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All Journal Majalah Farmaseutik JURNAL PENDIDIKAN TAMBUSAI Nusantara Hasana Journal Innovative: Journal Of Social Science Research Sains Medisina Advances in Healthcare Research IJF (Indonesia Jurnal Farmasi) Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Muhamad Khudzaifi
Universitas Muhammadiyah Kudus
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Other

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UJI AKTIVITAS ANTIJAMUR SEDIAAN KRIM EKSTRAK ETANOL DAUN CIPLUKAN (Physalis angulata L.) TERHADAP Candida albicans Muhamad Khudzaifi; Muhammad Nurul Fadel; Fahrudin Arif; Akhyasin Akhyasin; Eko Retnowati
IJF (Indonesia Jurnal Farmasi) Vol 7, No 2 (2022): Indonesia Jurnal Farmasi
Publisher : Universitas Muhammadiyah Kudus

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26751/ijf.v7i2.1762

Abstract

Latar belakang : Penyakit infeksi merupakan salah satu permasalahan yang banyak terjadi di Indonesia. Salah satu infeksi yang banyak ditemukan adalah infeksi yang disebabkan oleh jamur Candida albicans. Kejadian resistensi antijamur telah menjadi permasalahan sehingga diperlukan adanya inovasi baru. Salah satunya dengan pengembangan tanaman obat yang telah diteliti memiliki khasiat sebagai antijamur. Salah satunya adalah tanaman Ciplukan (Physalis angulata L.). Daun ciplukan memiliki kandungan senyawa aktif berupa alkaloid, saponin, tanin, dan flavonoid yang merupakan senyawa aktif biologis sebagai antimikroba. Tujuan : Mengetahui aktivitas antijamur krim ekstrak etanol daun Ciplukan (Physalis angulata L.) terhadap jamur Candida albicans. Metode : Penelitian ini menggunakan difusi cakram dengan konsentrasi yang digunakan yaitu 5%, 10%, dan 15% diletakkan pada media SDA yang telah ditumbuhi oleh jamur Candida albicans yang kemudian akan diinkubasi serta diukur diameter zona hambatnya. Hasil : Pada konsentrasi 5% pada hari ke 1 dan ke 21 didapatkan diameter zona hambat sebesar 15 mm dan 14 mm, konsentrasi 10% mendapatkan hasil pada hari ke 1 18 mm dan hari ke 21 sebesar 15 mm, kemudian konsentrasi 15% pada hari ke 1 dan ke 21 mendapat hasil 20 mm, dan pada kontrol positif didapati hasil 34 mm pada hari ke 1 dan pada hari ke 21 mendapat 33 mm. Kesimpulan : Berdasarkan data diatas dapat disimpulkan bahwa krim ekstrak etanol daun Ciplukan (Physalis angulata L.) dapat menghambat jamur Candida albicans.
Molecular Docking Senyawa Flavonoid Daun Sirsak (Annona muricata L.) Terhadap Reseptor Estrogen Alfa (RE-α) Sebagai Kandidat Obat Antikanker Payudara Khudzaifi, Muhamad; Kalsum, Saskia Amini; Nisak, Ana Zumrotun
Sains Medisina Vol 3 No 1 (2024): Sains Medisina
Publisher : CV. Wadah Publikasi Cendekia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63004/snsmed.v3i1.462

Abstract

Daun sirsak sudah lama dipercayai penggunaanya sebagai obat tradisional. Salah satu senyawa yang ditemukan dalam daun sirsak adalah flavonoid. Senyawa flavonoid memiliki potensi sebagai sitoksik. Tamoxifen sebagai obat antikanker payudara memiliki efek samping berupa kanker endometrium, sehingga diperlukan pengembangan lebih lanjut terkait obat antikanker payudara. Penelitian ini bertujuan untuk mengetahui senyawa flavonoid daun sirsak yang paling berpotensi sebagai antikanker payudara berdasarkan binding energy. Penelitian eksperimental berbasis in silico ini menggunakan sampel hasil isolasi daun sirsak yang berasal dari penelitian sebelumnya. Dengan menggunakan software Autodock Vina, ligan senyawa uji akan dilakukan docking terhadap reseptor estrogen alfa (PDB ID: 3ERT) dengan native ligand berupa 4-hydroxytamoxifen. Hasil penelitian menunjukkan bahwa senyawa flavonoid daun sirsak dapat berpotensi sebagai antikanker payudara. Hal ini ditunjukkan dengan nilai docking terhadap resptor estrogen alfa bernilai negatif. Senyawa uji yang terbaik secara berurutan berdasarkan binding energy yaitu geniestein, daidzein, catechin, kaempferol, epicatechin, argetinine, glycitein, robinetin, tangeretin, quercetin, isoferulic acid. Kesimpulan, senyawa uji yang paling berpotensi yaitu geniestein dengan nilai docking -9.0 kcal/mol. Nilai ini mendekati nilai docking native ligand sebesar -9.8 kcal/mol.
Safety evaluation of Oral NSAID Treatment on Blood Pressure in Osteoarthritis Patients: Preventive study to Cardiovascular Events Rosnarita, Intan Adevia; Khudzaifi, Muhammad; Priswa, Nindya
Majalah Farmaseutik Vol 21, No 1 (2025)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v21i1.103508

Abstract

Osteoarthritis (OA) is a degenerative joint disorder primarily affecting weight-bearing joints, causing pain, stiffness, and reduced mobility. Although there is no cure, symptom management focuses on pain relief and inflammation reduction, often through the use of nonsteroidal anti-inflammatory drugs (NSAIDs). However, NSAIDs are known to increase blood pressure, which poses concerns for long-term use, especially in patients with pre-existing cardiovascular risk factors. Given the chronic nature of OA and the common prescription of long-term NSAID therapy, it is important to assess their impact on blood pressure and cardiovascular health. This study aimed to evaluate the safety of oral NSAID therapy in terms of its effects on blood pressure in osteoarthritis patients at Dr. Moewardi Surakarta Regional General Hospital. An observational descriptive design was used with purposive sampling, analyzing data retrospectively from 35 OA patients receiving outpatient treatment for three months. The Wilcoxon signed-rank test was applied to assess changes in blood pressure, with statistical significance set at p<0.05. Results showed a significant increase in both systolic (11.3 ± 7.9 mmHg, p<0.05) and diastolic blood pressure (8.9 ± 7.0 mmHg, p<0.05) following NSAID use over the 3-month period. These findings highlight the need for careful monitoring of blood pressure in OA patients on long-term NSAID therapy, particularly those at higher cardiovascular risk. Long-term safety assessments are essential when considering NSAID treatment, and alternative therapeutic options should be considered for high-risk patients.
UJI RHODAMIN B PADA LIP CREAM YANG BEREDAR DI TOKO KOSMETIK KOTA KUDUS MENGGUNAKAN KROMATOGRAFI LAPIS TIPIS Safira Ramandani; Endang Setyowati; Muhammad Khudzaifi
Nusantara Hasana Journal Vol. 5 No. 2 (2025): Nusantara Hasana Journal, July 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i2.1515

Abstract

Cosmetic products, including lipstick, are products that require coloring agents, usually in the form of lip cream preparations. One of the dangerous coloring agents circulating in the market is Rhodamine B. Rhodamine B is a dangerous synthetic dye that is carcinogenic. The purpose of this study was to identify the presence of Rhodamine B in lip creams circulating in Kudus City. The research method was carried out quantitatively because it determined the levels of Rhodamine B using Thin Layer Chromatography (TLC). The lip cream samples studied were 5 samples with different brands and sold at the Kudus City Cosmetics Store. Rhodamine B identification test on lip cream by observing the number of Retention Factor (Rf) values, visual stain color, and fluorescence color under UV light 254 nm and 366 nm. The identification results of the five samples tested contained two samples suspected of containing synthetic rhodamine B dye, namely samples A and E, this can be seen from the color of the spots seen visually are pink and orange, while under UV light it is purple and fluoresces yellow. For the Rf value of rhodamine B of 0.68, it is the same as sample A, while samples B, C, D, and E have a value of 0.7. The conclusion of this study is that the five lip cream samples with different brands contain Rhodamine B, namely in sample A and E.
FORMULASI UJI AKTIVITAS ANTIOKSIDAN DAN UJI KARAKTERITIK FISIK SEDIAAN KRIM EKSTRAK DAUN PEPAYA (Carica Papaya L.) SEBAGAI KRIM PELEMBAB KULIT Muhammad Lathoiful Minan; Muhammad Nurul Fadel; Muhammad Khudzaifi
Nusantara Hasana Journal Vol. 5 No. 2 (2025): Nusantara Hasana Journal, July 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i2.1546

Abstract

Papaya leaves are known to contain high levels of antioxidants such as flavonoids, α- tocopherol, and ascorbic acid, which help combat free radicals that cause premature aging. This study aimed to evaluate the stability and antioxidant activity of a cream formulated with 70% ethanol extract of papaya leaves using the DPPH method. A total of 3000 g of young papaya leaves were macerated with 70% ethanol, yielding 56.38 g of thick extract, which was then formulated into a cream. The cream was evaluated through organoleptic tests, homogeneity, pH, spreadability, emulsion type, viscosity, and antioxidant activity. Results showed the cream was stable in terms of odor and form, with a pH range of 5–7, spreadability between 5.8–6.2 cm, homogeneous emulsion, and viscosity ranging from 5003–5990 cP. The highest antioxidant activity was observed at 3.5% concentration (78.45%), while the negative control was 222.4 and quercetin as a reference showed 9.08%. It was concluded that the cream formulated from 70% ethanol extract of papaya leaves demonstrated good stability and strong antioxidant activity.
FORMULASI DAN UJI FISIK SEDIAAN KRIM KOMBINASI MINYAK BIJI JINTEN HITAM (Nigella Sativa L.) DAN EKSTRAK DAUN PEPAYA (Papaya Carica L.) SEBAGAI TABIR SURYA Akbar Seno Syafriansyah; Muhammad Nurul Fadel; Muhammad Khudzaifi
Nusantara Hasana Journal Vol. 5 No. 2 (2025): Nusantara Hasana Journal, July 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i2.1547

Abstract

Prolonged exposure to sunlight can have harmful effects on the skin, both immediate and long-term. To prevent the negative impact of sun exposure, the use of additional protective products such as sunscreen is essential. To reduce the level of damage caused by the use of synthetic materials, the use of natural ingredients can be considered as components in the formulation of sunscreen creams. This study aims to evaluate the physical quality and determine the sunscreen activity of a cream formulation combining black cumin seed oil (Nigella sativa L.) and papaya leaf extract (Carica papaya L.). The evaluation was conducted through several tests, including organoleptic testing, homogeneity, emulsion type, pH, viscosity, and SPF testing using UV-Vis spectrophotometry. The results showed that the formulation met the required standards: organoleptic tests indicated that the scent and texture of the cream remained stable, although a change in color occurred. The formulation had good homogeneity with a pH ranging from 5 to 7. The recorded viscosities were 9732 cP, 1450 cP, 3030 cP, and 4414 cP, respectively. In the SPF test, the values obtained were 0.22; 4.37; 14.23; and 20.52. Based on these results, it can be concluded that the cream combining black cumin seed oil and papaya leaf extract demonstrated good stability and exhibited effective sunscreen activity.
Formulation Research and Antibacterial Activity Test of Face Mist Preparation from Ethanol Extract of Papaya Leaves (Carica Papaya L.) Against Propionibacterium Acnes Mustaanah, Aulia Nur; Fadel, Muhammad Nurul; Khudzaifi, Muhamad
Advances in Healthcare Research Vol. 3 No. 2 (2025): March - August
Publisher : Yayasan Pendidikan Bukhari Dwi Muslim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60079/ahr.v3i2.559

Abstract

Purpose: The purpose of this study was to formulate a face mist preparation containing ethanol extract of papaya leaves (Carica papaya L.) at concentrations of 10%, 15%, and 20%, and to evaluate its antibacterial activity against Propionibacterium acnes, a primary acne-causing bacterium. Research Method: This study employed a laboratory-based experimental design with a post-test-only control group. Data were collected through experimental observations. The face mist was formulated with three extract concentrations (F1: 10%, F2: 15%, and F3: 20%), with a face mist base as the negative control and clindamycin as the positive control. The preparations underwent organoleptic, pH, homogeneity, and spreadability tests. Antibacterial activity was evaluated using the disc diffusion method, and the data were analyzed using One-Way ANOVA with a significance level of p < 0.005. Results and Discussion: The formulations met the physical property standards, showing a brownish-green color, liquid consistency, and a characteristic papaya leaf aroma. All samples were homogeneous, with pH values ranging from 5.08 to 5.16, and spreadability between 5.33 and 5.75 cm. The highest antibacterial activity was observed in F3 (20%) with an average inhibition zone of 16.3 mm. Implications: The findings suggest that papaya leaf ethanol extract is a promising natural ingredient for face mist formulations with antibacterial properties, offering potential as an alternative acne treatment product.
Formulation and Physical Evaluation of a Combination of Pegagan Leaf Extract (Centella Asiatica L. Urb) and Patchouli Oil (Patchouli Oil) in Liquid Body Wash Preparation Sari, Dwi Maya Ratna; Fanani, Zaenal; Khudzaifi, Muhammad
Advances in Healthcare Research Vol. 3 No. 2 (2025): March - August
Publisher : Yayasan Pendidikan Bukhari Dwi Muslim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60079/ahr.v3i2.560

Abstract

Purpose: This study aimed to formulate and evaluate the physical quality of liquid body wash containing Centella asiatica (L.). Urb. Extract and patchouli oil to determine the optimal concentration for safe and effective use, with the hypothesis that varying concentrations would affect pH, viscosity, foam stability, and overall product quality. Research Method: An experimental post-test control design was conducted at the Pharmaceutical Technology Laboratory of Cendekia Utama Kudus Health Technology Institute, with irritation tests performed at Universitas Muhammadiyah Kudus. Four formulations (F0–F3) contained pegagan extract (0%, 5%, 10%, 15%) and patchouli oil (0%, 1%, 2%, 3%). Physical evaluations included organoleptic, homogeneity, pH, viscosity, foam height, and irritation tests. Data were analyzed using Shapiro-Wilk, Levene’s test, and One-Way ANOVA. Results and Discussion: All formulations met SNI standards for liquid soap. Formula 1 (5% extract, 1% patchouli oil) exhibited the most balanced properties, with a neutral pH (6.06), suitable viscosity (695 mPas), stable foam height (13.50 mm), and no irritation. Higher extract concentrations reduced viscosity but did not significantly affect foam height. No formula caused redness or itching in volunteers. Implications: Formula 1 is recommended for further development as a natural, skin-safe liquid body wash. Future studies should assess the long-term stability, consumer acceptance, and commercial feasibility of these products.
HUBUNGAN PEMBERIAN EDUKASI SWAMEDIKASI OBAT ANTINYERI DENGAN KEPUASAN PASIEN DI APOTEK BLUNYAH FARMA Vita Angraini; Ria Etikasari; Muhammad Khudzaifi
Nusantara Hasana Journal Vol. 5 No. 3 (2025): Nusantara Hasana Journal, August 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i3.1617

Abstract

Self-medication, particularly for pain, is becoming increasingly common. However, most patients still lack adequate understanding of the types of medications, dosages, and potential risks. Therefore, education provided by pharmacists plays a crucial role in improving patient understanding and satisfaction with the rational use of painkillers. This study aimed to determine the relationship between self-medication education on painkillers and patient satisfaction at Blunyah Farma Pharmacy, Sleman Regency, Yogyakarta. The study used a quantitative observational method with a cross-sectional design. The independent variable was self-medication education on painkillers, while the dependent variable was patient satisfaction. Data were collected through questionnaires completed directly by patients purchasing painkillers. The study sample consisted of 300 respondents from a total population of 1,200, with a margin of error of 5%. The results showed that the majority of respondents received high levels of education (57.7%) and expressed very high levels of satisfaction with the services they received (40.3%). A Spearman Rank correlation test using SPSS version 22 showed a very strong and significant relationship between the two variables, with a correlation coefficient of 0.941 and a significance level of 0.000 (<0.05). Therefore, the better the quality of education provided, the higher the patient satisfaction level.
Pengaruh Antibakteri Kombinasi Ekstrak Kulit Jeruk Manis (Citrus Sinensis (L.) Osbeck) dan Daun Pepaya (Carica Papaya L.) Terhadap Bakteri Escherichia Coli Regitha Adiba Fayza Purwoko; Riana Putri Rahmawati; Muhammad Khudzaifi
Jurnal Ilmu Kedokteran dan Kesehatan Indonesia Vol. 5 No. 2 (2025): Juli: Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jikki.v5i2.6079

Abstract

Sweet orange peel and papaya leaves have been used by the community to prevent and treat various diseases caused by bacterial, fungal, and viral infections. Sweet orange peel contains flavonoids, alkaloids, saponins, tannins, and terpenoids that can inhibit bacterial growth. While papaya leaves contain active compounds such as alkaloids, flavonoids, steroids, tannins, and terpenoids that can inhibit bacterial growth. Escherichia coli bacteria are gram-negative, facultative anaerobic bacteria that can cause intestinal infections, causing diarrhea. The combination of extracts from several plants has greater inhibitory power so that it has greater antibacterial activity than a single plant. The purpose of this study was to determine whether the combination of sweet orange peel and papaya leaf extracts has an effect on the growth of Escherichia coli bacteria. The test method used was the disc diffusion method on TSA agar media. Sweet orange peel and papaya leaf extracts in this study were obtained by the maceration method with 96% ethanol solvent. The ratio of extracts used was sweet orange peel and papaya leaves 1:3; 2:2; 3:1. The positive control used was ciprofloxacin. The negative control used was 10% dimethyl sulfoxide (DMSO). The results of this study indicate that the combination of sweet orange peel extract (Citrus sinensis L. Osbeck) and papaya leaves (Carica papaya L.) has an effect on the growth of Escherichia coli bacteria because it produces an inhibition zone around the disc paper. All comparisons, namely 1: 3; 2: 2; 3: 1 are optimal in inhibiting the growth of Escherichia coli bacteria with a diameter of the inhibition zone in sequence of 17.78 mm (strong category), 22.14 mm (very strong category), and 26.28 mm (very strong category). Likewise, the positive control produces an inhibition zone of 34.25 (very strong category). The most optimum antibacterial combination shows the diameter of the inhibition zone against Escherichia coli bacteria, namely at a ratio of 3: 1.
Co-Authors Akbar Seno Syafriansyah Akhyasin Akhyasin Ana Zumrotun Nisak, Ana Zumrotun Eko Retnowati Endang Setyowati Endang Setyowati Fahrudin Arif Faizin, Fadli Akbar GALIH KURNIAWAN Intan Adevia Rosnarita Kalsum, Saskia Amini Manik, Nirmala Mardhiyah, Sofiana Nur Muhammad Lathoiful Minan Muhammad Nurul Fadel Mustaanah, Aulia Nur Presticasari, Hardiyani Priswa, Nindya Putri, Riana Rahmawati, Irma Sari Rahmawati, Riana Putri Regitha Adiba Fayza Purwoko Ria Etikasari Riana Putri Rahmawati Safira Ramandani Sari, Dwi Maya Ratna Vita Angraini Widiansyah, Risma Anindya Zaenal Fanani