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All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Majalah Kedokteran Sriwijaya Biomedical Journal of Indonesia Paediatrica Indonesiana Molecular and Cellular Biomedical Sciences (MCBS) Jurnal Surya Medika SRIWIJAYA JOURNAL OF MEDICINE Majalah Kedokteran Andalas Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Best Journal (Biology Education, Sains and Technology) Open Access Indonesian Journal of Medical Reviews Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Kesehatan Gigi dan Mulut (JKGM) Conferences of Medical Sciences Dies Natalis eJournal Kedokteran Indonesia
Phey Liana
Bagian Patologi Klinik, Fakultas Kedokteran, Universitas Sriwijaya
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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THE COMPARISON OF EFFECTIVENESS AND SAFETY BETWEEN WARFARIN AND RIVAROXABAN IN HYPERCOAGULATED CENTRAL NERVOUS SYSTEM TUMORS Sri noviyanty Yusuf; Yunni Diansari; Mediarty Syahrir; Phey Liana
Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Vol. 11 No. 1 (2023): Jambi Medical Journal: Jurnal Kedokteran dan Kesehatan
Publisher : FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS JAMBI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/jmj.v11i1.25056

Abstract

Abstract:                                                                                                                                           Background: Central nervous system (CNS) tumors originate from the brain and spinal cord, and have complications, such as hypercoagulation. The administration of anticoagulants (warfarin and rivaroxaban) has been able to reduce hypercoagulation-related morbidity and mortality, however, the effectiveness and safety of their use has not been well studied. This study aims to compare the effectiveness and safety of anticoagulant drugs between warfarin and rivaroxaban in hypercoagulated CNS tumors. Methods: This was a randomized clinical trial study, double-blinded, conducted on CNS tumor patients from September-November 2020 at Mohammad Hoesin Hospital. The patients were given warfarin and rivaroxaban for 3 weeks. Coagulation status was measured before and after. Data were analyzed using SPSS ver.24. Results: The mean age of 20 patients was 42.70+8.14 years and majority were female (80%), with tumor characteristics were primary (80%), single (85%), and located in the brain (95%). In the warfarin group (n=10), there were significant improvements in PT (p 0.008), INR (p 0.013), Fibrinogen (p 0.041), and D-Dimer (p 0.008) value, also the rivaroxaban group (n=10) in PT (p 0.013), APTT (p 0.012), INR (p 0.028), Fibrinogen (p 0.047), D-Dimer (p 0.032), and Anti Fxa (p 0.028). However, there was no significant difference between groups, except when comparing the Anti Fxa delta (p 0.041). There was 1 person with major bleeding using warfarin, and 1 person (excluded) with GIT bleeding using rivaroxaban. Conclusion: There was a significant improvement of coagulation value in both groups, also side effects were seen as well. Keyword: CNS Tumor, Hypercoagulation, Warfarin, Rivaroxaban
Correlation between CRP Level and Neutrophil Extracellular Traps in Malignancy Patients with Neutropenic Fever Phey Liana; Kemas M. Yakub; Eny Rahmawati; Berliana Agustin
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 26 No. 3 (2020)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v26i3.1595

Abstract

The mortality and morbidity rate of neutropenic fever is quite high. The source and severity of infection must be evaluated quickly in neutropenic patients. C-Reactive Protein (CRP) and Neutrophil Extracellular Traps (NETs) are known as markers for severeinfection. Besides, NETs also play a role in the development and metastasis of cancer but the mechanism is still unclear. C-reactive protein is a marker that is routinely used for infection. However, the correlation between CRP levels and NETs in malignant patients with neutropenia is unknown. Therefore this study was conducted to determine the correlation between CRP levels and NETs in malignant patients with neutropenia. This research was a cross-sectional observational study. The samples were malignant patients with neutropenia who were treated in the Pediatric Ward of  Dr. Mohammad Hoesin Hospital, Palembang and met the inclusion and exclusion criteria. Sampling was done by consecutive sampling. C-reactive protein level and NETs weretested by immunoturbidimetry and ELISA methods. Data were analyzed with the Pearson test (p <0.05). The mean of CRP and NETs level were 170.17±121.52 mg/L and 0.77±0.39 ng/mL, respectively. The correlation test between CRP level and NETs in malignancy patients with neutropenic fever showed r=0.228 and p=0.362. The results showed no significant correlation between CRP level and NETs in malignant patients with neutropenic fever.
Comparison of Blood Gas Analysis between Benchtop and Handheld Device Phey Liana; Iza Netiasa Haris; Yan Effendi Hasyim
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 27 No. 1 (2020)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v27i1.1610

Abstract

The use of blood gas analysis is to determine the Acid-base status required to treat patients with emergency conditions such as metabolic disorders and respiratory diseases. Benchtop device is commonly used in hospitals to analyze blood gas; however, handheld devices are recently more often used in emergency settings due to its quick and simple process. This study was performed to compare blood gas analysis results between the i-STAT handheld device and the Nova pHox Ultra benchtop device that were currently being used in the central laboratory. This cross-sectional study was conducted by using 42 arterial blood patients that were measured with i-STAT handheld device dan Nova pHox Ultra benchtop device. The pH, pCO2, and pO2 parameters were then evaluated. The data were analyzed using Spearman's correlation test, Mann-Whitney test, and Bland-Altman plots. This study showed a very strong positive correlation for all parameters. Mann-Whitney comparison test showed that there was no significant difference between the result of the two devices (p-value > 0.05). All parameters showed that 95% of plots were within the acceptable limit. There was no clinical significance on the mean biases of blood gas results between both devices. The i-STAT and Nova pHox Ultra devices showed a good agreement for blood gas measurement. Therefore, both devices can be used interchangeably with minimal effect on clinical decision-making.
Prevalence of Extended-Spectrum Beta Lactamase-Producing Microorganisms in Dr. Mohammad Hoesin Hospital Palembang Phey Liana; Norlaila Binti Chahril; Sri Nita; Tungki Pratama Umar
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 28 No. 3 (2022)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v28i3.1897

Abstract

Production of Extended-Spectrum Beta-Lactamase (ESBL) by Enterobacteriaceae continues to be a problem of infectious diseases, especially in hospitals. The main causes of ESBL-producing bacteria colonization are urinary tract infections, length of hospital stay, invasive medical equipment, and antibiotics usage. This study aims to compare the incidence of ESBL based on the type of organism in Dr. Mohammad Hoesin Hospital for the 2017 and 2018 periods. The research design used was descriptive with a cross-sectional approach, which used secondary data at the Clinical Pathology Department of Dr. RSUP. Mohammad Hoesin Palembang. The findings of this study showed a decreasing pattern in the incidence of ESBL in 2017 and 2018, but with a similar pattern which was dominated by Klebsiella pneumoniae (followed by Escherichia coli and Klebsiella ozaenae), inpatients in pediatric wards, internal medicine, and intensive care units, and on sputum specimens. This study showed the presence of high levels of ESBL-producing bacteria (>60%) in Dr. Mohammad Hoesin Hospital, which was mainly caused by Klebsiella pneumoniae.
Comparative Evaluation of Electrochemiluminescence and Chemiluminescence Microparticle Immunoassays for Anti-Hepatitis C Virus (HCV) Detection Phey Liana; Mita Al Maida; Gita Dwi Prasasty; Desi Oktariana; Tungki Pratama Umar
Biomedical Journal of Indonesia Vol. 10 No. 3 (2024): Vol 10, No 3, 2024
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v10i3.208

Abstract

Introduction. Anti-hepatitis C virus (HCV) testing is an immunological analysis designed to identify the presence of antibodies against the HCV antigen. This investigation is typically conducted using the chemiluminescence immunoassay (CLIA) technique, which yields precise results. Current research attempts to evaluate the outcomes of the anti-HCV test utilizing the Chemiluminescence Microparticle Immunoassay (CMIA) and the Electrochemiluminescence Immunoassay (ECLIA) approaches. Methods. This cross-sectional study comprised 63 serum samples collected via consecutive sampling. The acquired data were subjected to statistical analysis utilizing Cohen's Kappa agreement test. Results. Both immunoassay methods yielded identical results, indicating four reactive samples out of 63, equating to 6.35%. The agreement test result for the anti-HCV test was κ=1.000, signifying an almost perfect level of agreement. Conclusion. The anti-HCV assessment utilizing CMIA and ECLIA methodologies demonstrated near-perfect agreement. This signifies that these two procedures can be employed in clinical laboratories concurrently or interchangeably for the test.
Cycle Threshold Value as A Death Predictor of COVID-19 Patients Oktariana, Desi; Saleh, Irsan; Banun, Syahri; Rahadiyanto, Kemas Ya’kub; Liana, Phey; Rahmawati, Eny; Hafizzanovian, Hafizzanovian; Lusiana, Evi; Tamzil, Nia Savitri; Prasasty, Gita Dwi; Aseptianova, Aseptianova
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 31 No. 3 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v31i3.2390

Abstract

For several years, COVID-19 has been a major problem in human health and also caused a global socio-economic crisis. However, the impact of viral load on patient mortality has not been thoroughly investigated. This study analyzes the association between CT value and the mortality of COVID-19 patients in inpatients at Mohammad Hoesin Hospital. This study used observational analysis with a longitudinal retrospective design. This study had 280 subjects. Fifty-four of the 280 patients died (19.3%) 33% had a CT <22.93; 16.7% had a CT 22.93-29.93; 31.5% had a CT 29.94-34.9, 18.5% had a CT >35 with p-value >0.05 for patient mortality. Analysis of age, comorbidities, and clinical severity of patient mortality showed a p-value <0.05. Meanwhile, gender analysis of patient mortality showed a p-value >0.05. These results indicate that the CT value cannot predict patient mortality. Patients with older age, comorbidities, and admission with severe clinical severity have a higher risk of death.
Risk Factors for Progressive Chronic Kidney Disease in Children with Idiopathic Nephrotic Syndrome at Dr. Mohammad Hoesin General Hospital Palembang Maulana, Mirza Gifari; Eka Intan Fitriana; Phey Liana; Hertanti Indah Lestari; Dalilah
Open Access Indonesian Journal of Medical Reviews Vol. 3 No. 1 (2023): Open Access Indonesian Journal of Medical Reviews
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/oaijmr.v3i1.274

Abstract

Nephrotic syndrome (NS) is a kidney disease that is often found in children. NS can cause infectious and non-infectious complications, such as upper respiratory tract infections, urinary tract infections, edema, acute kidney injury (AKI), and hypertension. This study aimed to determine the risk factors of age, gender, nutritional status, hypertension, hematuria, AKI, hyperfiltration, and steroid sensitivity to the progression of chronic kidney disease (CKD) in children with the initial idiopathic NS in the pediatric ward of Dr. Mohammad Hoesin General Hospital Palembang. This study was an analytic observational study with a cross-sectional design. A total of 72 secondary data of research subjects were included in this study. Risk factor analysis was carried out with the help of SPSS version 24 software in univariate, bivariate, and multivariate ways. The most common risk factor for children with the initial idiopathic NS is age ≥10 years, males and females gender obtained the same number, and the nutritional status of obesity, hematuria, AKI, and hyperfiltration have quite low rates. However, hypertension and SRNS have high rates in children with initial idiopathic NS. In conclusion, hypertension and hyperfiltration are risk factors that play a role in initiating the progression of idiopathic NS to CKD in the pediatric ward of Dr. Mohammad Hoesin General Hospital, Palembang.
POTENSI BONE GRAFT DARI CANGKANG TELUR AYAM TERHADAP PEMBENTUKKAN TULANG PASCAEKSTRAKSI GIGI Yunita, Rahma; Liana, Phey; Oktariana, Desi
Jurnal Kesehatan Gigi dan Mulut (JKGM) Vol 7 No 2 (2025): Jurnal Kesehatan Gigi dan Mulut (JKGM)
Publisher : Jurusan Kesehatan Gigi, Poltekkes Kemenkes Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36086/jkgm.v7i2.2997

Abstract

Latar Belakang: Ekstraksi gigi atau pencabutan gigi merupakan salah satu prosedur bedah minor pada kedokteran gigi yang dilakukan untuk mengeluarkan gigi dari soketnya dan berpotensi menyebabkan perlukaan pada jaringan Selama proses penyembuhan, volume tulang alveolar dapat berkurang hingga 40–60%, yang dapat berdampak signifikan pada pasien yang memerlukan terapi implan gigi. Pengurangan volume tulang alveolar dalam prosedur implan dapat diatasi dengan pemberian bone graft. Salah satu bahan bone graft yang paling banyak dikembangkan saat ini adalah hidroksiapatit (HA). Hidroksiapatit adalah komponen mineral utama dari tulang kortikal dan kanselus dewasa. Dikarenakan meningkatnya penggunaan HA sebagai bahan bone graft telah menyebabkan harganya menjadi mahal. Cangkang telur merupakan salah satu sumber alternatif HA yang banyak dikembangkan saat ini. Metode: Artikle dikumpulkan dengan mencari artikel penelitian eksperimental secara in vivo yang diterbitkan antara tahun 2014 dan Desember 2024. Artikel yang dikumpulkan diterbitkan dalam bahasa Inggris di database PubMed, ScienceDirect, dan Wiley menggunakan kata kunci “eggshells” yang dikombinasikan dengan istilah “bone graft” dan “bone formation”. Kesimpulan: Bone graft yang berasal dari cangkang telur dapat dimanfaatkan dalam perawatan pascaekstraksi gigi untuk kondisi infeksi dan non-infeksi.
Profil Awal Resiko Metabolik Pada Prediabetes Dengan Riwayat Keluarga Tingkat Pertama Diabetes Melitus Tipe 2 Afifah, Salwa Nur; Liana, Phey; Oktarina, Desi
BEST Journal (Biology Education, Sains and Technology) Vol 8, No 1 (2025): Juni 2025
Publisher : Program Studi Pendidikan Biologi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/best.v8i1.11341

Abstract

Prediabetes merupakan fase awal gangguan metabolik yang berpotensi berkembang menjadi Diabetes Melitus Tipe 2 (DMT2), terutama pada individu dengan riwayat keluarga tingkat pertama (First Degree Relative/FDR) penderita DMT2. Penelitian ini bertujuan untuk menggambarkan profil awal risiko metabolik pada individu prediabetes dengan riwayat keluarga tingkat pertama diabetes melitus tipe 2. Sebanyak 68 responden dibagi rata kelompok antara normal dan prediabetes. Analisis deskriptif menunjukkan bahwa kelompok prediabetes memiliki median usia 31,5 tahun, dengan dominasi perempuan (46,5%) dan riwayat keluarga diabetes melitus tipe 2 terutama dari pihak ayah (53,8%). Kelompok ini juga menunjukkan prevalensi lebih tinggi dalam durasi obesitas lebih dari 5 tahun (100%), tekanan darah sistolik median 124,5 mmHg, kadar HbA1c median 5,85%, kadar TNF-α median 150,21 pg/mL, indeks massa tubuh rata-rata 27,68 kg/m², dan lingkar pinggang rata-rata 86,91 cm. Selain itu, aktivitas fisik rutin lebih rendah (26,9%) dan proporsi perokok lebih tinggi (60%) dibandingkan kelompok normal. Temuan ini mengindikasikan bahwa individu prediabetes dengan riwayat keluarga diabetes melitus tipe 2 memiliki profil risiko metabolik yang lebih buruk, mendesak pentingnya intervensi dini untuk mencegah perkembangan menuju diabetes melitus tipe 2
PERAN IMUNOMODULATOR VITAMIN D TERHADAP INTERLEUKIN 6 PADA PENDERITA DIABETES MELITUS TIPE 2 Wulandari, Septi; Hafy, Zen; Liana, Phey
BEST Journal (Biology Education, Sains and Technology) Vol 8, No 1 (2025): Juni 2025
Publisher : Program Studi Pendidikan Biologi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/best.v8i1.11119

Abstract

Diabetes Melitus Tipe 2 (DMT2) adalah penyakit metabolik kompleks dengan peradangan kronis sebagai salah satu mekanisme penting dari patogenesisnya. Interleukin-6 (IL-6) memiliki peran signifikan dalam memperburuk resistensi insulin dan meningkatkan risiko komplikasi vaskular pada penderita DMT2. Vitamin D diketahui tidak hanya berfungsi dalam metabolisme tulang tetapi juga bertindak sebagai imunomodulator yang mampu memodulasi respons inflamasi. Tinjauan literatur ini bertujuan untuk menganalisis peran vitamin D dalam mengatur tingkat IL-6 pada pasien DMT2 berdasarkan studi yang dipublikasikan sebelumnya. Literature review ini bertujuan untuk menjelaskan pengaruh vitamin D dalam menurunkan sitokin proinflamasi IL-6 pada pasien diabetes mellitus tipe 2. Metode yang digunakan dalam artikel ini adalah penelusuran artikel melalui database Pubmed, Springer Link dan Google Scholar. Tahun penerbitan sumber pustaka adalah dari tahun 2011 hingga 2025 dengan 27 sumber pustaka. Hasil: Beberapa literatur menunjukkan bahwa kadar vitamin D serum yang cukup atau pemberian suplemen vitamin D memiliki kemampuan untuk mengurangi IL-6 dan berkontribusi terhadap perbaikan kontrol glikemik Hasil yang diperoleh antar studi belum sepenuhnya konsisten karena adanya perbedaan metodologi, dosis suplementasi, durasi intervensi, serta karakteristik subjek penelitian. Beberapa literatur menunjukkan bahwa kadar vitamin D serum yang cukup atau pemberian suplemen vitamin D memiliki kemampuan untuk mengurangi IL-6 dan berkontribusi terhadap perbaikan kontrol glikemik
Co-Authors Afifah, Salwa Nur Agustin, Berliana Agustin, Berliana Amalia Amalia Ari L. Runtunuwu Aseptianova Aseptianova Astari Rahayu Afifah Baity Indriani Banun, Syahri Berliana Agustin Berliana Agustin Bhagaskara Bhagaskara Budi Santoso Calvin Ienawi Catherine Ieawi Chris Alberto Amin Cornelia Agatha Dalilah Desi Oktariana Desi Oktariana Dini Cahyani Dodi Maulana Eka Intan Fitriana Eny Rahmawati Eny Rahmawati, Eny Erial Bahar Evi Lusiana Fadhilatul Hilda Gita D. Prasasty Gita Dwi Prasasty Gita Dwi Prasasty Gita Dwi Prasasty Hafizzanovian, Hafizzanovian Hertanti Indah Lestari Hidayatullah Iche Andriyani Liberty, Iche Andriyani Ieawi, Catherine Ieawi, Catherine Ienawi, Calvin Ienawi, Calvin Irfanuddin Irfanuddin Iza Netiasa Haris Jayawarsa, A.A. Ketut Jeanette I. Ch. Manoppo Jesica Sidabutar Jose M. Mandei Karina Rahma Meidiarti Kemas M. Yakub Kemas M. Yakub Kemas Y. Rahadiyanto Kemas Ya’kub Rahadiyanto Kemas Ya’kub Rahadiyanto Krisna Murti Kusumo Haryadi Kusumo Haryadi Laksono Trisnantoro Legiran Legiran Lusia Hayati Luthfiah, Qonita Mastiar Endang Frida Siahaan Maulana, Mirza Gifari Mediarty Syahrir Mita Al Maida Muhammad Irsan Saleh Muhammad Reagan Nelda Aprilia Salim Nia S. Tamzil Nia Savitri Tamzil Norlaila Binti Chahril Nova Kurniati Novita, Emma Nurmalia Purnama Sari Oktariana, Desi Oktarina, Desi Patricia, Venny Patwa Amani, Patwa Rahadiyanto, Kemas Ya’kub Rahardiyanto, Kemas Ya’kub Rahma Yunita, Rahma Rahmi Widiyawati Rahnowi Pradesta Rahnowi Pradesta Rocky Wilar Ronald Chandra SEPTI WULANDARI Soilia Fertilita Sri Nita Sri noviyanty Yusuf Swanny Swanny Tungki Pratama Umar Tungki Pratama Umar Tungki Pratama Umar Tungki Pratama Umar Tungki Pratama Umar Vena Sabputri Sutrisno Venny Patricia Veny Larasati Verdiansah Verdiansah Yakub, Kemas M Yakub, Kemas M Yan Effendi Hasyim Yulia Nugraha Karsita Yunni Diansari Zen Ahmad Zen Hafy