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All Journal Jurnal Ilmiah Farmasi Pharmaciana: Jurnal Kefarmasian Jurnal Riset Kimia Majalah Obat Tradisional Universa Medicina Acta Pharmaciae Indonesia : Acta Pharm Indo ALCHEMY Jurnal Penelitian Kimia JPSCR : Journal of Pharmaceutical Science and Clinical Research Lumbung Inovasi: Jurnal Pengabdian Kepada Masyarakat International Journal of Basic and Applied Science Journal of Science and Technology Research for Pharmacy Pharmaceutical Sciences and Research (PSR) Pharmaqueous Molekul: Jurnal Ilmiah Kimia Jurnal Pengabdian Gizi dan Kesehatan Masyarakat
Triyadi Hendra Wijaya
Department Of Pharmacy, Faculty Of Health Sciences, Universitas Jenderal Soedirman, Jl. Dr. Soeparno, Purwokerto, Indonesia, 53122.
Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Education Electrical & Electronics Engineering Energy Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health Social Sciences

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Chemometric analysis of fingerprinting derivative spectrophotometry for authentication of shallots Puteri, Adelia; Wijaya, Triyadi Hendra; Wasito, Hendri
International Journal of Basic and Applied Science Vol. 13 No. 2 (2024): Sep: Basic and Applied Science
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/ijobas.v13i2.406

Abstract

The Bima Brebes, variety of shallots, was in high demand, which led to mixing with other varieties. Derivative spectrophotometric fingerprinting combined with chemometrics was used to distinguish between authentic and adulterated shallot varieties. The objective of this study was to identify the original spectra and their derivative spectrophotometric fingerprinting, as well as classify and differentiate between shallot varieties using chemometrics. UV-Visible (UV-Vis) spectrophotometry was used to test essential oil samples from three shallot varieties and their mixtures, followed by spectral derivatization. The spectral data revealed distinct patterns for each sample, including individual varieties and mixtures, and was then analyzed using Principal Component Analysis (PCA) and Partial Least Square-Discriminant Analysis (PLS-DA). The original spectra and their derivatives showed similarities across the samples. PCA and PLS-DA results indicated that the second-order derivative data provided the greatest separation, with a total Principal Component 1 (PC1) and Principal Component 2 (PC2) value of 62.2%, a total component 1 and 2 value of 60.1%, and the highest Variable Importance in the Projection (VIP) score wavelength of 225 nm. The PLS-DA results were validated to ensure that the model was not overfit, as evidenced by a satisfactory cross-validation quality (Q2/R2) value of 0.693 and a significant permutation test. The combination of derivative spectrophotometry fingerprinting and a chemometric approach effectively classified different samples, allowing for the determination of the authenticity of a specific shallot variety.
Analisis Pengaruh Wadah, Suhu Dan Lama Penyimpanan Minyak Hati Ikan Cucut Botol Terhadap Bilangan Peroksida Wijaya, Triyadi Hendra; Issusilaningtyas, Elisa; Faiqoh, Maziyatul
Pharmaqueous: Jurnal Ilmiah Kefarmasian Vol. 1 No. 1 (2019): Volume 1, No. 1, November 2019
Publisher : Universitas Al-Irsyad Cilacap

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36760/jp.v1i1.14

Abstract

Stabilitas oksidatif digunakan untuk mengukur perubahan kualitas minyak seiring dengan cara, suhu dan lama waktu simpan. Stabilitas oksidatif dapat diukur menggunakan bilangan peroksida. Dalam penelitian ini telah diteliti mengenai pengaruh cara, suhu, lama waktu penyimpanan terhadap stabilitas oksidatif minyak hati ikan cucut botol. Bilangan peroksida diukur menggunakan titrasi iodimetri. Data dianalisis menggunakan statistik deskriptif dan Anova yang diikuti dengan uji Tukey untuk mengetahui perbedaan antar kelompok perlakuan. Kelompok dengan suhu 25 0C dengan wadah semi transparan dan transparan menunjukkan kenaikan bilangan peroksida yang cukup tajam dibandingkan dengan kelompok dengan wadah gelap dan pada kelompok dengan suhu -28 0C dan 5 0C. Wadah gelap dapat melindungi dari cahaya matahari (sinar uv) sehingga dapat meminimalisir terjadinya oksidasi. Suhu -28 0C dan 50C dapat melindungi minyak hati ikan cucut botol dari oksidasi dan tidak tergantung pada wadah yang digunakan.
Analisis Kandungan Boraks dan Formalin pada Bakso dan Cilok di Wilayah Cilacap Kota Faoziyah, Anita Ratna; Agustina, Laely Triyani; Wijaya, Triyadi Hendra
Pharmaqueous: Jurnal Ilmiah Kefarmasian Vol. 1 No. 1 (2019): Volume 1, No. 1, November 2019
Publisher : Universitas Al-Irsyad Cilacap

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36760/jp.v1i1.22

Abstract

Telah dilakukan penelitian kandungan borak dan formalin pada bakso dan cilok di Wilayah Cilacap Kota. Wilayah Cilacap Kota meliputi tiga kecamatan yaitu Kecamatan Cilacap Tengah, Kecamatan Cilacap Utara dan Kecamatan Cilacap Selatan. Jumlah sempel yang digunakan sebanyak 30 sempel dengan teknik pengembilan sempel mengunakan rendom sampling. Hasil identifikasi kandungan borak dengan metode analisis kualitatif menunjukan bahwa bakso dan cilok yang beredar di Wilayah Cilacap Kota tidak mengandung borak dengan presentase 100% negative (tidak mengandung borak), sedangan hasil identifikasi kandungan formalin pada bakso dan cilok di Wilayah Cilacap kota menunjukan sebanyak 73,33% bakso dan cilok mengandung formalin. Hasil identifikasi ini ditunjukan dengan adanya perubahan warna pada sempel bakso dan cilok setelah direaksikan dengan larutan KMnO4. Perubahan warna yang terjadi pada hasil identifikasi sempel yang mengandung formalin yaitu terjadi perubahan warna dari warna ungu menjadi warna kecoklatan.
Synthesis and Cytotoxic Activity of Methoxylated Chalcones in Breast Cancer MCF-7 and Prostate Cancer DU-145 Cell Lines Fareza, Muhamad Salman; Samudra, Genta Hafied Naga; Asrada, Syahdan; Fischellya, Dafi; Wijaya, Triyadi Hendra; Choironi, Nur Amalia; Wasito, Hendri; Suhesti, Tuti Sri; Mustikaningtyas, Ika; Rehana, Rehana; Setiyabudi, Lulu; Sarmoko, Sarmoko
Molekul Vol 20 No 3 (2025)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2025.20.3.13612

Abstract

Chalcones, a class of naturally occurring compounds, exhibit a broad spectrum of biological activities, including anticancer properties. In this study, a series of methoxylated chalcones were synthesized via Claisen-Schmidt condensation and evaluated for cytotoxic activity against breast cancer MCF-7 and prostate cancer DU-145 cell lines. The synthetic route involved Claisen-Schmidt condensation, leading to various methoxy-substituted chalcone derivatives. The structures of the synthesized chalcones were confirmed through NMR and mass spectrometry. Cytotoxicity was assessed using the PrestoBlue assay, with 4-bromochalcone (compound 2) displaying the highest cytotoxic activity against MCF-7 cancer cell lines (IC50 = 26.99 µM). These results indicate that methoxylated chalcones hold promise as potential lead compounds for the development of new anticancer agents targeting breast and prostate cancer.
Pemberdayaan Masyarakat melalui Pengembangan Kelompok Ternak Lebah Madu untuk Penguatan Ekonomi Lokal Berbasis Produk Alam : Madu Yunadi, Frisca Dewi; Indratmoko, Septiana; Issusilaningtyas, Elisa; Wijaya, Triyadi Hendra; Aji, Ajeng Puspo; Tahya, Khofifah; Rizkya, Dayna; Muslimah, Gadizza
Lumbung Inovasi: Jurnal Pengabdian kepada Masyarakat Vol. 10 No. 4 (2025): December
Publisher : Lembaga Penelitian dan Pemberdayaan Masyarakat (LITPAM)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36312/tc54q653

Abstract

Pemberdayaan ekonomi lokal berbasis potensi sumber daya alam merupakan strategi penting dalam meningkatkan kesejahteraan masyarakat perdesaan secara berkelanjutan. Kegiatan pengabdian kepada masyarakat ini bertujuan meningkatkan kapasitas teknis dan manajerial kelompok ternak lebah madu KUBE Banyu Aji di Desa Welahan Wetan, Kabupaten Cilacap, melalui pengembangan madu sebagai produk unggulan desa. Program dilaksanakan selama enam bulan menggunakan pendekatan Participatory Rural Appraisal (PRA), meliputi identifikasi kebutuhan dan potensi lokal, pelatihan teknis budidaya lebah madu, pendampingan produksi, penguatan manajemen usaha, serta evaluasi partisipatif. Data dikumpulkan melalui pre-test dan post-test, observasi lapangan, diskusi kelompok terarah, dan survei pendapatan rumah tangga. Hasil evaluasi menunjukkan peningkatan signifikan keterampilan teknis peternak, dengan skor rata-rata pre-test sebesar 35–45 meningkat menjadi 75–82 pada post-test. Peningkatan terbesar terjadi pada aspek teknik panen madu higienis dan manajemen koloni lebah. Observasi lapangan mengonfirmasi perbaikan praktik pemeliharaan sarang, penggunaan alat panen berbahan stainless steel, serta pengemasan madu sesuai standar mutu. Selain itu, kelompok berhasil mengembangkan produk turunan seperti madu herbal dan salep propolis serta memperluas jaringan pemasaran melalui koperasi desa dan pelaku usaha lokal. Dampak ekonomi menunjukkan peningkatan pendapatan rumah tangga peternak sebesar 30–45%. Program ini memperkuat kemandirian ekonomi masyarakat dan berpotensi direplikasi di desa lain dengan karakteristik serupa. Community Empowerment through the Development of Honey Bee Farming Groups to Strengthen the Local Economy Based on Natural Products: Honey Abstract Community empowerment based on local natural resource potential is a key strategy for strengthening sustainable rural economies. This community service program aimed to enhance the technical and managerial capacities of the honey bee farming group KUBE Banyu Aji in Welahan Wetan Village, Cilacap Regency, by developing honey as a flagship local product. The program was implemented over six months using a Participatory Rural Appraisal (PRA) approach, including needs and potential assessment, technical training in honey bee cultivation, production mentoring, business management strengthening, and participatory evaluation. Data were collected through pre-test and post-test assessments, field observations, focus group discussions, and household income surveys. Quantitative results indicated a significant improvement in participants’ technical skills, with average pre-test scores ranging from 35–45 and post-test scores increasing to 75–82. The most notable improvements were observed in hygienic honey harvesting techniques and colony management practices. Qualitative field observations confirmed better hive sanitation, use of stainless steel harvesting equipment, and standardized honey packaging. In addition, the group successfully developed value-added honey products, such as herbal honey and propolis ointment, and expanded market access through collaboration with village cooperatives and local businesses. Economic impact assessment showed an increase in household income of 30–45%. This program strengthened community economic independence and demonstrates strong potential for replication in other rural areas with similar ecological conditions.
Pemberdayaan Kelompok PKK Desa Welahan Wetan melalui Penguatan Ekonomi Lokal Berbasis Produk Alam: TOGA-LAMPOT Issusilaningtyas, Elisa; Yunadi, Frisca Dewi; Indratmoko, Septiana; Wijaya, Triyadi Hendra; Mubarak, Zulfikar Yusya; Rizqi, Titis Alvanur; Salsabila, Wilda Adelia; Wulandari, Mutia
Lumbung Inovasi: Jurnal Pengabdian kepada Masyarakat Vol. 10 No. 4 (2025): December
Publisher : Lembaga Penelitian dan Pemberdayaan Masyarakat (LITPAM)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36312/tm202n38

Abstract

Pemberdayaan kelompok PKK Desa Welahan Wetan merupakan upaya strategis dalam meningkatkan kesejahteraan masyarakat melalui penguatan ekonomi lokal berbasis potensi alam. Sebelum program dilaksanakan, komunitas sasaran menghadapi sejumlah tantangan, antara lain keterbatasan ekonomi rumah tangga, rendahnya keterampilan teknis dalam budidaya tanaman obat, serta belum optimalnya pemanfaatan lahan pekarangan yang relatif sempit. Hasil identifikasi awal menunjukkan bahwa lebih dari 60 persen anggota PKK belum memiliki pengetahuan standar mengenai budidaya Tanaman Obat Keluarga (TOGA), dan sekitar 70 persen pekarangan rumah belum dimanfaatkan secara produktif. Program ini berfokus pada pemanfaatan TOGA dan lahan pekarangan produktif dalam pot (TOGA-LAMPOT) sebagai basis pengembangan produk unggulan berbasis ekonomi lokal. Metode pelaksanaan menggunakan pendekatan partisipatif yang melibatkan anggota PKK secara aktif melalui pemetaan kebutuhan mitra, penyuluhan potensi ekonomi TOGA-LAMPOT, serta pelatihan budidaya dan pengolahan di pekarangan rumah. Hasil kegiatan menunjukkan peningkatan keterampilan teknis peserta, ditandai dengan keberhasilan sekitar 70% anggota PKK dalam mempertahankan minimal tiga jenis tanaman obat hingga akhir program, serta terbentuknya inisiatif pembentukan Kelompok Usaha Bersama (KUB) TOGA-LAMPOT. Pemberdayaan kelompok PKK melalui integrasi TOGA-LAMPOT dan penguatan ekonomi lokal terbukti efektif dalam mengoptimalkan lahan terbatas menjadi sumber daya produktif, sekaligus melestarikan pengetahuan tradisional tentang tanaman obat. Program ini direkomendasikan sebagai model pemberdayaan ekonomi komunitas berbasis produk alam di wilayah pedesaan dengan keterbatasan lahan dan sumber daya. Empowerment of the PKK Group in Welahan Wetan Village through Strengthening the Local Economy Based on Natural Products: TOGA-LAMPOT Abstraks The empowerment of the PKK women’s group in Welahan Wetan Village represents a strategic effort to improve community welfare through strengthening the local economy based on natural resources. Prior to program implementation, the target community faced several challenges, including limited household economic capacity, low technical skills in medicinal plant cultivation, and suboptimal utilization of relatively small home gardens. The initial needs assessment indicated that more than 60 percent of PKK members lacked standardized knowledge of Family Medicinal Plant (TOGA) cultivation, while approximately 70 percent of household yards had not been used productively. This program focused on utilizing TOGA and productive home-garden cultivation in pots (TOGA-LAMPOT) as a foundation for developing value-added local products. A participatory approach was employed, actively involving PKK members through partner needs mapping, education on the economic potential of TOGA-LAMPOT, and hands-on training in home-garden cultivation and processing. The results demonstrated an improvement in participants’ technical skills, as evidenced by approximately 70 percent of PKK members successfully maintaining at least three types of medicinal plants until the end of the program, as well as the initiation of plans to establish a TOGA-LAMPOT Joint Business Group (Kelompok Usaha Bersama). The empowerment of the PKK group through the integration of TOGA-LAMPOT and local economic strengthening proved effective in optimizing limited land into productive resources while preserving traditional knowledge of medicinal plants. This program is recommended as a replicable model for community-based economic empowerment using natural products in rural areas with limited land and resources.
Detection of Clove Essential Oil Purity Using a Combination of Chemometric Models with UV-Vis Spectrophotometry Wijaya, Triyadi Hendra; Rehana, Rehana; Endriastuti, Nialiana Endah; Suryoputri, Masita Wulandari; Defa, Ines Naila
Jurnal Riset Kimia Vol. 17 No. 1 (2026): March
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jrk.v17i1.846

Abstract

Clove Essential Oil (CEO) has extensive benefits for health, cosmetics, and food. Low extraction yield (<1%) causes relatively high production costs. This becomes an opportunity for deliberate adulteration to gain greater business profits. This study developed a combination of UV-Vis spectrophotometry with chemometrics to separate pure CEO and adulterated CEO. The adulterants used included Corn Oil (CO) and Olive Oil (OO) at several adulteration levels to see their spectrum and absorption profiles using UV-Vis spectrophotometry. The data were analyzed using PCA and HCA chemometric techniques through R Studio 4.3.3 software. The results of UV-Vis spectrophotometry measurements on CEO adulteration showed similarities in the spectrum profiles of pure CEO and adulterated CEO. Data analysis with PCA can separate pure CEO from adultered CEO with a percentage of cumulative variance of the resulting spectrum of 98.2%. The more similar the composition of a particular oil in a sample, the closer the position of the sample to the oil on the score plot of PCA. HCA analysis can cluster pure CEO separately from adultered CEO. Cluster I in the dendogram consists of samples with large CO concentrations, while samples with large CEO and OO concentrations will be included in Cluster II. The combination of UV-Vis spectrophotometry and chemometrics can be used as a method to separate pure CEO from adultered CEO.
Optimasi Formula Self-Nanoemulsifying Drug Delivery System (SNEDDS) Etil-p-metoksisinamat (EPMS) Nur Amalia Choironi; Beti Pudyastuti; Giri Gumelar; Muhamad Salman Fareza; Triyadi Hendra Wijaya; Joko Setyono
ALCHEMY Jurnal Penelitian Kimia Vol 18, No 2 (2022): September
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.18.2.56847.205-213

Abstract

Penelitian ini bertujuan untuk menentukan formula Self-Nanoemulsifying Drug Delivery System (SNEDDS) menggunakan zat aktif etil-p-metoksisinamat (EPMS). Formula SNEDDS terdiri dari cremophor RH 40 sebagai surfaktan, propilen glikol sebagai ko-surfaktan, Virgin Coconut Oil (VCO) sebagai fase minyak dan EPMS sebagai zat aktif. Penentuan perbandingan surfaktan dan ko-surfaktan menggunakan metode Simplex Lattice Design (SLD) dengan software Design-Expert versi 13.0. Formula optimum SNEDDS EPMS memiliki komposisi EPMS 100 mg/mL, cremophor RH 40 53,6%, propilen glikol 26,4% dan VCO 20% sesuai dengan rekomendasi dari SLD menghasilkan SNEDDS dengan transmitan 95,43%, waktu emulsifikasi dalam aquadest 8,33 menit, ukuran partikel 30,16 nm, zeta potensial -61,03 mV dan indeks polidispersitas 0,160. Penelitian ini menunjukkan bahwa dengan formula SNEDDS 53,6% cremophor RH 40; 26,4% propilen glikol dan EPMS dapat meningkatkan nilai transmitan dan waktu emulsifikasi.Formula Optimization of the Self-Nanoemulsifying Drug Delivery System (SNEDDS) of Ethyl-p-methoxycinnamate (EPMC). This research aimed to optimize the Self-Nanoemulsifying Drug Delivery System (SNEDDS) formula of the ethyl-p-methoxycinnamate (EPMS). The SNEDDS formula was prepared using cremophor RH 40 as a surfactant, propylene glycol as a co-surfactant, VCO as an oil phase, and EPMS as an active ingredient. Proportion surfactant and co-surfactant were determined using the simplex lattice design (SLD) method using the Design-Expert software version 13.0. The optimum formula of EPMC SNEDDS are EPMC cremophor RH 40, propylene glycol, VCO and EPMS was 100 mg/ml, 53.6%, 26.4%, and 20% based on SLD data. The formulation was a transmittance of 95.43%, an emulsification time of 8.33 minutes, a particle size of 30.16 nm, a zeta potential of -61.03 mV, and polydispersity index of 0.160. The result showed that the proportion of cremophor RH 40; 26,4% propylene glycol, and EPMC were able to increase the value of transmittance and emulsification time.
Narrative Review: Herbal Nanocosmetics for Anti Aging Garcella, Prilyano; Wijaya, Triyadi Hendra; Kurniawan, Dhadhang Wahyu
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 8, No 1 (2023)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v8i1.57675

Abstract

Skin aging is a complex biological process caused by intrinsic and extrinsic factors. There are various approaches to preventing skin aging, one of which is using herbal nanocosmetics. This narrative review aims to determine the natural ingredients, type of nanoformulations, and its effects of herbal nanocosmetics to prevent skin aging. The method used in this study was searching for articles related to herbal nanocosmetics to avoid aging skin through Google Scholar, PubMed, and Science Direct with the keywords herbal plants, anti-aging, herbal cosmetics, cosmetics, nanocosmetics, nanoformulations, nanoparticles, nanomaterials, and topical delivery. The inclusion criteria were research articles or review articles about herbal plants made into herbal nanocosmetics to prevent skin aging with the topical route of administration published between 2010-2021 in full text. The articles that have been obtained are then selected, reviewed, and analyzed. Herbal plants made into herbal nanocosmetics contain phenolic compounds for nanoformulations used, namely silver nanoparticles, solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC), nanoemulsions, liposomes, niosomes, ethosomes, and transfersomes. These nanocosmetics herbs affect skin aging, including UV protection, preventing wrinkles and dark spots, moisturizing and brightening the skin. The herbal nanocosmetics prevent the effects of skin aging through some mechanisms such as anti-oxidant, photoprotective agents, modulators of collagen or elastin synthesis, and inhibitors of melanin synthesis.
Co-Authors Agnes Yuliasari Agustina, Laely Triyani Ajeng Puspo Aji Anita Ratna Faoziyah, Anita Ratna Anjani, Sabrina Asrada, Syahdan Beti Pudyastuti Beti Pudyastuti Beti Pudyastuti, Beti Choironi, Nur Amalia Defa, Ines Naila Devitasari, Arinda Dhadhang Wahyu Kurniawan Elisa Issusilaningtyas Endriastuti, Nialiana Endah Faiqoh, Maziyatul Fareza, Muhamad Salman Fischellya, Dafi Fitriani, Novita Inawanda Garcella, Prilyano Giri Gumelar HENDRI WASITO Hendri Wasito Heny Ekowati Ilma Nugrahani Joko Setyono Kartawinata, Tutus Gusdinar Khoiriani, Izzati Nur Maryellen, Geeta Mubarak, Zulfikar Yusya Muslimah, Gadizza Mustikaningtyas, Ika Mutia Wulandari, Mutia Nur Amalia Choironi Nur Intan, Nur Nuraeni Ekowati, Nuraeni Oktavian, Firdaus Puteri, Adelia Rahma, Shesa Rahmah, Annisa Rehana, Rehana Rizkya, Dayna Rizqi, Titis Alvanur Salsabila, Wilda Adelia Samudra, Genta Hafied Naga Sarmoko Sarmoko Setiyabudi, Lulu Silitonga, Tasya Melinda Sri Sutji Susilowati Sri Sutji Susilowati Sunarto Sunarto Sunarto Sunarto Suryoputri, Masita Wulandari Tahya, Khofifah Teguh Jati Prasetyo Tuti Sri Suhesti Warsinah Warsinah Wicaksari, Sifa Aulia Yosephine, Samuella Yuliasari, Agnes yunadi, frisca dewi