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All Journal Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) JURNAL PHARMASCIENCE Pharmascience PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) CERATA Jurnal Ilmu Farmasi Jurnal Pengabdian Kepada Masyarakat (Mediteg) Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Borneo Journal Of Pharmascientech Jurnal Insan Farmasi Indonesia Tropical Health and Medical Research Journal Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Bakti Untuk Negeri Safari : Jurnal Pengabdian Masyarakat Indonesia J-ABDIPAMAS (Jurnal Pengabdian Kepada Masyarakat) Jurnal Nusantara Berbakti CERATA Jurnal Sains dan Kesehatan
Fadlilaturrahmah Fadlilaturrahmah, Fadlilaturrahmah
Program Studi Farmasi Fakultas MIPA Universitas Lambung Mangkurat, Banjarbaru
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Aktivitas Antibakteri Ekstrak Metanol Bunga Teratai (Nymphaea pubescens Willd) Amalia Khairunnisa; Nashrul Wathan; Mia Fitriana; Fadlilaturrahmah Fadlilaturrahmah; Nisriyati Fiddina
Jurnal Pharmascience Vol 7, No 2 (2020): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v7i2.8486

Abstract

Nymphaea pubescens Willd telah diketahui mempunyai efek antibakteri, terutama pada biji dan daunnya. Tetapi sampai saat ini bagian bunga dari tanaman tersebut belum dilakukan pengujian aktivitas antibakteri. Tujuan dari penelitian ini untuk melakukan skrining fitokimia, uji aktivitas antibakteri dan penentuan konsentrasi hambat minimum (KHM) dari ekstrak metanol bunga N. pubescens terhadap S. aureus dan E. coli. Proses ekstraksi bunga N. pubescens dimaserasi menggunakan pelarut metanol dengan perbandingan 1: 4 b/v. Metode pengujian yang digunakan ada dua yaitu metode difusi untuk pengujian aktivitas antibakteri dan metode dilusi untuk pengukuran konsentrasi hambat minimum (KHM). Hasil skrining fitokimia didapatkan bahwa ekstrak metanol bunga N. pubescens mengandung senyawa golongan fenolik, saponin dan flavonoid. Hasil pengujian aktivitas antibakteri menunjukkan bahwa ekstrak metanol bunga N.pubescens mampu menghambat S. aureus (diameter hambat 10 ± 0,29 mm) dan E.coli (diameter hambat 10,2 ± 0,50 mm). Konsentrasi hambat minimum dari ekstrak metanol bunga N. pubescens terhadap S.aureus sebesar 12,5% dan terhadap E.coli sebesar 25%. Dapat disimpulkan bahwa ekstrak metanol bunga N. pubescens memiliki aktivitas sebagai antibakteri. Nymphaea pubescens Willd has known to have antibacterial effects, especially on the seeds and leaves. However, until now the flower of the plant has not been tested for antibacterial activity. The purpose of this study was to perform phytochemical screening, antibacterial activity test and determine the minimum inhibitory concentration (MIC) of the methanol extract of N. pubescens flowers against S. aureus and E. coli. The process of extracting N. pubescens flowers is macerated using methanol as a solvent with a ratio of 1: 4 w / v. There are two test methods used, namely the diffusion method for testing antibacterial activity and the dilution method for measuring the minimum inhibitory concentration (MIC). The results of phytochemical screening showed that the methanol extract of N. pubescens flowers contained phenolic compounds, saponins, and flavonoids. The results of the antibacterial activity test showed that the methanol extract of N.pubescens flowers was able to inhibit S. aureus (inhibition diameter 10 ± 0.29 mm) and E. coli (inhibitory diameter 10.2 ± 0.50 mm). The minimum inhibitory concentration of the methanol extract of N. pubescens flowers against S.aureus was 12.5% and against E. coli was 25%. It can be concluded that the methanol extract of N. pubescens flowers has antibacterial activityKeywords: Nymphaea pubescens, lotus flower, methanol extract, antibacterial
Isolasi Dan Identifikasi Senyawa Antioksidan Dari Buah Kasturi (Mangifera casturi Kosterm.) Sutomo Sutomo; Hadi Azhari; Arnida Arnida; Fadlilaturrahmah Fadlilaturrahmah; Rahmat Yunus
Jurnal Pharmascience Vol 4, No 2 (2017): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v4i2.5778

Abstract

ABSTRAK Antioksidan berfungsi untuk menetralisir radikal bebas, sehingga dapat mencegah dan melindungi terjadinya kerusakan tubuh yang dapat menyebabkan timbulnya penyakit degeneratif. Salah satu tanaman endemik Kalimantan Selatan yang teridentifikasi mengandung antioksidan alami yaitu kasturi (Mangifera casturi Kosterm.). Penelitian ini bertujuan untuk mengisolasi dan mengidentifikasi senyawa antioksidan dari buah M. casturi. Ekstraksi dilakukan dengan metode maserasi. Pemisahan dan pemurnian dilakukan dengan KLT , KCV, dan kromatografi kolom gravitasi. Identifikasi senyawa dengan spektrofotometri UV-Vis dan FTIR serta uji kualitatif antioksidan dan aktifitas kuantitatif antioksidan isolat. Ekstraksi 2500 gram serbuk buah M. casturi dengan metanol diperoleh 840,69 gram ekstrak kental berwarna coklat. Fraksinasi 60 gram ekstrak metanol dengan fraksi etil asetat menghasilkan 8,3 gram ekstrak kering. Fraksi etil asetat difraksinasi kembali menggunakan KCV dengan eluen n-heksana : etil asetat (9:1; 8:2; 7:3; 6:4; 5:5; 4:6; 3:7) v/v, etil asetat : metanol (5:5 v/v), 100% metanol diperoleh fraksi A, B, C, D, E, F, G, dan H. Fraksi H dipilih untuk di isolasi menggunakan kromatografi kolom gravitasi dengan eluen n-heksana : etil asetat : metanol (5:3:0,5; 5:4:1; 5:4:2; 5:6:2; 5:6:2,5) v/v dan 100% metanol. Uji kualitatif KLT menunjukkan isolat H-7 mengandung senyawa antioksidan dengan pereaksi DPPH. Aktivitas antioksidan isolat H-7 memiliki nilai IC50¬ sebesar 4,61±0,57 ppm. Analisis isolat H-7 dengan UV-Vis menghasilkan puncak pada λ 274,8 nm (pita I) dan λ 218 nm (Pita II). Analisis FTIR menunjukkan gugus fungsi dari isolat H-7 yaitu -OH, C-H aromatik, C-H alifatik, C=O, C=C aromatik, dan C-O. Kata Kunci : Antioksidan, buah M. casturi, DPPH, fraksi etil asetat, Isolasi
Uji Aktivitas Antioksidan dan Antitirosinase Fraksi n-Butanol Daun Sungkai (Peronema canescens Jack.) Secara Kualitatif Menggunakan Kromatografi Lapis Tipis Fadlilaturrahmah Fadlilaturrahmah; Aditya Maulana Perdana Putra; Muhammad Ikhwan Rizki; Titin Nor
Jurnal Pharmascience Vol 8, No 2 (2021): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v8i2.11160

Abstract

Kerusakan oksidatif dalam tubuh manusia dapat disebabkan oleh radikal bebas, sehingga menimbulkan berbagai permasalahan. Daun P. canescens memiliki kandungan senyawa fenolik, tanin, alkaloid, steroid, saponin dan flavonoid yang potensial sebagai antioksidan. Tujuan penelitian ini yaitu untuk melakukan uji aktivitas antioksidan dan antitirosinase fraksi n-butanol daun sungkai secara kualittaif menggunakan kromatografi lapis tipis. Metode yang digunakan yaitu preparasi sampel dengan pembuatan simplisia yang kemudian diekstraksi secara maserasi menggunakan etanol 96%. Hasil ekstrak kental kemudian difraksinasi bertingkat dengan pelarut n-heksan, etil asetat, dan n-butanol. Selanjutnya dilakukan skrining fitokimia, uji aktivitas antioksidan, dan antitirosinase secara kualitatif menggunakan kromatografi lapis tipis. Hasil rendemen ekstrak etanol daun P. canescens yaitu sebesar 7,28% sedangkan rendemen fraksi yaitu 24,8%. Skrining fitokimia ekstrak etanol P. canescens mengandung alkaloid, flavonoid, terpenoid, steroid, tanin, saponin, dan fenol. Kesimpulan yang didapatkan dari penelitian ini yaitu fraksi n-butanol daun P. canscens berpotensi memiliki aktivitas antioksidan yang ditandai adanya noda kuning pucat setelah penyemprotan dengan reagen DPPH, serta berpotensi memiliki aktivitas antitirosinase secara kualitatif yang ditandai dengan adanya bercak putih pada plat KLT. Kata Kunci: DPPH, L-DOPA, Asam askorbat, Enzim  Oxidative damage in the human body can be caused by free radicals, causing various problems. P. canescens leaves contain phenolic compounds, tannins, alkaloids, steroids, saponins and flavonoids that have potential as antioxidants. The purpose of this study was to test the antioxidant and antityrosinase activity of the n-butanol fraction of sungkai leaves qualitatively using thin layer chromatography. The method used is sample preparation by making simplicia which is then extracted by maceration using 96% ethanol. The viscous extract was then fractionated with n-hexane, ethyl acetate, and n-butanol as solvents. Furthermore, phytochemical screening, antioxidant activity, and antityrosinase tests were carried out qualitatively using thin layer chromatography. The yield of P. canescens leaf ethanol extract was 7.28%, while the fraction yield was 24.8%. Phytochemical screening of P. canescens ethanol extract containing alkaloids, flavonoids, terpenoids, steroids, tannins, saponins, and phenols. The conclusion obtained from this study is that the n-butanol fraction of P. canscens leaves has the potential to have antioxidant activity which is indicated by a pale yellow stain after spraying with DPPH reagent, and has the potential to have qualitative antityrosinase activity which is indicated by the presence of white spots on the TLC plate.
UJI AKTIVITAS TABIR SURYA DAN ANTIOKSIDAN EKSTRAK ETANOL DAUN SUNGKAI (Perenema canescens Jack) Fadlilaturrahmah Fadlilaturrahmah; Amalia Khairunnisa; Aditya MP Putra; Ivanna Sinta
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 6 No 2 (2021): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (436.265 KB) | DOI: 10.36387/jiis.v6i2.737

Abstract

Indonesia, which is located in the tropics, causes people's skin to easily experience premature aging and tan. Most of these cosmetic products contain dangerous synthetic chemicals. For this reason, cosmetic products with natural active ingredients or phytocosmetics that are effective and safe to use need to be developed. One of the typical natural plant plants from South Kalimantan that has the potential to be developed as a cosmetic preparation is Sungkai (Peronema canescens Jack). The aim of the study was to determine the antioxidant activity and sunscreen activity of Sungkai leaves. The method used for the determination of antioxidant activity is the DPPH method using a uv-vis spectrophotometer and for the determination of sunscreen activity using a uv-vis spectrophotometer. The results showed that the P. canescens plant extract contained anthraquinones, flavonoids, saponins, tannins, and phenols. P.canescens plants have an Inhibitory Concentration 50 (IC50 ) of 42.219±19.440 ppm and have sunscreen activity with spf (Sun Protecting Factor) values ??with concentrations of 600 ppm, 400 ppm, 200 respectively as follows: 24±0.31; 16±0.34; and 8±0.3. The conclusion of this study Sungkai (Peronema canescens Jack) has antioxidant activity and has sunscreen activity so that it has the potential to be developed into natural skin care.
PENETAPAN KADAR FLAVONOID TOTAL DAN NILAI SUN PROTECTION FACTOR (SPF) DARI EKSTRAK KERING DAUN CEMPEDAK (Artocarpus integer) Muhammad Ikhwan Rizki; Syifa Auliani; Amalia Khairunnisa; Fadlilaturrahmah Fadlilaturrahmah; Normaidah Normaidah; Anna Khumaira Sari
Jurnal Insan Farmasi Indonesia Vol 5 No 1 (2022): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jifi.v5i1.868

Abstract

Ultraviolet rays cause wrinkles and premature ageing. The bad effects of sun exposure can be avoided by using sunscreen. Artocarpus integer is empirically used as a black spot remover and cold powder. Total flavonoid content is an extract quality parameter that is related to the consistency of the pharmacological effects produced. The purpose of this study was to determine the total flavonoid content and the value of Sun Protection Factor (SPF) from the dried extract Artocarpus integer. The study began with a drying of fresh leaves using an oven, making simplicia powder, extraction process by maceration, and drying extracts using a drying cabinet. The dry extract was measured for total flavonoid content using a spectrophotometer UV-Vis with quercetin as a marker. The dry extract also determined the SPF value at concentrations of 200, 400, 600, 800, and 1000 ppm. The results showed that the total flavonoid content of the dry extract of cempedak leaves was 1,283 ± 0.032 %w/w equivalent to quercetin. The SPF value of dry extract of cempedak leaves at concentrations of 200, 400, 600, 800, and 1000 ppm respectively, namely 2,923 ± 0.009, 5.990 ± 0.002, 8.846 ± 0.001, 13,181 ± 0.008 and 15.856 ± 0.1533
Pengaruh Pemberian Ekstrak Etanol Daun Kajajahi (Leucosyke capitellata Wedd.) Terhadap Efek Pembekuan Darah Dan Penurunan Agregasi Platelet Pada Darah Manusia Sehat Secara In Vitro Annisa Shalehah; Noor Cahaya; Fadlilaturrahmah Fadlilaturrahmah
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 12 No. 02 Desember 2015
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

ABSTRAK Tanaman kajajahi (Leucosyke capitellata Wedd.) dimanfaatkan oleh masyarakat Loksado, Kabupaten Hulu Sungai Selatan, Kalimantan Selatan sebagai tanaman obat. Berdasarkan penelitian sebelumnya, diketahui bahwa tanaman kajajahi mengandung beberapa senyawa kimia seperti tanin, saponin, dan flavonoid. Senyawa flavonid terbukti memiliki aktivitas sebagai antioksidan yang juga berperan dalam menghambat pelekatan, agregasi, dan sekresi platelet. Tujuan penelitian ini membuktikan pengaruh ekstrak kajajahi terhadap efek pembekuan darah dan penurunan agregasi platelet. Penelitian ini merupakan penelitian eksperimental dengan menggunakan sampel darah manusia sehat yang memenuhi kriteria inklusi dan eksklusi. Sampel dibagi menjadi 3 kelompok, yaitu kelompok kontrol positif (darah dengan EDTA), kelompok ekstrak kajajahi (0,1%) dan kontrol negatif (darah tanpa EDTA) dengan replikasi sebanyak 3 kali. Analisis data secara kualitatif dan kuantitatif. Data kualitatif berupa gambaran mikroskopik sel darah dan data kuantitatif berupa jumlah penurunan agregasi platelet yang dilakukan dengan cara menghitung selisih serapan plasma sebelum dan sesudah penambahan ADP. Data hasil penurunan jumlah platelet dianalisis secara statistik dengan uji t berpasangan dengan taraf kepercayaan 95%. Berdasarkan hasil penelitian dari uji efek pembekuan darah, terlihat pada kelompok kontrol negatif sel darah menggumpal, saling berikatan satu dengan lain dan tidak terpisah; kelompok kontrol positif terlihat sel darah tidak saling berikatan atau terpisah satu sama lain dan pada kelompok ekstrak terlihat sebagian besar tidak saling berikatan, terpisah satu dengan yang lain. Uji penurunan agregasi platelet pada kelompok kontrol negatif menunjukkan peningkatan agregasi platelet, kelompok kontrol positif dan kelompok ekstrak menunjukkan penurunan agregasi platelet. Dengan demikian, didapatkan kesimpulan bahwa ekstrak etanol daun kajajahi 0,1% berpengaruh terhadap penurunan agregasi platelet (p value 0,086) dan memberikan efek pembekuan darah. Kata kunci: agregasi platelet, Leucosyke capitellata Wedd., pembekuan darah. ABSTRACT Kajajahi (Leucosyke capitellata Wedd.), an Indonesian medicine plant, is often used in society as traditional medicine. One of kajajahi’s benefits that haven’t much been explored is antiplatelet activity. Previous research results have shown that kajajahi extract contain flavonoid compound and is effective as an antioxidants. Flavonoid is an antioxidant compound which can inhibit the adhering, aggregation, and secretion of platelets because it obstructs the metabolism of arachidonat acid by cyclooxygenase. The purpose of this research is to identify the effect of platelet’s anti-aggregation of ethanolic extract from kajajahi leaves. The testing of microscopically blood clotting effect showed that ethanol extract of kajajahi leaves could prevent blood cell from coagulating. The testing of plasma absorbance reduction before and after the addition of ADP showed comparison toward negative control to positive control with significance of 0.007 (0.05). There is a significant difference on the comparison of negative control to extract and positive control to negative control. Key words: blood clotting, Leucosyke capitellata Wedd., platelet aggregation.
PENGARUH METODE EKSTRAKSI TERHADAP AKTIVITAS ANTIOKSIDAN DAN KADAR FLAVONOID DAUN KAREHO (Callicarpa Longifolia Lam) Fadlilaturrahmah Fadlilaturrahmah; Nashrul Wathan; Akhmad Rezeki Firdaus; Saufy Arishandi
Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Vol 5 No 1 (2020): Pharma Xplore : Jurnal Sains dan Ilmu Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/farmasi.v5i1.977

Abstract

Tumbuhan Kareho (Callicarpa longifolia Lam. merupakan salah satu tanaman herbal yang mengandung senyawa flavonoid. Penelitian sebelumnya telah dilakukan untuk menilai kadar flavonoid tertinggi berdasarkan variasi pelarut, tetapi belum ada penelitian mengenai metode ekstraksi yang optimal untuk penentuan aktivitas antioksidan dan kadar flavonoid. Tujuan dari penelitian ini pada dasarnya adalah untuk mengevaluasi metode ekstraksi terbaik jika dilihat dari aktivitas antioksidan kadar flavonoid dan dari daun C.longifolia. Metode ekstraksi yang dilakukan dalam penelitian ini adalah maserasi, soxhlet dan perkolasi. Total kandungan flavonoid ditentukan dengan menggunakan metode aluminium klorida dan dihitung sebagai setara kuersetin (EK). Uji aktivitas antioksidan dilakukan secara in vitro dengan metode DPPH. Hasil menunjukkan bahwa semua ekstrak yang diperoleh dari metode ekstraksi yang berbeda menunjukkan antioksidan kuat, di mana aktivitas antioksidan tertinggi diperoleh dari metode ekstraksi perkolasi (IC50 = 20,82 ppm). Total kandungan flavonoid tertinggi diperoleh dari metode soxhlet (12,37 ± 0,03% b/b). Hasil penelitian menunjukkan bahwa perbedaan metode ekstraksi menghasilkan perbedaan yang signifikan (sig <0,05) pada aktivitas antioksidan dan kadar flavonoid dari daun C. longifolia. Kata kunci : Callicarpa longifolia Lam, Ekstraksi, Antioksidan, Flavononid
PELATIHAN MITIGASI BENCANA BANJIR, UPAYA PENGOBATAN MANDIRI, DAN KONSELING TRAUMA HEALING PASCA BENCANA DI DESA PEKAUMAN ULU KABUPATEN BANJAR KALIMANTAN SELATAN Muhammad Ikhwan Rizki; Fadlilaturrahmah Fadlilaturrahmah; Anna Khumaira Sari
Jurnal Bakti untuk Negeri Vol 1 No 2 (2021)
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (161.299 KB)

Abstract

South Kalimantan in early 2021 experienced the largest flooding in the last 50 years. Data in Banjar Regency shows that there are 27,368 houses, 2 bridges, 5 places of worship and 9 schools in 207 villages from 19 sub-districts in Banjar Regency that are affected. Pekauman Ulu Village was affected by flooding with a large potential for flooding. The purpose of this community service is to improve community skills in disaster mitigation, post-disaster counseling, and community knowledge in efforts to self-medicate in disaster situations. The service method carried out is through counseling, training, and distributing booklets related to self-medication. The results of the service activities were evaluated through the presence of the community, the results of the pretest and posttest, as well as the testimonies of the participants who attended. The data were analyzed descriptively and presented in the table. The service that has been carried out was attended by 48 participants, participants actively asked questions and were involved in discussions. Based on the results of the pretest and posttest, there was an increase in knowledge related to disaster mitigation from 49.77% to 83.55%, basic trauma healing abilities from 54.67% to 84.44%, and understanding of self-medication from 38.22% to 85. 77%. The conclusion from community service shows that there is an increase in knowledge related to disaster mitigation, basic trauma healing abilities, and understanding of self-medication
Identifikasi Fitokimia dan Uji Aktivitas Antiinflamasi In vitro Fraksi n- heksana Kapur Naga (Calophyllum soulattri Burm F) Dengan Metode Uji Penghambatan Denaturasi Protein Menggunakan Spektrofotometer Uv-Vis Fadlilaturrahmah Fadlilaturrahmah; Jariyah Amilia; Yuana Sukmawaty; Nashrul Wathan
Jurnal Pharmascience Vol 9, No 2 (2022): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v9i2.14372

Abstract

Tumbuhan kapur naga (Calophyllum soulattri Burm F) merupakan salah satu spesies dari  keluarga Calophyllum yang terdapat di hutan Kalimantan khususnya daerah lahan basah. Secara empiris dimasyarakat memanfaatkan kulit batang C. soulattri untuk mengobati penyakit kulit yang salah satu mekanisme proses penyembuhan melawati tahap inflamasi. Penelitian ini bertujuan untuk melakukan penulusuran kandungan fitokimia dari fraksi n-heksana kulit batang C. soulattri dan melakukan uji aktivitas antiinflamasi in vitro dengan metode uji penghambatan denaturasi protein menggunakan spektrofotometer uv-vis. Metode penelitian diawali dengan tahapan pembuatan simplisia, ekstraksi dengan etanol 96%, dan difraksinasi menggunakan n-heksana.  Setelah itu dilakukan  uji penelusuran kandungan fitokimia menggunakan uji tabung dan pengujian antiinflamasi menggunakan spektrofotometri uv-vis menggunakan metode penghambatan denaturasi protein secara kuantitatif dengan natrium diklofenak sebagai kontrol positif. Hasil dari identifikasi fitokimia diperoleh bahwa fraksi n-heksana mengandung alkaloid, fenol, tanin, flavonoid, saponin, dan triterpenoid. Uji aktivitas antiinflamasi fraksi n-heksana kulit batang C. soulattri menghasilkan nilai IC50 sebesar 27,43±0,74 ppm dan natrium diklofenak dengan nilai  IC50 sebesar 39,17±0,86 ppm. Berdasaran uji t-test diperoleh hasil yang menunjukkan berbeda bermakna  dengan IC50 Natrium diklofenak (sig = 0,00). Kesimpulan dari penelitian ini yaitu fraksi n-heksana kulit batang C. soulattri memiliki aktivitas antiinflamasi yang lebih baik dari natrium diklofenak. Kata Kunci: Bovine Serum Albumin, IC50, Natrium Diklofenak, Kuantitatif Kapur naga (Calophyllum soulattri Burm F) is a species of the Calophyllum family that found in the forests of Kalimantan, especially in wetland areas. Empirically, the community uses the bark of C. soulattri to treat skin diseases, which is one of the mechanisms of the healing process through the inflammatory stage. The purpose of this study was to investigate the phytochemical content of the n-hexane fraction of the stem bark of C. soulattri and to test its anti-inflammatory activity in vitro with the protein denaturation inhibition test method using uv-vis spectrophotometer. The research method begins with the steps of making simplicia, extraction with 96% ethanol, and fractionation using n-hexane. After that, a test for tracing the phytochemical content was carried out using a tube test and an anti-inflammatory test using uv-vis spectrophotometry using a quantitative protein denaturation inhibition method with diclofenac sodium as a positive control. The results of the phytochemical identification showed that the n-hexane fraction contained alkaloids, triterpenoids, phenols, tannins, flavonoids, and saponins. The anti-inflammatory activity test of the n-hexane fraction of C. soulattri stem bark produced an IC50 value of 27.43±0.74 ppm and diclofenac sodium with an IC50 value of 39.17±0.86 ppm. Based on the t-test, the results showed that it was significantly different from the IC50 of diclofenac sodium (sig = 0.00). The conclusion of this study is that the n-hexane fraction of the stem bark of C. soulattri has better anti-inflammatory activity than diclofenac sodium.
PENETAPAN KADAR FLAVONOID TOTAL DAN NILAI SUN PROTECTION FACTOR (SPF) DARI EKSTRAK KERING DAUN CEMPEDAK (Artocarpus integer) Muhammad Ikhwan Rizki; Syifa Auliani; Amalia Khairunnisa; Fadlilaturrahmah Fadlilaturrahmah; Normaidah Normaidah; Anna Khumaira Sari
Jurnal Insan Farmasi Indonesia Vol 5 No 1 (2022): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jifi.v5i1.868

Abstract

Ultraviolet rays cause wrinkles and premature ageing. The bad effects of sun exposure can be avoided by using sunscreen. Artocarpus integer is empirically used as a black spot remover and cold powder. Total flavonoid content is an extract quality parameter that is related to the consistency of the pharmacological effects produced. The purpose of this study was to determine the total flavonoid content and the value of Sun Protection Factor (SPF) from the dried extract Artocarpus integer. The study began with a drying of fresh leaves using an oven, making simplicia powder, extraction process by maceration, and drying extracts using a drying cabinet. The dry extract was measured for total flavonoid content using a spectrophotometer UV-Vis with quercetin as a marker. The dry extract also determined the SPF value at concentrations of 200, 400, 600, 800, and 1000 ppm. The results showed that the total flavonoid content of the dry extract of cempedak leaves was 1,283 ± 0.032 %w/w equivalent to quercetin. The SPF value of dry extract of cempedak leaves at concentrations of 200, 400, 600, 800, and 1000 ppm respectively, namely 2,923 ± 0.009, 5.990 ± 0.002, 8.846 ± 0.001, 13,181 ± 0.008 and 15.856 ± 0.1533
Co-Authors Adinda Dwina Hadiastuti Aditya MP Putra Akhmad Rezeki Firdaus Akhmad Rezeki Firdaus Amalia Khairunnisa Amalia Khairunnisa Amalia Khairunnisa Amalina Amalina, Amalina Anna Khumaira Sari Annisa Shalehah Annisa Shalehah, Annisa Annisa Sulistyowati Arnida Arnida Arnida Arnida Audya Rahmah Azhara, Desiya Damayanti Badruzsaufari Buih, Putri Helena Junjung Dina Rahmawanty Dina Rahmawanty Dokmauli Nainggolan, Dokmauli Eko Susilowati Hadi Azhari Hayatun Izma Heri Budi Santoso Hermalia Putri Herningtyas Nautika Lingga Hidayaturrahmah Ivanna Sinta Jariyah Amilia Khoerul Anwar Maria Dewi, Maria Maslia Rahmah Maulidya Najahidin Maulina, Rizka Maulina, Rizka Ma’shumah Ma’shumah Mia Fitriana Mia Fitriana Muhammad Ikhwan Rizki Nabila Nabila Nani Kartinah Nashrul Wathan Nisriyati Fiddina Noor Cahaya Normaidah, Normaidah Normilawati Nurlely, Nurlely Nurmalita Sari Putra, Aditya Maulana Perdana Rahmat Ramadhani Rahmat Yunus Rahmatullah, Satrio Wibowo Rahmawanty, Dina Rizka Maulina Rizka Putri Salsabila Samsul Hadi Sari, Fitri Novita Saufy Arishandi Saufy Arishandi Septiany Septiany Sutomo Sutomo Sutomo Sutomo Syifa Auliani Titin Nor Viogenta, Pratika Yuana Sukmawaty