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All Journal Jurnal Analis Medika Biosains (JAMBS) Abdimas: Jurnal Pengabdian Masyarakat Universitas Merdeka Malang Borneo Journal of Medical Laboratory Technology Community Development Journal: Jurnal Pengabdian Masyarakat Jurnal Penelitian Keperawatan Kontemporer (JPKK) Warmadewa Minesterium Medical Journal Asian Journal of Health Research Prosiding Seminar Nasional Pengabdian Kepada Masyarakat Jurnal Laboratorium Khatulistiwa SWARNA: Jurnal Pengabdian Kepada Masyarakat
Nathalya Dwi Kartika Sari
Universitas Nahdlatul Ulama Surabaya
Religion Arts Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Public Health

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The Effect of Antihypertensive Drugs (Diuretic, Non-Diuretic Types) on Serum Electrolyte Levels (Na+, K+, Cl-) in Hypertensive Patients Irmawati, Irmawati; Nidianti, Ersalina; Anggraini, Rahayu; Kartika Sari, Nathalya Dwi
Jurnal Laboratorium Khatulistiwa Vol 8, No 2 (2025): Mei 2025
Publisher : poltekkes kemenkes pontianak

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30602/jlk.v8i2.1550

Abstract

Hypertension is one of the most common cardiovascular diseases and is still a major problem in the world. The prevalence of hypertension continues to increase every year, especially increasing most rapidly in developing countries (80% in the world). Treatment of hypertension is adjusted to the results of the examination, the cause and the patient's health condition. Antihypertensive drugs are divided into diuretic and non-diuretic types. This study aims to evaluate the effect of antihypertensive drugs on serum electrolyte levels in hypertensive patients. This type of study is observational analytic with a cross-sectional approach, on the effect of diuretic and non-diuretic antihypertensive drugs on hypertensive patients with a sample population of 30 samples. The method of examining the levels of electrolytes Na +, K +, Cl- is Ion selective electrolyte (ISE) with the provisions of normal sodium values of 135-145 mmol / L, potassium 3.5-5.5 mmol / L, chloride 94-110 mmol / L. The results of statistical tests showed that the average value of those consuming diuretic antihypertensive drugs was 141.06 mmol/L sodium, 4.27 mmol/L potassium, 106.55 mmol/L chloride and those consuming non-diuretic antihypertensive drugs were 137.89 mmol/L potassium, 4.08 mmol/L chloride 102.29 mmol/L. From the results of the Kruskal Wallis test, the p-value for sodium levels was 0.164, potassium 0.221, chloride 0.046, which means that there is no effect on hypertensive patients consuming diuretic and non-diuretic antihypertensive drugs on serum electrolyte levels of sodium, potassium, but there is a significant effect on chloride levels. 
Relationship between C-Reactive Protein Levels and Preeclampsia in Pregnant Women Karmila, Hartatiek Nila; Sari, Nathalya Dwi Kartika; Mardiyanti, Ika; Matin, Nur Sophia
Asian Journal of Health Research Vol. 4 No. 3 (2025): Volume 4 No 3 (December) 2025
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v4i3.281

Abstract

Introduction: Preeclampsia remains a major contributor to maternal morbidity and mortality worldwide, including in Indonesia. Increasing evidence suggests that inflammation plays an important role in its development. C-reactive protein (CRP), an easily accessible inflammatory marker, has been proposed as a potential indicator for early identification. This study aimed to examine the association between CRP levels and preeclampsia in pregnant women. Material and Methods: A case–control study was conducted at RSI A. Yani Surabaya between August and October 2022. Fifty pregnant women beyond 20 weeks of gestation were enrolled, consisting of 25 normotensive and 25 preeclamptic participants. CRP levels were measured using the ichromsa™ system following standard laboratory procedures. Data were analyzed using the Mann–Whitney U test with a significance level of p<0.05. Results: The mean maternal age was slightly higher in the preeclampsia group. Most participants were in the late third trimester. CRP levels differed significantly between groups, with higher values observed among women with preeclampsia (p<0.001). A greater proportion of preeclamptic women had CRP concentrations ≥5 mg/L. Conclusion: This study demonstrates a significant difference in CRP levels between normotensive and preeclamptic pregnancies, supporting the role of inflammation in the condition. However, given the limited sample size and lack of adjustment for confounding factors, the findings should be interpreted cautiously. Larger studies with broader analytical approaches are needed before CRP can be considered for clinical screening or risk stratification.
Differences in Leukocyte (White Blood Cell) Levels and Their Potential as a Predictor of Preeclampsia in Pregnant Women Karmila, Hartatiek Nila; Nathalya Dwi Kartika Sari; Ika Mardiyanti; Nur Sophia Matin
Jurnal Penelitian Keperawatan Kontemporer Vol 6 No 2 (2026): Vol. 6 No. 2 (2026): April 2026
Publisher : Program Studi S1 Ilmu Keperawatan dan Ners IKBIS Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59894/jpkk.v6i2.1349

Abstract

Background: Preeclampsia is a pregnancy complication that significantly contributes to maternal and perinatal morbidity and mortality. Systemic inflammation plays a key role in its pathogenesis, and leukocytes (white blood cells/WBC) are potential biomarkers associated with this condition. Objective: This study aimed to analyze differences in leukocyte levels between normotensive and preeclamptic pregnant women and to evaluate their potential as predictors of preeclampsia. Methods: This was an observational analytic study with a cross-sectional design involving 62 pregnant women, consisting of 33 normotensive and 29 preeclamptic subjects. Leukocyte levels were obtained from laboratory examinations. Differences were analyzed using the independent t-test, while predictive ability was assessed using Receiver Operating Characteristic (ROC) analysis and Area Under the Curve (AUC). Results: The mean leukocyte level in the normotensive group was 9.79 ± 2.32 ×10³/µL, while in the preeclampsia group it was 10.45 ± 3.20 ×10³/µL. There was no statistically significant difference between the two groups (p = 0.363). ROC analysis showed an AUC value of 0.56, indicating weak predictive ability. Conclusion: Leukocyte levels tend to be higher in preeclamptic pregnant women; however, the difference is not statistically significant and shows poor predictive performance. Therefore, WBC cannot be used as a single predictor of preeclampsia.
Co-Authors Agus Aan Adriansyah Aizah Ari Setyana Yuli Akas Yekti Pulih Asih Andini, Ary Andreas Putro Ragil Santoso, Andreas Putro Ragil Bastiana Bastiana Brina Thursina Dibiasi Budhi Setianto dr Hartatiek Nila,Sp.OG Edijanto, Soebagijo Poegoeh Effendi Endah Prayekti Ersalina Nidianti Gilang Nugraha Hamiduumajid Ballihg Ballihgoo Hartatiek Nila Karmila Hidayatih, Nurul Ika Mardiyanti Irmawati Irmawati Karmila, Hartatiek Nila Khiliah Navis Kurniasari, Diyan Wahyu Layla Agustina, Nurul Ivada Lisnawati, Diana Arum Maat, Suprapto Matin, Nur Sophia Mery Susantri Mirshall Abiedama Prayoga Mufida, Nisaul Muhammad, Akbar Reza Nikmatus Sa’adah Nila, Hartatiek Nur Sophia Matin Prayekti, Endah Prihatini Prihatini, Prihatini Puspitasari, Renny Novi Rahayu Anggraini S, Widya Novida Sonia Fitriatul Qolbi Ulan, Della Citra Yauwan Tobing Lukiyono Zahroh, Chilyatiz