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All Journal PROSIDING SEMINAR NASIONAL JURNAL ILMIAH KESEHATAN KEPERAWATAN Journal Of Holistic Nursing Science Media Keperawatan Indonesia GEMASSIKA: Jurnal Pengabdian Kepada Masyarakat Jurnal Persatuan Perawat Nasional Indonesia (JPPNI) Community Empowerment Elastisitas Jurnal Ekonomi Pembangunan Jurnal Farmasi Sains dan Praktis Prosiding University Research Colloquium Borobudur Nursing Review Innovation in Health for Society Gaster GEMASSIKA: Jurnal Pengabdian kepada Masyarakat Jurnal Ilmiah Kesehatan Keperawatan Indonesia Jurnal Kebidanan
Heni Setyowati Esti Rahayu
Universitas Muhammadiyah Magelang, Magelang, Indonesia
Arts Humanities Computer Science & IT Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences

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Journal : JURNAL ILMIAH KESEHATAN KEPERAWATAN

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Efektivitas Perlakuan Kombinatif Plasma Medis dan Ekstrak Daun Sirih untuk Mempercepat Penyembuhan Luka Fase Proliferasi pada Model Mencit Diabetik Wahyuningtyas, Eka Sakti; Nasruddin, Nasruddin; Rahayu, Heni Setyowati Esti; Lutfiyati, Heni; Sikumbang, Isabella Meliawati; Nurani, Laela Hayu; Rohmani, Afiana; Salsabila, Nia; Putri, Gela Setya Ayu
Jurnal Ilmiah Kesehatan Keperawatan Vol 15, No 2 (2019): JURNAL ILMIAH KESEHATAN KEPERAWATAN
Publisher : LPPM STIKES MUHAMMADIYAH GOMBONG

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (566.983 KB) | DOI: 10.26753/jikk.v15i2.378

Abstract

The continued increase in the number of people with Diabetes Mellitus (DM) in Indonesia is a serious problem. One of the big problems for people with Diabetes Mellitus (DM) is the emergence of complications of diabetic wounds. To date the strategy for treatment of diabetic wounds has been limited to the use of wound dressing, cell therapy and oxygen therapy. The problem is that the strategy is not fully successful. Thus, it is very important to look for new strategies to improve the quality of diabetic wound healing, such as by applying a combination of plasma medicine and local natural product, like the extraction of Daun sirih (Piper betle) leaves. Plasma medicine is a relatively new and multidisciplinary study involving plasma science, biomedical, pharmaceutical and other health sciences aimed at applying plasma to therapeutic health. Plasma is the fourth phase of matter, after the solid, liquid and gas phase. The medical aspects of plasma are related to the ability of plasma to produce biological molecules Reactive Oxygen and Nitrogen Species (RONS). If RONS is controlled in the right dosage it can be efficacious for health therapy. This study intends to examine the effects of combinative treatment of plasma medicine and Piper betel leaf extract for proliferation phase of wound healing in diabetic small animal model. This study used male Balb c mice with acute wounds which were divided into 5 groups, namely groups of untreated normal mice (ND-TP), groups of untreated diabetic mice (D-TP), groups of diabetic mice wounds with Piper betel leaf extract (DS ), the wound group of diabetic mice with plasma medicine (DP) and the wound group of diabetic mice with plasma medicine and Piper betel leaf (DPS). The plasma medicine was treated on wound with condition non-contact style (the plasma jet did not touch the wound) with a distance of plasma jet reactor nozzle to the surface of wound about 20 mm, for 2 minutes, every day. Macroscopic observation of wounds is carried out every day from day 0 to 7. On day 7 it was seen that the size of the wound area for D-P-S was smaller than the other groups. The results of this study indicated that Piper betel leaf extract can potentially be used to optimize the performance of plasma medicine in accelerating diabetic wound healing during the proliferation phase. Further investigation, however, is important to be conducted to study the effect for all phases of wound healing and its mechanism histo-pathologically.
Co-Authors Abel Zulia Adhitama, Dimas Aji Afiana Rohmani Ahsan, Abdillah Ardianingrum, Nadia Arum Kartikadewi Ayu Lestari AYU LESTARI Chabibah, Puji Umi Desiana Dwi Utami Devi Kemala Dewi Dewanti, Amelia Cahya Dewi, Devi Kemala Dwi Rahayu Sulistyorini Dwi Sulistyono Eka Sakti Wahyuningtyas Eni Sulistiyowati Eni Sulistiyowati Estrin Handayani Evi Fajarwati Fajarwati, Evi Fajriyani, Safrina Fariza, Ida Gela Setya Ayu Putri Haryono, Hana Setiawati Heni Lutfiyati Heni Lutfiyati Heni Lutfiyati, Heni Herma Fanani Agusta Hikma Anisa Putri Imron Wahyu Hidayat Isabella Meliawati Sikumbang Isabella Meliawati Sikumbang Istikhomah Istikhomah, Istikhomah Kartika Wijayanti Kartika Wijayanti, S. Kep. Ns Kartikadewi, Arum Laela Hayu Nurani Laela Hayu Nurani Laela Hayu Nurani Lusiyati, Yeni M, Eva Novita Muji Setiyo Muta Aliva N Nasruddin Nadia Ardianingrum Nasruddin Nasruddin Nasruddin Nasruddin Nasruddin, N Nia Afifatul Ulya Nia Salsabila Nia Salsabila Nining Setiyo Apriyani Nur Wahyuni Nurul Umi Salamah Prasojo Pribadi Priyo - Putri Kurniasiwi Rahayu, Irna Fitriana Robiul Fitri Masithoh Rohmayanti Rohmayanti Rohmayanti Rohmayanti Rohmayanti, R Rusdjijati, Retno Salsabila, Nia Saputri, Rika Ariyanti Saputri, Rika Ariyanti Septi Wardani, Septi Setiyani, Dinda Sikumbang, Isabella Meliawati Siti Noor khikmah Sri Hananto Ponco Nugroho Sri Hananto Ponco Nugroho Sri Margowati Sri Margowati Sri, Margowati Sumarno Adi Subrata Thoriq Kurniawati Tiara Mega Kusuma Utami, Desiana Dwi Whanovita Prima Listiany Widiarta, Yuditya Wiji Astuti