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Ayu Nirmala Sari
Universitas Islam Negeri Ar-Raniry
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Potensi Antioksidan Alami pada Ekstrak Kulit Buah Jamblang (Syzigium cumini (L.) Skeels) Menggunakan Metode DPPH (The Potency of Natural Antioxidant in The Rind Extract of Jamblang (Syzigium cumini (L.) Skeels) using DPPH Method) Sari, Ayu Nirmala; Kusdianti, Kusdianti; Diningrat, Diky Setya
JURNAL BIOS LOGOS Vol 8, No 1 (2018): JURNAL BIOSLOGOS
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/jbl.8.1.2018.20593

Abstract

AbstrakStress oksidatif pada tubuh dapat memicu berbagai penyakit. Stress oksidatif ini disebabkan karena radikal bebas berlebih. Tubuh memerlukan antioksidan untuk mengurangi pengaruh radikal bebas dan meredam dampak negatifnya. Penelitian ini bertujuan untuk mengevaluasi daya antioksidan ekstrak kulit buah jamblang (Syzigium cumini (L.) Skeels) dengan menggunakan metode DPPH. Berdasarkan hasil pengujian daya antioksidan ekstrak kulit buah jamblang diketahui bahwa ekstrak kulit buah jamblang memiliki kandungan antioksidan yang tergolong aktivitas sedang dengan nilai IC50 sebesar 169.3. Hasil penelitian ini menunjukkan bahwa kulit buah jamblang berpotensi untuk dikembangkan sebagai sumber antioksidan alami bagi manusia.Kata Kunci : antioksidan, DPPH, ekstraksi, jamblang, radikal bebas, stress oksidatif AbstractOxidative stress can induce many diseases. Oxidative stress is caused by excessive free radicals in the body. The body required antioxidant to decrease and hush the negative effects of free radicals. The aim of this study was to evaluate the antioxidant potency of extract rind of jamblang (Syzigium cumini (L.) Skeels) using DPPH method. The result showed that the jamblang rind extract had moderate antioxidant activity and the IC50 value was 169.3.  Based on this result, jamblang rind was potential to be natural antioxidant for human.Keyword: antioxidant, DPPH, extraction, jamblang, free radicals, oxidative stress
MORFOLOGI SEL DARAH PADA APUSAN DARAH TEPI (SADT) MENGGUNAKAN PEWARNAAN ALTERNATIF EKSTRAK KOL UNGU (Brassica oleracea L) Nirmala Sari, Ayu; Masrillah, Masrillah
Prosiding Biotik Vol 9, No 1 (2021): PROSIDING SEMINAR NASIONAL BIOTIK IX 2021
Publisher : Prosiding Biotik

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (812.598 KB)

Abstract

Pewarnaan Giemsa adalah pewarnaan sintetis yang terdiri dari eosin dan metilen biru yang biasa digunakan dalam pewarnaan sediaan apus darah. Namun penggunaan pewarnaan sintetis ternyata memiliki beberapa kekurangan yaitu tidak ramah lingkungan, cukup mahal dan berbahaya bagi kesehatan. Maka dari itu, dibutuhkan pewarnaan alternatif alami yang lebih ramah lingkungan, murah dan tidak berbahaya bagi kesehatan. Dalam penelitian ini digunakan pewarna alternatif ekstrak etanol kol ungu (Brassica oleracea L) yang mengandung zat antosianin. Antosianin merupakan golongan senyawa kimia organik yang dapat larut dalam pelarut polar, serta bertanggung jawab dalam memberikan warna orange, merah, ungu, biru, hingga hitam pada tumbuhan tingkat tinggi seperti: bunga, buah-buahan, biji-bijian, sayuran dan umbi-umbian. Hasil dari penelitian ini menunjukkan bahwa preparat yang diberi pewarnaan Giemsa dapat menampilkan eritrosit, leukosit dan trombosit yang penampakan nya itu jelas di bawah mikroskop, sementara pada pewarnaan ekstrak etanol kol ungu yang mengandung zat antosianin yang bersifat asam menunjukkan bahwa pewarnaan ini hanya dapat mewarnai eritrosit, namun tidak untuk leukosit dan trombosit karena zat warna pada ekstrak kol ungu tidak mampu mewarnai inti sel. Maka dapat disimpulkan bahwa namun ekstrak kol ungu dapat dijadikan pewarnaan alternatif untuk sediaan apus darah yang tujuannya untuk melihat morfologi eritrosit.
Antioksidan Alternatif Untuk Menangkal Bahaya Radikal Bebas Pada Kulit Ayu Nirmala Sari
Elkawnie: Journal of Islamic Science and Technology Vol 1, No 1 (2015)
Publisher : Universitas Islam Negeri Ar-Raniry Banda Aceh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22373/ekw.v1i1.518

Abstract

Skin damage will impair human health. One of the causes of skin damage are free radicals form ultra violet rays. Antioxidants are needed to stabilize free radicals. Alternative sources of antioxidants which can be used to block the effects of free radicals on the skin are skin lotion of fruit black mangrove (Rhizophora mucronata Lamk.) and sunscreen of waste corn cob (Zea mays L). Mangrove fruit methanol extract shown to function as a source of natural antioxidants, which have very strong antioxidant activity, so the lotion containing fruit extracts exact mangrove can be used as inhibitors of free radicals on the skin. In addition, it has been proven that the active compound contained in a corn cob has the ability as a sunscreen active ingredient, with the highest SPF value.
POTENSI PROPOLIS SEBAGAI ANTIDIABETES BERDASARKAN ANALISIS SAYATAN HISTOLOGI PANKREAS Ayu Nirmala Sari
Elkawnie: Journal of Islamic Science and Technology Vol 1, No 2 (2015)
Publisher : Universitas Islam Negeri Ar-Raniry Banda Aceh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22373/ekw.v1i2.344

Abstract

Abstract: Diabetes mellitus is a chronic disease characterized by hyperglycemia for long time. Hyperglycemia is proven increase oxidative stress due to the production of reactive oxygen species that exceeds the ability of the natural antioxidant defenses, causing deficiency and insulin resistance. In this study, the effect of propolis as an antidiabetic was observed based on qualitative analysis of incision histology. 55 male mice (Mus musculus SW.) were divided into 5 groups: KN (normal control), P1, P2, P3 and KDM (diabetes control) induced diabetes with alloxan dose 200 mg/kg bw intraperitoneally. Propolis solution 50, 100 and 175 mg/kg bw given to P1, P2 and P3, while distilled water was given to KN and KDM by oral gavage for 21 days. Pancreatic incision histology is done every 7 days. Results of the qualitative analysis of histological cuts showed that the diameter of the islets of Langerhans in P1, P2 and P3 is smaller than KN (diameter 100-200 m). The heaviest pancreatic damage demonstrated by DM with no propolis treatment. Repairing of damage in the islets of Langerhans in mice treated with propolis showed that propolis potentially as an antidiabetic . Key words: diabetes, propolis, histology, pancreas, antioxsidan, alloxan Abstrak: Diabetes mellitus adalah penyakit kronis yang ditandai dengan hiperglikemia untuk waktu yang lama. Hiperglikemia terbukti meningkatkan stress oksidatif akibat produksi reactive oxygen species (ROS) yang melebihi pertahanan antioksidan alami sehingga menyebabkan defisiensi dan resistensi insulin. Pada penelitian ini dilihat peran propolis sebagai antidiabetes berdasarkan analisis terhadap sayatan histologist mencit. Sebanyak 55 ekor mencit (Mus musculus SW.) jantan dibagi menjadi 5 kelompok, yaitu KN (kontrol normal), P1, P2, P3 dan KDM (kontrol diabetes) yang diinduksi DM dengan pemberian dosis alloxan 200 mg/kg bb secara intraperitoneal. Larutan propolis 50, 100 dan 175 mg/kg bb diberikan kepada P1, P2 dan P3 sedangkan akuades diberikan kepada KN dan KDM secara oral gavage selama 21 hari. Pembuatan sayatan histologi pankreas dilakukan setiap 7 hari. Hasil analisis kualitatif sayatan histologi menunjukkan bahwa diameter pulau Langerhans pada P1, P2 dan P3 lebih kecil dibandingkan dengan KN (diameter 100-200 μm). Kerusakan pankreas terberat ditunjukkan oleh kelompok DM yang tidak mendapatkan perlakuan peropolis. Perbaikan kerusakan pulau Langerhans pada mencit yang diberi perlakuan propolis menunjukkan bahwa propolis berpotensi sebagai antidiabetes. Kata kunci: diabetes, propolis, histologi, pankreas, antioksidan, alloxan
Analisis GC-MS Senyawa Bioaktif Pencegah Penyakit Degeneratif Dari Ekstrak Etanol Kulit Buah Jamblang (Syzygium Cumini) Ayu Nirmala Sari; Kusdianti Kusdianti; Diky Setya Diningrat
Elkawnie: Journal of Islamic Science and Technology Vol 4, No 2 (2018)
Publisher : Universitas Islam Negeri Ar-Raniry Banda Aceh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22373/ekw.v4i2.4143

Abstract

Penelitian ini bertujuan untuk membuat inventarisasi database antioksidan alami dalam level molekuler dari tanaman jamblang (Syzygium cumini) dengan pendekatan Gas Chromatography Mass Spectrometer (GCMS) sehingga dapat dijadikan dasar pengembangan S. cumini sebagai antioksidan alami alternatif untuk mencegah kerusakan sel, kanker dan menurunkan kejadian penyakit degeneratif. Penelitian ini difokuskan pada S. cumini sebagai salah satu tanaman berkhasiat obat yang sudah mulai diteliti dalam khasiatnya sebagai tanaman yang mengandung senyawa bioaktif. Kehadiran teknologi GCMS ditengah belum adanya database tanaman jamblang merupakan peluang alternatif untuk memperoleh metabolom. Database metabolom pada jamblang penting dimiliki untuk menjaga plasma nutfah dari ekploitasi berlebihan yang menyebabkan kepunahan organisme dan budidaya tanaman tersebut. Dengan adanya penelitian inventarisasi level molekuler senyawa antioksidan yang dikandung tanaman jamblang dapat meningkatkan aktivitas penelitian lanjut pemanfaatan tanaman jamblang yang bisa ditingkatkan dalam skala industri nantinya. Untuk menjawab tujuan penelitian ini dilakukan tahapan penelitian sebagai berikut, pada tahap awal dilakukan isolasi metabolom dari kulit buah tanaman jamblang dengan cara ekstraksi. Tahap kedua adalah metabolome analysis menggunakan GCMS. Keluaran dari penelitian ini adalah diperolehnya data tentang hasil GCMS yang memuat senyawa bioaktif yang terkandung pada kulit buah tanaman jamblang yang akan menjadi landasan pengembangan pemanfaatan kulit buah jamblang sebagai antioksidan alternatif pencegah penyakit degenerasi. Pada penelitian selanjutnya perlu dilakukan analisis yang sama pada bagian tanaman jamblang lain untuk melengkapi database yang sudah ada.This research aims to create an antioxidant inventory databases of the Jamblang (Syzygium cumini) plant by Gas Chromatography-Mass Spectrometer (GCMS) approach.  This database can be used as the basis for the development of S. cumini as an alternative natural antioxidant to prevent cell damage, cancer and reduce disease incidence degenerative. This research is focused on S. cumini as one of the medicinal plants that have been studied in its usefulness as a plant containing the bioactive compound. The presence of GCMS technology amid the absence of Jamblang plant database is an alternative opportunity to obtain metabolome. The metabolome database in jamblang is important to keep the germplasm from excessive exploitation causing the extinction of the organism and the cultivation of the plant. Molecular level inventory of antioxidant compounds contained jamblang plants can increase research activities further utilization of jamblang plants that can be increased in the industrial scale later. To answer the purpose of this research carried out the following stages of research, in the early stages of metabolome isolation from the skin of jamblang fruit by way of extraction. The second stage is the metabolome analysis using GCMS. The output of this research is to obtain data about GCMS results that bioactive compounds contained in jamblang fruit skin that will become the foundation of the development of jamblang fruit skin as alternative antioxidant prevention of degeneration disease. In the next research needs to be done the same analysis on the jamblang plant to complete the existing database
Berbagai Tanaman Rempah Sebagai Sumber Antioksidan Alami Ayu Nirmala Sari
Elkawnie: Journal of Islamic Science and Technology Vol 2, No 2 (2016)
Publisher : Universitas Islam Negeri Ar-Raniry Banda Aceh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22373/ekw.v2i2.2695

Abstract

Radicals produced naturally in the body, can cause various diseases when present in large quantities. High levels of free radical compounds showed low antioxidant activity that leads to degeneration of the body cells, metabolic disorder, decreased immune response that trigger the emergence of a variety of degenerative diseases. Need extra antioxidants from outside the body in order to help prevent the adverse effects of free radicals, such as antioxidants derived from plants used as cooking ingredients or food ingredients. There are some herbal plants that are a source of natural antioxidants , which are also used as a spice, such as turmeric (Curcuma domestica), ginger (Zingiber offcinale), nutmeg (Myristica fragrans), paprika (Capsicum annum), lemongrass (Cymbopogon citratus), galangal (Alpinia galangal), onion (Allium cepa) and garlic (Allium sativum).
Analisis Ekstrak Etanol Tangkai Daun Buasbuas (Premna pubescens) Menggunakan Gas Chromatography Mass Spectrophotometer (GCMS) Diky Setya Diningrat; Martina Restuati; Kusdianti Kusdianti; Ayu Nirmala Sari; Erly Marwani
Elkawnie: Journal of Islamic Science and Technology Vol 4, No 1 (2018)
Publisher : Universitas Islam Negeri Ar-Raniry Banda Aceh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22373/ekw.v4i1.3075

Abstract

Buasbuas (Premna pubescens) is a plant that is traditionally known to have medicinal properties. This study aims to determine the content of bioactive compounds contained in the petiole by Gas Chromatography Mass Spectrophotometer (GCMS) method. Preparation of ethanol extract of petiole using maceration method with 96% ethanol solvent. The study used gas chromatographic tools and mass spectra which were evaluated using MASSLAB program. The data obtained from the GCMS machine is then analyzed using the NCBI database pubchem software (https://pubchem.ncbi.nlm.nih.gov/). The results of this study indicate that the content of bioactive compounds on the petioles of buasbuas more than 50 libraries contains about 150 species of compounds with a range of RT and% area respectively 4.684 to 28.155 and 0.16 to 15.56%. The content of bioactive compounds shown this data indicates that very large potential of buasbuas plants to be explored and exploitation as a nutritious plant. The results of this study can be used as the foundation in the development program of the potential utilization of bioassemblance of buasbuas plants. In further research it is necessary to analyze the other parts of the plant and make comparisons to complete the available databases.
Effect of Ethanol Extract of Jamblang Aceh (Syzygium cumini) in Diabetic Mice (Mus musculus) and Its Potential As Anti-Diabetic Agent Ayu  Nirmala Sari; Januardi Januardi; Diky Setya Diningrat
Elkawnie: Journal of Islamic Science and Technology Vol 6, No 1 (2020)
Publisher : Universitas Islam Negeri Ar-Raniry Banda Aceh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22373/ekw.v6i1.5496

Abstract

Abstract : This study was designed to evaluate the anti-diabetic activity of the ethanol extract of Syzygium cumini leaves in alloxan-induced diabetes mice. The anti-diabetic activity of EDS was investigated in mice (Mus musculus SW.) Alloxan-induced diabetes. The effect of ethanol extract of Syzygium cumini leaves on normal blood glucose levels and oral glucose tolerance tests were studied in normoglycemic mice while the anti-diabetic effect was evaluated in alloxan-induced hyperglycemic mice. Ethanol extract of Syzygium cumini leaves (200 and 400 mg/kg) is given orally for 21 days. Glibenclamide (5 mg/kg, oral for 21 days) is used as a reference standard. Giving ethanol extract of Syzygium leaves causes a significant decrease in blood glucose levels in normoglycemic and hyperglycemic mice and also increases glucose tolerance test. Ethanol extract of Syzygium leaves reduces glycosylated hemoglobin levels, lactate dehydrogenase, and creatinine kinase in alloxan-treated mice. Ethanol extract of Syzygium leaves also improves TBARS oxidative stress parameters, catalase and superoxide dismutase activity and glutathione levels. The ethanol extract of Syzygium cumini leaves shows anti-diabetic activity through increased insulin secretion and this effect can be attributed to the content of flavonoids and phenolic compounds present in the ethanol extract of Syzygium cumini leaves.Abstrak : Penelitian ini dirancang untuk mengevaluasi aktivitas anti-diabetes dari ekstrak etanol daun Syzygium cumini (L) Skeels (EDS) pada mencit diabetes yang diinduksi aloksan. Aktivitas anti-diabetes EDS diselidiki pada mencit (Mus musculus SW.) diabetes yang diinduksi aloksan. Pengaruh ekstrak etanol daun Syzygium cumini (EDS) pada kadar glukosa darah normal dan uji toleransi glukosa oral dipelajari pada mencit normoglikemik sedangkan efek antidiabetik dievaluasi pada mencit hiperglikemik yang diinduksi aloksan. EDS (200 dan 400 mg/kg) diberikan secara oral selama 21 hari. Glibenclamide (5mg/kg, oral selama 21 hari) digunakan sebagai standar referensi. Pemberian EDS menyebabkan penurunan signifikan dalam kadar glukosa darah pada mencit normoglikemik dan hiperglikemik dan juga meningkatkan uji toleransi glukosa. EDS mengurangi kadar hemoglobin glikosilasi, laktat dehidrogenase, dan kreatinin kinase pada mencit yang diberi aloksan. EDS juga memperbaiki parameter stres oksidatif TBARS, aktivitas katalase dan superoksida dismutase dan kadar glutathione. Ekstrak etanol daun Syzygium cumini (EDS) menunjukkan aktivitas antidiabetik melalui peningkatan sekresi insulin dan efek ini dapat dikaitkan dengan kandungan flavonoid dan senyawa fenolik yang ada dalam ekstrak daun.
The Potency of Trigona’s Propolis Extract as Reactive Oxygen Species Inhibitor in Diabetic Mice Ahmad Ridwan; Ayu Nirmala Sari; Ramadhani Eka Putra
Journal of Mathematical and Fundamental Sciences Vol. 47 No. 3 (2015)
Publisher : Institute for Research and Community Services (LPPM) ITB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/j.math.fund.sci.2015.47.3.4

Abstract

Hyperglycemia has been proven to increase oxidative stress due to the production of reactive oxygen species (ROS) that exceed the capabilities of the natural antioxidant defenses, causing a deficiency in insulin receptors and insulin resistance. In this study, the effect of propolis on ROS was observed. Fifty five (55) male mice (Mus musculus SW.) were divided into 5 groups, i.e. KN (normal control), KDM (diabetes control), and P1, P2, P3. Propolis solution 50, 100 and 175 mg/kg bw was given to groups P1, P2 and P3 respectively, while distilled water was given to groups KN and KDM by oral gavage for 21 days. Density of ROS was measured every 7 days, while measurement of plasma insulin was carried out every 3 days. The results show that the density of ROS in the groups treated with propolis was lower than in the KDM group. However, the plasma insulin levels in the propolis groups were higher than in the KDM group. It was concluded that propolis can decrease ROS density and causes an increase in plasma insulin levels.
POTENSI ANTIOKSIDAN ALAMI PADA EKSTRAK DAUN JAMBLANG (Syzigium cumini (L.) Skeels) Ayu Nirmala Sari
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 18 No. 02 (2017): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464)
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (150.667 KB) | DOI: 10.24036/eksakta/vol18-iss02/61

Abstract

Various diseases can be triggered by the condition of oxidative stress in the body. Oxidative stress is a condition that occurs in cells when free radicals are present in excess amounts. To reduce the negative effects and negative effects of these free radicals, the body needs antioxidants. The aim of this research is to know the antioxidant potential of black plum leaf extract (Syzigium cumini (L.) Skeel) using DPPH method. Based on the results of antioxidant potential testing in black plum leaf extract known that it has antioxidant content that is classified as very active with an IC 50 value of 8.85. The results of this study indicate that the leaves of black plum (Syzigium cumini (L.) Skeel have the potential to be developed as a source of natural antioxidants for humans.
Co-Authors -, Kusdianti Abdul Muin Sibuea Ahmad Ridwan Alifa Tazkiya Alifa Tazkiya Ananda Wahyu Rizkina Anggi Audila Asmin Asmin, Asmin Catur Putri Khairun Nisa Cut Nur Kemala Dewi Dewi, Gustianti Dhiyaul Falah Dhiyaul Falah Diana Anggraeyani Diningrat, Diky Setya Diningrat, Diky Setya Erly Marwani, Erly Fahmi, M. Haikal Faizah, Siti Farisa Sabila Farisa Sabila Farisa Sabilla Farisa Sabilla Fazri Ardian Syah Fazri Ardian Syah Firman M Nur Fitria Nelda Fautama Fitriani, Sonia Ginting, Alin Anggreni Gustianti Dewi Harahap, Diannita Harahap, Novita Sari Ilham Zulfahmi Iwan Hasri Januardi Januardi Kusdianti Kusdianti Kusdianti Kusdianti Kusdianti Kusdianti Kusdianti Kusdianti Lestari, Siti Diah Ayu Lucy Simorangkir Marwah, Sanasti Masrillah Masrillah Masrillah, Masrillah Maulana, Bagoes Mazaya Dirayathi Misdal Misdal Muslich Hidayat Mutia, Intan Winda Nisa, Catur Putri Khairun Novhirtamely Kahar Novita Sari Harahap Nur Amalina Marfani Nurfadhillah Nurfadhillah Purba, Febi Anjaini Ramadhani Eka Putra Reni silvia Nasution Restuati, Martina Ridwan Sahputra Ridwan Saputra Rizka, Putri Rahmitha Rizkina, Ananda Wahyu Rizky Ardila Rudy Agung Nugroho Sabilla, Farisa Sanasti Marwah Sinaga, Acong Jaya Sonya Adelina Sipayung Sri Winarsih Syafrina Sari Lubis Syah, Fazri Ardian Syarifah Ira Mefrina Tazkiya, Alifa Triya Elliyatri Ulva Usliana Umi Mai Sarah Yudi Mafira Zahara Afnita Zulaini Zulaini Zulaini, Zulaini