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All Journal Medula Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan Journal Of Vocational Health Studies PROSIDING SEMINAR NASIONAL AGRIBISNIS Jurnal Kesehatan Darmabakti Cendekia: Journal of Community Service and Engagements Jurnal Kesehatan Tambusai Mabsya: Jurnal Manajemen Bisnis Syariah Jurnal Ilmu Kesehatan MAKIA MOSIRAHA : Jurnal Pengabdian Farmasi Amal Ilmiah: Jurnal Pengabdian Kepada Masyarakat Lansau: Jurnal Ilmu Kefarmasian Molekul: Jurnal Ilmiah Kimia Borneo Journal of Pharmacy Sadewa: Jurnal Pengabdian Masyarakat
Rini Hamsidi
Department Of Health, Faculty Of Vocational Studies, Universitas Airlangga, Surabaya-Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Journal : Molekul: Jurnal Ilmiah Kimia

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Antioxidant and Anti-inflammatory Activities of Diarylheptanoid from Etlingera calophrys Fruit Karmilah, Karmilah; Yodha, Agung Wibawa Mahatva; Hamsidi, Rini; Daud, Nur Saadah; Malaka, Muhammad Hajrul; Musdalipah, Musdalipah; Sahidin, Sahidin
Molekul Vol 19 No 3 (2024)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2024.19.3.12413

Abstract

Diarylheptanoids compounds from the genus Etlingera have attracted widespread attention due to their various structural diversity and potential pharmacological effects. This is certainly an important part to continue to study, especially from Sulawesi endemic species, one of which is Etlingera calophrys. The fruit of E. calophrys is widely utilized in the Sulawesi community. The lack of information on the content of chemical compounds and their pharmacological activities, so the study is very important. Diarylheptanoid compounds were obtained by chromatography technique, molecular structure interpretation by spectroscopy technique while pharmacological activity was tested against radical scavenging as antioxidant and inhibition of protein denaturation as anti-inflammatory. Two diarylheptanoid compounds were successfully isolated from E. calophrys fruit namely 1-(3'-methoxy-4'- hydroxyphenyl)-7-phenyl- 3-heptanone and 1-(3'-methoxy-4'- hydroxyphenyl)-7-(4"-hydroxyphenyl)- 3-heptanone. Antioxidant properties showed very strong ability with IC50 values of 32.21 ± 0.42 and 21.64 ± 0.63 µg/mL, respectively, while anti-inflammatory properties were strongly shown by the compound with IC50 values of 25.71 ± 0.54 and 15.28 ± 0.66 µg/mL, respectively. The presence of diarylheptanoid content that has good pharmacological activity can support the used of E. calophrys as a nutraceutical source. Keywords: Anti-inflammatory, antioxidant, diarylheptanoid, Etlingera calophrys, fruit
Co-Authors A.A. Ketut Agung Cahyawan W Achmad Fuad Hafid Adryan Fristiohady Ahmad Zaeni Anem Alimdam Annisa Mayzealuna Ardiyanti Ardiyanti Arifa Mustika Ario Imandiri Ario Imandiri Asrul Sani Aty Widyawaruyanti Baane, Wa Berliana Devianti Putri Budikafa, Muhammad Jefriyanto Bunga Putri Salsabillah Efendi Carissa Alfreda Assyarahil Daud, Nur Saadah Dessy Harisanty Dwi Indah Dwi setiani Edith Frederika Puruhito, Edith Frederika Edith Frederika, Edith Erikha Magdalena Sjioen Fadhliyah Malik Firmansyah, Daniyal Fredy Talebong Fristiohady, Adryan Galuh Puja Hasnawati Hasnawati HM, Nurhayani Ilkafah Ilkafah, Ilkafah Karmilah, Karmilah Kasmawati, Henny L.O.M Fitrawan La Ode Muhammad Julian Purnama Loly Subhiaty Idrus Maasyitoh Sari Latifah Madjid, Waode Istiqamah Malaka, Muhammad Hajrul Malaka, Muhammad Hajrul Mallarangeng, Andi Nafisah Tendri Adjeng Marita Tri Santi Marjianto, Rachman Sinatriya Maulida Rizki Roswandi, Alyaa' Meilany, Elvianti Muhammad Azhar Muhammad Hajrul Malaka Muhammad Ilyas Yusuf Muhammad Israwan Azis Musabar, Nasyrah Musadar Mappasomba Musdalipah Musdalipah, Musdalipah Myrna Adianti Myrna Adiyanti Nasria, N Nasria, Nasria Nidaul Fauziah Nur Illiyyin Akib Nurlena Ikawati Nurlena Ikawati, Nurlena Onny Priskila Purwitasari, Neny Purwowati, Dewi Qodri, Rarasanti Rania Rahmanisa, Adiba RATNA WAHYUNI Rina Andriani Ruslin Ruslin Sabarudin Sabarudin Sabarudin Sabarudin Sahidin Sahidin . Sahidin Sahidin Sahidin, S Saikhunuddin Samy Bazher Santi, Marita Tri Saputra, Muhammad Juharisman Saripuddin Saripuddin Septriana, Maya Siska Arianti Sitti Raodah Nurul Jannah Sofiatun Sumardiko, Dwi Setiani Sunandar Ihsan, Sunandar Suryani Dyah Astuti Suryani Suryani Suryani Suryani Suryani Suryani Syarahiel Hamdani Taufiqurrahman Sidqi W Wahyuni, W Wa Ode Salma Wahyuni Wahyuni Waode Sukmawati Arsyad Wiwied Ekasari Yamin, Y Yamin, Yamin Yodha, Agung Wibawa Mahatva Yuliansyah Yuliansyah Zulbayu, La Ode Muhammad Andi