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All Journal VALENSI INDONESIAN JOURNAL OF PHARMACY Jurnal Pengabdian UntukMu NegeRI Abdimas Talenta : Jurnal Pengabdian Kepada Masyarakat Dinamisia: Jurnal Pengabdian Kepada Masyarakat Martabe : Jurnal Pengabdian Kepada Masyarakat Jurnal Riset Hesti Medan Akper Kesdam I/BB Medan Indonesian Journal of Pharmaceutical and Clinical Research International Journal Of Science, Technology & Management (IJSTM) Indonesian Journal of Applied Research (IJAR) Jurnal Natural Eduvest - Journal of Universal Studies Jurnal Farmasi Indonesia Molekul: Jurnal Ilmiah Kimia
Effendy De Lux Putra, Effendy De Lux
Departemen Kimia Farmasi Fakultas Farmasi Universitas Sumatera Utara, Medan, Sumatera Utara, Indonesia
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Journal : Eduvest - Journal of Universal Studies

 1 
Determination of The Level of Paracetamol and Tramadol Hcl Mixture in Tablets by Chemometric Method by Fourier Transform Infrared Spectrophotometry Purba, Gratia Apulina Cindylawsa; Muchlisyam, Muchlisyam; Putra, Effendy De Lux
Eduvest - Journal of Universal Studies Vol. 5 No. 1 (2025): Journal Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v5i1.50283

Abstract

Fixed-dose combinations of paracetamol and tramadol HCl are effective in the treatment of moderate to severe pain. Therefore, the determination of the levels of the mixture of paracetamol and tramadol HCl is very important for the pharmaceutical industry. The purpose of this study was to determine the levels of paracetamol and tramadol HCl mixture using Fourier Transform Infrared combined with partial least square (PLS) chemometric method. This study was conducted by making a calibration model and chemometric validation of each of the five concentrations measured absorbance at specific wave numbers of paracetamol and tramadol HCl. The results of the study on PLS multivariate calibration of paracetamol and tramadol HCl with RMSECV values of 0.06279 and 0.03785, PRESS values of 0.02366 and 0.00860, and R2 values of 0.9995  0.9998, respectively. All validation parameters are within the acceptable range.  This indicates that the method can be used to accurately determine drug levels without separation
Co-Authors Aminah Dalimunthe Angelyne, Metha Atika Mulyati BAKRI, TEDY KURNIAWAN Bunga Mari Sembiring CHRISTICA ILSANNA SURBAKTI Denny Satria Denny Satria, Denny Desyandri Desyandri Dian Ika Perbina Meliala Emil Salim Emil Salim Fathur Rahman Harun Furi, Mustika Henny Sri Wahyuni Hindri Syahputri Indah Pratiwi JIHAN SAFIRA Lia Laila, Lia Linda Margata Lisda Rimayani Nasution M. Fauzan Lubis Mahatir Muhammad Muchlisyam Muchlisyam, Muchlisyam Muhammad Daffa Al-Khairi Nadia, Syarifah Napitupulu, Pinastiara Nasri Nasri, Nasri Nerdy, Nerdy Nia Novranda Pertiwi Nilsya Febrika Zebua, Nilsya Febrika Nur Asnah Sitohang, Nur Asnah Panal Sitorus* Prasetyo, Bayu Eko Purba, Gratia Apulina Cindylawsa Rahman Harun, Fathur Rosidah, Rosidah Selamat Ginting Shafiyah, Miranda Siregar, Nina Ashariani Siti Morin Sinaga Tanaka, Gracelyn Tedy Kurniawan Bakri Thomi Baihaki Hijriyan Wahidah Ramadhani Manurung Wahyuni*, Henny Sri Wardono, Sri Waruwu, Syukur Berkat Yuandani Yuliasmi, Sri