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All Journal VALENSI INDONESIAN JOURNAL OF PHARMACY Jurnal Pengabdian UntukMu NegeRI Abdimas Talenta : Jurnal Pengabdian Kepada Masyarakat Dinamisia: Jurnal Pengabdian Kepada Masyarakat Martabe : Jurnal Pengabdian Kepada Masyarakat Jurnal Riset Hesti Medan Akper Kesdam I/BB Medan Indonesian Journal of Pharmaceutical and Clinical Research International Journal Of Science, Technology & Management (IJSTM) Indonesian Journal of Applied Research (IJAR) Jurnal Natural Eduvest - Journal of Universal Studies Jurnal Farmasi Indonesia Molekul: Jurnal Ilmiah Kimia
Effendy De Lux Putra, Effendy De Lux
Departemen Kimia Farmasi Fakultas Farmasi Universitas Sumatera Utara, Medan, Sumatera Utara, Indonesia
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Journal : Jurnal Natural

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Development of Fourier transform infrared spectrophotometric method for identification and determination of marketed metamizole tablet preparation NERDY NERDY; EFFENDY DE LUX PUTRA; NILSYA FEBRIKA ZEBUA; CHRISTICA ILSANNA SURBAKTI; JIHAN SAFIRA
Jurnal Natural Volume 21 Number 1, February 2021
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (330.847 KB) | DOI: 10.24815/jn.v21i1.18318

Abstract

Metamizole is a nonsteroidal antiinflammatory drug (NSAID) that functions as an analgesic, antipyretic, and antiinflammatory. Examination of active substance contents is a requirement that must be met to ensure the quality of drug preparations. The aims of this study were to develop and validate the Fourier Transform Infrared spectrophotometric method for the quantitation of metamizole content in marketed tablet preparation. Identification and determination of metamizole contents by Fourier Transform Infrared spectrophotometric method used methanol solvent in the wavenumber range 4000 cm–1 to 650 cm–1. The results showed that the specific wavenumbers of metamizole were 1649.3 cm–1; 1623.3 cm–1; and 1589.7 cm–1; and the contents metamizole in marketed tablet preparation ranged from (97.954 ± 0.121)% to (104.541 ± 0.257)%. From the validation method, the recovery result is 100.129%; the relative standard deviation is 0.057%; the limit of detection is 2.09526 mg/mL; the limit of quantitation is 6.34928 mg/mL; and the range 40 mg/mL to 60 mg/mL. The quantitation of metamizole contents can be carried out by Fourier Transform Infrared spectrophotometric method with accurate and precise quantitation results.
Development of Fourier transform infrared spectrophotometric method for identification and determination of marketed metamizole tablet preparation NERDY NERDY; EFFENDY DE LUX PUTRA; NILSYA FEBRIKA ZEBUA; CHRISTICA ILSANNA SURBAKTI; JIHAN SAFIRA
Jurnal Natural Volume 21 Number 1, February 2021
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jn.v21i1.18318

Abstract

Metamizole is a nonsteroidal antiinflammatory drug (NSAID) that functions as an analgesic, antipyretic, and antiinflammatory. Examination of active substance contents is a requirement that must be met to ensure the quality of drug preparations. The aims of this study were to develop and validate the Fourier Transform Infrared spectrophotometric method for the quantitation of metamizole content in marketed tablet preparation. Identification and determination of metamizole contents by Fourier Transform Infrared spectrophotometric method used methanol solvent in the wavenumber range 4000 cm–1 to 650 cm–1. The results showed that the specific wavenumbers of metamizole were 1649.3 cm–1; 1623.3 cm–1; and 1589.7 cm–1; and the contents metamizole in marketed tablet preparation ranged from (97.954 ± 0.121)% to (104.541 ± 0.257)%. From the validation method, the recovery result is 100.129%; the relative standard deviation is 0.057%; the limit of detection is 2.09526 mg/mL; the limit of quantitation is 6.34928 mg/mL; and the range 40 mg/mL to 60 mg/mL. The quantitation of metamizole contents can be carried out by Fourier Transform Infrared spectrophotometric method with accurate and precise quantitation results.
Co-Authors Aminah Dalimunthe Angelyne, Metha Atika Mulyati BAKRI, TEDY KURNIAWAN Bunga Mari Sembiring CHRISTICA ILSANNA SURBAKTI Denny Satria Denny Satria, Denny Desyandri Desyandri Dian Ika Perbina Meliala Emil Salim Emil Salim Fathur Rahman Harun Furi, Mustika Henny Sri Wahyuni Hindri Syahputri Indah Pratiwi JIHAN SAFIRA Lia Laila, Lia Linda Margata Lisda Rimayani Nasution M. Fauzan Lubis Mahatir Muhammad Muchlisyam Muchlisyam, Muchlisyam Muhammad Daffa Al-Khairi Nadia, Syarifah Napitupulu, Pinastiara Nasri Nasri, Nasri Nerdy, Nerdy Nia Novranda Pertiwi Nilsya Febrika Zebua, Nilsya Febrika Nur Asnah Sitohang, Nur Asnah Panal Sitorus* Prasetyo, Bayu Eko Purba, Gratia Apulina Cindylawsa Rahman Harun, Fathur Rosidah, Rosidah Selamat Ginting Shafiyah, Miranda Siregar, Nina Ashariani Siti Morin Sinaga Tanaka, Gracelyn Tedy Kurniawan Bakri Thomi Baihaki Hijriyan Wahidah Ramadhani Manurung Wahyuni*, Henny Sri Wardono, Sri Waruwu, Syukur Berkat Yuandani Yuliasmi, Sri