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All Journal Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Jurnal Ilmu Kefarmasian Indonesia Narra J Indonesian Journal of Cancer Pharmaceutical Sciences and Research (PSR) Borneo Journal of Pharmacy Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)
Rani Sauriasari, Rani
Faculty of Pharmacy, Universitas Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Fenomena Pengaruh Terapi Farmakologi Terhadap Kepatuhan Berobat dalam Perspektif Pasien Diabetes Melitus Tipe 2 Renaldi, Fransiskus Samuel; Sauriasari, Rani; Riyadina, Woro; Maulida, Irianti Bahana
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 8 No. 2 (2021): Oktober
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v8i2.3044

Abstract

Diabetes melitus tipe 2 merupakan penyakit yang kompleks dan membutuhkan manajemen terapi yang serius. Kepatuhan menjadi masalah utama dalam pengobatan diabetes melitus tipe 2 tersebut dan dapat berdampak pada komplikasi yang akan sulit ditangani. Penelitian ini ditujukan untuk mengungkap berbagai permasalahan yang mendorong seorang pasien memilih untuk tidak patuh sehingga dapat membantu tenaga kesehatan dalam mencari akar masalah ketidakpatuhan pada penderita diabetes melitus tipe 2. Sebanyak 30 penderita diabetes melitus tipe 2 terbagi atas beberapa golongan kriteria, yaitu komplikasi, usia, dan tingkat kepatuhan. Pemilihan pasien dilakukan menggunakan metode sampling bola salju. Pengambilan data dilakukan dengan metode wawancara mendalam pada pasien yang dilakukan dengan teknik probing melalui telepon dan observasi langsung sebagai bentuk validasi. Data diolah dengan metode transkrip dan dianalisis secara tematik untuk kemudian diinterpretasikan dalam bentuk pernyataan hasil wawancara. Dari hasil penelitian didapatkan bahwa sebagian besar pasien menggunakan metformin. Hal ini dikarenakan banyak pasien merasa sesuai dengan metformin. Metformin dapat memberikan efek normalisasi gula darah yang diharapkan dengan efek samping ke sistem gastrointestinal yang masih dapat ditolerir. Di sisi lain, terdapat beberapa pasien yang sudah merasa jenuh dengan penggunaan obat secara terus-menerus, mereka ingin segera lepas dari obat. Perbandingan manfaat yang dirasakan ketika meminum obat dan tidak juga turut memotivasi pasien dalam menggunakan obat. Dari berbagai data yang telah dihimpun dalam penelitian ini, dapat disimpulkan bahwa kepatuhan berobat sangat dipengaruhi oleh efek yang diterima pasca penggunaan.
Development of a Medication Compliance Determinant Instrument for Low-Middle Literate Patients with Type 2 Diabetes Mellitus Panduwiguna, Ivans; Sauriasari, Rani; Sartika, Ratu Ayu Dewi; Riyadina, Woro; Renaldi, Fransiskus Samuel
Kesmas Vol. 18, No. 3
Publisher : UI Scholars Hub

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Abstract

Diabetes, a leading cause of 6.7 million deaths in 2021, poses a significant challenge despite existing interventions. Non-adherence to treatment remains a barrier to diabetes management. However, a comprehensive instrument to assess medication adherence determinants in diabetes patients’ population in Indonesia with low-medium literacy levels and following the sociocultural characteristics of Indonesian society has been lacking. This study aimed to develop and evaluate a valid and reliable instrument for measuring medication adherence in type 2 diabetes mellitus patients based on the Borg and Gall model. Through the input of an expert panel, a valid and reliable instrument was developed, which comprised 21 questions and encompassed all medication adherence determinants, with a CVR and CVI value of 1 and a final Cronbach’s alpha value of 0.731. This instrument is still being tested and needs to be implemented in the right and wider population to obtain more accurate results.
Cognitive Function in Type 2 Diabetes Mellitus Patients Taking Metformin and Metformin-Sulfonylurea Rachman, Abu; Sauriasari, Rani; Syafhan, Nadia Farhanah; Prawiroharjo, Pukovisa; Risni, Hindun Wilda
Kesmas Vol. 17, No. 4
Publisher : UI Scholars Hub

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Abstract

The most prescribed antidiabetic drugs in Indonesian primary health care are metformin or a combination of metformin and sulfonylurea. Studies on metformin have shown various impacts on cognitive decline in patients with type 2 diabetes mellitus, whereas sulfonylurea has been shown to reduce this impact. This study aimed to compare the impacts of metformin and metformin-sulfonylurea on cognitive function and determine what factors affected it. This cross-sectional study was conducted at Pasar Minggu Primary Health Care involving 142 type 2 diabetes mellitus patients taking metformin or metformin-sulfonylurea for > 6 months and aged > 36 years. Cognitive function was assessed using the validated Montreal Cognitive Assessment Indonesian version. The effects of metformin and metformin-sulfonylurea on cognitive decline showed no significant difference, even after controlling for covariates (aOR = 1.096; 95% CI = 0.523–2.297; p-value = 0.808). Multivariate analysis showed age (OR = 4.131; 95% CI = 1.271–13.428; p-value = 0.018) and education (OR = 2.746; 95% CI = 1.196–6.305; p-value = 0.017) affected cognitive function. Since a lower education and older age are likely to cause cognitive decline, health professionals are encouraged to work with public health experts to address these risk factors for cognitive function.
Treatment Adherence and Incidence of Coronary Heart Disease in Type 2 Diabetes Mellitus Patients Baniu, Ahmad Sahlan; Sauriasari, Rani; Riyadina, Woro; Soewondo, Pradana
Kesmas Vol. 17, No. 2
Publisher : UI Scholars Hub

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Abstract

Previous studies showed that uncontrolled blood sugar and long-term use of several types of antidiabetic could increase the risk of coronary heart disease (CHD). This study aimed to compare the incidence of CHD in type 2 diabetes mellitus (T2DM) patients showing treatment adherence and non-adherence behavior over four years. This was a retrospective cohort study with data sets obtained from the Bogor Cohort Study of Non-Communicable Disease Risk Factors. All study subjects were not diagnosed with CHD at the beginning of the study. The sample was divided into two groups; one had adhered to treatment from health centers and followed the treatment instructions (adherent group), while the other had not followed the treatment instructions (non-adherent group). Of 5,690 subjects, 276 were eligible for this study (84 in the adherent and 192 in the non-adherent group). The incidence of CHD in the non-adherent group was 2.3% higher than in the adherent group (p-value = 0.564) and had a 1.7 times greater risk of developing CHD, but not statistically significant (adjusted HR = 1.739; 95% CI = 0.673-4.490). The non-adherent T2DM patients had a greater risk of developing CHD than adherent T2DM patients.
The Effectiveness and Safety of Favipiravir in COVID-19 Hospitalized Patients at Tertiary Referral Hospital, Bali, Indonesia Damayanti, Herni; Sajinadiyasa, I Gede K; Risni, Hindun Wilda; Sauriasari, Rani
Kesmas Vol. 16, No. 4
Publisher : UI Scholars Hub

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Abstract

COVID-19 is a major public health problem, with still questionable specific cure. Favipiravir is a COVID-19 antiviral that is potentially a therapy for COVID-19. This study aimed to analyze its effectivity and safety in moderate to critical hospitalized patients. This study was a retrospective cohort in a tertiary referral hospital in Denpasar City, Bali Province, Indonesia, from August 2020 to January 2021. There was a total of 192 patients; 96 in the favipiravir group and 96in the non-favipiravir group (remdesivir/oseltamivir). Effectivity was measured by assessing the clinical condition at the end of the isolation period of 14 days. The favipiravir group showed better clinical conditions than the non-favipiravir group (79.2% vs. 56.3%; adjusted RR = 2.196; 95% CI = 1.084 – 4.451; p-value= 0.029), seen from being free of fever and respiratory problems. Stratification analysis demonstrated that the clinical improvement was significantly differentin the severe/critical group in favor of favipiravir (RR = 1.573; 95% CI = 1.139-2.172). The most common non-serious adverse events (AE) found in the use offavipiravir were gastrointestinal disturbances (12.5%). In brief, favipiravir is effective in severe/critical cases, and less serious AE were found in its use. Appropriate treatment is expected to help in reducing the public health burden.
Tingkat Kejadian Hipoglikemia pada Pasien Diabetes Melitus Tipe 2 Peserta JKN dan Non-JKN pada Masa Pandemi COVID-19 di Kalimantan Tengah Veryanti, Putu Rika; Sartika, Ratu Ayu Dewi; Sauriasari, Rani; Elya, Berna; Puspitasari, Rara Merinda
JURNAL ILMU KEFARMASIAN INDONESIA Vol 21 No 2 (2023): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v21i2.1477

Abstract

Community activity restrictions during the COVID-19 pandemic in Indonesia impact the quantity and quality of health services for type 2 diabetes (T2DM). This limitation could increase the risk of hypoglycemia in type 2 diabetes patients. The study aimed to compare the incidence rate of hypoglycemia between national (NHIP) and non-national health insurance participants (N-NHIP) with T2DM during the COVID-19 pandemic in Indonesia. The study used a cross-sectional design and was conducted at a government hospital in Central Borneo. Data was collected by consecutive sampling from September to November 2021. Sixty-two participants were divided into two groups (NHIP and N-NHIP groups). Each group consisted of 31 participants. They were interviewed regarding their experience with hypoglycemia in the last three months. The incidence rate of hypoglycemia in N-NHIP was higher than in NHIP (93.55% vs. 87.10%; p>0.05). Hypoglycemia is mostly presented in patients using a combination of short-acting and long-acting insulin. The incidence rate of hypoglycemia in T2DM during the COVID-19 pandemic in Central Borneo was relatively high. In future studies, it is necessary to analyse the factors that significantly affect the incidence of hypoglycemia in the population of T2DM patients in Indonesia.
Diabetic Foot Ulcers: Impact on Quality of Life and Instruments for Its Measurement Qomariyanti, Khairunisa; Sauriasari, Rani; Sartika, Ratu Ayu Dewi
Borneo Journal of Pharmacy Vol. 7 No. 2 (2024): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v7i2.6554

Abstract

Diabetic foot ulcers (DFUs) are a major complication of diabetes mellitus, significantly impacting patients' quality of life (QoL) due to the heightened risk of infection and amputation. Pharmacists play a crucial role in managing diabetes and its complications, and assessing QoL can be a valuable tool for monitoring treatment success and medication effectiveness. This review explores instruments used to measure QoL in patients with DFUs, encompassing both general and disease-specific tools. We examine the impact of DFUs on QoL and discuss various theoretical frameworks used to understand this complex relationship.
Efficacy and Safety of Glibenclamide Compared with Insulin in Gestational Diabetes Mellitus: A Systematic Review and Meta-analysis Haifa, Alifia Fauziyyah; Qomariyanti, Khairunnisa; Sartika, Ratu Ayu Dewi; Sauriasari, Rani
Pharmaceutical Sciences and Research Vol. 12, No. 2
Publisher : UI Scholars Hub

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Abstract

Gestational diabetes mellitus (GDM) is a prevalent pregnancy complication associated with an increased risk of maternal and neonatal complications compared with non-diabetic pregnancies. Pharmacological treatments, such as glibenclamide, are expected to provide optimal glycemic control and reduce these risks. However, concerns regarding its safety persist and some regulatory agencies have not approved glibenclamide for GDM treatment. This systematic review and meta-analysis aimed to synthesize the most recent evidence on the efficacy and safety of glibenclamide compared with insulin in the management of GDM, with a focus on maternal and neonatal outcomes based on the most recent RCT. The objective is to provide updated insight and strengthen the evidence based supporting the use of glibenclamide as treatment option for GDM. Relevant studies were identified from Pubmed, Scopus, and CENTRAL databases, resulting in 11 randomized controlled trials (RCTs) involving 2,019 participants. The pooled analysis found that glibenclamide significantly increases the risk of neonatal hypoglycemia [RR 1.65; 95% CI 1.23 to 2.22; p-value 0.0009] and significantly decreases the risk of neonatal respiratory distress syndrome (NRDS) [RR 0.56; 95% CI 0.33 to 0.95; p-value 0.03], compared to insulin. No significant differences were observed in other maternal and neonatal outcomes between the two treatments. In conclusion, glibenclamide demonstrated comparable efficacy and safety to insulin in the management of GDM, making it a viable treatment option alongside insulin.
Development and Validation of an Indonesian Questionnaire for Assessing Paracetamol Self-Medication Knowledge, Attitude, and Practice Putri, Widyana Sagita; Sauriasari, Rani; Septyowati, Priharika
Kesmas Vol. 21, No. 2
Publisher : UI Scholars Hub

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Abstract

Paracetamol is a widely used over-the-counter medicine for self-medication and is often perceived as completely safe. However, inappropriate use may result in hepatotoxicity and other adverse effects, particularly at high doses. This study aimed to develop and validate a questionnaire to assess the general Indonesian population’s knowledge, attitude, and practice (KAP) regarding paracetamol self-medication. The validation procedure consisted of three stages: content, face, and construct validation. Three experts assessed the relevance of the items using the Content Validity Index, and five respondents were interviewed to assess the linguistic clarity and comprehensibility of the questions. Construct validity and reliability were assessed in 30 participants using Pearson’s correlation and Cronbach’s alpha. All items obtained excellent relevance scores. The final questionnaire demonstrated acceptable validity and reliability after revising and removing two low-performing practice items (P3 and P4), with Pearson’s correlation coefficients exceeding the r-table threshold (0.361) and Cronbach’s alpha values of 0.766, 0.734, and 0.640 for the KAP domains, respectively. The final instrument, comprising 20 items (10 knowledge items, 6 attitude items, and 4 practice items), was deemed suitable for assessing public KAP regarding safe self-medication with paracetamol.
Co-Authors Adisa Swastika, Adisa Annisa Azka Hikmawati Aulia, Annisa Azka Hikmawati Arifianti, Ayun Ariska Deffy Anggarany, Ariska Deffy Baniu, Ahmad Sahlan Berna Elya Cokro, Fonny Damayanti, Herni Evi Martha Haifa, Alifia Fauziyyah Hayatun Nufus Makau, Juliann Nzembi Marina Ika Irianti Maryati Kurniadi Maulida, Irianti Bahana Muhammad Alkaff Muhareva Raekiansyah Nadia Farhanah Syafhan Novita Sari Nurwijayanti Panduwiguna, Ivans Paramita, Diana Pradana Soewondo Pukovisa Prawiroharjo Pukovisa Prawiroharjo, Pukovisa Puspitasari, Rara Merinda Putri Ayuningtyas Putri, Risani Andalasia Putri, Widyana Sagita Qamar, Muhammad Qomariyanti, Khairunisa Qomariyanti, Khairunnisa Rachman, Abu Rahmasari, Ratika Ratu Ayu Dewi Sartika Renaldi, Fransiskus Samuel Risni, Hindun Wilda RR. Ella Evrita Hestiandari Sagala, Radoti Merlin Sajinadiyasa, I Gede K Septyowati, Priharika Sesilia Keban, Sesilia Soraya, Indana Ayu Syahdi, Rezi Riadhi Tahapary, Dicky L. Takhwifa, Famila Veryanti, Putu Rika Wawaimuli Arozal Woro Riyadina