Article Per Year (5 Year)
p-Index From 2021 - 2026
2.332
P-Index
This Author published in this journals
All Journal Jurnal Ilmiah Farmasi Pharmaciana: Jurnal Kefarmasian Majalah Obat Tradisional Universa Medicina Acta Pharmaciae Indonesia : Acta Pharm Indo ALCHEMY Jurnal Penelitian Kimia JPSCR : Journal of Pharmaceutical Science and Clinical Research Lumbung Inovasi: Jurnal Pengabdian Kepada Masyarakat International Journal of Basic and Applied Science Journal of Science and Technology Research for Pharmacy Pharmaceutical Sciences and Research (PSR) Pharmaqueous Molekul: Jurnal Ilmiah Kimia Jurnal Pengabdian Gizi dan Kesehatan Masyarakat
Triyadi Hendra Wijaya
Department Of Pharmacy, Faculty Of Health Sciences, Universitas Jenderal Soedirman, Jl. Dr. Soeparno, Purwokerto, Indonesia, 53122.
Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Education Electrical & Electronics Engineering Energy Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health Social Sciences

Published : 18 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 18 Documents
Search

 1   2 
Nephroprotective effect and untargeted metabolomic analysis of celery extract against diethylene glycol induced nephrotoxicity in rats Wijaya, Triyadi Hendra; Ekowati, Heny; Wasito, Hendri; Maryellen, Geeta; Silitonga, Tasya Melinda; Oktavian, Firdaus
Universa Medicina Vol. 44 No. 2 (2025)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2025.v44.190-200

Abstract

Background Diethylene glycol (DEG) is known for its nephrotoxic effects as a contaminant. Recent investigations suggest that celery extract potentially protects against DEG-induced renal toxicity, warranting an exploration of the non-targeted metabolomic profile of celery in renal tissue. This study aimed to determine celery nephroprotective effects and identify potential biomarkers using an untargeted metabolomic  celery profile in DEG-induced kidney injury in male rats. Methods An experimental study was conducted involving 24 male Wistar rats, randomized into control and three treatment groups receiving DEG at doses of 1, 3, and 5 g/BW for three days. After 14 days, all rats were sacrificed. For the celery nephroprotective and metabolomic study, 27 male rats were randomized into three groups:  control, DEG group at 3g/BW, and DEG-celery group (receiving celery extract 200mg/kg BW single dose for 6 days). After 14 days, blood was tested for creatinine level and untargeted metabolomic analysis using liquid chromatography-high resolution mass spectrometry. One-way ANOVA was used to analyze creatinine data. Results Diethylene glycol at doses of 1 and 3 g/kg BW caused mild renal damage, while 5 g/kg BW resulted in moderate damage. Creatinine levels in the normal, DEG-induced, and DEG-celery groups were 0.55 ± 0.14, 0.71±0.1, and 0.86± 0.17 mg/dL, respectively, but not statistically significantly different between groups (p>0.05). DEG lead tryptophan and phenylalanine levels increased 45-fold and 123-fold, respectively. Celery reduced levels of these metabolites 21-fold and 65-fold, respectively. Conclusion Diethylene glycol led to mild to moderate renal damage. Celery effectively diminished metabolite levels associated with renal damage, specifically tryptophan and phenylalanine.
Nephroprotective and Hepatoprotective Effects of Turmeric in Diethylene Glycol Induced Toxicity in Rats Ekowati, Heny; Devitasari, Arinda; Fitriani, Novita Inawanda; Endriastuti, Nialiana Endah; Wijaya, Triyadi Hendra
Majalah Obat Tradisional Vol 30, No 2 (2025)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.95225

Abstract

In 2022, children in Indonesia experienced acute renal failure due to antipyretic syrup contaminated with diethylene glycol (DEG). DEG is a known contaminant in pharmaceutical solvents that can induce inflammation and act as a free radical, leading to kidney and liver damage. Turmeric (Curcuma Longa) has been reported to have nephroprotective and hepatoprotective effects due to anti-inflammatory and antioxidant properties. This study aims to evaluate the protective effects of turmeric ethanol extract on rat kidneys and liver subjected to DEG toxicity. Rats were divided into five groups (n=5 per group): Group I served as the normal control, while Group II received DEG orally at 3 g/kg BW twice daily for three days. Groups III, IV, and V were treated with DEG (3 g/kg BW) along with turmeric ethanol extract at a doses of 100, 200, and 400 mg/kg BW, respectively, administered orally twice daily for six days. After 14 days, all rats were sacrificed for macroscopic and microscopic evaluation using hematoxylin-eosin (H&E) staining. The results showed that rats treated with turmeric extract exhibited significantly significantly less kidney and liver damage (p<0.05). Kidney protection was evidenced by improvements in endothelial tissue, glomeruli, and tubules, while liver protection was indicated by reduced Kupffer cell activation, sinusoidal dilatation, hepatocyte degeneration, and necrosis. In conclusion, turmeric ethanol extract effectively protects against DEG-induced kidney and liver toxicity in rats.
Chemometric analysis of fingerprinting derivative spectrophotometry for authentication of shallots Puteri, Adelia; Wijaya, Triyadi Hendra; Wasito, Hendri
International Journal of Basic and Applied Science Vol. 13 No. 2 (2024): Sep: Basic and Applied Science
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/ijobas.v13i2.406

Abstract

The Bima Brebes, variety of shallots, was in high demand, which led to mixing with other varieties. Derivative spectrophotometric fingerprinting combined with chemometrics was used to distinguish between authentic and adulterated shallot varieties. The objective of this study was to identify the original spectra and their derivative spectrophotometric fingerprinting, as well as classify and differentiate between shallot varieties using chemometrics. UV-Visible (UV-Vis) spectrophotometry was used to test essential oil samples from three shallot varieties and their mixtures, followed by spectral derivatization. The spectral data revealed distinct patterns for each sample, including individual varieties and mixtures, and was then analyzed using Principal Component Analysis (PCA) and Partial Least Square-Discriminant Analysis (PLS-DA). The original spectra and their derivatives showed similarities across the samples. PCA and PLS-DA results indicated that the second-order derivative data provided the greatest separation, with a total Principal Component 1 (PC1) and Principal Component 2 (PC2) value of 62.2%, a total component 1 and 2 value of 60.1%, and the highest Variable Importance in the Projection (VIP) score wavelength of 225 nm. The PLS-DA results were validated to ensure that the model was not overfit, as evidenced by a satisfactory cross-validation quality (Q2/R2) value of 0.693 and a significant permutation test. The combination of derivative spectrophotometry fingerprinting and a chemometric approach effectively classified different samples, allowing for the determination of the authenticity of a specific shallot variety.
Analisis Pengaruh Wadah, Suhu Dan Lama Penyimpanan Minyak Hati Ikan Cucut Botol Terhadap Bilangan Peroksida Wijaya, Triyadi Hendra; Issusilaningtyas, Elisa; Faiqoh, Maziyatul
Pharmaqueous: Jurnal Ilmiah Kefarmasian Vol. 1 No. 1 (2019): Volume 1, No. 1, November 2019
Publisher : Universitas Al-Irsyad Cilacap

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36760/jp.v1i1.14

Abstract

Stabilitas oksidatif digunakan untuk mengukur perubahan kualitas minyak seiring dengan cara, suhu dan lama waktu simpan. Stabilitas oksidatif dapat diukur menggunakan bilangan peroksida. Dalam penelitian ini telah diteliti mengenai pengaruh cara, suhu, lama waktu penyimpanan terhadap stabilitas oksidatif minyak hati ikan cucut botol. Bilangan peroksida diukur menggunakan titrasi iodimetri. Data dianalisis menggunakan statistik deskriptif dan Anova yang diikuti dengan uji Tukey untuk mengetahui perbedaan antar kelompok perlakuan. Kelompok dengan suhu 25 0C dengan wadah semi transparan dan transparan menunjukkan kenaikan bilangan peroksida yang cukup tajam dibandingkan dengan kelompok dengan wadah gelap dan pada kelompok dengan suhu -28 0C dan 5 0C. Wadah gelap dapat melindungi dari cahaya matahari (sinar uv) sehingga dapat meminimalisir terjadinya oksidasi. Suhu -28 0C dan 50C dapat melindungi minyak hati ikan cucut botol dari oksidasi dan tidak tergantung pada wadah yang digunakan.
Analisis Kandungan Boraks dan Formalin pada Bakso dan Cilok di Wilayah Cilacap Kota Faoziyah, Anita Ratna; Agustina, Laely Triyani; Wijaya, Triyadi Hendra
Pharmaqueous: Jurnal Ilmiah Kefarmasian Vol. 1 No. 1 (2019): Volume 1, No. 1, November 2019
Publisher : Universitas Al-Irsyad Cilacap

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36760/jp.v1i1.22

Abstract

Telah dilakukan penelitian kandungan borak dan formalin pada bakso dan cilok di Wilayah Cilacap Kota. Wilayah Cilacap Kota meliputi tiga kecamatan yaitu Kecamatan Cilacap Tengah, Kecamatan Cilacap Utara dan Kecamatan Cilacap Selatan. Jumlah sempel yang digunakan sebanyak 30 sempel dengan teknik pengembilan sempel mengunakan rendom sampling. Hasil identifikasi kandungan borak dengan metode analisis kualitatif menunjukan bahwa bakso dan cilok yang beredar di Wilayah Cilacap Kota tidak mengandung borak dengan presentase 100% negative (tidak mengandung borak), sedangan hasil identifikasi kandungan formalin pada bakso dan cilok di Wilayah Cilacap kota menunjukan sebanyak 73,33% bakso dan cilok mengandung formalin. Hasil identifikasi ini ditunjukan dengan adanya perubahan warna pada sempel bakso dan cilok setelah direaksikan dengan larutan KMnO4. Perubahan warna yang terjadi pada hasil identifikasi sempel yang mengandung formalin yaitu terjadi perubahan warna dari warna ungu menjadi warna kecoklatan.
Synthesis and Cytotoxic Activity of Methoxylated Chalcones in Breast Cancer MCF-7 and Prostate Cancer DU-145 Cell Lines Fareza, Muhamad Salman; Samudra, Genta Hafied Naga; Asrada, Syahdan; Fischellya, Dafi; Wijaya, Triyadi Hendra; Choironi, Nur Amalia; Wasito, Hendri; Suhesti, Tuti Sri; Mustikaningtyas, Ika; Rehana, Rehana; Setiyabudi, Lulu; Sarmoko, Sarmoko
Molekul Vol 20 No 3 (2025)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2025.20.3.13612

Abstract

Chalcones, a class of naturally occurring compounds, exhibit a broad spectrum of biological activities, including anticancer properties. In this study, a series of methoxylated chalcones were synthesized via Claisen-Schmidt condensation and evaluated for cytotoxic activity against breast cancer MCF-7 and prostate cancer DU-145 cell lines. The synthetic route involved Claisen-Schmidt condensation, leading to various methoxy-substituted chalcone derivatives. The structures of the synthesized chalcones were confirmed through NMR and mass spectrometry. Cytotoxicity was assessed using the PrestoBlue assay, with 4-bromochalcone (compound 2) displaying the highest cytotoxic activity against MCF-7 cancer cell lines (IC50 = 26.99 µM). These results indicate that methoxylated chalcones hold promise as potential lead compounds for the development of new anticancer agents targeting breast and prostate cancer.
Pemberdayaan Masyarakat melalui Pengembangan Kelompok Ternak Lebah Madu untuk Penguatan Ekonomi Lokal Berbasis Produk Alam : Madu Yunadi, Frisca Dewi; Indratmoko, Septiana; Issusilaningtyas, Elisa; Wijaya, Triyadi Hendra; Aji, Ajeng Puspo; Tahya, Khofifah; Rizkya, Dayna; Muslimah, Gadizza
Lumbung Inovasi: Jurnal Pengabdian kepada Masyarakat Vol. 10 No. 4 (2025): December
Publisher : Lembaga Penelitian dan Pemberdayaan Masyarakat (LITPAM)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36312/tc54q653

Abstract

Pemberdayaan ekonomi lokal berbasis potensi sumber daya alam merupakan strategi penting dalam meningkatkan kesejahteraan masyarakat perdesaan secara berkelanjutan. Kegiatan pengabdian kepada masyarakat ini bertujuan meningkatkan kapasitas teknis dan manajerial kelompok ternak lebah madu KUBE Banyu Aji di Desa Welahan Wetan, Kabupaten Cilacap, melalui pengembangan madu sebagai produk unggulan desa. Program dilaksanakan selama enam bulan menggunakan pendekatan Participatory Rural Appraisal (PRA), meliputi identifikasi kebutuhan dan potensi lokal, pelatihan teknis budidaya lebah madu, pendampingan produksi, penguatan manajemen usaha, serta evaluasi partisipatif. Data dikumpulkan melalui pre-test dan post-test, observasi lapangan, diskusi kelompok terarah, dan survei pendapatan rumah tangga. Hasil evaluasi menunjukkan peningkatan signifikan keterampilan teknis peternak, dengan skor rata-rata pre-test sebesar 35–45 meningkat menjadi 75–82 pada post-test. Peningkatan terbesar terjadi pada aspek teknik panen madu higienis dan manajemen koloni lebah. Observasi lapangan mengonfirmasi perbaikan praktik pemeliharaan sarang, penggunaan alat panen berbahan stainless steel, serta pengemasan madu sesuai standar mutu. Selain itu, kelompok berhasil mengembangkan produk turunan seperti madu herbal dan salep propolis serta memperluas jaringan pemasaran melalui koperasi desa dan pelaku usaha lokal. Dampak ekonomi menunjukkan peningkatan pendapatan rumah tangga peternak sebesar 30–45%. Program ini memperkuat kemandirian ekonomi masyarakat dan berpotensi direplikasi di desa lain dengan karakteristik serupa. Community Empowerment through the Development of Honey Bee Farming Groups to Strengthen the Local Economy Based on Natural Products: Honey Abstract Community empowerment based on local natural resource potential is a key strategy for strengthening sustainable rural economies. This community service program aimed to enhance the technical and managerial capacities of the honey bee farming group KUBE Banyu Aji in Welahan Wetan Village, Cilacap Regency, by developing honey as a flagship local product. The program was implemented over six months using a Participatory Rural Appraisal (PRA) approach, including needs and potential assessment, technical training in honey bee cultivation, production mentoring, business management strengthening, and participatory evaluation. Data were collected through pre-test and post-test assessments, field observations, focus group discussions, and household income surveys. Quantitative results indicated a significant improvement in participants’ technical skills, with average pre-test scores ranging from 35–45 and post-test scores increasing to 75–82. The most notable improvements were observed in hygienic honey harvesting techniques and colony management practices. Qualitative field observations confirmed better hive sanitation, use of stainless steel harvesting equipment, and standardized honey packaging. In addition, the group successfully developed value-added honey products, such as herbal honey and propolis ointment, and expanded market access through collaboration with village cooperatives and local businesses. Economic impact assessment showed an increase in household income of 30–45%. This program strengthened community economic independence and demonstrates strong potential for replication in other rural areas with similar ecological conditions.
Pemberdayaan Kelompok PKK Desa Welahan Wetan melalui Penguatan Ekonomi Lokal Berbasis Produk Alam: TOGA-LAMPOT Issusilaningtyas, Elisa; Yunadi, Frisca Dewi; Indratmoko, Septiana; Wijaya, Triyadi Hendra; Mubarak, Zulfikar Yusya; Rizqi, Titis Alvanur; Salsabila, Wilda Adelia; Wulandari, Mutia
Lumbung Inovasi: Jurnal Pengabdian kepada Masyarakat Vol. 10 No. 4 (2025): December
Publisher : Lembaga Penelitian dan Pemberdayaan Masyarakat (LITPAM)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36312/tm202n38

Abstract

Pemberdayaan kelompok PKK Desa Welahan Wetan merupakan upaya strategis dalam meningkatkan kesejahteraan masyarakat melalui penguatan ekonomi lokal berbasis potensi alam. Sebelum program dilaksanakan, komunitas sasaran menghadapi sejumlah tantangan, antara lain keterbatasan ekonomi rumah tangga, rendahnya keterampilan teknis dalam budidaya tanaman obat, serta belum optimalnya pemanfaatan lahan pekarangan yang relatif sempit. Hasil identifikasi awal menunjukkan bahwa lebih dari 60 persen anggota PKK belum memiliki pengetahuan standar mengenai budidaya Tanaman Obat Keluarga (TOGA), dan sekitar 70 persen pekarangan rumah belum dimanfaatkan secara produktif. Program ini berfokus pada pemanfaatan TOGA dan lahan pekarangan produktif dalam pot (TOGA-LAMPOT) sebagai basis pengembangan produk unggulan berbasis ekonomi lokal. Metode pelaksanaan menggunakan pendekatan partisipatif yang melibatkan anggota PKK secara aktif melalui pemetaan kebutuhan mitra, penyuluhan potensi ekonomi TOGA-LAMPOT, serta pelatihan budidaya dan pengolahan di pekarangan rumah. Hasil kegiatan menunjukkan peningkatan keterampilan teknis peserta, ditandai dengan keberhasilan sekitar 70% anggota PKK dalam mempertahankan minimal tiga jenis tanaman obat hingga akhir program, serta terbentuknya inisiatif pembentukan Kelompok Usaha Bersama (KUB) TOGA-LAMPOT. Pemberdayaan kelompok PKK melalui integrasi TOGA-LAMPOT dan penguatan ekonomi lokal terbukti efektif dalam mengoptimalkan lahan terbatas menjadi sumber daya produktif, sekaligus melestarikan pengetahuan tradisional tentang tanaman obat. Program ini direkomendasikan sebagai model pemberdayaan ekonomi komunitas berbasis produk alam di wilayah pedesaan dengan keterbatasan lahan dan sumber daya. Empowerment of the PKK Group in Welahan Wetan Village through Strengthening the Local Economy Based on Natural Products: TOGA-LAMPOT Abstraks The empowerment of the PKK women’s group in Welahan Wetan Village represents a strategic effort to improve community welfare through strengthening the local economy based on natural resources. Prior to program implementation, the target community faced several challenges, including limited household economic capacity, low technical skills in medicinal plant cultivation, and suboptimal utilization of relatively small home gardens. The initial needs assessment indicated that more than 60 percent of PKK members lacked standardized knowledge of Family Medicinal Plant (TOGA) cultivation, while approximately 70 percent of household yards had not been used productively. This program focused on utilizing TOGA and productive home-garden cultivation in pots (TOGA-LAMPOT) as a foundation for developing value-added local products. A participatory approach was employed, actively involving PKK members through partner needs mapping, education on the economic potential of TOGA-LAMPOT, and hands-on training in home-garden cultivation and processing. The results demonstrated an improvement in participants’ technical skills, as evidenced by approximately 70 percent of PKK members successfully maintaining at least three types of medicinal plants until the end of the program, as well as the initiation of plans to establish a TOGA-LAMPOT Joint Business Group (Kelompok Usaha Bersama). The empowerment of the PKK group through the integration of TOGA-LAMPOT and local economic strengthening proved effective in optimizing limited land into productive resources while preserving traditional knowledge of medicinal plants. This program is recommended as a replicable model for community-based economic empowerment using natural products in rural areas with limited land and resources.
Co-Authors Agnes Yuliasari Agustina, Laely Triyani Ajeng Puspo Aji Anita Ratna Faoziyah, Anita Ratna Anjani, Sabrina Asrada, Syahdan Beti Pudyastuti Beti Pudyastuti Beti Pudyastuti, Beti Choironi, Nur Amalia Devitasari, Arinda Dhadhang Wahyu Kurniawan Dhadhang Wahyu Kurniawan Elisa Issusilaningtyas Endriastuti, Nialiana Endah Faiqoh, Maziyatul Fareza, Muhamad Salman Fischellya, Dafi Fitriani, Novita Inawanda Giri Gumelar HENDRI WASITO Hendri Wasito Heny Ekowati Ilma Nugrahani Joko Setyono Kartawinata, Tutus Gusdinar Khoiriani, Izzati Nur Maryellen, Geeta Mubarak, Zulfikar Yusya Muhamad Salman Fareza Muhamad Salman Fareza Muslimah, Gadizza Mustikaningtyas, Ika Mutia Wulandari, Mutia Nur Amalia Choironi Nur Intan, Nur Nuraeni Ekowati, Nuraeni Oktavian, Firdaus Prilyano Garcella Puteri, Adelia Rahma, Shesa Rahmah, Annisa Rehana, Rehana Rizkya, Dayna Rizqi, Titis Alvanur Salsabila, Wilda Adelia Samudra, Genta Hafied Naga Sarmoko Sarmoko Setiyabudi, Lulu Silitonga, Tasya Melinda Sri Sutji Susilowati Sri Sutji Susilowati Sunarto Sunarto Sunarto Sunarto Tahya, Khofifah Teguh Jati Prasetyo Tuti Sri Suhesti Warsinah Warsinah Wicaksari, Sifa Aulia Yosephine, Samuella Yuliasari, Agnes yunadi, frisca dewi