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All Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Indonesian Journal of Pharmaceutical Science and Technology MNJ (Malang Neurology Journal) Jurnal Ilmiah Kedokteran Wijaya Kusuma Universa Medicina Journal of Medicine and Health Jurnal Ilmu Kedokteran dan Kesehatan Jurnal Medika Malahayati Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education Health and Medical Journal Medika Kartika : Jurnal Kedokteran dan Kesehatan Jurnal Ilmiah Kesehatan Jurnal Prima Medika Sains Keluwih: Jurnal Kesehatan dan Kedokteran Indonesian Journal of Cancer Journal of Medicine and Health
Ardo Sanjaya
Maranatha Christian University
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Journal : Indonesian Journal of Cancer

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The Differential Gene Expression of Squamous Cell Carcinoma Versus Basal Cell Carcinoma Highlights Oxidative Phosphorylation As A Potential Factor in Metastasis: A Single-Cell Gene Expression Analysis Study Soekmadji, Peter Nugraha; Sanjaya, Ardo; Tangano, Justin Javier; Gunadi, Julia Windi
Indonesian Journal of Cancer Vol 19, No 2 (2025): June
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v19i2.1264

Abstract

Background: Nonmelanoma skin cancer (NMSC) can be classified into basal (BCC) and squamous cell carcinoma (SCC). Combined, they rank 5th among the highest incidences of cancer in the world. Despite their low mortality rate, metastasis remains a significant concern. Basal cell carcinoma grows slowly and rarely metastasizes, unlike squamous cell carcinoma, which usually metastasizes when left untreated. However, it is currently unknown what influences their metastatic potential.Method: This research uses single-cell RNA expression data from the Gene Expression Omnibus database. The data will be preprocessed, normalized, and integrated before differential expression and enrichment analyses. Additionally, the 5 most upregulated genes in basal cell carcinoma compared to squamous cell carcinoma and vice versa will be discussed.Results: 165 genes highly expressed in BCC were identified and enriched, with the most significant enrichment for genes promoting apoptosis. We also identified 143 genes highly expressed in SCC, which had the most significant enrichment for genes involved in oxidative phosphorylation. The top 5 upregulated genes in BCC were KRT17, CXCL8, RPS17, CCL20, and IER3, and in SCC were KRT1, LY6D, FABP5, S100A8, and KRT10.Conclusion: We identified differentially expressed genes, including those related to oxidative phosphorylation and cell multiplication, which may help explain the varying behaviors of these cancers, particularly the higher metastatic potential of SCC. However, further research is needed to examine the effects of oxidative phosphorylation on these cancer cells.
Co-Authors Abraham Adiwidjaja Sutjiono Abraham Adiwidjaja Sutjiono Abram P Tanuatmadja Ade K Surawijaya Ade Kurnia Surawijaya Alyssa F Ryanto Arief Budiono Camillo, Keyshia Valentine Christine Sugiarto Christine Sugiarto, Christine Daniel Welson Daud, Fari Ananda Decky Gunawan, Decky Dedeh Supantini Demes Chornelia Martantiningtyas Dhyfa, Najwa aulia Diana K Jasaputra Diana Krisanti Jasaputra Diana Krisanti Jasaputra Dominika, Katharina Ellen Edwin, Christian Eko Fuji Ariyanto Fanny Rahardja Fellicia Tan Fen Tih Fen Tih Fidelia, Catrinne Gaga Irawan Nugraha Ginting, Justin Gunadi, Julia Windi HANA RATNAWATI Hana Ratnawati Hutagalung, Albert Rodney Indah Kusuma Dewi, Indah Kusuma Indriany, Dini Irna Permanasari Gani Ishak, Lani Jason, Daniel Jeremi Christianto Jalil Tanggulungan Jeremi Christianto Jalil Tanggulungan Julia W Gunadi Julia Windi Gunadi Julia Windi Gunadi Kasnadi, Crystallica Luna Katherine Marcella Kwan, Clarissa Liliana, Teresa Limdawati Kwee Mangape, Hiro Salomo Maratantiningtyas, Demes Chornelia Miguna, Landry Natasia, Caroline Putri Nathania, Kezia Nirwana, Edwin Octavallen, Andri Octavia, Chitra Oeij Anindita Adhika Pamungkas, Raden Aprian Surya Putra Pratono, Dono Raden Ghita Sariwidyantry Rizamena, Melya Ikbar Ronald Jonathan Ronald Jonathan, Ronald Rosali, Alexandrina Everdine Rudijanto, Yohanes Rumanti, Rizna Tyrani Saiman, Erik Dwikurnia Sariwidyantry, Raden Ghita Selonan Susang Obeng Sihotang, Sharon Kolose Siringo Ringo, Nalaraty Wahyu Soekmadji, Peter Nugraha Sylvia Tanumihardja Tangano, Justin Javier Tanuwijaya, Farrell Teresa Lilliana Wargasetya Valerie, Rachel Vanessa Agatha Wijaya Waty, Wenny Yusuf, Inez Felia