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All Journal ODONTO Dental Journal Dental Journal (Majalah Kedokteran Gigi) Padjadjaran Journal of Dentistry Indonesian Journal of Dental Medicine Sinnun Maxillofacial Journal Odonto dental journal
Diah Savitri Ernawati
Departement Of Oral Medicine, Faculty Of Dental Medicine, Universitas Airlangga
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Hubungan Tingkat Pengetahuan Terhadap Sikap Orang dengan HIV/AIDS pada Oral Hairy Leukoplakia dan Kandidiasis Oral Radithia, Desiana; Ernawati, Diah Savitri; Surboyo, Meircurius Dwi Condro; Ayuningtyas, Nurina Febriyanti; Mahdani, Fatma Yasmin; Pratiwi, Aulya Setyo; Sismiyanti, Rossy; Kuntardjo, Yuhanna; Puspitasari, Yeni
Sinnun Maxillofacial Journal Vol. 6 No. 02 (2024): Oktober 2024
Publisher : Fakultas Kedokteran Gigi Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/smj.v6i02.128

Abstract

Pendahuluan: HIV/AIDS telah menjadi masalah kesehatan masyarakat global. Infeksi HIV dapat menyebabkan gangguan kekebalan tubuh dan bermanifestasi di beberapa tempat baik secara sistemik maupun di rongga mulut. Manifestasi oral yang paling umum terkait dengan HIV/AIDS adalah Kandidiasis Oral dan Oral Hairy Leukoplakia. Sebagai orang yang hidup dengan HIV/AIDS (ODHIV) mungkin menemukan manifestasi tersebut, pengetahuan mereka dapat menentukan sikap mereka terhadap temuan tersebut.Tujuan Penelitian: Mengamati sikap ODHIV di kota Surabaya terhadap dua manifestasi oral HIV yang paling umum ditemukan, yaitu Oral Hairy Leukoplakia dan Kandidiasis Oral, serta menentukan hubungan antara pengetahuan dan sikap mereka terhadap hal tersebut. Bahan dan Metode: Sebanyak 30 responden diberikan kuesioner untuk menilai pengetahuan dan sikap mereka mengenai Oral Hairy Leukoplakia dan Kandidiasis Oral. Pengetahuan didefinisikan dengan kriteria baik, cukup, dan rendah. Sikap didefinisikan sebagai positif, netral, dan negatif. Hasil: Tingkat pengetahuan mengenai Oral Hairy Leukoplakia dan Kandidiasis  Oral menunjukkan hasil tinggi (33%), sedang (54%) dan rendah (13%). Responden menunjukkan sikap positif (30%) dan sikap tidak setuju (27%), sedangkan netral (43%). Terdapat hubungan positif yang signifikan antara tingkat pengetahuan responden dengan sikap mereka (p = 0,46). Kesimpulan: Terdapat hubungan antara pengetahuan yang baik dengan sikap positif pada masyarakat.
White sponge nevus as a hereditary disease: A brief narrative review Mahdani, Fatma Yasmin; Puspasari, Karlina; Manuaba, Ida Bagus Pramana Putra; Putri, Salsabila Fitriana; Ayunnisa, Naqiya; Ernawati, Diah Savitri; Hendarti, Hening Tuti
Indonesian Journal of Dental Medicine Vol. 8 No. 1 (2025): Indonesian Journal of Dental Medicine
Publisher : Faculty of Dental Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijdm.v8i1.2025.49-52

Abstract

Background: White sponge nevus (WSN) is an autosomal dominant hereditary genetic disorder characterized by thickened keratin in the oral mucosa that appears folded, wavy, spongy, thick, and rough. WSN do not have the potential to become malignant, but an accurate diagnosis is still needed to prevent unnecessary treatment and reduce potential remissions and exacerbations due to infection. Purpose: to provide a detailed description of white sponge nevus as a hereditary disease by means of narrative review. Review: A literature search using ScienceDirect and PubMed yielded results between 2012 and 2024. The keywords of the search strategy were “hereditary disease” and “white sponge nevus” or “Cannon’s disease” or “white folded gingivostomatitis” or “leukokeratosis.”. White sponge nevus (WSN) was first discovered by Hyde in 1909 and usually occurs in children and people under 20 years old. The main etiology of WSN is an autosomal dominant hereditary genetic disorder; KRT4 and KRT13 are specific keratin encoders that cause WSN, and there are predisposing factors such as bacterial infection, smoking, and alcohol consumption. Conclusion: In determining the diagnosis of WSN, it is necessary to carry out blood tests, subjective examinations, objective examinations, and supporting examinations in the form of exfoliative cytology and biopsies. As well as the need for comprehensive treatment, even though the prognosis of this disorder is good.
The effect of musa acuminata stem in increasing macrophage and neovascular cells of healing process Apriasari, Maharani Laillyza; Puspitasari, Dewi; Rahayu, Retno Pudji; Ernawati, Diah Savitri
Padjadjaran Journal of Dentistry Vol 30, No 2 (2018): July 2018
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (838.226 KB) | DOI: 10.24198/pjd.vol30no2.18324

Abstract

Introduction: Musa acuminata stem has both of imunostimulatory and imunosuppressant effects that are influenced by their concentrations. The study aimed to analyze the effect of Mauli banana stem extract (EMBS) to increase the number of macrophage and neovascular cells in traumatic ulcer healing. Methods: Rattus norvegicus of male Wistar strain  were used  as model of traumatic ulcer. The left buccal mucous was biopsied, then used the histopathology method to find the number of macrophage and neovascular cells. Results: EMBS gel was effected when administered at a concentration of 37.5% because it significantly increased the number of macrophage and neovascular cells in traumatic ulcer healing on the 3rd day to 5th days. Conclusion:  It can be concluded that EMBS within concentration of 37.5% can accelerate ulcer healing through the increasing  number of macrophage and neovascular cells.
Effect of freeze-dried platelet-rich plasma on FGF-2 and type I collagen expression in traumatic ulcers of diabetes mellitus: An in vivo study Riskayanti, Ni Putu; Radithia, Desiana; Maharani, Annissaqiella; Hendarti, Hening Tuti; Rahayu, Retno Pudji; Surboyo, Meircurius Dwi Condro; Ernawati, Diah Savitri
Dental Journal (Majalah Kedokteran Gigi) Vol. 58 No. 4 (2025): December
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v58.i4.p361-366

Abstract

Background: Diabetes mellitus is a chronic disease characterized by the pancreas’s inadequate production of insulin or the body’s impaired utilization of insulin, resulting in dysregulation of blood sugar levels. Diabetes mellitus causes prolonged wound healing due to decreased growth factors, including fibroblast growth factor 2 (FGF-2) and type I collagen. Purpose: This research analyzes the effect of topical administration of freeze-dried platelet-rich plasma (FD-PRP) on the healing process of traumatic ulcers in diabetic Wistar rats by increasing FGF-2 and type I collagen expression. Methods: Allogenic FD-PRP was obtained from the blood of 35 Wistar rats and 2% carboxymethyl cellulose (CMC) was added to make a gel formulation. Diabetes was induced in 30 Wistar rats using streptozotocin, followed by the creation of traumatic ulcers on the lower labial mucosa using a hot burnisher. The traumatic ulcers were then topically treated with FD-PRP gel in the treatment group and 2% CMC gel in the control group. Analysis of FGF-2 and type I collagen expression was performed through indirect immunohistochemical methods following treatment for 3, 5, and 7 days. Results: The expression of FGF-2 and type I collagen in the FD-PRP was higher than in the control group (p < 0.05). Conclusion: Topical application of FD-PRP plays an important role, especially in increasing the FGF-2 and type 1 collagen expression, in the healing process of traumatic ulcers in diabetic Wistar rats.
Oral field cancerization: Genetic profiling for a prevention strategy for oral potentially malignant disorders Puspasari, Karlina; Pasaribu, Togu Andrie Simon; Surboyo, Meircurius Dwi Condro; Ayuningtyas, Nurina Febriyanti; Santosh, Arvind Babu Rajendra; Ernawati, Diah Savitri
Dental Journal (Majalah Kedokteran Gigi) Vol. 56 No. 3 (2023): September
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v56.i3.p189-196

Abstract

Background: Oral cancer therapy, such as radiation or surgical treatment, has pernicious long-term effects that patients suffer throughout their life, the disability being considerable with delayed diagnosis. It is well known that many oral cancers develop from oral potentially malignant disorders (OPMDs). Patients diagnosed with OPMDs may have an increased risk of developing cancer anywhere in the oral cavity. Early detection and intervention could be essential prevention strategies to inhibit oral cancer progression. OPMDs may not immediately develop into carcinoma. However, this condition provides a "field” of specific abnormalities wherein evolving altered genetic cells can be explained with the "field cancerization” concept. Purpose: This review aims to describe the "field cancerization” concept in oral cancer and OPMD, which is expected to contribute to a better clinical management strategy for oral cancer prevention. Review: "Oral field cancerization” describes oral cancers that develop in multifocal areas of pre-cancerous changes. It can be found as histologically abnormal tissue surrounding the tumor, suggesting that oral cancer often consists of multiple independent lesions. Conclusion: The oral field cancerization concept should prompt healthcare professionals to remind their patients that frequent oral examination with histological studies and molecular testing is mandatory for those at high risk of developing malignancies.
Co-Authors Adiastuti Endah Parmadiati Ayunnisa, Naqiya Bagus Soebadi Bagus Soebadi Bagus Soebadi Bagus Soebadi, Bagus Basalamah, Fatimah F. Desiana Radithia, Desiana Dewi Puspitasari Dewi, Gremita Kusuma Dian Angriany Dorisna Prijaryanti Fatma Yasmin Mahdani Femilian, Afryla Ferry Sandra Haryono Utomo Hening Tuti Hendarti Ika Rhisty Cendana Sari Indah Listiana Kriswandini Indrayadi Gunardi Iwan Hernawan Kuntardjo, Yuhanna Maharani Laillyza Apriasari Maharani, Annissaqiella Manuaba, Ida Bagus Pramana Putra Maretaningtias Dwi Ariani, Maretaningtias Dwi Mertaniasih, Ni Putu Made Ni Made Mertaniasih Nurina Febriyanti Ayuningtyas Pasaribu, Togu Andrie S. Pasaribu, Togu Andrie Simon Pramitha, Selviana R. Pramitha, Selviana Rizky Pratiwi, Aulya Setyo Priyo Hadi Priyo Hadi Puspasari, Karlina Puspitasari, Yeni Putri, Salsabila Fitriana Rahmi Amtha Reiska Kumala Bakti Retno Pudji Rahayu Rina Kartika Sari Rini Devijanti Ridwan Riskayanti, Ni Putu Rosnah Binti Zain Saka Winias Santosh, Arvind Babu Rajendra Sismiyanti, Rossy Surboyo, Meircurius Dwi Condro Winda Dwi Malinda Masuku