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All Journal HAYATI Journal of Biosciences Jurnal Dedikasi Farmasains : Jurnal Farmasi dan Ilmu Kesehatan EKSAKTA: Journal of Sciences and Data Analysis El-Hayah : Jurnal Biologi Pharmaciana: Jurnal Kefarmasian Journal of Biomedicine and Translational Research Jurnal Kesehatan Masyarakat (JKM) CENDEKIA UTAMA Jurnal Ilmiah Biosaintropis (Bioscience-Tropic) Journal of Islamic Pharmacy Jurnal Farmasi Sains dan Komunitas AKSIOLOGIYA : Jurnal Pengabdian Kepada Masyarakat Jurnal Biologi Tropis Majalah Farmaseutik SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Eksakta : Berkala Ilmiah Bidang MIPA Medical Technology and Public Health Journal Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Jurnal Penelitian Farmasi dan Herbal Jurnal Kesehatan Tambusai Journal of Fundamental and Applied Pharmaceutical Science Nusantara Hasana Journal Jurnal EduHealth AJAD : Jurnal Pengabdian kepada Masyarakat Borneo Journal of Pharmacy
Ahmad Shobrun Jamil
Universitas Muhammadiyah Malang
Agriculture, Biological Sciences & Forestry Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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POTENSI KAWISTA (LIMONIA ACIDISSIMA) DALAM PENGELOLAAN HIPERTENSI : ANALISIS JEJARING FARMAKOLOGI Pertiwi, Cinta Junaidi Putri; Muchlisin, M. Artabah; Jamil, Ahmad Shobrun; Astuti, Engrid Juni; Rafikayanti, Agustin
Jurnal Kesehatan Tambusai Vol. 5 No. 2 (2024): JUNI 2024
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v5i2.28226

Abstract

Hipertensi adalah kondisi kronis yang dapat menyebabkan komplikasi kardiovaskular serius, dan kawista (L. acidissima) telah digunakan dalam pengobatan tradisional untuk berbagai penyakit, termasuk hipertensi. Namun mekanisme molekuler L. acidissima dalam mengatur tekanan darah belum sepenuhnya dipahami. Penelitian ini bertujuan untuk menyelidiki potensi kawista L. acidissima dalam pengelolaan hipertensi melalui pendekatan jejaring farmakologi. Senyawa metabolit sekunder L. acidissima diambil dari literatur, protein yang dapat berinteraksi dengan metabolit sekunder diprediksi dengan menggunakan SwissTargetPrediction, protein yang berhubungan dengan hipertensi diperoleh dari GeneCards. Hasil irisan protein dari SwissTargetPrediction dan GeneCards dianalisis lebih lanjut menggunakan STRING dengan metode GO (Gene Ontology) dan KEGG (Kyoto Encyclopedia of Genes and Genomes) enrichment. Protein yang paling memiliki peranan dalam hipertensi dianalisis dengan menggunakan algoritma MCC (Maximal Clique Centralit) dari CytoHubba. Analisis GO enrichment menunjukkan keterlibatan protein-protein dalam regulasi tekanan darah sistemik dan respons biologis lainnya yang relevan dengan hipertensi. Analisis KEGG enrichment mengungkap keterlibatan jalur-jalur sinyal utama seperti cGMP-PKG dan HIF-1, serta jalur regulasi hormonal penting dalam regulasi tekanan darah. Analisis MCC top 10 dari CytoHubba menyoroti peran sentral gen-gen seperti ACE, NOS3, dan EDNRA dalam jaringan biologis, menunjukkan potensi mereka sebagai target terapeutik dalam pengelolaan hipertensi. Senyawa metabolit sekunder L. acidissima memiliki potensi digunakan sebagai terapi untuk hipertensi.
Integrative Network Pharmacology Unveils Limonia acidissima as a Potential Natural Product for Targeting Cancer Wahyuni, Reni Sri; Muchlisin, M. Artabah; Jamil, Ahmad Shobrun; Astuti, Engrid Juni; Rafikayanti, Agustin
Borneo Journal of Pharmacy Vol. 7 No. 3 (2024): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v7i3.6988

Abstract

Cancer remains a formidable health challenge worldwide, with complex molecular mechanisms driving its initiation, progression, and therapeutic resistance. In this study, we employed bioinformatics analyses to elucidate the molecular underpinnings of cancer biology, focusing on Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis. Our GO analysis revealed the enrichment of key biological processes such as protein phosphorylation, regulation of programmed cell death, and transmembrane receptor signaling pathways, underscoring the critical roles of signaling cascades and regulatory mechanisms in tumorigenesis. Similarly, molecular functions such as protein kinase activity and ATP binding were identified as significantly enriched, highlighting the importance of protein kinases and molecular interactions in cancer development and progression. The KEGG pathway analysis further delineated dysregulated signaling pathways associated with cancer, including the MAPK and PI3K-Akt signaling pathways, implicating these pathways as central regulators of cancer progression. These findings deepen our understanding of cancer biology and offer potential targets for therapeutic intervention. Integrating multi-omics data and systems biology approaches may provide deeper insights into the intricate networks underlying cancer pathogenesis, paving the way for developing more effective treatments for cancer patients.
A Network Pharmacology Analysis of Secondary Metabolites of Noni (Morinda citrifolia) as Immunomodulators M. Helmi; Ahmad Shobrun Jamil; M. Artabah Muchlisin; Irsan Fahmi Almuhtarihan
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 21, No 2 (2024)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.006183

Abstract

Immunomodulators are substances or compounds that can modulate or help increase the activity and function of the immune system. The medicinal use of herbal plants is now increasing again among Indonesian people. Noni (Morinda citrifolia) is a plant commonly found in Indonesia that has long been known to have many benefits for treating and preventing various diseases and the secondary metabolites have potential as immunomodulators. This study aimed to determine the protein network associated with the body's immune system, which was activated by the administration of noni. The explorative descriptive research was conducted with in silico analysis using a computational model with software, including KNApSAck, Dr. Duke, Pubchem, Swiss ADME, Swiss Target Prediction, Gene Cards, Venny, STRING, and KEGG. Based on the results of pharmacological network analysis, noni contains 128 secondary metabolites, and 83 of them have high bioavailability. Based on pharmacological network analysis, (z,z,z)-8,11,14-eicosatrienoic-acid and 1-5-6-trihydroxy-anthraquinone are important compounds that play a role in the immune system because they are expected to interact with five crucial pathways related to immunomodulators.
Penyuluhan Penggunaan Obat yang Benar (Dagusibu) dan Pengelolaan Obat di Rumah Tangga Masyarakat Bumi Mondoroko Raya Malang Nailis Syifa'; Alvina Arum Puspitasari; Ahmad Shobrun Jamil
AJAD : Jurnal Pengabdian kepada Masyarakat Vol. 5 No. 3 (2025): DECEMBER 2025
Publisher : Divisi Riset, Lembaga Mitra Solusi Teknologi Informasi (L-MSTI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59431/ajad.v5i3.607

Abstract

Insufficient public knowledge about appropriate medication use, storage, and disposal practices poses significant health risks and environmental hazards. This community service program sought to enhance understanding of the Dagusibu concept (obtain, use, store, dispose) among PKK mothers in Bumi Mondoroko Raya, Singosari, Malang. The intervention employed pre-test questionnaires, interactive presentations, and question-and-answer sessions involving 13 participants. Pre-test findings revealed substantial misconceptions: eight participants (62%) perceived paracetamol solely as an antipyretic, four participants (31%) deemed household waste disposal acceptable for all expired medications, and three participants (23%) believed antibiotics were available for purchase at local stalls. Following the educational intervention and discussion sessions, participants demonstrated accurate identification of paracetamol's multiple therapeutic indications, appropriate disposal protocols for expired medications, and prescription requirements for antibiotic acquisition. The program successfully enhanced community knowledge regarding rational medication use and household pharmaceutical management. Educational leaflets were disseminated as follow-up materials, with plans established for ongoing monitoring of household medication storage practices.
Network-Based and Experimental Evaluation of Vitamin D and Tinospora cordifolia in Immune Modulation Jamil, Ahmad Shobrun; Syifa, Nailis; Puspitasari, Alvina Arum; Rachmawati, Hidajah; Anggraeni, Amaliyah Dina; Farmasari, Novan Visia
Journal of Fundamental and Applied Pharmaceutical Science Vol. 7 No. 1 (2026): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v7i1.31191

Abstract

Vitamin D (VD) and Tinospora cordifolia (TC) play important roles in maintaining immune homeostasis and combating infections by modulating the immune response. This study aimed to investigate the combined effects of VD and TC on immune modulation, particularly inflammatory cytokine expression and immune cell maturation. The in silico analysis identified TC compounds using the Knapsack and PubChem databases, followed by ADME profiling with SwissADME. Putative target proteins were predicted using SwissTargetPrediction and STRING-DB. In vivo experiments were conducted using female BALB/c mice assigned to five experimental groups to evaluate the effects of VD, TC, and their combination in an Escherichia coli infection model established by intraperitoneal injection. Hematological parameters were analyzed using a hematology analyzer, while inflammatory cytokine and granulocyte cell marker expression were assessed by flow cytometry. Statistical analysis employed one-way analysis of variance (ANOVA) followed by Tukey’s HSD post hoc test. In silico network analysis identified 183 overlapping proteins between hematopoiesis-related proteins and the target proteins of 15 bioactive TC compounds, suggesting potential interactions within hematopoiesis pathways. Network visualization further demonstrated complex interactions involving receptors, enzymes, and transcription factors, supporting the potential immunomodulatory roles of TC. Flow cytometry revealed that VD, TC, and their combination significantly reduced IL-1β expression, indicating anti-inflammatory activity. CD11b+ expression remained unchanged across treatment groups, whereas the combination of VD and TC enhanced the maturation of Gr1+-marked granulocytes. These findings suggest that combined VD and TC may have potential as an anti-inflammatory intervention and may support granulocyte maturation in the immune system.
Co-Authors Ahyana Fitrian, S.Farm. Apt Ahyana Fitrian, S.Farm. Apt, Ahyana Fitrian, Alamsyah, Fakhruddin Almutahrihan, Irsan Fahmi Alvina Arum Puspitasari Amaliyah Dina Anggraeni Andika Aliviameita Aris Soewondo Astri Ariani Astri Ariani, Astri Asyhari, Firda Nuri Azka Khoirunnisa Bayu Prasaja Bayu Prasaja, Bayu Buhari Adi, Buhari Buhari Buhari Burhanuddin Burhanuddin Burhanuddin Burhanuddin Dina Siti Rahma M. Hentu Dinda Farida Dliyauddin, Moh Dra. Uswatun Chasanah, Apt. Dra. Uswatun Chasanah, Apt., Dra. Uswatun Drs. Ahmad Inoni, Apt Drs. Ahmad Inoni, Apt, Drs. Ahmad Dwi Retno Nur Syahida Eko Budi Cahyono Engrid Juni Astuti Faiznanda Awwaluddin Fakhruddin Alamsyah Farmasari, Novan Visia Fath, Dwi Hanif Muluqul Fitria Dwi Damayanti Hentu, Dina Siti Rahma M. Hidajah Rachmawati Hidayaturrahman Hidayaturrahman Hidayaturrahman, Hidayaturrahman Hilmy, Fauzan Irsan Fahmi Almuhtarihan Irsan Fahmi Almutahrihan Izuddin Karim Karim, Izuddin Khasna Shafwatul Jihan Lely Mauliana Lena, Nour Lilik Yusetyani Luqman Hakim Luqman Hakim M Artabah Muchlisin M. Artabah Muchlisin M. Artabah Muchlisin M. Helmi Mansur Ibrahim Miftahul Mushlih Moch Sasmito Djati Muchlisin, M. Artabah Muhammad Halim Natsir Mujahidin Ahmad Nabilatul Auliyana Nailis Syifa Nailis Syifa' Nour Lena Nurul Amalia Azhari Nuryasin, Ilyas Pertiwi, Cinta Junaidi Putri Puspitasari Puspitasari Puspitasari, Alvina Arum Putri, Nenis Try Melani Rafikayanti, Agustin Resi Puguh Prihantono Rifa’i, Muhaimin Risma Ayu Setiawan Satriawan, Herland Siti Rofida SRI RAHAYU Sumadi, Firasti Agung Nugrahening Syabana, Nada Laela Syadqamullah, Dikky Syadqomullah, Dikky Thoat Stiawan Tri Luthfiana Maretha Trikxy Viori Andhani Trimianti Hidahyatun Nazah Veda, Adella Infia Helga wahyuni, reni sri Zulfatim, Heni Sukma Zulkipli Hardi Zulkipli Hardi, Zulkipli