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All Journal CAKRA KIMIA (Indonesian E-Journal of Applied Chemistry) Meditory : The Journal of Medical Laboratory JFM (Jurnal Farmasi Malahayati) JURNAL ILMIAH KESEHATAN SANDI HUSADA Medicra (Journal of Medical Laboratory Science/Technology) Jurnal Farmasi dan Sains Indonesia (JFSI) Muhammadiyah Medical Journal Jurnal Pengabdian kepada Masyarakat Wahana Usada JURNAL SKALA HUSADA: THE JOURNAL OF HEALTH Jurnal Yoga Dan Kesehatan Jurnal Ilmiah Kesehatan Sandi Husada Jurnal Pharmactive
Ni Wayan Rika Kumara Dewi
Institut Teknologi Dan Kesehatan Bintang Persada
Religion Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Electrical & Electronics Engineering Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Andrografolid : Potensi Sebagai Antiaterosklerosis Pada Sitokin Il-1β Putu Yudha Ugrasena; Iwan Saka Nugraha; Ni Wayan Rika Kumara Dewi
Jurnal Ilmiah Kesehatan Sandi Husada Vol 12 No 1 (2023): Jurnal Ilmiah Kesehatan Sandi Husada
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Akademi Keperawatan Sandi Karsa (Merger) Politeknik Sandi Karsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35816/jiskh.v12i1.991

Abstract

The focus is how the role of cytokines in atherosclerosis as a chronic inflammatory disease, as it is known that cytokines regulate complex inflammatory responses in atherosclerotic plaques, especially IL-1β. Sambiloto (Andrographis paniculata) is a plant with various pharmacological activities. Andrographolide (AND) is the main bioactive compound in the diterpene lactone group. This literature study aims to assess the potential of AND on the proinflammatory cytokine IL-1 β as an antiatherosclerosis. This type of research is a qualitative review of various studies using sambiloto plants or andrographolide compounds (AND). Search literature using the Google Scholar database. Keywords used "Andrographis paniculata, andrographolide, IL-1β, Atherosclerosis. The results showed that AND has effects as an anti-inflammatory, antiatherosclerosis as well as cardiovascular-related diseases. There are not many articles on the activity of AND in IL-1β against atherosclerosis, but AND can provide inhibitory activity of the cytokine IL-1β against inflammation. Not many researchers have discussed the pharmacological effects of AND as an antiatherosclerotic on IL-1β therapeutic targets, but from the results of the review AND has a strong potential in inhibiting IL-1 cytokine secretion β.
PEMANFAATAN DAN POTENSI ANTIOKSIDAN PADA BUNGA TELANG (Clitorea ternatea L.) : Literatur Review Ni Wayan Rika Kumara Dewi
Journal Pharmactive Vol. 1 No. 2 (2022): Jurnal Pharmactive Oktober
Publisher : Institut Teknologi dan Kesehatan Bintang Persada

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Abstract

Abstrak Latar belakang : Bunga telang memiliki potensi antioksidan karena memiliki kandungan antosianin dan flavonoid lainnya. Antosianin diketahui mampu memberikan aktivitas antioksidan. Selain itu bunga telang juga sering dimanfaatkan dalam bidang pangan. Hal ini menunjukkan potensi besar pemanfaatan bunga telang oleh masyarakat luas, sehingga perlu dikaji terkait pemanfaatan dan potensi antioksidan bunga telang (Clitoria ternatea L.) Tujuan: Untuk mengetahui manfaat dan potensi antioksidan dari bunga telang (Clitoria ternatea L.) dengan berbagai metode yaitu DPPH, FRAP, ABTS, BTA, CUPRAC. Metode: Penelitian ini menggunakan metoda deskriptif dengan menggunakan metode review artikel terstruktur. Pengumpulan data dilakukan menggunakan basis data Google Scholar, Science Direct danPubMed dengan kata kunci “Clitoria ternatea L. antioxidant activity”, “Clitoria ternatea L.”, “phytochemical analysis of Clitoria ternatea L.”, “traditional use of Clitoria ternatea L.”Hasil: Berdasarkan studi literatur pemanfaatan bunga telang digunakan dalam bidang pangan dan kesehatan yaitu mencegah glikasi protein dan kerusakan DNA oksidatif, Mengerahkan efek protektif terhadap Bisphenol A (BPA) terhadap kinerja reproduksi dalam meningkatkan persentase kehamilan dan ukuran anak, memodulasi efek perlindungan terhadap paparan UVR pada kulit, dan meningkatan stabilitas dalam pangan fungsional dalam bentuk bubuk minuman fungsional dan sebagai pewarna makanan Kesimpulan: Bunga telang (Clitoria ternatea L.) memiliki aktivitas biologis sebagai antioksidan dan memiliki manfaat di bidang pangan dan kesehatan. Pada potensi antioksidan yang diperoleh dari beberapa literatur dengan metode yang berbeda memberikan perbedaan nilai IC50.
VOLUME PENOTOLAN MEMPENGARUHI FINGERPRINT EKSTRAK METANOL HERBA SAMBILOTO (ANDROGRAPHIS PANICULATA (BURM. F.) NEES) DENGAN KLT-SPEKTROFOTODENSITOMETRI Ugrasena Putu Yudha; Puspita Sari Dyah Ratna Ayu; Kumara Dewi Ni Wayan Rika
Journal Pharmactive Vol. 2 No. 1 (2023): Jurnal Pharmactive April
Publisher : Institut Teknologi dan Kesehatan Bintang Persada

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Abstract

Spotting volume is an important factor affecting the resolution value of the chromatogram, the number of peaks and separation, peak profile and peak broadening, as well as the asymmetry of the peaks. This study aims to determine the effect of bottling volume on fingerprint chromatography of the methanol extract of Andrographis paniculata (Burm. F.) Nees herb and to determine fingerprint chromatography at optimum volume. The chromatographic system used refers to the Indonesian Herbal Pharmacopoeia. Sambiloto herbal samples were spotted with a variety of 3 µL bottling volumes; 5µL; 10µL; 15µL; 20 µL and 25 µL on a 60 GF254 silica gel plate were then eluted with a mixture of chloroform P and methanol P (9:1) v/v. The plates were scanned with a TLC Scanner 3 (CAMAG) at a wavelength of 210 nm. Spectra were made for each spot at a wavelength of 190-400 nm. Parameters that were calculated were resolution values, tailing factor from andrographolid peaks, and cosine functions (C) from volume variation chromatograms to determine the effect of spotting volume. The bottling volume selected from the optimization step was 5 µL with andrographolid peak resolution with the previous and following peaks being 1.57 and 1.16, respectively. The tailing factor value was 1 and the number of peaks that appeared was 10. The average value of C in the 5 µL bottling volume precision test was 99.36 with a VC of 1.17% (VC <2%)
ANTIBACTERIAL POTENTIAL OF RED BETEL LEAVES (Piper crocatum Ruiz and Pav) Kumara Dewi Ni Wayan Rika; Ugrasena Putu Yudha; Puspita Sari Dyah Ratna Ayu
Journal Pharmactive Vol. 2 No. 1 (2023): Jurnal Pharmactive April
Publisher : Institut Teknologi dan Kesehatan Bintang Persada

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Abstract

Background: Red betel leaf (Piper crocatum Ruiz and Pav.) is one of the medicinal plants which empirically has the efficacy of healing spiritual ailments. The secondary metabolite compounds contained in red betel leaves are essential oils, flavonoids, alkaloids, saponins, tannins, terpenoids, and phenolic compounds which have antibacterial activity. Objective: To determine the antibacterial potential of red betel leaves (Piper crocatum Ruiz and Pav.) Method: This study uses a descriptive method using a structured article review method. Data collection was carried out using the Google Scholar database, Science Direct and PubMed with keywords “Piper crocatum Ruiz and Pav”, “Piper crocatum”, “Screening phytochemical”, Piper crocatum”, “Leaf Piper crocatum”, and “antibacterial Piper crocatum”. Results: Based on literature studies, the antibacterial potential of red betel leaves (Piper crocatum Ruiz and Pav.) can be seen from the inhibition zones produced for both gram-positive and gram-negative bacteria, although with different values of the resulting inhibition zones.
Antibacterial Activity of 96% Ethanol Extract from Red Rice Bran (Oryza nivara) Against Escherichia coli: Uji Aktivitas Antibakteri Ekstrak Etanol 96% Bekatul Beras Merah (Oryza nivara) terhadap Escherichia coli Ni Luh Gde Mona Monika; Ni Wayan Rika Kumara Dewi; Ni Putu Gita Puspita Sari
Journal Pharmactive Vol. 2 No. 2 (2023): Jurnal Pharmactive Oktober
Publisher : Institut Teknologi dan Kesehatan Bintang Persada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64036/pharmactive.v2i2.45

Abstract

Red rice bran is a by-product produced from rice milling in Jatiluwih village, Tabanan, Bali which has secondary metabolites that have the potential to inhibit bacterial activity. The purpose of this study was to determine the potential of 96% ethanol extract of red rice bran to inhibit bacterial growth Escherichia coli. The research method started with the extraction process by maceration method using 96% ethanol solvent. The viscous extract obtained was then subjected to phytochemical screening which showed the presence of compounds flavonoid, alkaloid, and tannin. Antibacterial activity test using disc diffusion method paper disk, measured by looking at the clear zone formed and analyzed using the mean test. The antibacterial activity test results of red rice bran extract at concentrations of 20% (8.63 mm) and 25% (9.93 mm) were categorized as moderate, concentration 30% (10.33 mm) was categorized as strong inhibition. Positive control in this study using chloramphenicol 250 mg which resulted in an inhibition zone of 21.42 mm in the strong inhibition zone category. Comparison of the antibacterial activity of the 96% ethanol extract of red rice bran showed significant difference with p value <0.05.
The Anti-Inflammatory Potential of Fermented Red Ginger Extract (Zingiber officinale var. Rubrum) Against In Vitro Protein Denaturation Kusdiharti, Meutia Sri; Dewi, Ni Wayan Rika Kumara; Artika, Made Prita
Jurnal Skala Husada : The Journal of Health Vol 22, No 1 (2025): Jurnal Skala Husada (JSH): The Journal of Health
Publisher : Poltekkes Kemenkes Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33992/jsh:tjoh.v22i1.4093

Abstract

Background:Red ginger (Zingiber officinale var. Rubrum) is known for many phytochemical components and various pharmacological activities, such as anti-inflammation. However, red ginger also has a high cellulose level. Special treatment is needed to degrade the cellulose so that phytochemicals can be maximally extracted. Trichoderma harzianum, a cellulase enzyme-producing fungus, can degrade cellulose and increase the efficiency of phytochemical extraction. Aims:This study aimed to evaluate the in vitro anti-inflammatory potential of red ginger extract fermented with T. harzianum. Methods:This research is an experimental method involving the fermentation of red ginger powder before extraction, followed by an in vitro protein denaturation inhibition assay using a UV-Vis spectrophotometer. Bovine Serum Albumin (BSA) was used as a negative control, diclofenac sodium as a positive control, and the fermented red ginger extract (FRGE) was tested at concentrations of 25, 50, 75, 100, and 125 ppm. The results: Phytochemical screening of FRGE confirmed the presence of alkaloids, flavonoids, saponins, phenols, and triterpenoids. The extract yield was 14.29%, with the highest inhibition of protein denaturation at 62.62% observed at 125 ppm. The IC50 value is 93.61 ppm. Conclusions: Based on these research results, FRGE had strong antiinflammatory potency in vitro. Keywords: Red ginger, Fermentation, Anti-inflammatory, Protein denaturation, Trichoderma harzianum
In Silico Study of Gingerol and Shogaol from Red Ginger Rhizome (Zingiber Officinale var. rubrum) as Anti-Inflamatory Kumara Dewi, Ni Wayan Rika; Sukma Dinda, Ni Made Ayu; Suastini, Ni Made
Jurnal Skala Husada : The Journal of Health Vol 22, No 1 (2025): Jurnal Skala Husada (JSH): The Journal of Health
Publisher : Poltekkes Kemenkes Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33992/jsh:tjoh.v22i1.4125

Abstract

ABSTRACTInflammation occurs when the enzyme phospholipase A2 (PLA2) releases arachidonic acid from cell membranes, leading to the production of pro-inflammatory mediators. Gingerol and shogaol are bioactive compounds with anti-inflammatory properties found in red ginger (Zingiber Officinale var. rubrum). This research aims to investigate the potential anti-inflammatory activity of gingerol and shogaol against osteoarthritis using in silico methods. The in silico tests utilized Hyperchem 8, Chimera 1.10.1, and molecular docking was performed using AutoDock Tools, supplemented with Autogrid and Autodock 4. The results of molecular docking showed hydrogen bonds and binding energy. The binding energy values for 10-gingerol were -9.01 kcal/mol, 10-shogaol -8.85 kcal/mol, 8-shogaol -8.72 kcal/mol, and 6-gingerol -8.07 kcal/mol. The results indicate that gingerol and shogaol compounds have higher binding energies compared to the target protein Phospholipase A2 (Sodium Diclofenac) at -7.57 kcal/mol. This suggests that gingerol and shogaol compounds from red ginger rhizome (Zingiber Officinale var. rubrum) have potential as anti-inflammatory agents.Keywords:  gingerol; shogaol; anti-inflammatory; phospoliphase A2; in silicoABSTRAKInflamasi atau peradangan terjadi akibat enzim phospoliphase A2 (PLA2) yang melepaskan asam arakidonat dari membran sel, sehingga menghasilkan mediator proinflamasi. Gingerol dan shogaol merupakan senyawa bioaktif yang memiliki kandungan antiinflamasi pada tanaman jahe merah (Zingiber Officinale var. rubrum). Penelitian ini bertujuan untuk mengetahui potensi aktivitas dari gingerol dan shogaol sebagai antiinflamasi terhadap penyakit osteoartritis secara in silico. Uji in silico menggunakan program Hyperchem 8, Chimera 1.10.1 dan pengujian molecular docking menggunakan program  AutoDock Tools, dilengkapai dengan program (Autogrid dan Autodock 4). Hasil pengujian molecular docking adalah ikatan hidrogen dan energi ikatan. Nilai energi ikatan pada senyawa 10-gingerol sebesar -9,01 kkal/mol, 10-shogaol sebesar -8,85 kkal/mol, 8-shogaol sebesar -8,72 kkal/mol dan 6-gingerol sebesar -8,07 kkal/mol, Hasil menyatakan bahwa senyawa gingerol dan shogaol memiliki energi ikatan yang lebih besar dibandingkan dengan protein target Phospholiphase A2 (Natrium Diclofenac) sebesar -7,57 kkal/mol. Hal ini menunjukan bahwa senyawa gingerol dan shogaol dari Rimpang Jahe Merah (Zingiber Officinale var. rubrum) berpotensi sebagai antiinflamasi.Kata kunci:gingerol; shogaol; antiinflamasi; phospoliphase A2; in silico
Optimasi dan Formulasi Sediaan Antiinflamasi Nano Spray Gel Ekstrak Fermentasi Jahe Merah (Zingiber officinale var. rubrum) Dewi, Ni Wayan Rika Kumara; Putri, Pande Putu Cintya Wiarni; Artika, Made Prita
Jurnal Farmasi & Sains Indonesia Vol 8 No 1 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no1p108-118

Abstract

Abstract Red ginger (Zingiber officinale var. rubrum) is one of the herbal plants that has anti-inflammatory activity. This study aims to determine the effect of red ginger fermented extract concentration on the physical quality test of nano spray gel preparation. The research method used was laboratory experimentation including fermentation process, extraction, and preparation of nano spray gel. Fermentation of red ginger powder simplisia using Trichoderma harzianum. Formulation of nano spray gel dosage form with active ingredient of red ginger fermented extract with variation of extract concentration 0% (F0); 0.25% (F1); 0.50% (F2); 0.75% (F3); and 1% (F4). Physical quality evaluation included organoleptic test, homogeneity, pH, viscosity, adhesive spreadability, spray pattern, dry time, percent transmittance and phase separation. The results showed that all formulations had good characteristics. Organoleptic tests met the criteria, all preparations were homogeneous with a pH range of 5.6-5.9, viscosity 1884-513 cps, optimal adhesive spreadability, good spray pattern, dry time less than 5 minutes, percent transmittance 98.8-99.9% and no phase separation. Statistical analysis using ANOVA showed significant differences in viscosity test (p = 0.000), dry time test (p = 0.000) and percent transmittance test (p = 0.000), while pH test (p = 0, 059) did not show significant differences. The conclusion of this study is that the concentration of red ginger fermented extract affects the physical quality of nano spray gel preparations with 1% concentration declared the most optimal. Keywords: red ginger, anti-inflammatory, fermentation, nano spray gel
Pengaruh Motivasi Dan Dukungan Keluarga Terhadap Kepatuhan Minum Obat Pada Pasien Hipertensi Di Puskesmas X Kabupaten Badung suryantara, a.a bagus; Kumara Dewi, Ni Wayan Rika
Jurnal Skala Husada : The Journal of Health Vol 20, No 2 (2023): JSH: Jurnal Skala Husada-The Journal of Health
Publisher : Poltekkes Kemenkes Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33992/jsh:tjoh.v20i2.3143

Abstract

Latar Belakang: Salah satu faktor kunci keberhasilan penatalaksanaan hipertensi adalah kepatuhan dalam meminum obat hipertensi. Kepatuhan minum obat sangat diperlukan untuk mengendalikan tekanan darah pada pasien hipertensi untuk menghidari terjadinya komplikasi. Penelitian ini bertujuan untuk mengetahui pengaruh Motivasi dan dukungan keluarga terhadap kepatuhan minum obat pada pasien hipertensi. Penelitian ini merupakan penelitian deskriptif analitik dengan pendekatan cross sectional. Sampel penelitian adalah 133 pasien hipertensi di suatu Puskesmas di Kabupaten Badung yang dipilih dengan menggunakan teknik acak sederhana. Kriteria inklusi meliputi pasien yang terdiagnosa medis hipertensi oleh Dokter dan pasien hipertensi yang berkunjung untuk berobat ke Puskesmas. Data dikumpulkan dengan menggunakan kuesioner yang valid dan reliabel. Data yang diperoleh dalam penelitian dianalisis menggunakan uji statistik chi-square, has?l dari penelitian menunjukan Bahwa responden yang memiliki motivasi tingi sebanyak (53,6%) dan responden yang mendapat dukungan keluarga tinggi sebesar (66,2%). Hasil uji statistik korelasi menunjukkan ada pengaruh yang Kuat antara motivasi dan dukungan keluarga terhadap kepatuhan minum obat pada pasien hipertensi. Dapat disimpulkan bahwa dimana responden yang memiliki motivasi tinggi dan dukungan keluarga yang tinggi akan berpengaruh kuat terhadap kepatuhan minum obat pada pasien hipertensi.
PENGARUH PEMBERIAN EDUKASI TERHADAP TINGKAT PENGETAHUAN DAN RASIONALITAS PENGOBATAN GOUT SECARA SWAMEDIKASI DI APOTEX X Suastini, Ni Made; Artika, Made Prita; Kumara Dewi, Ni Wayan Rika
Jurnal Skala Husada : The Journal of Health Vol 21, No 2 (2024): Jurnal Skala Husada (JSH): Volume 21, No 2, Tahun 2024
Publisher : Poltekkes Kemenkes Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33992/jsh:tjoh.v21i2.3816

Abstract

ABSTRACT Gout is a condition where there is an accumulation of monosodium urate crystals and leading to inflammation. Self-medication for gout therapy is commonly practiced by patients who have prior experience with gout treatment. Self-medication in gout therapy is highly influenced by the patient’s knowledge, which impacts the rationality of using the therapy. This study aims to assess the impact of providing education on the level of knowledge and gout therapy rationality at Apotek X. Method: Cross-sectional method, with a questionnaire to assess the respondents' knowledge and rationality in using gout therapy. Education will be provided using a brochure that the researcher will explain, and to assess the outcome of the education, the same questionnaire will be given to respondents. Results: A total of 30 respondents participated in this study, all of whom completed both the pre-test and post-test and received education about gout. The results showed that the provision of education significantly improved the respondents' knowledge about gout (p=0.000) and significantly improved the rationality of respondents in self-medication for gout therapy (p=0.000). Conclusion: Providing education can improve the knowledge and rationality of using self-medication for gout therapy at Apotek X. Keyword: gout; education; knowledge; rationality; self-medication ABSTRAKGout merupakan suatu kondisi dimana terjadi penumpukan kristal monosodium urat di sendi dan mengakibatkan terjadinya inflamasi. Swamedikasi terapi gout banyak dilakukan oleh pasien yang memiliki pengalaman menggunakan terapi gout sebelumnya. Swamedikasi terapi gout sangat dipengaruhi oleh pengetahuan pasien terhadap gout sehingga akan berdampak pada rasionalitas penggunaan terapi gout itu sendiri. Penelitian ini bertujuan untuk menilai pengaruh pemberian edukasi terhadap tingkat pengetahuan dan rasionalitas menggunaan terapi gout di apotek X. Metode: penelitian ini menggunakan metode cross-sectional, dengan menggunakan kuesioner untuk melihat pengetahuan dan rasionalitas responden dalam menggunakan terapi gout, kemudian akan dilakukan edukasi dengan menggunakan brosur yang akan dijelaskan oleh peneliti dan untuk menilai hasil edukasi, responden akan diberikan kuesioner yang sama kembali. Hasil: total responden yang berpartisipasi dalam penelitian ini berjumlah 30 responden yang telah mengikuti proses pre-test dan post-test dan sudah diberikan edukasi terkait gout. Hasil dari penelitian ini didapatkan bahwa pemberian edukasi secara signifikan dapat meningkatkan pengetahuan responden terhadap penyakit gout (p=0,000) serta pemberian edukasi secara signifikan dapat meningkatkan rasionalitas responden terhadap penggunaan terapi gout secara swamedikasi (p=0,000). Kesimpulan: Pemberian edukasi dapat meningkatkan pengetahuan dan rasionalitas penggunaan terapi gout secara swamedikasi di apotek X. Kata Kunci: gout; edukasi; pengetahuan; rasionalitas; swamedikasi
Co-Authors ANDI UDIN SARANSI Artika, Made Prita Arwati, Ketut Lilik Burhannuddin Dewi, Ni Nyoman Astika Dyah Ratna Ayu Puspita Sari Gede Terima Yasa Heri Setiyo Bekti I Wayan Gunawan, I Wayan Iwan Saka Nugraha Iwan Saka Nugraha Kusdiharti, Meutia Sri Made Dwike Swari Santi Made Prita Artika Mochamad Choirul Hadi Ni Komang Omik Trianita Udiana Ni Luh Gde Mona Monika Ni Luh Gde Mona Monika Ni Made Puspawati Ni Made Suastini, Ni Made Ni Putu Ditya Prabandari Dewi Ni Putu Gita Puspita Sari Ni Putu Gita Puspita Sari Ni Putu Yulia Rahma Dewi Nur Habibah Prita Artika, Made Putri, Pande Putu Cintya Wiarni Putu Ayu Ratna Darmayanti Putu Yudha Ugrasena Rakhmawati, Aprilia Rinawati, Luh Putu Sukma Dinda, Ni Made Ayu suryantara, a.a bagus Yasa, Gede Trima