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All Journal Jurnal Kesehatan Window of Health : Jurnal Kesehatan Jurnal Mandala Pharmacon Indonesia Bantenese Jurnal Pengabdian Masyarakat JURNAL KAJIAN VETERINER Indonesian Journal of Health Sciences Research and Development (IJHSRD) Jurnal Penelitian Inovatif Lansau: Jurnal Ilmu Kefarmasian Jurnal Abdi dan Dedikasi kepada Masyarakat Indonesia Jurnal Riset Ilmiah Indonesian Journal of Community Empowerment Jurnal Pengabdian Masyarakat Jurnal Analis Kesehatan Kendari
Apriyanto Apriyanto
Politeknik Bina Husada Kendari
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Anti-hyperuricemia Activity of Ethanol Extract of Bajakah Stem (Spatholobus litoralis Haask) on In Vivo Model: Analysis of Uric Acid and Cyclooxygenase-2 Levels Muhammad Ilyas Y.; Apriyanto; Adriatman Rasak; Nirwati Rusli; Asriullah Jabbar; Ufu Rindang; Fadhliyah Malik
Window of Health : Jurnal Kesehatan Vol 9 No 2 (April 2026)
Publisher : Fakultas Kesehatan Masyarakat Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/woh.vi.1517

Abstract

Investigation of bajakah (Spatholobus littoralis Hassk), a typical plant of the island of Borneo, as an anti-hyperuricemia and anti-inflammatory agent through the cyclooxygenase-2 (COX-2) inhibition pathway is important to reveal. This is supported by previous research indicating that bajakah has strong anti-inflammatory and antioxidant effects, with a higher flavonoid content. Evidence-based studies were conducted to determine whether the bajakah stem extract can reduce uric acid levels and inhibit COX-2 as an anti-hyperuricemia therapy. This study was conducted in vivo on mice with a hyperuricemia model induced by potassium oxonate. The treatment consisted of a normal control group, a negative control (Na-CMC, 0.5%), a positive control (allopurinol), and a dose-variation group of Bajakah stem ethanol extract at 100, 200, and 300 mg/kg BW. Uric acid levels were determined at hours 1, 2, and 3 by lateral chromatography and COX-2 levels by the sandwich ELISA method. The study results showed that bajakah stem ethanol extract in the 300 mg/kg body weight dose group was effective in reducing uric acid levels at the 3rd hour from 3.60 ± 0.25 mg/dL to 2.33 ± 0.35 mg/dL, with the greatest reduction of 0.33 ± 0.06 mg/dL, equivalent to 92%, and reduced COX-2 levels by 1.14 ± 0.02 ng/mL, which was significantly different from the negative control (p<0.05), and there was a positive correlation between the reduction in uric acid levels and COX-2 inhibition in hyperuricemic animal models. The conclusion of this study is that administration of bajakah wood can increase uric acid levels while simultaneously inhibiting inflammation, making it a potential candidate for development as an antihyperuricemic and anti-inflammatory drug.
Co-Authors Adriatman Rasak Akib, Nur Illyyin Anggraeni Anggraeni Angriani Fusvita Asriullah Jabbar Asriullah Jabbar Asriullah Jabbar Aulia Amala Azlimin Azlimin Azlimin, Azlimin Badia, Esti Balaka, Kemal Idris Bambang Bambang Bonni Rubak Chatarina Umbul Wahyuni Darmayanita Wenty Elfirah Elfirah Elma Winarti Fadhliyah Malik Fadhliyah Malik Firdayanti Firdayanti Hafifah, Salsabillah Hajir Mayana Halik Halik Halik Halik, Halik Heni Umar Ilyas Y, Muhammad Ilyas Y., Muhammad - Imran, Shintia Agrifa Ali Indriani Ishar Jabbar, Asriullah Kemal Idris Balaka Lidya Agriningsih Haruna Marlin, Nova Marningsih, Elfi Mega Fatimah Rosana Mery Erfiani Miftahul Jannah Mubarak Mubarak Mubarak Mubarak Mubarak Muhammad Ilyas Y Muhammad Ilyas Y. Muhammad Sultanul Aulya Musdalipah Nasrudin Nasrudin Nasrudin Niluh Eka Ayu Pratiwi Nirwati Rusli Nur Mardatillah Al Mubaidillah Nurhikma Nurhikma Nurhikma Nurhikma, Nurhikma Nurul Afdhaliyah Nurdin Pascayantri, Asniar Riska Amelia Zulkarnain Savirah Hardiyanti Selfyana Austin Tee Setiawan, La Ode Roni Solo, Dian Munasari Sri Aprilianti Idris Sri Rasniawaty Suci Devianti Ningsih Suhikma Sofyan Sulsiah, Sulsiah sultanaulya muhammad Susanti Susanti Susanty, Sry Susi Soviana Ufu Rindang Upik Kesumawati Hadi wahyuni wahyuni Wisnianti, Dwi Y, Muhammad Ilyas Yulidyah Syaffanie Lilikay Yusuf, Muh Ilyas Zulkifli Halid