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All Journal JURNAL KIMIA SAINS DAN APLIKASI KOVALEN: Jurnal Riset Kimia Jurnal Sains dan Teknologi Pangan Jurnal Progres Kimia Sains Jurnal Penelitian Pendidikan IPA (JPPIPA) Chemistry Indonesian Journal of Chemical Research Jurnal Ilmu Kefarmasian Indonesia Sarwahita : Jurnal Pengabdian Kepada Masyarakat Cokroaminoto Journal of Chemical Science Jurnal Mandala Pengabdian Masyarakat Jurnal Akademika Kimia Amal Ilmiah: Jurnal Pengabdian Kepada Masyarakat Jurnal Akademika Kimia Jurnal Analis Kesehatan Kendari
THAMRIN AZIS
UNIVERSITAS HALU OLEO
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health Social Sciences Other

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Journal : Jurnal Analis Kesehatan Kendari

 1 
UJI AKTIVITAS ANTIOKSIDAN SENYAWA METABOLIT SEKUNDER DARI EKSTRAK KULIT BATANG PALIASA (Kleinhovia hospita Linn) Imran; Angga Febrian; Zainal Syam Arifin; Thamrin Azis; I Wayan Sutapa; Nohong; La Agusu; Syahrir; Alwahab
Jurnal Analis Kesehatan Kendari Vol. 7 No. 2 (2025): Jurnal Analis Kesehatan Kendari (JAKK) : Vol. 7 (2) Juni 2025)
Publisher : Program Study of Medical Laboratory Technology , Politeknik Bina Husada Kendari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46356/jakk.v7i2.351

Abstract

This study aims to test the antioxidant activity of secondary metabolite compounds contained in paliasa (Kleinhovia hospita Linn) stem bark extract. This plant is traditionally known to have health benefits, but research on the antioxidant activity of its stem bark is still limited. Extraction was done using a maceration method using a methanol solvent, followed by liquid-liquid fractionation using n-hexane and ethyl acetate to separate compounds based on their polarity. Phytochemical screening showed that the n-hexane fraction contained alkaloids and terpenoids, while the ethyl acetate fraction contained alkaloids, flavonoids, tannins, and saponins. The antioxidant activity of both fractions was tested using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method with absorbance measurements at a wavelength of 517 nm. The test results showed that the ethyl acetate fraction had an IC50 value of 51.7687 ppm, while the n-hexane fraction had an IC50 value of 60.5442 ppm. Based on the classification of antioxidant activity, both fractions are categorized as strong antioxidants (IC50 between 50-100 ppm). For comparison, vitamin C has an IC50 value of 14.3421 ppm, indicating strong antioxidant activity. The results of this study indicate that paliasa bark extract, especially the ethyl acetate fraction, has the potential as a source of natural antioxidants that can be further developed in the pharmaceutical, cosmetic, and food industries as an alternative to synthetic antioxidants with toxicity risks.
Co-Authors A. Nurwahida Aceng Haetami, Aceng Aden Mula Pratiwi Alimin Alwahab Alwahab Amalia, Fajri Fitra Angga Febrian Bijang, Catherina M. C Bijang C Bijang Caterina Bijang Catherina Bijang Dewi Sri Dewi, Dian Puspita Dian Permana Fajrin E. Rosa Fransina, Eirene G. Haris W Hasanela, Nurani Holilah Holilah, Holilah I Wayan Sutapa Imran Imran Imran Imran Imran Irwan Irwan Joris, Shielda N. Juwita, Citra Kadir, La Ode Abd Keke Awaliyah Kelrey, Adhi G. La Aba La Agusu La O. Ahmad La Ode Abd Kadir La Ode Abd Kadir La Ode Abd Kadir La Ode Ahmad La Ode Kadidae, La Ode La Ode Santiaji Bande La Rudi Laily Nurliana Laily Nurliana Laode A. Kadir Laode A. Kadir Laode Abdul Kadir Laode Abdul Kadir M. Natsir Mansur, Inda Ulfa Matheis F. J. D. P. Tanasale Maulidiyah Maulidiyah Maulidiyah Maulidiyah Maulidiyah MAULIDIYAH MAULIDIYAH Maulidiyah Maulidiyah Muh Natsir Muh. Natsir Muh. Natsir Muh. Natsir Muh. Nurdin Muh. Nurdin, Muh. Muh. Zakir Muzakkar Muhammad Nurdin Muhammad Nurdin Muhammad Nurdin Muhammad Nurdin Muhammad Zakir Muzakkar Muhammad Zakir Muzakkar Muslia, Wa O. Muzakkar, Muhammad Zakir Muzakkari, Muhammad Z. Nasriadi Dali Nasriadi, Nasriadi Nohong Nohong Nohong Nohong Nohong Nohong, Nohong Nur Illyyin Akib Nurhaeni R, Halimatussaddiyah Ratna Ratna Ratna Ruslan Ruslan Ruslan Ruslin Ruslin Sahidin SITTI HADIJAH SABARWATI Sitti Ratna Sri Wahyuni Syahrir T Nurwahida Tahril Tanasale, M.F.J.D.P. Tehuayo, Ahmadin Ulfa H. Syam Viesta Valentin Octavian Wa Ode Harlis Wiwik Handayani Yodha, Agung Wibawa Mahatva Zainal Syam Arifin Zul Arham