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All Journal Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) JURNAL PHARMASCIENCE PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) CERATA Jurnal Ilmu Farmasi Jurnal Pengabdian Kepada Masyarakat (Mediteg) Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Borneo Journal Of Pharmascientech Jurnal Insan Farmasi Indonesia Jurnal Ilmiah Kesehatan (JIKA) Tropical Health and Medical Research Journal Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Bakti Untuk Negeri Safari : Jurnal Pengabdian Masyarakat Indonesia J-ABDIPAMAS (Jurnal Pengabdian Kepada Masyarakat) Jurnal Nusantara Berbakti CERATA Jurnal Sains dan Kesehatan Journal of Pharmascience
Fadlilaturrahmah Fadlilaturrahmah, Fadlilaturrahmah
Program Studi Farmasi Fakultas MIPA Universitas Lambung Mangkurat, Banjarbaru
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Identifikasi Fitokimia dan Uji Aktivitas Antiinflamasi In vitro Fraksi n- heksana Kapur Naga (Calophyllum soulattri Burm F) Dengan Metode Uji Penghambatan Denaturasi Protein Menggunakan Spektrofotometer Uv-Vis Fadlilaturrahmah Fadlilaturrahmah; Jariyah Amilia; Yuana Sukmawaty; Nashrul Wathan
Journal of Pharmascience Vol. 9 No. 2 (2022): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v9i2.14372

Abstract

Tumbuhan kapur naga (Calophyllum soulattri Burm F) merupakan salah satu spesies dari  keluarga Calophyllum yang terdapat di hutan Kalimantan khususnya daerah lahan basah. Secara empiris dimasyarakat memanfaatkan kulit batang C. soulattri untuk mengobati penyakit kulit yang salah satu mekanisme proses penyembuhan melawati tahap inflamasi. Penelitian ini bertujuan untuk melakukan penulusuran kandungan fitokimia dari fraksi n-heksana kulit batang C. soulattri dan melakukan uji aktivitas antiinflamasi in vitro dengan metode uji penghambatan denaturasi protein menggunakan spektrofotometer uv-vis. Metode penelitian diawali dengan tahapan pembuatan simplisia, ekstraksi dengan etanol 96%, dan difraksinasi menggunakan n-heksana.  Setelah itu dilakukan  uji penelusuran kandungan fitokimia menggunakan uji tabung dan pengujian antiinflamasi menggunakan spektrofotometri uv-vis menggunakan metode penghambatan denaturasi protein secara kuantitatif dengan natrium diklofenak sebagai kontrol positif. Hasil dari identifikasi fitokimia diperoleh bahwa fraksi n-heksana mengandung alkaloid, fenol, tanin, flavonoid, saponin, dan triterpenoid. Uji aktivitas antiinflamasi fraksi n-heksana kulit batang C. soulattri menghasilkan nilai IC50 sebesar 27,43±0,74 ppm dan natrium diklofenak dengan nilai  IC50 sebesar 39,17±0,86 ppm. Berdasaran uji t-test diperoleh hasil yang menunjukkan berbeda bermakna  dengan IC50 Natrium diklofenak (sig = 0,00). Kesimpulan dari penelitian ini yaitu fraksi n-heksana kulit batang C. soulattri memiliki aktivitas antiinflamasi yang lebih baik dari natrium diklofenak. Kata Kunci: Bovine Serum Albumin, IC50, Natrium Diklofenak, Kuantitatif Kapur naga (Calophyllum soulattri Burm F) is a species of the Calophyllum family that found in the forests of Kalimantan, especially in wetland areas. Empirically, the community uses the bark of C. soulattri to treat skin diseases, which is one of the mechanisms of the healing process through the inflammatory stage. The purpose of this study was to investigate the phytochemical content of the n-hexane fraction of the stem bark of C. soulattri and to test its anti-inflammatory activity in vitro with the protein denaturation inhibition test method using uv-vis spectrophotometer. The research method begins with the steps of making simplicia, extraction with 96% ethanol, and fractionation using n-hexane. After that, a test for tracing the phytochemical content was carried out using a tube test and an anti-inflammatory test using uv-vis spectrophotometry using a quantitative protein denaturation inhibition method with diclofenac sodium as a positive control. The results of the phytochemical identification showed that the n-hexane fraction contained alkaloids, triterpenoids, phenols, tannins, flavonoids, and saponins. The anti-inflammatory activity test of the n-hexane fraction of C. soulattri stem bark produced an IC50 value of 27.43±0.74 ppm and diclofenac sodium with an IC50 value of 39.17±0.86 ppm. Based on the t-test, the results showed that it was significantly different from the IC50 of diclofenac sodium (sig = 0.00). The conclusion of this study is that the n-hexane fraction of the stem bark of C. soulattri has better anti-inflammatory activity than diclofenac sodium.
Determination of SPF Value and Total Tannin in Ethyl Acetate Fraction of Peronema canescens Jack Amalia Khairunnisa; Fadlilaturrahmah Fadlilaturrahmah; Septiany Septiany
Journal of Pharmascience Vol. 10 No. 2 (2023): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v10i2.16484

Abstract

Daun Sungkai (Peronema canescens Jack) mengandung metabolit sekunder antara lain tannin, alkaloid, terpenoid, steroid, dan flavonoid. P. canescens merupakan tanaman asli Kalimantan Selatan yang berpotensi sebagai perawatan kulit alami berdasarkarkan kandungan tannin yang memiliki aktivitas antioksidan sehingga dapat dikembangkan sebagai produk tabir surya. Penelitian ini bertujuan untuk menentukan nilai SPF dan tannin total fraksi etil asetat daun Sungkai (P. canescens) menggunakan spektrofotometri UV-Vis. Metode ekstraksi dilakukan dengan maserasi menggunakan etanol 96% dan penggunaan fraksi n-heksana dan etil asetat. Penentuan tanin total menggunakan standar katekin dengan konsentrasi 40,60, 80, 100 dan 120 ppm. Hasil kadar tannin total sebesar 0,5586% ±0.01516 ekivalen katekin dan nilai SPF sebesar 5.703±0.021. Dengan demikian dapat disimpulkan daun Sungkai (Peronema canescens Jack) dapat dikembangkan sebagai tabir surya alami.  Kata Kunci: Daun Sungkai, Tabir Surya, Tannin Total, UV-Vis, SPF  Sungkai leaves (Peronema canescens Jack). contains secondary metabolites i.e tannins, alkaloids, terpenoids, steroids, and flavonoids. P. canescens, natural plant from South Kalimantan, has potential benefits as natural skincare based on tannin which contains antioxidant activity that can be developed as a sunscreen product. This study aimed to determine the sun protection factor (SPF) and total tannin ethyl acetate fraction of sungkai leaves (P. canescens) using UV-vis spectrophotometry. The extraction method was maceration with 96% ethanol and the fraction used n-hexane and ethyl acetate. The determination of total tannin with catechin standards concentration 40,60,80, 100 and 120 ppm. The result of total tannin was 0.5586% ±0.01516 catechin equivalents and the SPF value was 5.703±0.021. The conclusion of the research is that Peronema canescens Jack can be developed into natural sunscreen. 
Uji Sun Protection Factor (SPF) Ekstrak Etanol Daun Mitragyna speciosa Korth. Normaidah Normaidah; Maulidya Najahidin; Maslia Rahmah; Fadlilaturrahmah Fadlilaturrahmah; Hayatun Izma
Journal of Pharmascience Vol. 10 No. 2 (2023): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v10i2.17038

Abstract

Kratom (Mitragyna speciosa Korth.) merupakan tanaman tropis yang memiliki kemampuan melindungi kulit dari paparan sinar matahari. Tujuan dari penelitian ini adalah untuk mengetahui aktivitas tabir surya ekstrak etanol daun M. speciosa kuantitatif menggunakan spektrometri UV-Vis. Ekstraksi dilakukan dengan metode maserasi menggunakan pelarut etanol 96%. Kandungan metabolit sekunder secara kualitatif dilakukan menggunakan skrining fitokimia. Aktivitas tabir surya diuji menggunakan lambda 290-320 nm dengan interval 5 nm. Ekstrak etanol daun M. speciosa diperoleh sebesar 86,09 gram (17,218%) dan pada konsentrasi 250 ppm menunjukkan adanya aktivitas tabir surya dengan nilai SPF sebesar 8,433. Daun kratom asal Kalimantan Selatan berpotensi sebagai produk kosmetik tabir surya. Kata Kunci: Kratom, Spektrofotometri UV-Vis, Tabir Surya, Flavonoid Kratom (Mitragyna speciosa Korth.) is a tropical plant that has the ability to protect the skin from sun exposure due to the presence of flavonoids. The purpose of this study was to determine the sunscreen activity of the M. speciosa leaves ethanolic extract, quantitatively by UV-Vis spectrometry. Extraction was carried out by maceration method in 96% ethanol. The content of secondary metabolites were qualitatively determined using the phytochemistry screening study. The sunscreen activity was tested using 290-320 nm (5 nm intervals). The ethanol extract of M. speciosa leaves was obtained by 86.09 grams (17.218%) and with a concentration of 250 ppm showed sunscreen activity with an SPF value of 8.433. Kratom leaves from South Kalimantan have potential as a sunscreen.
Determination of Total Phenolic and Caffeine Content and Their Correlation with Antioxidant Activity in Local Coffee Brews from South Kalimantan Nashrul Wathan; Naura Azmira; Nurul Khasanah Anaini; Nur Aulia Yahya; Dhian Ririn Lestari; Joharman Joharman; Fadlilaturrahmah Fadlilaturrahmah
Journal of Pharmascience Vol. 13 No. 1 (2026): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v13i1.22576

Abstract

Coffee brews are widely consumed beverages known to contain bioactive compounds such as phenolic compounds and caffeine that provide health benefits, including antioxidant activity. The objective of this research is to evaluate the antioxidant activity, total phenolic content, and caffeine content of coffee brews made from local coffee beans of South Kalimantan, demonstrating their potential as functional beverages with health promoting properties. The local coffee beans used in this study originated from Pengaron, Aranio, Mataraman and Bati-Bati. The research included sample identification, beverage formulation, antioxidant activity assay using the DPPH method, and analysis of total phenolic and caffeine content using UV-Vis spectrophotometry. The results showed that the antioxidant activity, as indicated by IC₅₀ values, was lowest in coffee from Pengaron (202.962 ± 0.89 ppm), followed by Aranio (166.716 ± 0.358 ppm), Mataraman (150.043 ± 0.345 ppm), and the strongest in Bati-Bati (113.242 ± 0.122 ppm). The total phenolic content ranged from 58.327 ± 0.017 mg GAE/mL in Pengaron, 83.993 ± 0.017 in Aranio, 104.536 ± 0.032 in Mataraman, to 108.646 ± 0.042 in Bati-Bati. Caffeine levels were 123.876 ± 0.331, 139.340 ± 0.238, 175.495 ± 0.715, and 131.833 ± 0.620 mg/serving, respectively. The findings reveal a strong positive relationship between total phenolic content and antioxidant activity, while caffeine content did not consistently align with antioxidant performance. These findings support the significant role of phenolic compounds in determining the antioxidant potential of South Kalimantan’s local coffee beverages. The highest antioxidant activity and phenolic content were observed in coffee beverages made from Coffea liberica beans originating from Bati-Bati, suggesting its superior potential as a functional beverage with health benefits.
Co-Authors Adinda Dwina Hadiastuti Aditya MP Putra Akhmad Rezeki Firdaus Akhmad Rezeki Firdaus Amalia Khairunnisa Amalia Khairunnisa Amalia Khairunnisa Amalia Khairunnisa, Amalia Amalina Amalina, Amalina Anna Khumaira Sari Annisa Shalehah Annisa Shalehah, Annisa Annisa Sulistyowati Arnida Arnida Arnida Arnida Audya Rahmah Azhara, Desiya Damayanti Badruzsaufari Buih, Putri Helena Junjung Dhian Ririn Lestari Dina Rahmawanty Dina Rahmawanty Dokmauli Nainggolan, Dokmauli Eko Susilowati Hadi Azhari Hayatun Izma Heri Budi Santoso Hermalia Putri Herningtyas Nautika Lingga Hidayaturrahmah Ivanna Sinta Izma, Hayatun Jariyah Amilia Joharman Joharman Khoerul Anwar Khoerul Anwar Maria Dewi, Maria Maslia Rahmah Maulidya Najahidin Maulina, Rizka Maulina, Rizka Ma’shumah Ma’shumah Mia Fitriana Mia Fitriana Muhammad Ikhwan Rizki Nabila Nabila Nani Kartinah Nashrul Wathan Naura Azmira Nisriyati Fiddina Noor Cahaya Normaidah, Normaidah Normilawati Nur Aulia Yahya Nurlely, Nurlely Nurmalita Sari Nurul Khasanah Anaini Putra, Aditya Maulana Perdana Rahmah, Maslia Rahmat Ramadhani Rahmat Yunus Rahmatullah, Satrio Wibowo Rahmawanty, Dina Rizka Maulina Rizka Putri Salsabila Samsul Hadi Sari, Fitri Novita Saufy Arishandi Saufy Arishandi Septiany Septiany Sutomo Sutomo Sutomo Sutomo Sutomo Sutomo Sutomo Sutomo Sutomo Sutomo Syifa Auliani Titin Nor Viogenta, Pratika Yuana Sukmawaty