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All Journal Medical Journal of Indonesia Paediatrica Indonesiana Majalah Patologi Indonesia Narra J eJournal Kedokteran Indonesia Makara Journal of Health Research Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education and Research Institute
Lisnawati Rachmadi
Department Of Anatomical Pathology, Faculty Of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Comprehensive Histopathological Properties of Dartos Tissue Associated with Hypospadias Severity and Chordee: A Prospective Study Raharja, Putu Angga Risky; Birowo, Ponco; Rachmadi, Lisnawati; Wibowo, Heri; Kekalih, Aria; Duarsa, Gede Wirya Kusuma; Wahyudi, Irfan
Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education Research Institute Vol. 8 No. - (2024): Proceedings Book of International Conference and Exhibition on The Indonesian M
Publisher : Writing Center IMERI FMUI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69951/proceedingsbookoficeonimeri.v8i-.243

Abstract

Background: The cause of chordee in hypospadias is not fully understood. Dartos fascia resection has been shown to correct penile curvature, suggesting its potential involvement. This study aimed to evaluate the histopathological properties of dartos tissue and their association with hypospadias severity and chordee.Methods and Materials: Dartos tissue samples were collected from 37 children with hypospadias and ten controls undergoing circumcision between March and October 2024. Histopathological analysis using hematoxylin-eosin and Masson’s trichrome staining assessed for collagen, smooth muscle, and vascular density. Assessment and quantification of all histopathological components were blinded. Results: The hypospadias group showed lower collagen density (60.85±6.75% vs. 67.31±4.61%; p=0.003) and higher smooth muscle density (7.34±4.92% vs. 2.51±2.24%; p<0.001) compared to controls, with no significant difference in vessel density. Sub-analysis showed severe chordee was linked to lower collagen density compared to mild (Mean Difference [MD] -6.24±2.41%; p=0.014) and moderate chordee (MD -5.73±2.54%; p=0.031). Conclusions: The dartos tissue in hypospadias patients exhibited lower collagen density and higher smooth muscle density, with chordee severity specifically linked to decreased collagen density.
Co-Authors Abror Irsan Andi Yasmon Anna Rozaliyani Antonius H. Pudjiadi Aria Kekalih Aryono Hendarto Astrid E Greijer Chuang, Hsiao-Chi David Sitinjak Diana Natalia Diana Natalia Dilawar, Ismail Djajadiman Gatot Djatikusumo, Ari Dwi Wulandari Effiana Effiana Effiana, Effiana Gede Wirya Kusuma Duarsa Gunawan, Andrew N. Halim, Brigitta N. Heri Wibowo Heriyanto, Didik S. I Bing Tan Ika Trisnawati, Ika Ikhwan Rinaldi Irfan Wahyudi Jaap M Middeldorp Junita Indarti Kusumowidagdo, Gladys Laiman, Vincent Lau, Vincent Linggodigdo, Michelle Lukman Edwar Mardhia, Mardhia Mardhia, Mardhia Mardianto, Umar Maria Mayella Vianney Marlinda Adham Mulyadi M. Djer Murni, Indah K. Najib Advani Namira Kesuma Jelita Piprim B. Yanuarso, Piprim B. Ponco Birowo Raharja, Putu Angga Risky Rubiana Sukardi, Rubiana Sari Rahmayanti Soehartati Argadikoesoema Gondhowiardjo Soehartati Gondhowiardjo Supriatna, Novianti Susanti, Dhama S. Tenggara, Jeffry B. Tjahjani M. Sudiro Yayi Dwina Billianti Yudantha, Anggun R. Yuliani, Fara S.