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All Journal HAYATI Journal of Biosciences Perspektif : Review Penelitian Tanaman Industri Indonesian Journal of Pharmaceutical Science and Technology Elkawnie Majalah Obat Tradisional Abditani : Jurnal Pengabdian Masyarakat Jurnal Ilmiah Farmasi Farmasyifa Perspektif, Review Penelitian Tanaman Industri Jurnal Abdimas Kartika Wijayakusuma Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Medical Sains : Jurnal Ilmiah Kefarmasian Riset Informasi Kesehatan AGRIC kawanad Jurnal Medika: Medika Kartika : Jurnal Ilmiah Farmasi Medical Sains : Jurnal Ilmiah Kefarmasian Pharmacon: Jurnal Farmasi Indonesia Jurnal Farmasi Galenika
Akhirul Kahfi Syam
Fakultas Farmasi Universitas Jenderal Achmad Yani
Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Control & Systems Engineering Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Journal : Indonesian Journal of Pharmaceutical Science and Technology

 1 
Potency of Honje Hutan Flowers (Etlingera Hemisphaerica (Blume) R.M.Sm.) as Alpha-Glucosidase Inhibitor Soraya Riyanti; Nandi Agustian; Akhirul Kahfi Syam
Indonesian Journal of Pharmaceutical Science and Technology Vol 10, No 1 (2023)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v10i1.35453

Abstract

The Pangandaran people process honje flowers into fresh drinks that are consumed for health. Theforest honje leaf extract provides antidiabetic activity at a dose of 0.39 mg/g BW can reduce bloodglucose levels by 36.16% has been reported. Limited scientific information from honje hutan flowers,it is necessary on its activity as an alpha-glucosidase inhibitor and study its chemical content. Theextraction process was macerated in 70% ethanol for 24 hours and the fractionation process wascarried out by liquid-liquid extraction method with n-hexane, ethyl acetate and water as solvents.Testing the activity of alpha-glucosidase inhibitors colorimetrically using the chromogenic substratep-nitrophenyl α-D-glucopyranoside, alpha-glucosidase enzymes derived from Saccharomycescerevisiae, measurement of absorption at a maximum wavelength of 401.3 nm and acarbose usedas a comparison drug alpha-glucosidase inhibitors. The results showed that the forest honje flowerscontain flavonoids, polyphenols, tannins, quinones, monoterpenoids, and sesquiterpenoids. IC50 valuesfor 70% ethanol extract, n-hexane, ethyl acetate, water and acarbose fractions were 136.79, 307.18,277.12, 66.18, and 14.63 g/mL respectively. The water fraction gave the best inhibitory activity againstalpha-glucosidase with an IC50 value of 66.18 g/mL.Keywords: Etlingera hemisphaerica (Blume) R.M.Sm, honje hutan flowers, alpha-glucosidaseinhibitor.
Co-Authors Adinda Fitriani Adinugraha, Irham M. Akbar, Tzazkia Febriyana Ami Soega Dwigantina Ananda Tunjung Pertiwi Anggita Esa Putri Fitrichia Anna Choirunnisa Anna Choirunnisa, Anna Ari Sri Windyaswari Ari Sri Windyaswari Ari Sri Windyaswari Ari Sri Windyaswari, Ari Sri Azhar, Farah Salsabilla Saidah Dadan Suryasaputra Desti Hermawati Dewilestari, Meyra Pratami Dwi Ayu Pratiwi Elfahmi Elfahmi, Elfahmi Ema Mutya Esanda Zulfi Amedea Fahrauk Faramayuda Fahrauk Faramayuda, Fahrauk Faizal Hermanto Farah Salsabilla Saidah Azhar Faramayudha, Fahrauk Farhan Febrinella, Catellya Florence Meliawaty Handayani, Dewi Ratih Hermawati, Desti Hestiary Ratih Ismail, Nursafira Khairunnisa Jaka Permana Julia Ratnawati Julia Ratnawati Julia Ratnawati Julia Ratnawati, Julia Juliastuti, Henny Khaerunnisa, Rahmadaniah Komar Ruslan Wirasutisna Lahagu, Helga Nitulo Berliana Mardiana, Grace Selly Meyra Pratami Dewilestari Muhamad Insanu Muhammad Irwan Nandi Agustian Purwoko, Agus Puspita Satriyani Permatasari Surasa Putri, Dhiffa Namira Alifia Rahaju, Asih Rakhmat, Iis Inayati Ramdhani, Amalia Kusuma Remare Halomoan Limbong Renata Ananda Marthasedana Renti Mutiara Dewi Sabirin, Indah Puti R. Septiani, Vina Sheila Nur Hasanah Sheila Nur Hasanah Sigid Pamungkas Wicaksono Soraya Riyanti Soraya Riyanti Soraya Riyanti Soraya Riyanti Soraya Riyanti, Soraya Sri Restu Andriyani Suci Nar Vikasari, Suci Nar Sufyan Zainul Arifin Sukrasno Suntana, Mutiara Sukma Surasa, Puspita Satriyani Permatasari SURYANI Syahra Asfi Sabilia Totik Sri Mariani Trialisa Aprilia Usi Septiani Vina Septiani Wulan Anggraeni Yeni Karlina Yeni Karlina Yesi Wulandari Yuslianti, Euis Reni