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All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Majalah Kedokteran Sriwijaya Biomedical Journal of Indonesia Paediatrica Indonesiana Jurnal Penelitian Sains Molecular and Cellular Biomedical Sciences (MCBS) Jurnal Surya Medika SRIWIJAYA JOURNAL OF MEDICINE Majalah Kedokteran Andalas Bioscientia Medicina : Journal of Biomedicine and Translational Research Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Best Journal (Biology Education, Sains and Technology) Open Access Indonesian Journal of Medical Reviews Bioscientia Medicina : Journal of Biomedicine and Translational Research Conferences of Medical Sciences Dies Natalis eJournal Kedokteran Indonesia
Phey Liana
Bagian Patologi Klinik, Fakultas Kedokteran, Universitas Sriwijaya
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Education Health Professions Immunology & microbiology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health

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Correlation of Absolute Lymphocyte Count with Severity of COVID-19 at Dr. Mohammad Hoesin General Hospital Palembang Zen Ahmad; Yulia Nugraha Karsita; Phey Liana; Erial Bahar
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 11 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i11.601

Abstract

Background: The rRT-PCR examination is very effective as a diagnostic tool for COVID-19 but cannot be a full reference as an evaluation examination because rRT-PCR is able to capture the genetic material of the virus without ensuring that the virus is still alive or only dead particles. This study aims to explore the correlation between absolute lymphocyte values and the severity of COVID-19 at Dr. Mohammad Hoesin General Hospital Palembang. Methods: This study is an observational study involving 413 research subjects at Dr. Mohammad Hoesin General Hospital. Data analysis was carried out univariate and bivariate. Results: The absolute number of lymphocytes with the severity of COVID-19 has a negative correlation, with a strong correlation strength, which is expressed by the value of r = -0.617 and the degree of significance of p = 0.000. Conclusion: There is a correlation between absolute lymphocyte count and the severity of COVID-19 at Dr. Mohammad Hoesin General Hospital Palembang.
Transplantasi Stem Cell untuk Keganasan Hematologi Desi Oktariana; Legiran Legiran; Phey Liana; Kemas Y. Rahadiyanto; Gita D. Prasasty; Evi Lusiana; Nia S. Tamzil
eJournal Kedokteran Indonesia Vol. 10 No. 2 - Agustus 2022
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23886/ejki.10.123.186-93

Abstract

Insiden keganasan hematologi terus bertambah serta memiliki tingkat morbiditas dan mortalitas yang tinggi. Keganasan hematologi adalah kondisi sel-sel hematologi seperti eritrosit, leukosit, dan trombosit, tumbuh tidak terkendali dan tidak mengalami kematian sehingga mendominasi populasinya dan tidak dapat berfungsi normal. Terapi stem cell pada keganasan hematologi yang disebut juga terapi transplantasi sumsum tulang, merupakan modalitas terapi utama untuk gangguan hematologi dan keganasan yang memungkinkan pemulihan komponen seluler darah, termasuk monosit, limfosit, basofil, eosinofil, neutrofil, eritrosit, dan trombosit. Stem cell yang dapat digunakan pada keganasan hematologi adalah kombinasi hematopoietic stem cell (HSC) dan mesenchymal stem cells (MSC) untuk transplantasi sumsum tulang dan pemulihan kekebalan untuk gangguan hematologi. Penggunaan HSC dengan ko-terapi MSC dapat memfasilitasi kelangsungan hidup cangkok dari transplantasi HSC. Kata kunci: keganasan, hematologi, stem cell.   Stem Cell Transplantation for Hematology Malignancy Abstract The incidence of hematological malignancies continues to increase and has a high rate of morbidity and mortality. Hematological malignancies are conditions of hematological cells such as erythrocytes, leukocytes, and platelets, growing uncontrollably and not dying so that they dominate the population and cannot work normally. Stem cell therapy in hematological malignancies, also known as bone marrow transplantation therapy, is the main therapeutic modality for hematological disorders and malignancies that supports the restoration of cellular components of blood, including monocytes, lymphocytes, basophils, eosinophils, neutrophils, erythrocytes, and platelets. Stem cells that can be used in hematological malignancies are a combination of hematopoietic stem cells (HSC) and mesenchymal stem cells (MSC) for bone marrow transplantation and immune restoration for hematological disorders. The use of HSCs with MSC co-therapy can help revive grafts from HSC transplants. Key words: malignancy, hematology, stem cell.
C-Reactive Protein as The Predictor of Mortality for COVID-19 Patients in Indonesia Astari Rahayu Afifah; Phey Liana; Soilia Fertilita; Nelda Aprilia Salim; Verdiansah Verdiansah; Fadhilatul Hilda; Chris Alberto Amin; Tungki Pratama Umar
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 29 No. 2 (2023)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v29i2.1997

Abstract

Coronavirus Disease 2019 (COVID-19) confirmed cases and deaths continue to rise. When a virus infects the body, the immune system tries to eliminate the virus. C-Reactive Protein (CRP) is a substance produced in the body in response to infection and inflammation. The study aimed to determine the role of CRP in predicting COVID-19 patients’ mortality. From the 1st of March to the 31st of August 2020, data on patients confirmed with COVID-19 were collected from medical records. The correlation between CRP levels and patient mortality was determined using a Chi-Square test. A Receiver Operator Curve (ROC) analysis was used to determine the best CRP cut-off point, and a survival analysis was used to assess the patient outcome. This study included a total of 210 eligible patients. Survivors and non-survivors were divided into two groups of patients (159 patients and 51 patients, respectively). The CRP cut-off was 54 mg/L, with an AUC of 0.817 (p<0.001). C-reactive protein levels were related to COVID-19 patient mortality (p=0.000). According to the survival analysis, patients with CRP levels > 54 mg/L had a lower chance of 30-day survival (p=0.0001). This study presented that CRP levels can be used to predict mortality in COVID-19 patients.
THE COMPARISON OF EFFECTIVENESS AND SAFETY BETWEEN WARFARIN AND RIVAROXABAN IN HYPERCOAGULATED CENTRAL NERVOUS SYSTEM TUMORS Sri noviyanty Yusuf; Yunni Diansari; Mediarty Syahrir; Phey Liana
Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Vol. 11 No. 1 (2023): Jambi Medical Journal: Jurnal Kedokteran dan Kesehatan
Publisher : FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS JAMBI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/jmj.v11i1.25056

Abstract

Abstract:                                                                                                                                           Background: Central nervous system (CNS) tumors originate from the brain and spinal cord, and have complications, such as hypercoagulation. The administration of anticoagulants (warfarin and rivaroxaban) has been able to reduce hypercoagulation-related morbidity and mortality, however, the effectiveness and safety of their use has not been well studied. This study aims to compare the effectiveness and safety of anticoagulant drugs between warfarin and rivaroxaban in hypercoagulated CNS tumors. Methods: This was a randomized clinical trial study, double-blinded, conducted on CNS tumor patients from September-November 2020 at Mohammad Hoesin Hospital. The patients were given warfarin and rivaroxaban for 3 weeks. Coagulation status was measured before and after. Data were analyzed using SPSS ver.24. Results: The mean age of 20 patients was 42.70+8.14 years and majority were female (80%), with tumor characteristics were primary (80%), single (85%), and located in the brain (95%). In the warfarin group (n=10), there were significant improvements in PT (p 0.008), INR (p 0.013), Fibrinogen (p 0.041), and D-Dimer (p 0.008) value, also the rivaroxaban group (n=10) in PT (p 0.013), APTT (p 0.012), INR (p 0.028), Fibrinogen (p 0.047), D-Dimer (p 0.032), and Anti Fxa (p 0.028). However, there was no significant difference between groups, except when comparing the Anti Fxa delta (p 0.041). There was 1 person with major bleeding using warfarin, and 1 person (excluded) with GIT bleeding using rivaroxaban. Conclusion: There was a significant improvement of coagulation value in both groups, also side effects were seen as well. Keyword: CNS Tumor, Hypercoagulation, Warfarin, Rivaroxaban
Correlation between CRP Level and Neutrophil Extracellular Traps in Malignancy Patients with Neutropenic Fever Phey Liana; Kemas M. Yakub; Eny Rahmawati; Berliana Agustin
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 26 No. 3 (2020)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v26i3.1595

Abstract

The mortality and morbidity rate of neutropenic fever is quite high. The source and severity of infection must be evaluated quickly in neutropenic patients. C-Reactive Protein (CRP) and Neutrophil Extracellular Traps (NETs) are known as markers for severeinfection. Besides, NETs also play a role in the development and metastasis of cancer but the mechanism is still unclear. C-reactive protein is a marker that is routinely used for infection. However, the correlation between CRP levels and NETs in malignant patients with neutropenia is unknown. Therefore this study was conducted to determine the correlation between CRP levels and NETs in malignant patients with neutropenia. This research was a cross-sectional observational study. The samples were malignant patients with neutropenia who were treated in the Pediatric Ward of  Dr. Mohammad Hoesin Hospital, Palembang and met the inclusion and exclusion criteria. Sampling was done by consecutive sampling. C-reactive protein level and NETs weretested by immunoturbidimetry and ELISA methods. Data were analyzed with the Pearson test (p <0.05). The mean of CRP and NETs level were 170.17±121.52 mg/L and 0.77±0.39 ng/mL, respectively. The correlation test between CRP level and NETs in malignancy patients with neutropenic fever showed r=0.228 and p=0.362. The results showed no significant correlation between CRP level and NETs in malignant patients with neutropenic fever.
Comparison of Blood Gas Analysis between Benchtop and Handheld Device Phey Liana; Iza Netiasa Haris; Yan Effendi Hasyim
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 27 No. 1 (2020)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v27i1.1610

Abstract

The use of blood gas analysis is to determine the Acid-base status required to treat patients with emergency conditions such as metabolic disorders and respiratory diseases. Benchtop device is commonly used in hospitals to analyze blood gas; however, handheld devices are recently more often used in emergency settings due to its quick and simple process. This study was performed to compare blood gas analysis results between the i-STAT handheld device and the Nova pHox Ultra benchtop device that were currently being used in the central laboratory. This cross-sectional study was conducted by using 42 arterial blood patients that were measured with i-STAT handheld device dan Nova pHox Ultra benchtop device. The pH, pCO2, and pO2 parameters were then evaluated. The data were analyzed using Spearman's correlation test, Mann-Whitney test, and Bland-Altman plots. This study showed a very strong positive correlation for all parameters. Mann-Whitney comparison test showed that there was no significant difference between the result of the two devices (p-value > 0.05). All parameters showed that 95% of plots were within the acceptable limit. There was no clinical significance on the mean biases of blood gas results between both devices. The i-STAT and Nova pHox Ultra devices showed a good agreement for blood gas measurement. Therefore, both devices can be used interchangeably with minimal effect on clinical decision-making.
Prevalence of Extended-Spectrum Beta Lactamase-Producing Microorganisms in Dr. Mohammad Hoesin Hospital Palembang Phey Liana; Norlaila Binti Chahril; Sri Nita; Tungki Pratama Umar
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 28 No. 3 (2022)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v28i3.1897

Abstract

Production of Extended-Spectrum Beta-Lactamase (ESBL) by Enterobacteriaceae continues to be a problem of infectious diseases, especially in hospitals. The main causes of ESBL-producing bacteria colonization are urinary tract infections, length of hospital stay, invasive medical equipment, and antibiotics usage. This study aims to compare the incidence of ESBL based on the type of organism in Dr. Mohammad Hoesin Hospital for the 2017 and 2018 periods. The research design used was descriptive with a cross-sectional approach, which used secondary data at the Clinical Pathology Department of Dr. RSUP. Mohammad Hoesin Palembang. The findings of this study showed a decreasing pattern in the incidence of ESBL in 2017 and 2018, but with a similar pattern which was dominated by Klebsiella pneumoniae (followed by Escherichia coli and Klebsiella ozaenae), inpatients in pediatric wards, internal medicine, and intensive care units, and on sputum specimens. This study showed the presence of high levels of ESBL-producing bacteria (>60%) in Dr. Mohammad Hoesin Hospital, which was mainly caused by Klebsiella pneumoniae.
Risk Factors for Progressive Chronic Kidney Disease in Children with Idiopathic Nephrotic Syndrome at Dr. Mohammad Hoesin General Hospital Palembang Mirza Gifari Maulana; Eka Intan Fitriana; Phey Liana; Hertanti Indah Lestari; Dalilah
Open Access Indonesian Journal of Medical Reviews Vol. 3 No. 1 (2023): Open Access Indonesian Journal of Medical Reviews
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/oaijmr.v3i1.274

Abstract

Nephrotic syndrome (NS) is a kidney disease that is often found in children. NS can cause infectious and non-infectious complications, such as upper respiratory tract infections, urinary tract infections, edema, acute kidney injury (AKI), and hypertension. This study aimed to determine the risk factors of age, gender, nutritional status, hypertension, hematuria, AKI, hyperfiltration, and steroid sensitivity to the progression of chronic kidney disease (CKD) in children with the initial idiopathic NS in the pediatric ward of Dr. Mohammad Hoesin General Hospital Palembang. This study was an analytic observational study with a cross-sectional design. A total of 72 secondary data of research subjects were included in this study. Risk factor analysis was carried out with the help of SPSS version 24 software in univariate, bivariate, and multivariate ways. The most common risk factor for children with the initial idiopathic NS is age ≥10 years, males and females gender obtained the same number, and the nutritional status of obesity, hematuria, AKI, and hyperfiltration have quite low rates. However, hypertension and SRNS have high rates in children with initial idiopathic NS. In conclusion, hypertension and hyperfiltration are risk factors that play a role in initiating the progression of idiopathic NS to CKD in the pediatric ward of Dr. Mohammad Hoesin General Hospital, Palembang.
Comparative Evaluation of Electrochemiluminescence and Chemiluminescence Microparticle Immunoassays for Anti-Hepatitis C Virus (HCV) Detection Phey Liana; Mita Al Maida; Gita Dwi Prasasty; Desi Oktariana; Tungki Pratama Umar
Biomedical Journal of Indonesia Vol. 10 No. 3 (2024): Vol 10, No 3, 2024
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v10i3.208

Abstract

Introduction. Anti-hepatitis C virus (HCV) testing is an immunological analysis designed to identify the presence of antibodies against the HCV antigen. This investigation is typically conducted using the chemiluminescence immunoassay (CLIA) technique, which yields precise results. Current research attempts to evaluate the outcomes of the anti-HCV test utilizing the Chemiluminescence Microparticle Immunoassay (CMIA) and the Electrochemiluminescence Immunoassay (ECLIA) approaches. Methods. This cross-sectional study comprised 63 serum samples collected via consecutive sampling. The acquired data were subjected to statistical analysis utilizing Cohen's Kappa agreement test. Results. Both immunoassay methods yielded identical results, indicating four reactive samples out of 63, equating to 6.35%. The agreement test result for the anti-HCV test was κ=1.000, signifying an almost perfect level of agreement. Conclusion. The anti-HCV assessment utilizing CMIA and ECLIA methodologies demonstrated near-perfect agreement. This signifies that these two procedures can be employed in clinical laboratories concurrently or interchangeably for the test.
Cycle Threshold Value as A Death Predictor of COVID-19 Patients Oktariana, Desi; Saleh, Irsan; Banun, Syahri; Rahadiyanto, Kemas Ya’kub; Liana, Phey; Rahmawati, Eny; Hafizzanovian, Hafizzanovian; Lusiana, Evi; Tamzil, Nia Savitri; Prasasty, Gita Dwi; Aseptianova, Aseptianova
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 31 No. 3 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v31i3.2390

Abstract

For several years, COVID-19 has been a major problem in human health and also caused a global socio-economic crisis. However, the impact of viral load on patient mortality has not been thoroughly investigated. This study analyzes the association between CT value and the mortality of COVID-19 patients in inpatients at Mohammad Hoesin Hospital. This study used observational analysis with a longitudinal retrospective design. This study had 280 subjects. Fifty-four of the 280 patients died (19.3%) 33% had a CT <22.93; 16.7% had a CT 22.93-29.93; 31.5% had a CT 29.94-34.9, 18.5% had a CT >35 with p-value >0.05 for patient mortality. Analysis of age, comorbidities, and clinical severity of patient mortality showed a p-value <0.05. Meanwhile, gender analysis of patient mortality showed a p-value >0.05. These results indicate that the CT value cannot predict patient mortality. Patients with older age, comorbidities, and admission with severe clinical severity have a higher risk of death.
Co-Authors Afifah, Salwa Nur Agustin, Berliana Agustin, Berliana Amalia Amalia Ari L. Runtunuwu Aseptianova Aseptianova Astari Rahayu Afifah Baity Indriani Banun, Syahri Berliana Agustin Berliana Agustin Bhagaskara Bhagaskara Budi Santoso Calvin Ienawi Catherine Ieawi Chris Alberto Amin Cornelia Agatha Desi Oktariana Desi Oktariana Dini Cahyani Dodi Maulana Eka Intan Fitriana Eny Rahmawati Eny Rahmawati, Eny Erial Bahar Evi Lusiana Fadhilatul Hilda Gita D. Prasasty Gita Dwi Prasasty Gita Dwi Prasasty Gita Dwi Prasasty Hafizzanovian, Hafizzanovian Hertanti Indah Lestari Hidayatullah Iche Andriyani Liberty, Iche Andriyani Ieawi, Catherine Ieawi, Catherine Ienawi, Calvin Ienawi, Calvin Irfanuddin Irfanuddin Iza Netiasa Haris Jayawarsa, A.A. Ketut Jeanette I. Ch. Manoppo Jesica Sidabutar Jose M. Mandei Karina Rahma Meidiarti Kemas M. Yakub Kemas M. Yakub Kemas Y. Rahadiyanto Kemas Ya’kub Rahadiyanto Kemas Ya’kub Rahadiyanto Krisna Murti Kusumo Haryadi Kusumo Haryadi Laksono Trisnantoro Larasati, Veny Legiran Legiran Lusia Hayati Mastiar Endang Frida Siahaan Mediarty Syahrir Mirza Gifari Maulana Mita Al Maida Muhammad Irsan Saleh Nelda Aprilia Salim Nia S. Tamzil Nia Savitri Tamzil Norlaila Binti Chahril Nova Kurniati Novita, Emma Nurmalia Purnama Sari Oktariana, Desi Oktarina, Desi Patricia, Venny Patwa Amani, Patwa Rahadiyanto, Kemas Ya’kub Rahmi Widiyawati Rahnowi Pradesta Rahnowi Pradesta Rocky Wilar Ronald Chandra SEPTI WULANDARI Soilia Fertilita Sri Nita Sri noviyanty Yusuf Sulistiani Sulistiani, Sulistiani Susilawati Susilawati Swanny Swanny Tungki Pratama Umar Tungki Pratama Umar Tungki Pratama Umar Tungki Pratama Umar Tungki Pratama Umar Vena Sabputri Sutrisno Venny Patricia Verdiansah Verdiansah Yakub, Kemas M Yakub, Kemas M Yan Effendi Hasyim Yulia Nugraha Karsita Yunni Diansari Zen Ahmad Zen Hafy