, 218 neuro-related proteins was identified potentially interacting with kawista's secondary metabolites. Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and disease-gene association analyses highlighted key biological processes, molecular functions, cellular components, and pathways relevant to neurodegenerative disease mechanisms. The findings suggest that kawista's bioactive compounds could modulate critical pathways and receptor activities, offering insights into developing novel, effective therapies for neurodegenerative disorders. This research providing a scientific basis for kawista-based therapeutic strategies aimed at improving neurodegenerative disease outcomes.
In Silico Study Potential Secondary Metabolite Candidate of Citronella Grass (Cymbopogon nardus) on Immunity Cases Veda, Adella Infia Helga; Muchlisin, M. Artabah; Jamil, Ahmad Shobrun; Almutahrihan, Irsan Fahmi; Satriawan, Herland
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 24 No. 03 (2023): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464)
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol23-iss03/418

Abstract

Foreign invaders in the form of bacteria, fungi, or viruses can cause various diseases if they enter the body, both molecularly and cellularly. Hence, the body needs a compound that can maintain and enhance the immune and immune systems to recognize abnormal cells that can become a source of disease for the body. Improving immunity/resistance for people with diseases is very important so that people undergoing treatment are given immunostimulant drugs or pharmaceutical preparations. This study aimed to determine the protein network associated with the body's immune system, which was activated by the administration of citronella (Cymbopogon nardus). The research method used is explorative descriptive with in silico analysis using a computational model with software including KNApSAck, Dr. Duke, Pubchem, Swiss ADME, Swiss Target Prediction, Gene Cards, Venny, STRING, and KEGG. Based on the results of pharmacological network analysis, C. nardus contains 40 secondary metabolites, 25 of them have high bioavailability. Based on pharmacological network analysis, (-)-menthol is an important compound that plays a role in the immune system because it is expected to interact with three crucial pathways related to immunomodulators.
A Network Pharmacology Analysis of Secondary Metabolites of Noni (Morinda citrifolia) as Immunomodulators Helmi, M.; Jamil, Ahmad Shobrun; Muchlisin, M. Artabah; Almuhtarihan, Irsan Fahmi
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 21, No 2 (2024)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.006183

Abstract

Immunomodulators are substances or compounds that can modulate or help increase the activity and function of the immune system. The medicinal use of herbal plants is now increasing again among Indonesian people. Noni (Morinda citrifolia) is a plant commonly found in Indonesia that has long been known to have many benefits for treating and preventing various diseases and the secondary metabolites have potential as immunomodulators. This study aimed to determine the protein network associated with the body's immune system, which was activated by the administration of noni. The explorative descriptive research was conducted with in silico analysis using a computational model with software, including KNApSAck, Dr. Duke, Pubchem, Swiss ADME, Swiss Target Prediction, Gene Cards, Venny, STRING, and KEGG. Based on the results of pharmacological network analysis, noni contains 128 secondary metabolites, and 83 of them have high bioavailability. Based on pharmacological network analysis, (z,z,z)-8,11,14-eicosatrienoic-acid and 1-5-6-trihydroxy-anthraquinone are important compounds that play a role in the immune system because they are expected to interact with five crucial pathways related to immunomodulators.
dakwah.pwpmjatim.id: Webtool untuk Gen Z tentang Sebaran Fasilitas Layanan Ibadah dan Kanal Media Sosial Masjid Binaan Muhammadiyah Jawa Timur Hakim, Luqman; Nuryasin, Ilyas; Muchlisin, M Artabah; Hidayaturrahman, Hidayaturrahman; Karim, Izuddin; Burhanuddin, Burhanuddin; Stiawan, Thoat; Alamsyah, Fakhruddin; Syadqamullah, Dikky; Jamil, Ahmad Shobrun
Aksiologiya: Jurnal Pengabdian Kepada Masyarakat Vol 7 No 2 (2023): Mei
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/aks.v7i2.15442

Abstract

Muhammadiyah memang sudah banyak menggunakan teknologi modern, termasuk media sosial, untuk melakukan komunikasi dan menyampaikan informasi dakwah, namun intensitas dan kapasitasnya masih terbilang rendah dibandingkan dengan komunitas yang harus dijangkau. Pemuda Muhammadiyah sebagai penerus gerakan Muhammadiyah tentu harus merumuskan dan segera mengeksekusi langkah-langkah konkrit dalam mendigitalisasi program dakwahnya. Platform digital http://dakwah.pwpmjatim.id adalah salah satu upaya Pemuda Muhammadiyah Jawa Timur bersama dengan Tim Pengabdian Masyarakat Universitas Muhammadiyah Malang dalam membangun ekosistem digital dakwah yang simpel dan mudah.  Fitur web disusun sebaran fasilitas layanan ibadah dan kanal media sosial masjid binaan Muhammadiyah Jawa Timur. Pin titik lokasi tunggal (berwarna biru putih merah), akan menunjukkan menu tautan media sosial instagram, facebook dan youtube sehingga dapat dimanfaatkan pengguna untuk lebih jauh menikmati layanan online masjid. Namun fitur ini masih terus dikembangkan karena mayoritas masjid belum memiliki kanal media sosial. Platform ini dibangun untuk membantu Muhammadiyah di Jawa Timur menampilkan peta lokasi, fasilitas, layanan dan kanal-kanal media sosial masjid dalam binaannya. Kedepan, platform ini dapat diintegrasikan dengan berbagai platform digital dalam binaan Muhammadiyah sehingga manfaatnya dapat lebih luas meliputi bidang pendidikan, sosial, budaya dan tentunya bidang dakwah Muhammadiyah. Platform ini juga direncanakan akan diperluas hingga dapat memetakan masjid binaan Muhammadiyah dalam skala nasional bahkan internasional.
Analisis Jejaring Farmakologi Metabolit Sekunder Tanaman Alang-Alang (Imperata cylindrica) Terhadap Penyakit Stroke Iskemik Syabana, Nada Laela; Rofida, Siti; Jamil, Ahmad Shobrun
Jurnal Ilmiah Biosaintropis (Bioscience-Tropic) Vol 11 No 1 (2025): Agustus 2025
Publisher : Fakultas Matematika & Ilmu Pengetahuan Alam - Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/ejbst.v11i1.601

Abstract

Stroke iskemik disebabkan oleh adanya plak aterosklerosis sehingga aliran darah menuju otak tersumbat. Hal ini terjadi karena adanya faktor risiko, yaitu hipertensi, diabetes melitus, dan kolesterol. Untuk mencegahnya, dilakukan penelitian menggunakan tanaman Imperata cylindrica yang sudah terbukti memiliki efek antihipertensi, antikolesterol, dan antidiabetes pada penelitian sebelumnya. Metode penelitian yang digunakan yaitu jejaring farmakologi menggunakan cytoscape dan analisis komputasi menggunakan molecular docking. Dilakukan analisis penunjang seperti, evaluasi farmakokinetik obat, kemiripan obat, prediksi dan validasi target. Didapatkan sebanyak 59 protein gen memiliki keterkaitan dengan tanaman Imperata cylindrica dan penyakit stroke iskemik dengan PTGS2 menjadi protein paling berpengaruh karena terhubung dengan hampir seluruh jalur persinyalan, seperti jalur metabolisme, resistensi insulin, AGE-RAGE pada komplikasi diabetes, biosintesis hormon steroid, dan kardiomiopati diabetes.
Co-Authors Ahyana Fitrian, S.Farm. Apt Ahyana Fitrian, S.Farm. Apt, Ahyana Fitrian, Alamsyah, Fakhruddin Almutahrihan, Irsan Fahmi Amaliyah Dina Anggraeni Andika Aliviameita Aris Soewondo Astri Ariani Astri Ariani, Astri Asyhari, Firda Nuri Azka Khoirunnisa Bayu Prasaja Bayu Prasaja, Bayu Buhari Adi, Buhari Buhari Buhari Burhanuddin Burhanuddin Burhanuddin Burhanuddin Dikky Syadqamullah Dina Siti Rahma M. Hentu Dinda Farida Dliyauddin, Moh Dra. Uswatun Chasanah, Apt. Dra. Uswatun Chasanah, Apt., Dra. Uswatun Drs. Ahmad Inoni, Apt Drs. Ahmad Inoni, Apt, Drs. Ahmad Dwi Retno Nur Syahida Eko Budi Cahyono Engrid Juni Astuti Faiznanda Awwaluddin Fakhruddin Alamsyah Fath, Dwi Hanif Muluqul Fitria Dwi Damayanti Hentu, Dina Siti Rahma M. Hidayaturrahman Hidayaturrahman Hidayaturrahman, Hidayaturrahman Hilmy, Fauzan Irsan Fahmi Almuhtarihan Irsan Fahmi Almutahrihan Izuddin Karim Karim, Izuddin Khasna Shafwatul Jihan Lely Mauliana Lena, Nour Lilik Yusetyani Luqman Hakim Luqman Hakim M Artabah Muchlisin M. Artabah Muchlisin M. Artabah Muchlisin M. Helmi Mansur Ibrahim Miftahul Mushlih Moch Sasmito Djati Muchlisin, M. Artabah Muhammad Halim Natsir Mujahidin Ahmad Nabilatul Auliyana Nour Lena Nurul Amalia Azhari Nuryasin, Ilyas Pertiwi, Cinta Junaidi Putri Puspitasari Puspitasari Puspitasari, Alvina Arum Putri, Nenis Try Melani Rafikayanti, Agustin Resi Puguh Prihantono Rifa’i, Muhaimin Risma Ayu Setiawan Satriawan, Herland Siti Rofida Solly Aryza SRI RAHAYU Sumadi, Firasti Agung Nugrahening Syabana, Nada Laela Syadqamullah, Dikky Syifa', Nailis Thoat Stiawan Tri Luthfiana Maretha Trikxy Viori Andhani Trimianti Hidahyatun Nazah Veda, Adella Infia Helga wahyuni, reni sri Zulfatim, Heni Sukma Zulkipli Hardi Zulkipli Hardi, Zulkipli