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All Journal VALENSI JURNAL KIMIA SAINS DAN APLIKASI REKAYASA Biology, Medicine, & Natural Product Chemistry EduChemia: Jurnal Kimia dan Pendidikan KOVALEN: Jurnal Riset Kimia IJFAC (Indonesian Journal of Fundamental and Applied Chemistry) JC-T (Journal Cis-Trans): Jurnal Kimia dan Terapannya Science and Technology Indonesia AKSIOLOGIYA : Jurnal Pengabdian Kepada Masyarakat ALCHEMY Jurnal Penelitian Kimia JMM (Jurnal Masyarakat Mandiri) SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Chemistry Indonesian Journal of Chemical Research Jurnal Serambi Engineering Walisongo Journal of Chemistry Jurnal Kreativitas PKM Jurnal Farmasi Indonesia Jurnal Nuansa Akademik: Jurnal Pembangunan Masyarakat Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Pengabdian Pada Masyarakat Molekul: Jurnal Ilmiah Kimia Jurnal Pengabdian Masyarakat (Jupemas) Jurnal Kesehatan Bakti Tunas Husada Medical Sains : Jurnal Ilmiah Kefarmasian
Gatut Ari Wardani
Universitas Bakti Tunas Husada
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Journal : JURNAL KIMIA SAINS DAN APLIKASI

 1 
Utilization of Jengkol Peel (Pithecellobium jiringa (Jack) Prain) as Lead (II) Ions Bio-sorbent with Column Method Gatut Ari Wardani; Lia Nuramalia; Winda Trisna Wulandari; Estin Nofiyanti
Jurnal Kimia Sains dan Aplikasi Vol 23, No 5 (2020): Volume 23 Issue 5 Year 2020
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2637.893 KB) | DOI: 10.14710/jksa.23.5.160-166

Abstract

Problems arising from laboratory waste include the content of lead metal ions in it, which can affect health. While on the other hand, Jengkol peel is a market waste and has no economic value. Jengkol peel contains hydroxyl groups and carboxylates to bind heavy metals such as lead (II) ions. So, this study aims to determine the effect of variations in flow rate, adsorbent height, and solution acidity and determine the ability of Jengkol peel in adsorbing lead (II) ions in the laboratory liquid by the column method. Organic groups that include active sides can be removed using 1N sodium hydroxide to increase the adsorption ability. Sodium hydroxide functions to dissolve lignin in lignocellulose compounds so that carboxylic groups are formed in cellulose, which has a role in binding metal ions. The determination of functional groups was carried out by Fourier-transform Infrared Spectroscopy. The identification of the adsorbent morphology was carried out by Scanning Electron Microscope. The adsorption of lead (II) ions by Jengkol peel was determined by calculating the difference between the lead (II) ions in the solution after and before passing through the column. The amount of lead metal remaining in solution was determined using Atomic Absorption Spectroscopy. Sodium hydroxide solution with a concentration of 1N can separate lignin from cellulose contained in lignocellulose to enhance the bio-sorbent ability of the Jengkol peel in binding metal ions. The smaller the flow rate in the column, the higher the amount of lead (II) ions adsorbed in the bio-sorbent. The acidity of the solution has the best adsorption at pH 5. The metal ions from the simulation sample can reduce the number of lead (II) metal ions adsorbed by 11%.
Synthesis and Computational Study of Bis-(1-(3-Chlorobenzoyl)-3-Phenylthiourea) Cobalt (III) as Anticancer Candidate Ruswanto Ruswanto; Nisa Uswatun Khasanah; Gatut Ari Wardani; Richa Mardianingrum
Jurnal Kimia Sains dan Aplikasi Vol 26, No 7 (2023): Volume 26 Issue 7 Year 2023
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jksa.26.7.238-248

Abstract

Cancer is a disease characterized by cells forming abnormally so that a buildup can cause lumps. Drug compounds used for anticancer treatment by chemotherapy become a severe problem because they have dangerous side effects and can affect patient’s quality of life. This study aims to discover new drug compounds with lowered toxicity effects. This was achieved by modifying their structures through synthesis, characterization, and estimating the interactions of the synthesized compounds with specific target receptors, utilizing a docking method. The result obtained was a synthesis yield of 36.2%. The characterization of complex compounds was characterized by the presence of a maximum wavelength of 273 nm and a molecular weight of 652 g/mmol, indicating the absorption of Co-O and Co-S at respective wavenumbers of 498 cm-1 and 604 cm- 1. The docking results showed that the Bis-(1-(3-Chlorobenzoyl)-3-Phenylthiourea) Cobalt (III) complex had the best activity on human estrogen receptor alpha (hER alpha) with a binding affinity value of - 9.40 kcal/mol and an inhibition constant of 0.129 M, which was lower than the comparison compound (cisplatin) and had a better pharmacokinetic profile than cisplatin. This study shows that the Bis-(1-(3-Chlorobenzoyl)-3-Phenylthiourea) Cobalt (III) complex is predicted to have potential as an anticancer candidate.
Co-Authors Ade Yeni Ade Yeni Aprilia Ade Yeni Apriliani Adinda Nur Octavia Agustina, Ariyanti Ahmad Tantowi Jaohari Alfanaar, Rokiy Ana Noviana Rachmadhiani Andyny Dwinovia Rianty Anindita Tri Kusuma Pratita Anindita Tri Kusuma Pratita Anisa Pebiansyah Anisa Pebiansyah Annazalia Rustandi Putri Annissya, Widia Primi Apriani, Nurul Aprillia, Ade Yeni Ardiansyah, Dandi Ariyanti Agustina Ayu Erviena Bayu Tri Laksono Clarisa Kartika Putri Cucu Nurpatonah Dea Dara Pamungkas Denis Pajriati Diana Sri Zustika Diana Sri Zustika, Diana Sri Dichy Nuryadin Zain Ditha Rizqi Aulia Utami Dwi Puspa Syahirrah Ega Maulana Qudsi Estin Nofiyanti Estin Nofiyanti Estin Nofiyanti Estin Nofiyanti Eva Saefatuzzahro Fadilah, Refi Tazhqiyatul Fajar Setiawan FAJAR SETIAWAN Fajar Setiawan Fajar Setiawan Fajar Setiawan Fasya Ammatul Hawa Fathurohman, Mochamad Firma Gustaman Firman Gustaman Firman Gustaman Firman Gustaman Gustaman, Firman Hanna Nurul Husna Hanna Nurul Husna Hanna Nurul Husna Haura Aklina Elyasin Hendy Suhendy Heri Herdiana Hertikawati, Hesi Hesi Hertikawati Idacahyati, Keni Iis Sukmawati Indra Indra Indra Indra Indra, Indra Ira Rahmiyani Ismi Syahrani Itmam Milataka Izfadllillah, Thesa Julyanti, Ai Rian Keni Ida Cahyani Keni Idacahyati Keni Idacahyati Keni Idacahyati Khoeruman Nur, Fauzan Lena Yulianti Lia Nuramalia Lilis Tuslinah Lilis tuslinah Lilis Tuslinah Lilis Tuslinah Lusi Nurdianti, Lusi Luthfi Najdah Mujahidah Mellyanawaty, Melly Meri Meri Meri, Meri Micola, Muhammad Yolanda Mochamad Fathurohman Mochamad Fathurohman Nandhini Huda A Nisa Uswatun Khasanah Noer Laelly BTAG Nur Laili Dwi Hidayati Nur Rahayuningsih, Nur Nurcholis Salman Nurhidah, Mia Nurlita, Putri Octavani, Salsabila Hanifah Pebiansyah, Anisa Pikri Adit Praditya R Pratama, Azril Pratita, Anindita Tri Kusuma Rahma, Aisyah Alpiah Ratih Damayanti Richa Mardianingrum Rissa Putri Aulia Yulianto Rizki Abdurochman Assidik Rohganala, Vinka Fitria Rubiansyah Dio Lazuardi Ruswanto, Ruswanto Sagita Wulandari Salman, Nurcholis Salsabila Hanifah Octavani Salsabila Putri Awalia Rahmat Septian, Ade Dwi Shal Nurdinda Fauziah Sindi Lestari Siti Laila Abiya Sri Asih Sri Juari Santosa Sugiharti, Mulya Tri Syahirrah, Dwi Puspa Syahputra, Ricky Andi Taofik Hidayat Taufik Hidayat Taufik Hidayat Taufik Hidayat Taufik Hidayat Tiara Permata Sari Tiffani Navisha Auli Tita Nofianti, Tita Tresna Lestari, Tresna Vera Nurviana Wawan rismawan Wawan Rismawan Widdy Erlinasari Widya Puspitasari Winda Trisna Wulandari, Winda Trisna Zain, Dichy Nuryadin