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All Journal HAYATI Journal of Biosciences Jurnal Ilmu Dasar AL KAUNIYAH BERKALA SAINSTEK REKAYASA UNEJ e-Proceeding REINWARDTIA Jurnal Biodjati Caraka Tani: Journal of Sustainable Agriculture BIOEDUKASI JPSCR : Journal of Pharmaceutical Science and Clinical Research Journal of Natural Sciences Makara Journal of Science Jurnal Malikussaleh Mengabdi Life Science and Biotechnology Biosaintifika: Journal of Biology & Biology Education Reinwardtia Jurnal Penelitian Sains dan Teknologi Indonesia Jurnal Hasil Pengabdian Kepada Masyarakat Universitas Jember Biodiversitas Journal of Biological Diversity
Fuad Bahrul Ulum
Department Of Biology, Faculty Of Mathematics And Natural Sciences, Universitas Jember. Jl. Kalimantan No. 37, Jember 68121, East Java, Indonesia
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Control & Systems Engineering Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Immunology & microbiology Industrial & Manufacturing Engineering Library & Information Science Materials Science & Nanotechnology Mathematics Physics Public Health Social Sciences Other

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Morphological, molecular, and phytochemical characteristics of wild edible fern (Diplazium esculentum) from Jember, East Java, Indonesia YUSRINA RISKY AMALINI; KAHAR MUZAKHAR; MUKHAMAD SU’UDI; DWI SETYATI; EDIA FITRI DWINIANTI; FUAD BAHRUL ULUM
Biodiversitas Journal of Biological Diversity Vol. 26 No. 6 (2025)
Publisher : Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/biodiv/d260624

Abstract

Abstract. Amalini YR, Muzakhar K, Su’udi M, Setyati D, Dwinianti EF, Ulum FB. 2025. Morphological, molecular, and phytochemical characteristics of wild edible fern (Diplazium esculentum) from Jember, East Java, Indonesia. Biodiversitas 26: 2794-2805. Diplazium esculentum, an edible pteridophyte with medicinal potential, exhibits morphological variation that risks improper medicinal use. This study aimed to comprehensively characterize D. esculentum from Jember, Indonesia, through an integrative approach, including morphological analysis, DNA barcoding, phytochemical profiling, and antioxidant activity assessment. Fifteen specimens, locally referred to as pakis menir, were collected from a single site within a rubber-mixed coffee plantation in Panti, Jember District, East Java, Indonesia. The examination of morphological traits, molecular identification using the rbcL marker, analysis of phytochemical profiles through GC-MS, prediction of biological activities using PASS online, and evaluation of antioxidant activity using the DPPH assay all pointed to the potential of D. esculentum. Morphological analysis confirmed D. esculentum's diagnostic traits, while rbcL DNA barcoding validated a 100% sequence match with D. esculentum (OL536867.1). GC-MS analysis of young fronds identified 25 bioactive metabolites, including 11 phenolics, 9 terpenoids, and 5 alkaloids, with 96% exhibiting high biological activity (Pa>0.7) according to PASS predictions. The dominant compound, 3,6-dimethylquinoline (12.38%), exhibited significant anticancer potential, while the frond extract showed strong antioxidant activity (IC50: 91.25±7.60 ppm), reflecting its phenolic richness. These results highlight the potential of D. esculentum's phytochemical wealth and pharmacological promise, supporting further exploration in pharmacognosy, nutraceuticals, and bioactive compounds.
Phytochemical and pharmacological evaluation of Vanda tricolor from Gumitir, East Java, Indonesia FUAD BAHRUL ULUM; YUSI ANANDA PUTRI; ABDILLAH MAULANA FARHAN; DWI SETYATI; RANJITHKUMAR RAJAMANI; BAMBANG SUGIHARTO; MUKHAMAD SU’UDI
Biodiversitas Journal of Biological Diversity Vol. 26 No. 9 (2025)
Publisher : Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/biodiv/d260947

Abstract

Abstract. Ulum FB, Putri YA, Farhan AM, Setyati D, Rajamani R, Sugiharto B, Su’udi M. 2025. Phytochemical and pharmacological evaluation of Vanda tricolor from Gumitir, East Java, Indonesia. Biodiversitas 26: 4783-4792. Vanda tricolor an epiphytic orchid native to the coffee agroforest of Gumitir, East Java, Indonesia, represents a promising source of pharmacologically active compounds. This study aimed to characterize the bioactive constituents of V. tricolor and evaluate their antioxidant, antimicrobial, and anticancer potential. Methanolic leaf extracts were analyzed using gas chromatography-mass spectrometry (GC-MS) for metabolite profiling. Its biological activities were assessed through the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay, agar well diffusion method, and molecular docking against the antiapoptotic Bcl-2 protein. GC-MS analysis identified 48 metabolites, with 4-butylphenol (7.57%) as the predominant compound. The extract demonstrated very strong antioxidant activity (IC??: 37.25 ppm), along with moderate antibacterial effects against Staphylococcus aureus and Escherichia coli; however, it showed no growth inhibition against Salmonella typhi. Molecular docking revealed that 4-butylphenol exhibited the highest binding affinity toward Bcl-2 (-5.50 kcal/mol), indicating its potential as a lead compound for anticancer therapy. These findings represent the first integrated phytochemical and pharmacological profile of V. tricolor from Gumitir, underscoring its value as a source of natural bioactive agents. The results also provide a scientific basis for further exploration of orchids in drug discovery and contribute to the conservation of this underutilized native species.
Bioactivities and phytochemical profile of Cyclosorus parasiticus from East Java, Indonesia via GC-MS and LC-MS FUAD BAHRUL ULUM; DWI SETYATI; IKA OKTAVIANAWATI; MOH. IKMAL ALFI RIZQONI; ERLIN NOVITA SARI; KAHAR MUZAKHAR; MUKHAMAD SU’UDI
Biodiversitas Journal of Biological Diversity Vol. 27 No. 2 (2026)
Publisher : Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/biodiv/d270234

Abstract

Abstract. Ulum FB, Setyati D, Oktavianawati I, Rizqoni MIA, Sari EN, Muzakhar K, Su’udi M. 2026. Bioactivities and phytochemical profile of Cyclosorus parasiticus from East Java, Indonesia via GC-MS and LC-MS. Biodiversitas 27 (2): d270234. https://doi.org/10.13057/biodiv/d270234. Cyclosorus parasiticus is a terrestrial fern abundantly distributed in the area of Gumitir Mountain, East Java, Indonesia. Despite its ecological abundance, its pharmacological potential remains undercharacterised, although leaf tissues from Gumitir populations accumulate relatively high levels of flavonoids and alkaloids. Through an integrative bioassay–metabolomics approach, this study presents the first systematic evaluation of the antibacterial and antioxidant activities, together with comprehensive chemical profiling, of C. parasiticus from the Gumitir region. Metabolite annotation revealed pronounced chemical diversity, with 39 compounds identified by GC-MS and six dominant LC-MS features. Importantly, the diterpene euphornin and the alkaloids canthiumine and haplophytine were detected and are reported here for the first time in a fern, substantially expanding current knowledge of pteridophyte secondary metabolism and highlighting previously overlooked alkaloid diversity in fern taxa. The methanolic extract exhibited concentration-dependent antibacterial inhibition against Staphylococcus aureus, Kocuria rosea, Pseudomonas aeruginosa, and Escherichia coli, with greater susceptibility observed in Gram-positive bacteria. Antioxidant activity measured by the DPPH radical-scavenging assay yielded an IC50 value of 176.66±14.64 ppm, indicating moderate radical-scavenging capacity. Collectively, these findings establish C. parasiticus (Gumitir population) as a chemically rich fern with measurable antibacterial and antioxidant potential, supporting its promise as a natural source of pharmacologically relevant metabolites.
Diversity of Hoya Species across Three Plantation Landscapes in Jember Regency and the Phytochemical and Antioxidant Potential of Hoya lacunosa Blume Fuad bahrul Ulum; Asa Hanifatul Hayyinah; Hari Sulistiyowati; Tri Ratnasari; Mukhamad Su'udi; Edia Fitri Dwinianti; Dwi Setyati
Biosaintifika: Journal of Biology & Biology Education Vol. 17 No. 3 (2025): November 2025
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/biosaintifika.v17i3.22001

Abstract

Jember Regency encompasses several plantation areas characterized by diverse ecological conditions, notably the Gumitir, Garahan, and Tancak plantations. Among the flora in these regions, the genus Hoya is notable for its medicinal potential. This study aimed to characterize the diversity of Hoya species, provide detailed morphological documentation, and evaluate the phytochemical and antioxidant properties of a medicinally used species. Field exploration employed a systematic plot-based design consisting of 150 plots (5 × 5 m²) with 3 m spacing. The most vegetatively dominant species, Hoya lacunosa, was subjected to GC–MS phytochemical analysis and DPPH-based antioxidant evaluation. A total of eleven Hoya species were recorded across the three plantation sites. The Gumitir plantation exhibited the highest diversity, containing ten species., i.e. Hoya burtoniae, H. camphorifolia, H. carnosa, H. cinnamomifolia, H. dennisii, H. fuscomarginata, H. lacunosa, H. micrantha, H. purpureofusca, and two unidentified Hoya spp. In contrast, the Garahan plantation supported only H. dennisii and H. fuscomarginata, while H. lacunosa was exclusively found in Tancak indicating a highly localized distribution. GC-MS profiling on H. lacunosa leaves revealed 26 compounds, comprising 16 secondary metabolites (12 phenolics, 2 alkaloids, and 2 terpenes) and 5 primary metabolites. The methanol extract exhibited strong antioxidant activity (IC₅₀ = 50.89 ppm), reflecting its potential as a natural source of bioactive compounds. These findings demonstrate substantial Hoya diversity in Jember Regency and underscore the potential of H. lacunosa as a valuable source of bioactive metabolites for pharmaceutical development.
Co-Authors ABDILLAH MAULANA FARHAN AFIATRI PUTRIKA Afiatri Putrika AFIATRI PUTRIKA, AFIATRI Afidah, Yusfi Andiana, Jocelin Angraeni, Devi Silvia Ardiyansah, Muhammad Ari Satia Nugraha Arif Mohammad Siddiq Arsetyo Rahardianto Arum, Asyifa Yasmin Asa Hanifatul Hayyinah ‘Ain, Salsabila Qurrotu BAMBANG SUGIHARTO DIAN APRIANI DIAN APRIANI DWI INDAHNING ROHMAH Dwi Setyati Dwinianti, Edia Fitri Dwinianti, Edia Fitria Dyah Retno Wulandari Eny Yuniati ERLIN NOVITA SARI FADZILAH AG FADZILAH AG. KANAK FADZILAH AG. KANAK, FADZILAH AG. Farhan, Abdillah Maulana Firda Fadri Fitri, Edia Fitri, Nurfajri Eka Gilani, Noor Azizah Hidayat Teguh Wiyono Hidayatullah, Alhabsy Ika Oktavianawati INDAH WAHYUNI Indah Wahyuni KAHAR MUZAKHAR KAHAR MUZAKHAR KANAK KANJANA WONGKUNA KANJANA WONGKUNA KANJANA WONGKUNA, KANJANA Khoirunnisa, Gita Ayu Kurniawan, Ludfi Laili, Alvina Nur LESLEY C. LUBOS LESLEY C. LUBOS LESLEY C. LUBOS, LESLEY C. LUONG THIEN TAM LUONG THIEN TAM LUONG THIEN TAM, LUONG THIEN M. Akbar, Salahuddin Miatin Alvin Septianasari MIKA RIZKI PUSPANINGRUM Mika Rizki Puspaningrum MIKA RIZKI PUSPANINGRUM, MIKA RIZKI Moh. Ikmal Alfi Rizqoni MOH. IKMAL ALFI RIZQONI MOHD RAWIYANI PG. HJ. SERUDIN MOHD RAWIYANI PG. HJ. SERUDIN MOHD RAWIYANI PG. HJ. SERUDIN, MOHD RAWIYANI PG. MONICA SULEIMAN MONICA SULEIMAN MONICA SULEIMAN, MONICA Mudinillah, Adam Muhammad Ardiyansah MUKHAMAD SU’UDI MUKHAMAD SU’UDI Mukhamad Su'udi Mukhamad Su'udi Mukhamad Su'udi Mukhamad Su'udi Mukhamad Su’udi MUKHAMAD SU’UDI Munaa Aqidatul Ulaa MUSYAROFAH ZUHRI Musyarofah Zuhri Musyarofah Zuhri NG AIK MIN NG AIK MIN NG AIK MIN, NG AIK Nurfajri Eka Fitri NURLISMA JUNITA NURLISMA JUNITA NURLISMA JUNITA, NURLISMA NURSAHARA PASARIBU Nursahara Pasaribu Nursahara Pasaribu Rajamani, Ranjithkumar RANJITHKUMAR RAJAMANI Rendy Setiawan Rizqoni, Moh Ikmal Alfi ROBBERT GRADSTEIN ROBBERT GRADSTEIN ROBBERT GRADSTEIN, ROBBERT Robi’atul Adawiyah Rosida, Waki'atil Rosida, Wakiatil Rosyadi, Achmad SATRIYAS ILYAS Sattya Arimurti Sa’adah, Kurnia SOONTHREE KORNOCHALERT SOONTHREE KORNOCHALERT SOONTHREE KORNOCHALERT, SOONTHREE Su'udi, M. Su'udi, Mukhamad Sudarmadji, S. Sulistiyowati, Hari Sutoyo Su’udi, Mukhamad Tri Handoyo Tri Ratnasari Tri Ratnasari Veren Yuliana Saputri Wulandari, Dyah Retno YONG KIEN–THAI, YONG YONG KIEN–THAI YONG KIEN–THAI YUSI ANANDA PUTRI YUSRINA RISKY AMALINI