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All Journal HAYATI Journal of Biosciences Farmaka Pharmaciana: Jurnal Kefarmasian Plasma - Jurnal Kesehatan Dharmakarya : Jurnal Aplikasi Ipteks Untuk Masyarakat Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Klinik Indonesia Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan The Indonesian Biomedical Journal Molecular and Cellular Biomedical Sciences (MCBS) Pharmacology and Clinical Pharmacy Research JSFK (Jurnal Sains Farmasi & Klinis) FITOFARMAKA: Jurnal Ilmiah Farmasi Majalah Farmasetika Jurnal Ilmiah Farmako Bahari Indonesian Journal of Biological Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal An-Najat: Jurnal Ilmu Farmasi dan Kesehatan Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan Medical Sains : Jurnal Ilmiah Kefarmasian Journal of Tropical Pharmacy and Chemistry
Tina Rostinawati
Departemen Biologi Farmasi, Fakultas Farmasi, Universitas Padjadjaran, Sumedang
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Journal : Jurnal Ilmiah Farmako Bahari

 1 
EXPLORATION OF CHITINOLYTIC MICROORGANISMS FROM SEAWATER AS ANTI-CANDIDIASIS AGENTS USING FUNCTIONALIZED CHITIN SUBSTRATE DERIVED FROM GREEN MUSSEL WASTE Adnyanaschah, Rahadhyan; Ismail, Dzava Prawinsyah Fairus; Mahardika, Bintang Satrio; Putri, Yolla Adellia; Shafa, Nafis; Rostinawati, Tina
Jurnal Ilmiah Farmako Bahari Vol 16 No 1 (2025): Jurnal Ilmiah Farmako Bahari
Publisher : Faculty of Mathematic and Natural Science, Garut University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52434/jifb.v16i1.41855

Abstract

Candidiasis is a Candida sp. infection (Candida albicans in common) that happens in nails, hairs, skin, and oesophagus, with around 20-25% prevalence in Indonesia. Chitin is one of the main components of its cell wall and serves as a target for candidiasis therapy using natural degradant compounds, such as chitinase enzyme. Chitinase enzyme is collected from chitinolytic bacteria found massively in chitin-rich environments like seawater. The screening is needed to identify the varieties of bacteria with chitinolytic activity. The screening was done using green mussel waste (Perna viridis), which contains 14-35% chitin and reached 10.776,75 tons of trash in 2020. This research aims to get a chitinolytic bacteria using green mussels as a chitin substrate source and a chitinolytic bacteria with anti-candidiasis activity. This research was conducted by isolating chitin from green mussel shells, chitinolytic bacteria screening, and anti-candidiasis activity test. Results collected from 5.00, 5.08, and 5.18 km isolates were the Vibrio alginolyticus, Vibrio neocaledonicus, and Marinobacter persicus species, which had a chitinolytic index of 1.246, 1.560, 1.492 also 64.29; 61.30; 69.01 U/ml chitinase enzymatic activity. The highest anti-candidiasis activity was found in a sample 5,18 km from the coast of Kejawanan Beach based on the number of chitinase enzyme activity and the chitinolytic index.  
Co-Authors Adinda Putri Lestari, Adinda Putri Adnyanaschah, Rahadhyan AMALIA, NISA AYU Anas Subarnas Anggita Putri Unggaran Anis Yohana Chaerunisaa, Anis Yohana Anna Safarrida, Anna Annisa Khalilah ANNISA MAYANGSARI Apriani, Diana Kurnia ASMAN SADINO, ASMAN Assyifa, Fahroziah Astrina Fuji Nurfadilah ATHIYAGUSTI PONCO PUTRI Atmedi Surendra Atmedi Surendra Auliya A. Suwantika Cynthia Retna Sartika, Cynthia Retna Cysilia K Hindarto Debbie Retnoningrum, Debbie Debbie S Retnoningrum DEBBIE SOEFIE RETNONINGRUM DEBBIE SOFIE RETNONINGRUM Devinna Kang Dihan Laziba Dika P. Destiani Driyanti Rahayu Dudi Hardianto, Dudi Dwiya, Reiva Farah Efrida Martius Elfahmi Elfahmi, Elfahmi ERLIN ELISABETH HUTAPEA Ernawati Giri Rahman, Ernawati Giri ERVITA INDRIANI Facicilia, Geofanny Fadhlillah, Muhammad Fadhlurrahman, Ahmad Fahim Fajar, Desi Reski Fajrin, Maulida FEBBY VALENTINE PURWADI Fitri Qoriawaty Hotma Hutapea, Hotma IIS NURAENI Imam Adi Wicaksono IMAM ADI WICAKSONO, IMAM ADI Irma Melyani Puspitasari Ismail, Dzava Prawinsyah Fairus JAMES PRASETYO LAKSONO Jutti Levita Juwartina Ida Royani, Juwartina Ida K Hindarto, Cysilia Kang, Devinna KENNY DWI SIDHARTA Laniyati Hamijoyo, Laniyati Lestari, Hilda Shinta Mahardika, Bintang Satrio Melisa Intan Barliana, Melisa Intan Moelyono Muktiwardojo Mohammad R. Akbar Muchtaridi Muchtaridi Mutakin Mutakin Norisca A. Putriana Nugrahani, Hanny Nuraeni, Yen Yen Ade Pamungkas, Barolym Tri Putri, Yolla Adellia Rano K. Sinuraya Renggana, Hesti Resmi Mustarichie Reza Laila Najmi Risrina Nur Ekawati Rizky Abdulah Ronny Lesmana S Retnoningrum, Debbie Salma Tri Octaviany SANTOSO, IVANA SARAH SYAFIRA Shafa, Nafis Sinuraya, Rano K. Sitinjak, Bernap Dwi Putra Sri Adi Sumiwi Sri Agung Fitri Kusuma, Sri Agung Steffi Liem Sumirtapura, Yeyet Cahyati Surendra, Atmedi Suryana, Shendi Suryanto Suryanto Suwandi, Deden Winda Taofik Rusdiana TIANA MILANDA Woro Supadmi Yen Yen Ade Nuraeni