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Putu Astawa
Departemen Ortopedi Dan Traumatologi, Universitas Udayana, Denpasar
Humanities Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Health Professions Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Social Sciences Transportation Veterinary Other

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Journal : Journal of Global Pharma Technology

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The Comparative Effect of Liquid and Tablet Preparation of Purple Sweet Potato (Ipomoea batatas L) Extract to Lipid Profile, MDA, and SOD Level in Male Wistar Rats After Given High-Cholesterol Diet I Wayan Putu Sutirta Yasa; I Made Jawi; Putu Astawa
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
Publisher : Journal of Global Pharma Technology

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Background: Recent developments in tablet preparation of extract have brought advantages to keep active ingredients from plants in stable forms physically and chemically. This study aims to compare the liquid and tablet preparation of purple sweet potato (Ipomoea batatas L.) extract to lipid profile, MDA, and SOD level in rats after given high-cholesterol diet. Methods: A randomized pre- and post-test control group experimental study was conducted during 4 weeks among 21 male Wistar rats. They were divided into 3 groups in this study namely: control (only high-cholesterol diet), Treatment 1 (T1) group (high-cholesterol diet and 200mg/day tablet of purple sweet potato extract), and Treatment 2 (T2) group (high-cholesterol diet and liquid form of purple sweet potato tubers extract about 2 mL/day). Lipid profile, MDA, and SOD level examination were performed twice from retro orbital sinus blood drawn and analyzed using ANOVA in SPSS version 17.Results: Mean value of lipid profile was significantly lower in T2 group (Cholesterol 84.48 ± 3.38; LDL 23.05 ± 2.32; HDL 63.39 ± 1.56; and triglycerides 96.03 ± 3.82; P < 0.05) after study period. The mean value of MDA was also significantly lower in T2 group (1.25 ± 0.09; P < 0.05) and SOD level was significantly higher in T2 group (73.72 ± 4.14; P < 0.05) in the end of study. Conclusion: Liquid preparation of purple sweet potato extract showed a better efficacy in reducing lipid profile and MDA level, as well as enhancing SOD level in rats given high-cholesterol diet.Keywords: Lipid Profile, Liquid, MDA and SOD Level, Purple Sweet Potato, Tablet.
COMPARISON THE ANTIHYPERTENSIVE AND ANTIOXIDANT POTENTIAL BETWEEN YOUNG MAHOGANY SEEDS EXTRACT WITH MATURE MAHOGANY SEEDS EXTRACT IN RATS WITH HYPERTENSION I Wayan Putu Sutirta Yasa; Putu Astawa; I Made Jawi
Journal of Global Pharma Technology Volume 09 Issue 05
Publisher : Journal of Global Pharma Technology

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Mahogany seeds have been used in the community as an antihypertensive and antioxidant. Antihypertensive and antioxidant efficacy of mature mahogany seeds has been proven in hypertensive rats. The purpose of this study was to compare the antihypertensive and antioxidant effect of mature mahogany seeds extract with young mahogany seeds extract. This study is a laboratory experimental design with pre-test and post-test design control groups, with Wistar rats as samples. Thirty rats were divided into 5 groups, each group consist of 6 rats. The control group was given saline every day as a rat model of hypertension. 1-4 treatment groups were each given NaCl and water extract of young mahogany seeds for treatment 1, the ethanol extract of young mahogany seeds as treatment 2, water extract of mature mahogany seeds as treatment 3 and ethanol extract of mature mahogany seeds as treatments 4. Dosages of extract mahogany seeds is 100 mg / head / day for 4 weeks. Before treatment, evaluation of rat blood pressure with special sphygmomanometer was held, and examination of blood MDA as a pre-test data. Further evaluation of MDA and SOD blood pressure are at the end of the study. The data were tested by ANOVA to see the difference between the groups. The results showed a decrease in blood pressure and levels of MDA were significant in all treatments (p <0.05) compared with control as well as an increase in SOD were significantly (p <0.05). The ethanol extract of mature mahogany seeds showed the most excellent antihypertensive and antioxidant properties (p <0.05). From these results, it can be concluded that the ethanol extract of mature mahogany seeds is better than young mahogany seeds extract as an antihypertensive and antioxidant in hypertensive rats.Keywords – antioxidants, hypertensive rats, mature and young mahogany seeds
Co-Authors Anak Agung Gede Eka Septian Utama Anak Agung Wiradewi Lestari Andy Sirada Ardo Sabir, Ardo Ari Asih Purnamawati Dewi Ari Asih Purnamawati Dewi Aryana, I Gusti Ngurah Wien Bagus Komang Satriyasa Cokorda Istri Sri Widhari Desak Made Wihandani Dimas Agusta Dwiwahyonokusuma Dwiwahyonokusuma Eka Wiratnaya Elysanti Dwi Martadiani Gede Adi Yuniarta Gede Parta Kinandana Gusti Ngurah Putra Stanu Herryanto Agustriadi Simanjuntak I Dewa Ayu Inten Dwi Primayanti I Gede Epi Paramarta I Gusti Agung Bagus Mataram I Gusti Ngurah Pramartha Wijaya Putra I Gusti Ngurah Wien Aryana I Gusti Putu Sutarma I Kadek Arya Gangga Permana I Ketut Suarja I Ketut Sutama I Ketut Suyasa I Made Ady Wirawan I Made Jawi I MADE MULIARTA . I Nyoman Adi Putra I Nyoman Adiputra I Nyoman Mangku Karmaya I Nyoman Rajin Aryana I Putu Adiartha Griadhi I Putu Budiarta I Putu Gede Adiatmika I Putu Sudira I Wayan Putu Sutirta Yasa I Wayan Siwantara I Wayan Subawa I Wayan Suryanto Dusak Ida Ayu Elistyawati Ida Bagus Subanada Ivander Purvance Ketut Gede Mulyadi Ridia Ketut Siki Kawiyana Ketut Tirtayasa Komang Septian Sandiwidayat Kuswara, Leonardus William Luh Eka Armoni Made Bramantya Karna Made Sudiarta Made Sudiarta Made Wirabhawa Maharjana, Made Agus Muh. Ali Imron Muhammad Ali Imron Ni Kadek Hera Silawati Ni Luh Eka Armoni Ni Made Puspa Dewi Astawa Ni Nyoman Sri Astuti Ni Putu Siadi Purniti Ni Wayan Rismayanti Nyoman Indah Kusuma Dewi Nyoman Suadnyana Pasek, Nyoman Suadnyana Putra, Agus Suarjaya Putra, Made Winatra Satya Putu Satriya Yudha Permadi Putu Wila Pradnya Paramita Raden Ayu Trisnayoni Savio, Sherly Desnita Soehartono Hadi Pranata Stedy Adnyana Christian Surya Adisthanaya, Surya Susy Purnawati Tamzil, Kezia Aurelia Tjokorda Gde Bagus Mahadewa Wahyuddin, Wahyuddin Wiwekowati