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All Journal International Journal of Public Health Science (IJPHS) Media Kesehatan Masyarakat Indonesia JURNAL KESEHATAN LINGKUNGAN (Journal of Environmental Health) Medical Laboratory Technology Journal Jaringan Laboratorium Medis ARTERI : Jurnal Ilmu Kesehatan Borneo Journal of Medical Laboratory Technology Nursing Sciences Journal Jurnal Abdi Masyarakat Indonesia Borneo Community Health Sevice Journal Aurelia: Jurnal Penelitian dan Pengabdian Masyarakat Indonesia Gema Lingkungan Kesehatan Jurnal Dunia Ilmu Kesehatan Jurnal Laboratorium Khatulistiwa Abdi Reksa Poltekita: Jurnal Ilmu Kesehatan
Maulana, Mochamad Rizal
Poltekkes Kemenkes Semarang
Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary

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Peningkatan Derajad Kesehatan Ibu Hamil dengan Pemantauan Kadar Hemoglobin dan Edukasi Pada Ibu Hamil Untuk Mencegah Stunting Setyowatiningsih, Lilik; Surati, Surati; Maulanah, Mochamad Rizal; Duri, Iin Desmiany
Borneo Community Health Service Journal VOLUME 4 NOMOR 1 TAHUN 2024
Publisher : Fakultas Ilmu Kesehatan Universitas Borneo Tarakan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35334/neotyce.v4i1.4988

Abstract

Maternal Mortality Rate (MMR), both during pregnancy, childbirth and postpartum, is an important thing that must be considered, as an effort to increase the health status of mothers and the life expectancy of babies born. Maternal death cases describe the mother's health status, nutritional status, environmental health conditions and the level of availability of health services and health personnel for the mother. Based on 2019 Central Java Health Office data, the maternal mortality rate was 331 cases and Sukoharjo district recorded 5 cases of maternal death. This community service activity aims to improve the level of health of pregnant women by monitoring hemoglobin levels and increasing knowledge by providing education about anemia in pregnant women and the impact of stunting. This activity was carried out in 2 stages and 3 ways, namely by providing pre, material and post. The material is delivered directly and using leaflets. The number of participants in this activity was 50 people. The results show that the average knowledge of pregnant women increased after education was provided by providing materials and leaflets.
Proteksi Biji Kopi Dalam Memperbaiki Morfologi Sperma Pada Tikus Yang Diinduksi Streptozotocin Maulana, Mochamad Rizal; Sofyanita, Eko Naning
Jurnal Laboratorium Khatulistiwa Vol 7, No 2 (2024): Mei 2024
Publisher : poltekkes kemenkes pontianak

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30602/jlk.v7i2.1421

Abstract

Pemberian induksi Streptozotocin (Stz) dapat menurunkan kualitas sperma salah satunya morfologi sel spermatozoa, kopi mempunyai kandungan antikosidan yang tinggi yaitu asam klorogenat yang merupakan antioksidan kuat, mampu bertindak sebagai antioksidan eksogen yang melawan ROS dalam sel. Tujuan dari penelitian ini untuk mengatahui pengaruh pemberian kopi pada tikus yang diinduksi Stz. Post Test Control Group Design dengan sampel 24 tikus jantan Rattus norvegicus umur 3 bulan, berat badan ± 250 gram, dibagi menjadi 4 kelompok secara random. Setelah 1 minggu aklimasi, pengobatan diberikan 1 kali sehari selama 14 hari. Hari ke 15 dilakukan pemerkksaan morfologi sperma.. Hasil penelitian morfologi spermatozoa (%) pada kelompok KN (50,46) kelompok KP (64,58) kelompok KK1 (59,50) dan kelompok KK2 (72,05) berbeda artinya, p< 0,05. Kesimpulan pada penelitian ini yaitu Pemberian kopi mampu memperbaiki morfologi spermatozoa pada tikus yang diinduksi Stz.
Correlation of climate factors and the number of SARS-CoV-2 cases at Semarang, Central Java Maulana, Mochamad Rizal; Sofyanita, Eko Naning; Swastya Putri, Adita Puspitasari
International Journal of Public Health Science (IJPHS) Vol 13, No 4: December 2024
Publisher : Intelektual Pustaka Media Utama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijphs.v13i4.24206

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a new type of coronavirus that has symptoms of acute respiratory distress in general. In more severe, it can cause kidney failure, pneumonia, and death. Environmental conditions that cannot be anticipated, such as climate factors, can have an impact on the transmission and survival of viruses, including the severe acute respiratory syndrome (SARS) viruses, which are responsible for the emergence of respiratory diseases. This research is a quantitative study using an ecological approach with secondary data from the Meteorology, Climatology, and Geophysics Agency (temperature, humidity, and precipitation), and SARS-CoV-2 cases were sourced from the Semarang City COVID-19 Task Force in 2021 were univariate and bivariate analyzing. The highest temperature average occurs in October (29.8 ⁰C), the humidity average occurs in February (91.4%), and the average precipitation occurs in February (1,130 mm). Analysis of the correlation found that there was a correlation between the SARS-CoV-2 cases with humidity (p=0.000; r=-0.245) and temperature (p=0.016; r=-0.127), but there was no correlation between precipitation (p=0.403; r=-0.044). Analysis of the influence of meteorological elements related to temperature, humidity, and precipitation on the incidence of COVID-19 in Semarang City in 2021, it can be concluded that there is correlation between temperature and humidity on COVID-19 cases except for precipitation.
Pengaruh Pemberian Kopi Robusta (Coffea canephora) terhadap Penurunan Kadar Glukosa Darah pada Tikus Rattus norvegicus dengan Kondisi Diabetes Melitus Sofyanita, Eko Naning; Maulana, Mochamad Rizal; Auliya, Qurrotu A'yuni; Setyowatiningsih, Lilik; Swastyaputri, Adita Puspitasari
ARTERI : Jurnal Ilmu Kesehatan Vol 5 No 3 (2024): Mei
Publisher : Puslitbang Sinergis Asa Professional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37148/arteri.v5i3.439

Abstract

Diabetes Mellitus (DM) leads to an increase in Reactive Oxygen Species (ROS), which disrupts the function of pancreatic β-cells. The dependency on medications often occurs, hence there is a need for natural remedies with antihyperglycemic properties, such as coffee. Coffee contains high levels of antioxidants like chlorogenic acid, flavonoids, and caffeine, which are exogenous antioxidants that can activate NRF-2 and increase the activity of the enzyme Superoxide Dismutase (SOD), thus acting as an antihyperglycemic agent. This study aims to determine the effect of robusta coffee on blood glucose levels in rats with DM conditions. This experimental study used a Randomized Control Pretest-Posttest Group Design. The sample in this study included 24 male Rattus norvegicus rats, aged 3 months, with a body weight of 230-250 grams, divided into 4 groups randomly after a one-week acclimation period. The DM condition was induced by administering streptozotocin at 40 mg/KgBW, followed by a pretest blood glucose level examination after 3 days of streptozotocin induction. The diabetic rats were then given robusta coffee once a day for a period of 14 days. On the 15th day, a posttest blood glucose level examination was conducted. The results showed that the control group (KN) had no significant difference (p=0.530), while the treatment groups KP (p=0.003), KK1 (p=0.013), and KK2 (p=0.000) showed significant differences (p<0.05). The conclusion of this study is that the administration of robusta coffee (Coffea canephora) can reduce blood glucose levels in rats with diabetes mellitus.
Training on Early Detection of Breast Cancer Through Sadari (Breast Self Examination) as Control of Non-Communicable Diseases (NCDs) Sofyanita, Eko Naning; Maulana, Mochamad Rizal; Kurniasiwi, Putri
AURELIA: Jurnal Penelitian dan Pengabdian Masyarakat Indonesia Vol 3, No 2 (2024): July 2024
Publisher : CV. Rayyan Dwi Bharata

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57235/aurelia.v3i2.2746

Abstract

Breast cancer is the most common type of cancer in women in Indonesia. Early detection through SADARI can help identify changes in the breast that may be early signs of cancer. The aim of this activity is to increase the knowledge and skills of women in carrying out SADARI as an effort to detect breast cancer early. The method used is counseling and practical training on SADARI. The training participants were 40 women of productive age who lived in the Sendang mulyo sub-district. The results of this activity showed an increase in participants' knowledge and skills in carrying out SADARI as measured through pre-test and post-test. Before the training, only 5% of participants understood the correct way to SADARI. After training, this figure increased to 97.5%. The conclusion of this activity is that SADARI training is effective in increasing the knowledge and skills of women in the Sendang mulyo sub-district.
Profil SGOT, SGPT, dan Kreatinin Pada Pasien MDR TB di RS KRMT Wongsonegoro Semarang Surati, Surati; Khairunnisa, Afifah; Setyaji, Yoki; Maulana, Mochamad Rizal
Jaringan Laboratorium Medis Vol 6, No 1 (2024): May 2024
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jlm.v6i1.10951

Abstract

Tuberculosis (TB) is an infectious disease caused by infection with the bacterium Mycobacterium tuberculosis. Tuberculosis apabila is not treated immediately or the treatment is not complete can result in complications leading to death. Multidrugs resistant tuberculosis (MDR-TB) is one of the complications where the germ Mycobacterium tuberculosis can no longer bekilled with several Anti-Tuberculosis Drugs (OAT). The prevalence of MDR-TB cases in Semarang City has increased from 35 cases in 2017 to 79 cases in 2018. MDR-TB therapy takes a longer time, which is about 18-24 months. Prolonged exposure to drugs can affect body functions, especially the kidneys and liver organs which play a role in the process of removing toxins and metabolic waste. This study aims to determine the health profile of the kidney and liver organs of MDR TB sufferers through the SGOT SGPT and Creatinine parameters and describe them based on age and age range. This research is adescriptive quantitative research with a cross-sectional approach. Sampling using total samples of 18 patients. The results showed that 33% (n= 6) of patients had increased levels of SGOT and SGPT, while examination of creatinine levels showed that 33% of patients had kidney problems. Men have upnormal SGOT and SGPT levels of 40% ( n=4) compared to women, which is 25% (n=2), while upnormal creatinine levels in men are 40% (n=4) while in women it is 50% (n = 8). Patients over the age of 46 years have the most levels of SGOT SGPT and upnormal creatinine, which is 61% (n=4). The results showed that age and gender had an effect on increasing SGOT SGPT and Creatinine levels in MDR-TB patients.
The Effect of Robusta Coffee (Coffea canephora) on the Expression of SOD and Nrf-2 in Diabetes Mellitus condition (Animal Model) Sofyanita, Eko Naning; Maulana, Mochamad Rizal; Lestari, Puji; Burhannudin
Poltekita: Jurnal Ilmu Kesehatan Vol. 18 No. 3 (2024)
Publisher : Poltekkes Kemenkes Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33860/jik.v18i3.3753

Abstract

Hyperglycemia is a condition that occurs when Diabetes Mellitus (DM) is uncontrolled, which causes an increase in free radicals and disruption of cell function and endogenous antioxidants. Coffee, especially robusta coffee, is known to have benefits as an exogenous antioxidant that can increase the activity of endogenous. This study aims to examine the effect of giving robusta coffee on the expression of Nuclear Factor-erythroid-2 Related Factor 2 (Nrf-2) and Superoxide Dismutase (SOD) in DM model mice. The design of this study was experimental with the Post Test Control Group Design method. A total of 24 male Rattus norvegicus mice aged 3 months with a body weight of 230-250 grams were randomly divided into four groups. After undergoing acclimatization for one week, the mice were given robusta coffee once a day for 14 days. On the 15th day, Nrf-2 and SOD expression were examined. The results showed that the average expression of Nrf-2 in each group was: 23.15 ± 1.96 (normal group/KN), 62.14 ± 1.30 (positive DM group/KP), 50.66 ± 2.18 (DM group with low dose coffee/KK1), and 71.13 ± 1.51 (DM group with high dose coffee/KK2). Meanwhile, SOD expression was: 4.95 ± 0.62 (KN), 8.14 ± 0.54 (KP), 6.10 ± 0.79 (KK1), and 9.26 ± 0.31 (KK2). The results of the ANOVA and Post Hoc LSD tests showed a p value <0.05, which indicated a significant difference between groups. In conclusion, administration of robusta coffee (Coffea canephora) was able to increase the activity of the Nrf-2 and SOD enzymes in mice suffering from diabetes mellitus.
Gambaran Kadar Glukosa Darah Pada Tikus Wistar Sebagai Pendahuluan Uji Terapi Ektrak Daun Bandotan: Description of Blood Glucose Levels In Wistar Rats as an Introduction to The Therapy Test of Bandotan Leaf Extract Kurniasiwi, Putri; Rosa, Hilari Rio; Nastiti, Nastiti; Maulana, Mochamad Rizal
Borneo Journal of Medical Laboratory Technology Vol. 6 No. 2 (2024): Borneo Journal of Medical Laboratory Technology
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjmlt.v6i2.7094

Abstract

Diabetes Melitus (DM) termasuk salah satu penyakit tidak menular yang telah menjadi masalah serius bagi kesehatan masyarakat di Indonesia maupun di dunia. Indonesia menduduki peringkat ke 7 di dunia dengan penderita diabetes sebanyak 10,7 juta pada tahun 2019 dan jumlah tersebut diperkirakan akan meningkat menjadi 13,7 juta pada tahun 2030 dan 16,6 juta pada tahun 2045 (1,2). Komplikasi yang terjadi pada penderita DM adalah karena kerusakan dan kematian sel yang disebabkan peningkatan stress oksidatif dan aktivitas mediator inflamasi temasuk interleukin-6 (Il-6). Pemberian obat hipoglikemi oral pada pasien DM tidak menunjukkan perbaikan pada stress oksidatif. Oleh karena itu, diperlukan terapi tambahan untuk pasien DM yang dapat menurunkan stress oksidatif dan mediator inflamasi serta mendukung kerja antioksidan endogen. Daun bandotan merupakan tanaman yang mengandung antioksidan dan digunakan sebagai obat tradisional untuk pasien DM. Tujuan dari penelitian ini adalah untuk mengetahui kadar guloksa darah sebetlum terapi ekstrak daun bandotan. Penelitian ini menggunakan tikus wistar jantan yang diinduksi dengan streptozotocin (stz) untuk menjadi DM tipe 2. Kemudian diperiksa kadar glukosa darah pada hari ke lima setelah induksi stz. Hasil menunjukkan secara keseluruhan kadar glukosa darah telah mencapai lebih dari 200 mg/dl. Hal tersebut menunjukkan bahwa tikus telah mengalami hiperglikemi dan bisa dilanjutkan untuk perlakuan terapi.
The Effects of Sungkai Leaf and Cinnamon Bark Extracts on MDA and IL-10 in MSG Induced Chronic Kidney Disease in Wistar Rats Afrianti, Dina; Maulana, Mochamad Rizal; Sakdiah, Siti; Febriyani, Erisa; Wahyudi, Wahyudi; Ali, Irwan
Medical Laboratory Technology Journal Vol. 11 No. 2 (2025): December
Publisher : Poltekkes Kemenkes Banjarmasin Jurusan Analis Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31964/mltj.v11i2.661

Abstract

Monosodium glutamate (MSG) is known to trigger oxidative stress and inflammation, contributing to kidney tissue damage. This study aimed to evaluate the protective effects of sungkai leaf extract (Peronema canescens Jack) and cinnamon bark extract (Cinnamomum burmannii) on kidney histology, as well as malondialdehyde (MDA) and interleukin-10 (IL-10) levels in male Wistar rats induced with excessive MSG. A total of 30 rats were divided into six groups: normal control, positive control (MSG only), and four treatment groups receiving MSG alongside sungkai leaf extract (28 mg or 56 mg) or cinnamon bark extract (4% or 8%) for 10 days. MDA and IL-10 levels were measured using ELISA, and kidney tissue was examined histologically. The results showed that both extracts significantly reduced MDA (P= 0,000)  levels and increased IL-10 (P= 0,000)   levels compared to the positive control. The most prominent protective effect was observed in the group treated with 56 mg of sungkai leaf extract, followed by the 8% cinnamon bark group. Histopathological analysis revealed notable improvements in kidney structure, approaching normal conditions in treated groups. These findings suggest that sungkai leaf and cinnamon bark extracts, particularly at higher doses, offer protective benefits against MSG-induced kidney damage through antioxidant and anti-inflammatory mechanisms.
BANDOTAN LEAF EXTRACT THERAPY ON IL 6 PROFILE IN WISTAR RATS WITH TYPE 2 DIABETES MELLITUS Putri Kurniasiwi; Hilari Rio Rosa Nastiti; Mochamad Rizal Maulana
Nursing Sciences Journal Vol 10 No 1 (2026): April 2026
Publisher : Universitas Kadiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30737/nsj.v10i1.7516

Abstract

Diabetes Mellitus (DM) is a non-communicable disease that has become a serious public health problem in Indonesia and the world. Indonesia ranks 7th in the world with 10.7 million diabetes sufferers in 2019 and this number is expected to increase to 13.7 million in 2030 and 16.6 million in 2045. Complications that occur in DM sufferers are due to cell damage and death caused by increased oxidative stress and the activity of inflammatory mediators including interleukin-6 (Il-6). Administration of oral hypoglycemic drugs to DM patients does not show improvement in oxidative stress. Additional therapy is needed for DM patients that can reduce oxidative stress and inflammatory mediators and support the work of endogenous antioxidants. Bandotan leaves are plants that contain antioxidants and are used as a traditional medicine for DM patients. The purpose of this study was to determine the profile of Il-6 as a marker of inflammation due to oxidative stress in DM patients after administration of bandotan leaf extract. The research revealed significant differences between the control, bandotan, and glimberclamide groups. The bandotan group had the lowest IL-6 levels at 1.63 pg/ml. Bandotan leaf extract caused the least inflammation compared to the control and glimberclamide groups.
Co-Authors Afifah Khairunnisa Ali, Irwan Auliya, Qurrotu A'yuni Burhannudin Dina Afrianti1 Djoko Priyatno Djoko Priyatno Duri, Iin Desmiany Eko Naning Sofyanita Febriyani, Erisa Fransisca Susilastuti Hilari Rio Rosa Nastiti Ichsan Hadipranoto Iin Desmiany Duri Khairunnisa, Afifah Khuliyah Candraning Diyanah Lilik Setyowatiningsih Maseva Wijayanti Nanik Aryani Putri Nastiti, Nastiti PUJI LESTARI Putri Kurniasiwi Qurrotu A&#039;yuni Auliya Qurrotu A'yuni Auliya Qurrotu A’yuni Auliya Retno Kurniawati Roni Afriansya Rosa, Hilari Rio Sakdiah, Siti Setyaji, Yoki Surati Surati Surati Sutji Kuswarini Sutji Kuswarini Swastya Putri, Adita Puspitasari Swastyaputri, Adita Puspitasari Wahyudi Wahyudi Yoki Setyaji Zulian Safitri