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All Journal ODONTO Dental Journal Dental Journal (Majalah Kedokteran Gigi) Padjadjaran Journal of Dentistry Indonesian Journal of Dental Medicine Sinnun Maxillofacial Journal Odonto dental journal
Diah Savitri Ernawati
Departement Of Oral Medicine, Faculty Of Dental Medicine, Universitas Airlangga
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Mauli banana stem extract application increased expression of NF-κB in traumatic ulcer healing Maharani Laillyza Apriasari; Retno Pudji Rahayu; Diah Savitri Ernawati
Dental Journal (Majalah Kedokteran Gigi) Vol. 51 No. 2 (2018): June 2018
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v51.i2.p67-70

Abstract

Background: A traumatic ulcer represents one of the most prevalent disorders affecting the oral cavity. Ulceration of the oral cavity potentially results in secondary infection requiring topical medication which involves the use of antiseptics to accelerate wound healing. Previous research has shown that Mauli banana (Musa acuminata) stem extract (MBSE) contains bioactive material from terpenoid saponin present in Ambon bananas. The terpenoid saponin in Ambon banana stems will be captured by a G protein receptor in the macrophages, subsequently producing a protein kinase C that activates nuclear factor kappa beta (NF-κB). This increases both the activity and number of macrophages. Purpose: To analyze the expression of NF-κB (p50) in traumatic ulcers as an effect of MBSE. Methods: A true experimental design with a post-test only control group. It involved 40 male Rattus norvegicus strain rats as traumatic ulcer models divided into four groups: the negative control group administered gel, and the other treatment groups administered 25%, 37.5% and 50% ethanol extracts of MBSE gel respectively. A biopsy was performed on days 3 and 5. The preparation was produced to analyze the expression of NF-κB (p50) by means of immunohistochemistry examination. Results: There was a significant difference (p<0.05) in NF-κB (p50) expression (p=0.005) following MBSE gel administration of 37.5% concentration on day 3 compared to day 5. Conclusion: It can be concluded that MBSE gel topical application can increase expression of NF-κB (p50) in traumatic ulcer healing.
Acid fast bacilli detected in the oral swab sample of a pulmonary tuberculosis patient Reiska Kumala Bakti; Ni Made Mertaniasih; Diah Savitri Ernawati; Bagus Soebadi; Priyo Hadi
Dental Journal (Majalah Kedokteran Gigi) Vol. 51 No. 2 (2018): June 2018
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v51.i2.p91-94

Abstract

Background: Tuberculosis (TB) is an infectious disease that persists as a health problem worldwide. Mycobacterium tuberculosis, as an etiological agent, is transmitted from infected to uninfected individuals via airborne droplet nuclei. Oral health care workers or dental practitioners may be at high risk of TB infection because of their close proximity to infected individuals during treatment procedures. Simple and rapid screening of mycobacterium tuberculosis in the oral cavity is necessary in order to prevent transmission of infection. Purpose: To investigate the presence of acid-fast bacilli in the buccal mucosa of pulmonary TB patients. Methods: Nineteen pulmonary TB patients of both sexes, ranging in age from 19 to 74 years old participated in this study. The diagnosis of tuberculosis was performed by clinical symptom assessment and supporting examination, including acid-fast bacilli on sputum examination. Two buccal mucosa swabs taken from pulmonary TB patients were collected for acid fast bacilli direct smear by Ziehl Neelsen staining. Results: With regard to mycobacterium tuberculosis, acid-fast bacilli presented in 10.5% of the oral buccal mucosa swabs of subjects, whereas in the sputum specimens, bacilli were found in 52.6% of subjects. Conclusion: Acid-fast bacilli can be found in the buccal epithelial mucosa of pulmonary tuberculosis patients, although its presence was very limited.
Effects of sidestream tobacco smoke on P53 expressions in Rattus novergicus tongue epithelial mucosa Dian Angriany; Diah Savitri Ernawati; Adiastuti Endah Parmadiati; Hening Tuti Hendarti; Rosnah Binti Zain
Dental Journal (Majalah Kedokteran Gigi) Vol. 52 No. 3 (2019): September 2019
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v52.i3.p138-141

Abstract

Background: Smoking, both active and passive, has been widely recognised as toxic to the human body, since it induces several forms of cancer, including that affecting the oral cavity. Benzopyrene, the carcinogen contained in tobacco smoke, can even lead tocarcinogenesis which potentially affects the regulation of cell apoptosis in both active and passive smokers. Purpose: This study aims to investigate the carcinogenic effects of cigarette smoke on apoptosis of rat tongue mucosae through p53 expression. To determine the risk of malignant transformation through tumor suppressor genes in the apoptotic pathway. Methods: Rattus norvegicus subjects were divided into four groups, namely Treatment Group 1 exposed to sidestream cigarette smoke for four weeks (P1), Treatment Group 2 exposed to sidestream cigarette smoke for eight weeks (P2), Control Group not exposed to sidestream cigarette smoke for four weeks (K2), and Control Group (K) not exposed to sidestream cigarette smoke for eight weeks (K2). The exposure process was conducted using a smoking pump and alternating exposure. Four micron-thick sections of formalin were subsequently fixed together with paraffin embedded biopsy material from tongue mucosa of Rattus norvegicus. The tissue sections from the treatment groups were then analyzed immunohistochemically to compare the expressions of p53 and Bcl-2 proteins with those of the control groups. Results: The T-test results indicated statistically significant differences in the expressions of p53 between the 4-week control group (K1) and the 4-week treatment group (P1) (p=0.01, p<0.05) as well as between the 8-week control group (K2) and the 8-week treatment group (P2) (p=0.03, p<0.05). Conclusion: Exposure to cigarette smoke can induce changes in tumor suppressor genes and also affect the regulation of cell apoptosis, thus changing cell structure and leading to malignancy.
The correlation between exposure to cigarette smoke and the degree of mucosal epithelium-based dysplasia in Rattus norvegicus tongues Dorisna Prijaryanti; Diah Savitri Ernawati; Desiana Radithia; Hening Tuti Hendarti; Rosnah Binti Zain
Dental Journal (Majalah Kedokteran Gigi) Vol. 52 No. 4 (2019): December 2019
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v52.i4.p187-191

Abstract

Background: Cigarette smoke contains various carcinogenic substances such as polycyclic aromatic hydrocarbons and nitrosamines. These chemicals not only have the potential to damage DNA, but can also induce genetic mutations and activate genes that function during apoptosis. Thus, if the gene is dysregulated, it will cause cells to survive, proliferate and subsequently lead to the development of cancerous ones. Histologically, the carcinogenic process affecting the oral cavity starts with hyperplasia and dysplasia, followed by severe dysplasia then leading to invasive cancer and metastatic processes in other bodies. Purpose: This study aims to reveal the correlation between exposure to cigarette smoke and the degree of epithelial dysplasia evident in research subjects. Methods: This study used 27 samples of Rattus norvegicus tongue, divided into three groups, namely; a control group, a treatment group subjected to four weeks’ exposure to cigarette smoke, and a treatment group subjected to exposure lasting eight weeks. Each rat was placed in an individual chamber and exposed to smoke from 20 cigarettes introduced by a pump via a pipe for 7.5 minutes. The degree of epithelial dysplasia in each case was subsequently observed microscopically using HE staining technique. Results: Mild epithelial dysplasia increased by 0.82%, during the fourth week of exposure to cigarette smoke and by 2.99% during the eighth week. Similarly, moderate epithelial dysplasia rose by 5.29% during the fourth week of exposure and 5.99% during the eighth week. Severe epithelial dysplasia also increased by 2.2% during the fourth week of exposure and by 2.66% during the eighth week. Conclusion: The longer the exposure to cigarette smoke, the higher the degree of ensuing dysplasia.
Clinical appearance of acute pseudomembranous candidiasis in children and the importance of good communication, information and education to patients: A case report Afryla Femilian; Winda Dwi Malinda Masuku; Nurina Febriyanti Ayuningtyas; Diah Savitri Ernawati; Fatma Yasmin Mahdani; Meircurius Dwi Condro Surboyo
Dental Journal (Majalah Kedokteran Gigi) Vol. 55 No. 2 (2022): June 2022
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v55.i2.p105-108

Abstract

Background: Oral candidiasis is a common opportunistic infection of the oral cavity caused by an overgrowth of the Candida species, in particular, Candida albicans. The incidence varies depending on age and certain predisposing factors. In the practice of dentistry, doctor-patient communication is an important component. Effective communication between doctor and patient is needed to convey information and educate patients so that treatment can be administered appropriately. Purpose: This case aimed to discuss the clinical appearance of acute pseudomembranous candidiasis (APC) in children and the importance of good communication, information and education of patients. Case: A five-year-old male patient came with his mother on November 6, 2020 complaining of white deposits on the mucosa of the upper and lower lips that had been present for a week. Case management: The diagnosis was defined as a typical APC lesion although the potassium hydroxide (KOH) test showed negative results. Characteristic lesions found in APC are often seen clearly in some cases and treatment can begin immediately. Patients receive the empirical therapy, Nystatin oral suspension 100.000 i.u, and the patient is instructed to maintain optimal oral hygiene care, maintain nutrient intake and book a follow-up consultation. Conclusion: Mistakes in patient preparation procedures in taking supporting examinations will result in false negative/positive results, so communication and education information regarding the preparation of supporting examinations for patients is important to note.
RECURRENT APHTHOUS STOMATITIS RELATED TO PSYCHOLOGICAL STRESS, FOOD ALLERGY AND GERD Rina Kartika Sari; Diah Savitri Ernawati; Bagus Soebadi
Odonto : Dental Journal Vol 6, No 1 (2019): July 2019
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (755.149 KB) | DOI: 10.30659/odj.6.0.45-51

Abstract

Background: Recurrent Aphthous Stomatitis (RAS) is inflammation in oral mucosa characterized by recurrent single or multiple ulcers that usually affected in non keratinized mucosa. Etiology RAS is unknown but psychological stress, allergy, and gastrointestinal disease can be predisposing factors Case Management: A 23rd years old complained recurrent oral ulcer with free ulcer period for 3-5 days. The patient had a history of food allergy, GERD and psychological stress. Intraoral examination showed recurrent multiple ulcers in variation site of the mouth. DASS 42 screening showed high stress and high anxiety. Skin Prick Test showed positive allergy to kapok, beef, chicken, cow milk, white egg, duck egg, shrimp, cob fish, milkfish, chocolate, and peanut. Ulcers treated with nonsteroid antiinflammation Aloe Vera gel and stress management by reading assignment method.Discussion: Psychological stress altered the immune system so oral mucosa prone to inflammation, and make the history of GERD getting worse. Stress causes cortisol secretion that changes the imbalance of proinflammatory and antiinflammatory cytokines. Oral mucosa becomes more susceptible to hypersensitivity. In addition, stress decreased oral and esophageal mucosa resistance to GERDConclusion: RAS triggered by psychological stress, allergy, and GERD. Treatment of RAS is by elimination predisposing factors to prevent recurrence.
Prevalensi Lesi Oral sebagai Manifestasi HIV/AIDS pada Orang Dengan HIV (ODHIV) yang Mengonsumsi Highly Active Antiretroviral Therapy di Komunitas Mahameru Surabaya Indonesia Radithia, Desiana; Ernawati, Diah Savitri; Bakti, Reiska Kumala; Pratiwi, Aulya Setyo; Ayuningtyas, Nurina Febriyanti; Mahdani, Fatma Yasmin; Pasaribu, Togu Andrie Simon; Puspasari, Karlina; Pramitha, Selviana Rizky; Dewi, Gremita Kusuma
Sinnun Maxillofacial Journal Vol. 6 No. 01 (2024): April 2024
Publisher : Fakultas Kedokteran Gigi Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/smj.v6i01.127

Abstract

Pendahuluan: Terjadinya lesi oral pada Orang Dengan HIV (ODHIV) telah banyak dihubungkan dengan peningkatan viral load, penurunan jumlah CD4+, dan konsumsi Highly Active Antiretroviral Therapy (HAART) yang walaupun penggunaannya dapat meningkatkan kondisi umum ODHIV, tetapi penggunaan dalam jangka panjang juga akan memicu berbagai perubahan secara sistemik dan lokal. Tujuan Penelitian: Penelitian ini bertujuan untuk mendata prevalensi terjadinya lesi oral pada ODHIV yang menggunakan HAART. Metode: Penelitian ini menggunakan jenis penelitian observasi cross sectional dengan total sampling sesuai dengan STOBE statement. Data dicatat pada formulir kuesioner dan formulir pemeriksaan klinis. Hasil: Sebanyak total 40 orang peserta dilaporkan dalam penelitian ini. Jenis HAART yang paling banyak dilaporkan penggunaannya dalam jangka panjang tanpa perubahan adalah TLD (27,5%), sementara jenis terapi dengan perubahan regimen adalah terapi awal dengan Duviral Neviral menjadi terapi dengan TLD (12,5%). Durasi terapi HAART selama lebih dari 3 tahun tercatat pada 29 peserta (72,5%) dan durasi terapi kurang dari 3 tahun tercatat pada 11 peserta (27,5%). Lesi oral yang paling banyak diobservasi adalah diffuse oral hyperpigmentation (47,62%), diikuti oleh coated tongue (23,81%), traumatic ulcer (4,76%), linea alba (4,76%), torus palatinus (4,76%), dan lesi-lesi lainnya. Kesimpulan: Lesi oral yang paling banyak ditemukan adalah oral diffuse hyperpigmentation dan korelasinya dengan penggunaan HAART masih perlu ditelaah lebih lanjut.
Sialorrhea with Neurological Diseases in Oral Medicine Fields: A Narrative Review Ernawati, Diah Savitri; Pasaribu, Togu Andrie Simon
Indonesian Journal of Dental Medicine Vol. 5 No. 2 (2022): Indonesian Journal of Dental Medicine
Publisher : Faculty of Dental Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijdm.v5i2.2022.54-56

Abstract

 Background: Sialorrhea also known as drooling, literally means excessive saliva flow. In patients with neurological conditions such as Parkinson's disease, cerebral palsy, and stroke. drooling or sialorrhea conditions can be a problem in their lives. In patients with neurological disorders, they experience impaired coordination of facial and mouth muscle movement. Purpose: To describe a review comprehensive management of sialorrhea in neurological, then quality of life can be improved. Reviews: literature search was done thorough literature search between 2008-2020 was done using Science direct, Pubmed and Google Scholar. Conclusion: Treatment for sialorrhea includes non-medical therapy, medical therapy, botulinum toxin, radiotherapy and surgical treatment. Oral medicine specialist dentists have a role in the care of sialorrhea patients with neurological disorders in terms of oral care related as a result of sialorrhea such as perioral dermatitis.
Stress-induced Oral Lichen Planus Immunopathogenesis and Potential Therapy: A Narrative Review Basalamah, Fatimah F.; Pramitha, Selviana R.; Pasaribu, Togu Andrie S.; Rahayu, Retno Pudji; Ayuningtyas, Nurina Febriyanti; Ernawati, Diah Savitri
Indonesian Journal of Dental Medicine Vol. 5 No. 2 (2022): Indonesian Journal of Dental Medicine
Publisher : Faculty of Dental Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijdm.v5i2.2022.57-61

Abstract

 Background: Oral lichen planus is a chronic inflammatory condition that only involves in the oral cavity and is mediated by the cellular immune system. The etiology of OLP is unclear but autoreactive T lymphocytes are considered to play an important role in the development of OLP. Factors like stress and psychological anxiety have been associated with OLP but their roles in the development of OLP is yet explored. Purpose: To describe stress-induced OLP immunopathogenesis and therapeutic potential. Reviews: In the early stages, the mechanism of OLP involves the expression of keratinocyte antigens or exposure to an antigen in the form of self-peptide or heat shock protein (HSP). HSP90 is the most expressed heat shock protein in the basal layer of keratinocytes and plays a role in recruitment of cellular immune cells through the production of cytokines due to TLR2/4 and CD91 activation, inflammatory cell migration due to 4 integrin activation, and increased antigen presentation due to HSP90-peptide binding to MHC class I/II. Stress as a physiological response triggers the release of the hormone cortisol from the adrenal cortex and catecholamine hormones such as epinephrine/ adrenaline and norepinephrine/noradrenaline from the adrenal medulla. Catecholamines increase the migration of T lymphocyte cells through the interaction of integrins and integrin ligands on the endothelium through the expression of 2-integrin after binding to adrenergic receptors on the cell membrane. Conclusion: Oral lichen planus is a chronic inflammatory condition caused by various factors where stress increases the migration of T lymphocyte cells on the side that expresses self-peptides and antigens through the interaction of immune cells with catecholamines. Topical nonselective beta blockers can be supporting therapy in reducing pain and size of OLP lesions.
The Role of Mycobacterium Tuberculosis Detection on Oral Mucosa in Diagnosis of Pulmonary Tuberculosis Bakti, Reiska Kumala; Soebadi, Bagus; Ernawati, Diah Savitri; Mertaniasih, Ni Putu Made
Indonesian Journal of Dental Medicine Vol. 6 No. 1 (2023): Indonesian Journal of Dental Medicine
Publisher : Faculty of Dental Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijdm.v6i1.2023.8-12

Abstract

Background. Tuberculosis is one of the world's health problems, with larger mortality rate than HIV/AIDS. In order to control this disease, a new and inexpensive diagnostic method is needed. Oral samples, such as buccal mucosa epithelium, can be an alternative specimen, other than sputum, in the diagnosis of tuberculosis. Purpose. This study aimed to analyze the presence of Mycobacterium tuberculosis on buccal swabbing of tuberculosis patients. Method. Study was conducted on 18 new pulmonary tuberculosis patients in TB DOTS unit of Dr. Soetomo General Hospital. Each subject was swabbed on the buccal mucosa of the oral cavity for subsequent examination of PCR, AFB, and culture to detect Mycobacterium tuberculosis in the oral cavity. Result. The results showed that Mycobacterium tuberculosis was detected from 2 study subjects (11%) using PCR, whereas in AFB and culture examination methods no Mycobacterium tuberculosis was detected on buccal mucosa of the oral cavity. Conclusion. This study showed that Mycobacterium tuberculosis was detected on buccal mucosa swab of tuberculosis patients based on PCR technique, but this method is less suitable in diagnosis of pulmonary tuberculosis.
Co-Authors Adiastuti Endah Parmadiati Ayunnisa, Naqiya Bagus Soebadi Bagus Soebadi Bagus Soebadi Bagus Soebadi, Bagus Basalamah, Fatimah F. Desiana Radithia, Desiana Dewi Puspitasari Dewi, Gremita Kusuma Dian Angriany Dorisna Prijaryanti Fatma Yasmin Mahdani Femilian, Afryla Ferry Sandra Haryono Utomo Hening Tuti Hendarti Ika Rhisty Cendana Sari Indah Listiana Kriswandini Indrayadi Gunardi Iwan Hernawan Kuntardjo, Yuhanna Maharani Laillyza Apriasari Maharani, Annissaqiella Manuaba, Ida Bagus Pramana Putra Maretaningtias Dwi Ariani, Maretaningtias Dwi Mertaniasih, Ni Putu Made Ni Made Mertaniasih Nurina Febriyanti Ayuningtyas Pasaribu, Togu Andrie S. Pasaribu, Togu Andrie Simon Pramitha, Selviana R. Pramitha, Selviana Rizky Pratiwi, Aulya Setyo Priyo Hadi Priyo Hadi Puspasari, Karlina Puspitasari, Yeni Putri, Salsabila Fitriana Rahmi Amtha Reiska Kumala Bakti Retno Pudji Rahayu Rina Kartika Sari Rini Devijanti Ridwan Riskayanti, Ni Putu Rosnah Binti Zain Saka Winias Santosh, Arvind Babu Rajendra Sismiyanti, Rossy Surboyo, Meircurius Dwi Condro Winda Dwi Malinda Masuku