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All Journal Medical Journal of Indonesia Paediatrica Indonesiana Indonesian Journal of Rheumatology Jurnal Respirologi Indonesia Majalah Patologi Indonesia Narra J Cermin Dunia Kedokteran Makara Journal of Health Research Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education and Research Institute Cermin Dunia Kedokteran
Lisnawati Rachmadi
Department Of Anatomical Pathology, Faculty Of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Comprehensive Histopathological Properties of Dartos Tissue Associated with Hypospadias Severity and Chordee: A Prospective Study Raharja, Putu Angga Risky; Birowo, Ponco; Rachmadi, Lisnawati; Wibowo, Heri; Kekalih, Aria; Duarsa, Gede Wirya Kusuma; Wahyudi, Irfan
Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education Research Institute Vol. 8 No. - (2024): Proceedings Book of International Conference and Exhibition on The Indonesian M
Publisher : Writing Center IMERI FMUI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69951/proceedingsbookoficeonimeri.v8i-.243

Abstract

Background: The cause of chordee in hypospadias is not fully understood. Dartos fascia resection has been shown to correct penile curvature, suggesting its potential involvement. This study aimed to evaluate the histopathological properties of dartos tissue and their association with hypospadias severity and chordee.Methods and Materials: Dartos tissue samples were collected from 37 children with hypospadias and ten controls undergoing circumcision between March and October 2024. Histopathological analysis using hematoxylin-eosin and Masson’s trichrome staining assessed for collagen, smooth muscle, and vascular density. Assessment and quantification of all histopathological components were blinded. Results: The hypospadias group showed lower collagen density (60.85±6.75% vs. 67.31±4.61%; p=0.003) and higher smooth muscle density (7.34±4.92% vs. 2.51±2.24%; p<0.001) compared to controls, with no significant difference in vessel density. Sub-analysis showed severe chordee was linked to lower collagen density compared to mild (Mean Difference [MD] -6.24±2.41%; p=0.014) and moderate chordee (MD -5.73±2.54%; p=0.031). Conclusions: The dartos tissue in hypospadias patients exhibited lower collagen density and higher smooth muscle density, with chordee severity specifically linked to decreased collagen density.
Co-Authors A S Sulaiman Abror Irsan Agus Setiyono Andi Yasmon Anna Rozaliyani Antonius H. Pudjiadi Aria Kekalih Aryono Hendarto Astrid E Greijer Bambang Setiyohadi C Matin Rumende Chuang, Hsiao-Chi Cleopas Martin Rumende David Sitinjak Diana Natalia Diana Natalia Dilawar, Ismail Djajadiman Gatot Djatikusumo, Ari Dwi Wulandari Effiana Effiana Effiana, Effiana Elisna Syahruddin F Oktaviana Gede Wirya Kusuma Duarsa Gunawan, Andrew N. Halim, Brigitta N. Harry Isbagio Heri Wibowo Heriyanto, Didik S. I Bing Tan Ika Trisnawati, Ika Ika Wulan Yuliani Ikhwan Rinaldi Indira Priya Darsini Indira Priya Darsini Irfan Wahyudi Iris Rengganis Iris Rengganis Jaap M Middeldorp Jasin, Madeleine Ramdhani Joedo Prihartono Junita Indarti Kusumowidagdo, Gladys Laiman, Vincent Lau, Vincent Linggodigdo, Michelle Lukman Edwar M A Yudharto M S Azizi M Simadibrata Mardhia, Mardhia Mardhia, Mardhia Mardianto, Umar Maria Mayella Vianney Marlinda Adham Mulyadi M. Djer Murni, Indah K. N Anggraini N Sukmana Najib Advani Namira Kesuma Jelita Nia Kurniati Nyoman Kertia Piprim B. Yanuarso, Piprim B. Ponco Birowo Pramita Gayatri R Sandra R Wahyuningsih Raharja, Putu Angga Risky Rianto Setiabudy Romi Baginta Rubiana Sukardi, Rubiana Sarah Fitriani Sari Rahmayanti Setyanto, Darmawan Budi Shanty R. Kusumawardani Sitinjak, David Soehartati Argadikoesoema Gondhowiardjo Soehartati Gondhowiardjo Sri Rezeki Hadinegoro Suhendro Suhendro Supriatna, Novianti Susanti, Dhama S. Tenggara, Jeffry B. Tjahjani M. Sudiro Wibowo, Suryo Anggoro Kusumo Yayi DB Susanto Yayi Dwina Billianti Yudantha, Anggun R. Yuliani, Fara S. Zaini, Jamal