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EFFECT OF COMBRETUM INDICUM LEAF EXTRACT ON BLOOD SUGAR LEVELS AND PANCREAS HISTOLOGY OF ALLOXAN INDUCED MICE Pertiwi, Anggita Endar; Aryani, Retno; Rosadi, Imam; Nugroho, Rudy Agung
BIOLINK (Jurnal Biologi Lingkungan Industri Kesehatan) Vol. 10 No. 2 (2024): February
Publisher : Universitas Medan Area

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31289/biolink.v10i2.11159

Abstract

Diabetes is a health problem that affects more than half a billion people in the world. Several plants are known to have anti-diabetic activity, one of which is Dutch jasmine (Combretum indicum). This research was conducted to determine the effect of Combretum indicum leaf extract on blood sugar levels and histology of islets of Langerhans in mice. A total of 36 male mice aged 6-8 weeks were divided into 6 treatment groups, namely normal control (KN) without treatment; negative control (K) with alloxan treatment; positive control (K+) with alloxan and glibenclamide treatment; P1 treated with alloxan and Combretum indicum leaf extract at a dose of 100 mg/kgBW; P2 with treatment with alloxan and Combretum indicum leaf extract at a dose of 200 mg/kgBW; P3 with alloxan treatment and Combretum indicum leaf extract at a dose of 200 mg/kgBW. Mice that have been induced by alloxan will be treated with leaf extract and glibenclamide for 20 days. Blood sugar levels 3 days after alloxan induction were checked and checked again on the 10th and 20th days of treatment by taking blood through the blood vessels in the mice's tails and then measuring them using a glucometer. The pancreas was dissected on the 20th day and pancreatic histology preparations were made for histological analysis. The results of this study indicate that Combretum indicum leaf extract has antihyperglycemic effects by protecting islets of Langerhans cells from alloxan-induced oxidative stress.
Nutritional Benefits of Black Soldier Fly Larvae Oil in Animal Feed Nugroho, Rudy Agung; Aryani, Retno; Hardi, Esti Handayani; Manurung, Hetty; Rudianto, Rudianto
Bioeksperimen: Jurnal Penelitian Biologi Vol 10, No 1: March 2024
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/bioeksperimen.v10i1.23015

Abstract

Black Soldier Fly Larvae (BSFL) oil is currently an insect oil that potentially replaces fish oils in animal feed. However, there are limited information on its benefits and nutritional comparison of BSLF oil to fish oil. Present study was to evaluate the benefits of BSFL oil in animal feed and compare the BSFL to Fish oil. Collected data of BSFL oil in the animal feed and its physiological effects was obtained from several articles of  reputable journal and compiled into a table. Meanwhile, BSFL was reared and extract their oil to determine the fatty acid composition and compare to fish oil. The current study indicated that BSFL oil can be used in various animal feeds, such as aquafeed, broiler feed, and pets. The BSFL oil which is included in the feed showed an improvement in growth and other physiological responses of animals. Meanwhile, in comparison to fish oil, BSFL oil has a similar composition of fatty acids such as Omega 3 and Omega 6. Eicosapentaenoic acid (EPA; 20:5n3) is detected in the BSFL oil, though the quantity is much lower than in fish oil.  Further, the BSFL oil also contains lauric acid. In conclusion, BSFL oil can be an alternative feed ingredient to substitute fish oil and has beneficial to the growth and physiological responses of the animal.
Co-Authors Abd. Rasyid Syamsuri Abdul Kadir Jaelani ALIM ISNANSETYO Allo, Veliyana Londong Andi Asikin Noor Andi Noor Asikin Andy Nurcahyono Angela Mariana Lusiastuti Anggi Audila Anton Rahmadi Apri Pauci Florentino Aprilya Mustari Ari Sanjaya Ari Susandi Sanjaya Ari Susandy Sanjaya, Ari Susandy Arianto, Reza Fahyuzi Ariyanto, Febri Aryani, Retno Aryani., Retno Auliana Auliana Ayu Nirmala Sari Bambang Purnama Blegur Megaria Ismawati Deasy Ladyescha Deasy Ladyescha, Deasy Dewi Saraswati Dewi Saraswati, Dewi Dewi, Novia Chamala Sari Dharma, Bodhi Didit Suprihanto Didit Suprihanto, Didit Dwi Anastasia, Putri Ayu Dwikie Setiawan Dyah Noprianti Eko Kusumawati Eno Framita Esti Handayani Hardi Fatmawati Patang Febri Ariyanto Firman M Nur Firman Muhammad Nur Firman Muhammad Nur, Firman Muhammad Florentino, Apri Pauci Gina Saptiani Hadi Purwo Wiyono Halim, Aldi M. Haroh, Istik Hendra Saputra Hetty Manurung Hetty Manurung Hetty Manurung Hetty Manurung Hetty Manurung Hetty Manurung Hetty Manurung Hetty Manurung Hetty Manurung Hetty Manurung, Hetty Idris Mandang, Idris Idwan Jul Ulum Ilham Zulfahmi Ilmania Laora Sunan Tias Imam Rosadi Imam Rosadi Ingga Lies Dastin Islamiati Islamiati Iwan Hasri Iwan Muhammad Ramdan Iyut Jaya Toimsar Jawatir Pardosi Jawea, Jasman Julinda Romauli Manullang Kurniawan, Fandy Ahmad Kusneti, Monica Kusumawati, Eko Kusumawati, Eko Lariman Lariman Lariman Lariman Lariman, Lariman Lepong, Piter Mardi Irwanto Mardianto, Nawwar Meicahayanti, Ika Meliyana, Yeni Mira Mawardi Moh. Mustakim Monica Kusneti Muhammad Erwhyn Salim Muhammad Fauzi Arif Nasution, Annio Indah Lestari Niklani, Andi Normala Sari Nova Hariani Nur Aini Nuraeni Muzdalifah Nurlilayanti, Nurlilayanti Panggabean Panggabean Patimah Patimah Pertiwi, Anggita Endar Prahastika, Widha Prima Hidayat Priyanggi, Rizki Wira Purnama, Bambang Rahayu, Sekar Rahayu, Widianingsih Rahma Suci Retno Aryani Retno Aryani Retno Aryani Retno Aryani Retno Aryani Retno Aryani Retno Aryani Retno Aryani. RR Dirgarini Julia Nurlianti Subagyono Rudianta Rudianta Rudianto Rudianto Rudianto Rudianto Rudianto Rudianto Rudianto Rudianto Rudianto Rudianto Rudianto Rudianto Rudianto Rudianto Rudianto Rudianto Rudianto Rudianto Rudianto Rudianto Rudianto Rudianto Rudianto Rudianto Saibun Sitorus Sanjaya, Ari Susandi Sari, Wulan Iyhig Ratna Subagyono, Dirgarini Nurlianti Julia Subagyono, RR Dirgarini Julia Sudiastuti Sudiastuti Sudiastuti, Sudiastuti Syafrizal Fachmy Syaharani, Ramada Wardina Masdalifa Widha Prahastika Widha Prahastika Widha Prahastika Widha Prahastika Windi Rosiana Dewi Wulan Iyhig Ratna Sari Yana, Nova Yanti Dami Yanti Puspita Sari Yanti Puspita Sari Yerwanto Ilang Yudha Aulia Firnanda