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All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Majalah Kedokteran Sriwijaya Biomedical Journal of Indonesia Paediatrica Indonesiana Jurnal Penelitian Sains Molecular and Cellular Biomedical Sciences (MCBS) Jurnal Surya Medika SRIWIJAYA JOURNAL OF MEDICINE Majalah Kedokteran Andalas Bioscientia Medicina : Journal of Biomedicine and Translational Research Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Best Journal (Biology Education, Sains and Technology) Open Access Indonesian Journal of Medical Reviews Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Kesehatan Gigi dan Mulut (JKGM) Conferences of Medical Sciences Dies Natalis eJournal Kedokteran Indonesia
Phey Liana
Bagian Patologi Klinik, Fakultas Kedokteran, Universitas Sriwijaya
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Education Health Professions Immunology & microbiology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health

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Journal : Paediatrica Indonesiana

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Serum nitric oxide and pediatric sepsis outcomes Ronald Chandra; Jose M. Mandei; Jeanette I. Ch. Manoppo; Rocky Wilar; Ari L. Runtunuwu; Phey Liana
Paediatrica Indonesiana Vol 54 No 4 (2014): July 2014
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (111.69 KB) | DOI: 10.14238/pi54.4.2014.213-8

Abstract

Background Sepsis is the complex pathophysiologic responsesof the host against systemic infection. Sepsis can cause severeconditions such as septic shock and multiple organ failure.Although we have a better understanding of the molecular basisof sepsis as well as aggressive therapy, the mortality rate remainshigh, between 20-80%. Nitric oxide (NO) is one of the mediatorsassociated with cardiovascular failure, apoptosis and organdysfunction in sepsis.Objective To evaluate for a possible correlation between NOlevels and outcomes in pediatric sepsis.Methods A prospective cohort study was conducted at thepediatric intensive care unit (PICU) of Prof. Dr. R.D. KandouGeneral Hospital in Manado, from June to November 2012. Fortychildren aged one month to five year old, fulfilled the InternationalPediatrics Sepsis Consensus Conference 2 005 criteria were recruited.Nitrite oxide metabolites (nitrite and nitrate) levels were measuredusing a calorimetric assay kit (Cayman®, Catalog No.780001)from venous blood specimens collected at admission. All patientsreceived antibiotics empirically within an hour of the diagnosis.Outcomes of patients recorded were survivor or died, and lengthof stay in PICU.Results Mann-Whitney U test revealed a significant differencebetween median serum NO levels ins urvivors and those who died(18.60 vs. 36.50 fLM/L, respectively; P= 0.016).Conclusion Serum NO concentration is higher in those whodied than in survivors of pediatric sepsis. Specific NO inhibitionmay be beneficial in decreasing morbidity and mortality in thiscondition.
Co-Authors Afifah, Salwa Nur Agustin, Berliana Agustin, Berliana Amalia Amalia Ari L. Runtunuwu Aseptianova Aseptianova Astari Rahayu Afifah Baity Indriani Banun, Syahri Berliana Agustin Berliana Agustin Bhagaskara Bhagaskara Budi Santoso Calvin Ienawi Catherine Ieawi Chris Alberto Amin Cornelia Agatha Dalilah Desi Oktariana Desi Oktariana Dini Cahyani Dodi Maulana Eka Intan Fitriana Eny Rahmawati Eny Rahmawati, Eny Erial Bahar Evi Lusiana Fadhilatul Hilda Gita D. Prasasty Gita Dwi Prasasty Gita Dwi Prasasty Gita Dwi Prasasty Hafizzanovian, Hafizzanovian Hertanti Indah Lestari Hidayatullah Iche Andriyani Liberty, Iche Andriyani Ieawi, Catherine Ieawi, Catherine Ienawi, Calvin Ienawi, Calvin Irfanuddin Irfanuddin Iza Netiasa Haris Jayawarsa, A.A. Ketut Jeanette I. Ch. Manoppo Jesica Sidabutar Jose M. Mandei Karina Rahma Meidiarti Kemas M. Yakub Kemas M. Yakub Kemas Y. Rahadiyanto Kemas Ya’kub Rahadiyanto Kemas Ya’kub Rahadiyanto Krisna Murti Kusumo Haryadi Kusumo Haryadi Laksono Trisnantoro Larasati, Veny Legiran Legiran Lusia Hayati Luthfiah, Qonita Mastiar Endang Frida Siahaan Maulana, Mirza Gifari Mediarty Syahrir Mita Al Maida Muhammad Irsan Saleh Muhammad Reagan Nelda Aprilia Salim Nia S. Tamzil Nia Savitri Tamzil Norlaila Binti Chahril Nova Kurniati Novita, Emma Nurmalia Purnama Sari Oktariana, Desi Oktarina, Desi Patricia, Venny Patwa Amani, Patwa Rahadiyanto, Kemas Ya’kub Rahardiyanto, Kemas Ya’kub Rahma Yunita, Rahma Rahmi Widiyawati Rahnowi Pradesta Rahnowi Pradesta Rocky Wilar Ronald Chandra SEPTI WULANDARI Soilia Fertilita Sri Nita Sri noviyanty Yusuf Sulistiani Sulistiani, Sulistiani Susilawati Susilawati Swanny Swanny Tungki Pratama Umar Tungki Pratama Umar Tungki Pratama Umar Tungki Pratama Umar Tungki Pratama Umar Vena Sabputri Sutrisno Venny Patricia Verdiansah Verdiansah Yakub, Kemas M Yakub, Kemas M Yan Effendi Hasyim Yulia Nugraha Karsita Yunni Diansari Zen Ahmad Zen Hafy