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All Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Indonesian Journal of Pharmaceutical Science and Technology MNJ (Malang Neurology Journal) Jurnal Ilmiah Kedokteran Wijaya Kusuma Universa Medicina Journal of Medicine and Health Jurnal Ilmu Kedokteran dan Kesehatan Jurnal Medika Malahayati Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education Health and Medical Journal Medika Kartika : Jurnal Kedokteran dan Kesehatan Jurnal Ilmiah Kesehatan Jurnal Prima Medika Sains Keluwih: Jurnal Kesehatan dan Kedokteran Indonesian Journal of Cancer Journal of Medicine and Health
Ardo Sanjaya
Maranatha Christian University
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Journal : Jurnal Ilmiah Kedokteran Wijaya Kusuma

 1 
Modulated Hepatic Expression of NF-kB and CCN1 Genes in a Breast Cancer Mouse Model Induced by DMBA and High-Fat Diet Demes Chornelia Martantiningtyas; Raden Ghita Sariwidyantry; Hana Ratnawati; Teresa Lilliana Wargasetya; Ardo Sanjaya
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 14, No 1 (2025): EDISI MARET 2025
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v14i1.4002

Abstract

Background: The study investigates the combined effects of 7,12-dimethylbenz[a]anthracene (DMBA) and a high-fat diet (HFD) on hepatic gene expression in a breast cancer mouse model. Both DMBA and HFD are associated with oxidative stress, inflammation, and fibrosis, which may contribute to cancer progression.Methods: Female C57BL/6 mice were divided into three groups: standard diet (ND), ND + DMBA, and HFD + DMBA. Mice in the ND + DMBA and HFD + DMBA groups received DMBA injections weekly for six weeks. The HFD + DMBA group was also fed a high-fat diet for four weeks prior to DMBA administration. After a 12-week treatment period, liver tissues were collected and analyzed for NF-κB and CCN1/CYR61 gene expression using semi-quantitative RT-PCR.Results: The study revealed significant upregulation of NF-κB and CCN1/CYR61 expression in the ND + DMBA and HFD + DMBA groups compared to the control group. Notably, the HFD + DMBA group exhibited the highest expression levels of these genes, suggesting that the combination of HFD and DMBA synergistically exacerbates hepatic inflammation and fibrosis.Conclusion: The findings indicate that a high-fat diet in combination with carcinogen exposure can significantly enhance hepatic gene expression related to inflammation and fibrosis, highlighting the importance of dietary management in cancer prevention and treatment. 
Co-Authors Abraham Adiwidjaja Sutjiono Abraham Adiwidjaja Sutjiono Abram P Tanuatmadja Ade K Surawijaya Ade Kurnia Surawijaya Alyssa F Ryanto Arief Budiono Camillo, Keyshia Valentine Christine Sugiarto Christine Sugiarto, Christine Daniel Welson Daud, Fari Ananda Decky Gunawan, Decky Dedeh Supantini Demes Chornelia Martantiningtyas Dhyfa, Najwa aulia Diana K Jasaputra Diana Krisanti Jasaputra Diana Krisanti Jasaputra Dominika, Katharina Ellen Edwin, Christian Eko Fuji Ariyanto Fanny Rahardja Fellicia Tan Fen Tih Fen Tih Fidelia, Catrinne Gaga Irawan Nugraha Ginting, Justin Gunadi, Julia Windi HANA RATNAWATI Hana Ratnawati Hutagalung, Albert Rodney Indah Kusuma Dewi, Indah Kusuma Indriany, Dini Irna Permanasari Gani Ishak, Lani Jason, Daniel Jeremi Christianto Jalil Tanggulungan Jeremi Christianto Jalil Tanggulungan Julia W Gunadi Julia Windi Gunadi Julia Windi Gunadi Kasnadi, Crystallica Luna Katherine Marcella Kwan, Clarissa Liliana, Teresa Limdawati Kwee Mangape, Hiro Salomo Maratantiningtyas, Demes Chornelia Miguna, Landry Natasia, Caroline Putri Nathania, Kezia Nirwana, Edwin Octavallen, Andri Octavia, Chitra Oeij Anindita Adhika Pamungkas, Raden Aprian Surya Putra Pratono, Dono Raden Ghita Sariwidyantry Rizamena, Melya Ikbar Ronald Jonathan Ronald Jonathan, Ronald Rosali, Alexandrina Everdine Rudijanto, Yohanes Rumanti, Rizna Tyrani Saiman, Erik Dwikurnia Sariwidyantry, Raden Ghita Selonan Susang Obeng Sihotang, Sharon Kolose Siringo Ringo, Nalaraty Wahyu Soekmadji, Peter Nugraha Sylvia Tanumihardja Tangano, Justin Javier Tanuwijaya, Farrell Teresa Lilliana Wargasetya Valerie, Rachel Vanessa Agatha Wijaya Waty, Wenny Yusuf, Inez Felia