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All Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Indonesian Journal of Pharmaceutical Science and Technology MNJ (Malang Neurology Journal) Jurnal Ilmiah Kedokteran Wijaya Kusuma Universa Medicina Journal of Medicine and Health Jurnal Ilmu Kedokteran dan Kesehatan Jurnal Medika Malahayati Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education Health and Medical Journal Medika Kartika : Jurnal Kedokteran dan Kesehatan Jurnal Ilmiah Kesehatan Jurnal Prima Medika Sains Keluwih: Jurnal Kesehatan dan Kedokteran Indonesian Journal of Cancer Journal of Medicine and Health
Ardo Sanjaya
Maranatha Christian University
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Journal : Jurnal Prima Medika Sains

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Radiological imaging of pulmonary cavitations in adult multidrug-resistance and extensively drug-resistance tuberculosis patients Ginting, Justin; Dominika, Katharina Ellen; Sanjaya, Ardo; Gunadi, Julia Windi
Jurnal Prima Medika Sains Vol. 6 No. 2 (2024): December
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v6i2.5639

Abstract

Mycobacterium tuberculosis is a pathogen that causes the infectious disease tuberculosis. Based on its resistance, tuberculosis can be divided into Drug-susceptible Tuberculosis (DS-TB) and Drug-resistant Tuberculosis (DR-TB). MDR-TB is one type of DR-TB when M. tuberculosis complex strains unresponsive to rifampicin and isoniazid. Another type of DR-TB is XDR-TB, A strain of M. tuberculosis that was unresponsive to rifampicin, isoniazid, fluoroquinolones, and at least 1 drug from group A. Research on the comparison of lung cavities in DS-TB, MDR-TB, and XDR-TB is still limited, this literature review is intended to explore comparative studies of lung cavity radiography in adult MDR-TB and XDR-TB patients. This literature review uses secondary data from literature searches through PubMed and Google Scholar by searching for keywords such as "Pulmonary Cavity", "Multidrug Resistance Tuberculosis", "Extensively Drug Resistance". Articles were included in the inclusion criteria if published in national or international journals with topics that match the research objectives within the last ten years. We found 7 studies that compared the radiologic features of lung cavities in individuals who have been diagnosed with DS-TB, MDR-TB, and XDR-TB. The literature review results showed that the radiologic features of cavities from DR-TB appear to be more massive than those in DS-TB. Similarly, in XDR-TB, the radiological picture of cavities appears more massive than in MDR-TB. The conclusion that can be drawn is that cavitation can be seen in DS-TB and DR-TB, and more cavitation in XDR-TB than in MDR-TB and DS-TB.
The role of catechol-o-methyltransferase in postpartum depression Dewi, Indah Kusuma; Natasia, Caroline Putri; Gunadi, Julia Windi; Sanjaya, Ardo
Jurnal Prima Medika Sains Vol. 7 No. 1 (2025): June
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v7i1.5844

Abstract

The global prevalence of postpartum depression is increasing annually. This condition has been associated with polymorphisms in the catechol-O-methyltransferase (COMT) enzyme, which plays a critical role in the degradation of catecholamines. Therefore, a literature review was conducted to examine the influence of COMT enzyme variants on postpartum depression, with a focus on specific time periods and genetic variants implicated in the disorder. The review methodology involved a systematic search of articles on the PubMed database using the keywords "catechol-O-methyltransferase," "postpartum depression," and "role of COMT in postpartum depression." Inclusion criteria required full-text availability in either Indonesian or English. Four relevant studies were identified that investigated the relationship between COMT enzyme variants and postpartum depression. Evidence suggests that the COMT Val158Met polymorphism may affect the risk of postpartum depression in the context of elevated estrogen levels, as high estrogen concentrations are known to downregulate COMT expression. Additionally, certain single nucleotide polymorphisms (SNPs), including rs2020917 (TT genotype), rs737865 (GG genotype), and the COMT rs4680 Met variant allele, have been shown to modulate the influence of COMT on postpartum depression independently of estrogen levels, possibly through interactions with other enzymatic pathways.
Co-Authors Abraham Adiwidjaja Sutjiono Abraham Adiwidjaja Sutjiono Abram P Tanuatmadja Ade K Surawijaya Ade Kurnia Surawijaya Alyssa F Ryanto Arief Budiono Camillo, Keyshia Valentine Christine Sugiarto Christine Sugiarto, Christine Daniel Welson Daud, Fari Ananda Decky Gunawan, Decky Dedeh Supantini Demes Chornelia Martantiningtyas Dhyfa, Najwa aulia Diana K Jasaputra Diana Krisanti Jasaputra Diana Krisanti Jasaputra Dominika, Katharina Ellen Edwin, Christian Eko Fuji Ariyanto Fanny Rahardja Fellicia Tan Fen Tih Fen Tih Fidelia, Catrinne Gaga Irawan Nugraha Ginting, Justin Gunadi, Julia Windi HANA RATNAWATI Hana Ratnawati Hutagalung, Albert Rodney Indah Kusuma Dewi, Indah Kusuma Indriany, Dini Irna Permanasari Gani Ishak, Lani Jason, Daniel Jeremi Christianto Jalil Tanggulungan Jeremi Christianto Jalil Tanggulungan Julia W Gunadi Julia Windi Gunadi Julia Windi Gunadi Kasnadi, Crystallica Luna Katherine Marcella Kwan, Clarissa Liliana, Teresa Limdawati Kwee Mangape, Hiro Salomo Maratantiningtyas, Demes Chornelia Miguna, Landry Natasia, Caroline Putri Nathania, Kezia Nirwana, Edwin Octavallen, Andri Octavia, Chitra Oeij Anindita Adhika Pamungkas, Raden Aprian Surya Putra Pratono, Dono Raden Ghita Sariwidyantry Rizamena, Melya Ikbar Ronald Jonathan Ronald Jonathan, Ronald Rosali, Alexandrina Everdine Rudijanto, Yohanes Rumanti, Rizna Tyrani Saiman, Erik Dwikurnia Sariwidyantry, Raden Ghita Selonan Susang Obeng Sihotang, Sharon Kolose Siringo Ringo, Nalaraty Wahyu Soekmadji, Peter Nugraha Sylvia Tanumihardja Tangano, Justin Javier Tanuwijaya, Farrell Teresa Lilliana Wargasetya Valerie, Rachel Vanessa Agatha Wijaya Waty, Wenny Yusuf, Inez Felia