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All Journal Current Biochemistry Jurnal Penelitian Pendidikan IPA (JPPIPA) AcTion: Aceh Nutrition Journal Meditory : The Journal of Medical Laboratory GANEC SWARA Jurnal Keperawatan Terpadu (Integrated Nursing Journal) Indonesian Journal of Global Health research Buletin Poltanesa Bioscientist : Jurnal Ilmiah Biologi MAHESA : Malahayati Health Student Journal Jurnal Kolaboratif Sains Jurnal Ilmiah Pengabdian dan Inovasi Biomedika Jurnal Info Kesehatan
I Putu Bayu Agus Saputra
Faculty Of Medicine, Al-Azhar Islamic University, Mataram, West Nusa Tenggara, Indonesia
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Journal : Jurnal Penelitian Pendidikan IPA (JPPIPA)

 1 
Noni (Morinda Citrifolia) Ethanol Extract Lowered Blood Glucose Levels, Increased Glutathione Peroxidase Activity, And Decreased Malondialdehyde in White Rats Model of Diabetes Arjita, I Putu Dedy; Saputra, I Putu Bayu Agus; Sukmana, Dhika Juliana
Jurnal Penelitian Pendidikan IPA Vol 9 No 12 (2023): December
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v9i12.6076

Abstract

Diabetes mellitus can increase oxidative stress and damage cells. Noni fruit has antibacterial, antifungal, antitumor, analgesic, hypotensive, and anti-inflammatory benefits, can boost immunity, and has antioxidant content. Noni contains phenolic compounds (anthraquinones, acuities, asperulosides, and scopoletin), organic acids (capric and caprylic acids), and alkaloids (xeronine). The effect of noni ethanol extract can significantly reduce blood glucose (P<0.05) of the T2 group (177.00±137.78) and T3 (159.40±86.53) when compared to the C+ group (511.00±131.45). The T1 group (387.40±170.06) had no significant difference (P>0.05) when compared to the C+ group (511.00±131.45), but there was a decrease in the average yield at T1 (387.40±170.06). Serum malondialdehyde (MDA) examination showed a significant decrease (p<0.05) in T1 (1188.32±93.41), while in T2 (1385.35±38.65) and T3 (1460.32±42.51) was not significant (p<0.05). Examination of serum glutathione peroxidase (GPX) showed a significant decrease in T1 (119.97±37.45), there was a decrease in GPX levels, while in the T2 group (236.14±6.05) and T3 (185.24±43.07), there was no decrease. Noni ethanol extract can lower blood glucose levels, reduce Malondialdehyde levels, and prevent increased activity of the enzyme glutathione peroxidase. Flavonoid compounds in noni ethanol extract can avoid increased blood glucose and reduce free radicals formed due to hyperglycemia conditions.  
Potensi senyawa turunan flavonoid dalam menjadi inhibitor enzim HMG-Coa reductase kandidat obat h Saputra, I Putu Bayu Agus; Arjita, I Putu Dedy
Jurnal Penelitian Pendidikan IPA Vol 10 No 5 (2024): May
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i5.6237

Abstract

Cardiovascular disease (CVD) is a disease that causes death in the world. Behavioral risk factors are crucial in dealing with CVD disease. High levels of cholesterol in the blood are associated with hypercholesterolemia. It can increase the risk of CVD disease. The HMG-CoA reductase enzyme is an enzyme that plays a role in cholesterol synthesis. It will convert the HMG-CoA compound into the mevalonate. Inhibition of this enzyme can reduce cholesterol synthesis because it inhibits the formation of mevalonate, which is the initial stage of cholesterol synthesis. Herbal compounds are compounds produced by plants. It has good benefits for the body. Flavonoid compounds can be beneficial for health. Molecular docking is a method used to determine the binding affinity and interaction values ​​of the enzyme protein interaction with the ligand to be bound. The results of Apigenin binding affinity values is -7.7 kcal/mol, Luteolin is -8 kcal/mol, Quercetin is -8.2 kcal/mol, Kaempferol is -7.4 kcal/mol, Phloretin is -6.8 kcal/mol, Chalconaringenin is -6.9 kcal/mol, Cyanidin is -7.9 kcal/mol, Delphinidin is -7.8 kcal/mol, Hesperetin is -7.7 kcal/mol, Narigenin is -7.8 kcal/mol, Daidzein is -6.8 kcal/mol, Genistein is -7 kcal/mol, Rutin is -9.2 kcal/mol, Taxifolin is -8 kcal /mol, Diosmetin is -7.6 kcal/mol, and its native ligand Rosuvastatin is -8.5 kcal/mol. Flavonoid derivative compounds can bind to the HMG-CoA reductase enzyme. They can be candidates for antihyperlipidemia drugs.
Co-Authors Adnyana , I Gede Angga ANISAH Arjita, I Putu Dedy Ayu Anulus Benvenuto, Ananta Fittonia Deny Sutrisna Wiatma Dewi, Novianti Tysmala Dhika Juliana Sukmana Diani Sri Hidayati Dwik Putra Nickontara Fachrudi Hanafi Farida Ariani Hardani, H Hermawati, Resna I Gede Angga Adnyana I Gede Angga Adnyana I GEDE ANGGA ADNYANA I Putu Deddy Arjita Keninten, Ida Surya Prabawa Satya Kresnapati, I Nyoman Bagus Aji Kurniawan, Nadi Laksmi Nur Fajriani Lina Yunita Mamang Bagiansah Manutama, Putu Agi Abhimana Maruni Wiwin Diarti Maruni Wiwin Diarti Maruni Wiwin Diarti Muhamad Wahyu Rizal Musviratunnisah, Bintang Yuniar Ni Made Wiasty Sukanty Purnawan, Desak Putu Diva Mayra Putri Putu Sudiasa Rozikin RR. Ella Evrita Hestiandari Ruqayyah, Siti Sabariah Sabariah Sabariah Samoedra, Reksa Setia, Bayu Sukanty, Ni Made Wiasty Sukmana, Dhika Juliana Syuhada, Irwan Wiasty Sukanty, Ni Made Widani Darma Isasih Yunan Jiwintarum Yunan Jiwintarum Yunita, Lina Zhalifunnafsi, Baiq Nabila