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All Journal BIOLINK (Jurnal Biologi Lingkungan, Industri, Kesehatan) Jurnal Pendidikan Kimia (JPKim) EKSAKTA : Jurnal Penelitian dan Pembelajaran MIPA Martabe : Jurnal Pengabdian Kepada Masyarakat Jurnal Pembelajaran dan Biologi Nukleus IJOEP : International Journal of Ecophysiology Community Development Journal: Jurnal Pengabdian Masyarakat Jurnal Abdidas Jurnal Jeumpa Journal of Natural Sciences JOMPA ABDI: Jurnal Pengabdian Masyarakat Jurnal Pengabdian Masyarakat Bangsa Herbal Medicine Journal Jurnal ABDIMAS MUTIARA Jurnal Kesehatan Bakti Tunas Husada
Helen Anjelina Simanjuntak
Program Studi Farmasi, Universitas Senior, Medan
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Education Energy Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Uji Aktivitas Antioksidan Ekstrak Etanol Daun Belimbing Wuluh (Averrhoa bilimbi L.) dengan Metode DPPH Helen Anjelina Simanjuntak; Ester Angelina Manurung; Herlina Simanjuntak; Nurbaiti Br. Singarimbun; Defacto Firmawati Zega; Lydia Br. Barus; Suharni Pintamas Sinaga
Herbal Medicine Journal Vol 9 No 1 (2026): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58996/hmj.v9i1.223

Abstract

Plants contain antioxidants, are easily found around homes, and offer various health benefits, including starfruit, a member of the Oxalidaceae family. The leaves are the plant part used. Empirically, people use them to treat various ailments, including fever, stomach ache, cough, hypertension, rheumatism, headache, diabetes, and pain. Objective to determine the antioxidant activity of ethanol extracts from starfruit (Averrhoa bilimbi L.) leaves and to determine the strength of this activity based on the IC50 using the DPPH method. This study employed an experimental method, including leaf collection, preparation of crude drugs, characterization, phytochemical screening, extraction, preparation of extracts from starfruit leaves, and testing the antioxidant activity of ethanol extracts from starfruit leaves. Examination of the characteristics of the simplicia powder obtained an ethanol-soluble extract content of 29.66%, a water-soluble extract content of 22.66%, a total ash content of 4.0%, an acid-insoluble ash content of 1.83%, and a drying loss of 11.83%. The phytochemical extract screening results contained alkaloids, flavonoids, saponins, and tannins. The results of the antioxidant activity test of starfruit (Averrhoa bilimbi L.) leaf extract with an IC50 value of 39.71983 ppm. The results of this study indicate that starfruit (Averrhoa bilimbi L.) leaf extract has very strong antioxidant activity with an IC50 value of 39.71983 ppm.
Profil Fisik, Kimia dan Biologi Pupuk Organik Cair Ampas Teh Rahmiati Rahmiati; Helen Anjelina Simanjuntak; Toberni S Situmorang; Hayyu Nisa Abdillah; Vera Novita Manalu; Deswita Asriani Tanjung
Herbal Medicine Journal Vol 9 No 2 (2026): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58996/hmj.v9i2.250

Abstract

Tea waste is an organic by-product that still contains essential nutrients and organic compounds, making it a promising raw material for the production of liquid organic fertilizer (LOF). This study aimed to evaluate the physical, chemical, and biological characteristics of LOF produced through the fermentation of tea waste. A quantitative descriptive method was employed using a seven-day fermentation process. The evaluated parameters included physical characteristics (color, odor, and pH), chemical properties (organic carbon, total nitrogen, and C/N ratio), and biological characteristics based on the total bacterial count. The results showed that the resulting LOF was dark brown in color, exhibited a characteristic tea aroma with a distinct acidic odor due to fermentation, and had a pH of 5.5. These physical characteristics complied with the quality requirements for liquid organic fertilizer stipulated in the Indonesian Ministry of Agriculture Regulation No. 70 of 2011. Chemical analysis revealed an organic carbon content of 9.8%, a total nitrogen content of 0.75%, and a C/N ratio of 13.06. The relatively low C/N ratio indicated that the fermentation process had proceeded effectively and that the produced LOF had reached an adequate level of maturity. This finding was supported by the total bacterial count of 6.56 × 10⁸ CFU mL⁻¹, indicating active microbial growth during the fermentation process. Overall, tea waste has considerable potential as a raw material for producing liquid organic fertilizer and may contribute to sustainable organic waste management practices
Uji Aktivitas Antioksidan dan Penetapan Kadar Flavonoid Total Pada Ekstrak Etanol Daun Bandotan (Ageratum conyziodes) dengan Metode DPPH Mahral Effendi Sembiring; Lydia Br. Barus; Defacto Firmawati Zega; Nurbaiti Br. Singarimbun; Suharni Pintamas Sinaga; Elseria Saragih; Junita Manullang; Parsaoran Pardede; Sahat Sinaga; Helen Anjelina Simanjuntak; Herlina Simanjuntak
Herbal Medicine Journal Vol 9 No 2 (2026): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58996/hmj.v9i2.254

Abstract

Daun bandotan, also known as Ageratum conyzoides L., contains flavonoids that may have anti-alami properties. The purpose of this study is to determine the total flavonoid content and anti-oxidant activity of the ekstrak etanol daun bandotan. With 96% ethanol as the pelarut, ekstraksi is carried out using the maserasi method. The DPPH (2,2-difenil-1-pikrilhidrazil) method is used to decrease antioksidan activity by decreasing absorption at 517 nm. To determine the total flavonoid content, spectrophotometry is used as a reference. The study's findings indicate that the antioksidan activity of ekstrak etanol daun bandotan is rather high, with an IC50 of 33,619 μg/mL in the Kadar category. The study's findings indicate that ekstrak etanol daun bandotan can function as an alami antioksidan, with an estimated 33,7938 mg of flavonoids per QE.
Formulation Cream of Ethanol Patikan Kebo Weeds (Euphorbia hirta L.) Extract As An In Vitro Anti-Acne Lydia Br Barus; Sanna Kamisna Royani Purba; Sesilia Sri Susandri Br. Gultom; Helen Anjelina Simanjuntak; Hermawan Purba; Nurbaiti Br. Singarimbun; Defacto Firmawati Zega
JURNAL PEMBELAJARAN DAN BIOLOGI NUKLEUS Vol 11, No 2: Jurnal Pembelajaran Dan Biologi Nukleus June 2025
Publisher : Universitas Labuhanbatu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36987/jpbn.v11i2.6698

Abstract

Background: Acne is a skin inflammation that is prevalent in 80-100% of the population, particularly during adolescence.  The Patikan Kebo (Euphorbia hirta L.) weed plant is employed in a cream formulation to treat acne. Therefore, this study aims to determine the formula of the Patikan Kebo (E. hirta L.) weed cream preparation that is as effective as an in vitro anti-acne. Methodology: the research method was carried out experimentally with the stages of sample preparation, phytochemical screening, extraction, formulation, evaluation, and antibacterial activity test that caused acne using the well diffusion method. Findings: The results showed the Patikan Kebo (E. hirta L.) weed has secondary metabolites consisting of alkaloids, flavonoids, saponins, tannins, and steroids/triterpenoids. The evaluation of the cream preparation of each formula has met cosmetic standards. The diameter of the F4 inhibition zone has antibacterial activity against acne-causing Propionibacterium acnes (12.03 ± 0.81 mm), Staphylococcus epidermidis (11.48 ± 1.10 mm), S. aureus (12.07 ± 0.06 mm), and the F5 inhibition zone P. acnes (13.53 ± 0.15 mm), S. epidermidis (12.54 ± 0.75 mm), and S. aureus (13.03 ± 0.61 mm). Formulas F4 and F5 are more effective as anti-acne with a strong inhibition zone diameter. Contribution: These findings indicate that formulas F4 and F5 can be further developed as alternative natural active ingredients in cosmetic or pharmaceutical products for acne therapy, thus contributing to the development of safer, more economical, and more sustainable local herbal medicine
Clay Mask Formulation of Coconut Dregs and Virgin Coconut Oil as an Antibacterial Against Propionibacterium acnes Ketrin Evelia Pinondang Sitanggang; Ningsih Prastika Zega; Wulan Anggreni Br. Manurung; Elya Cytra Bonaparti Silaban; Helen Anjelina Simanjuntak
JURNAL PEMBELAJARAN DAN BIOLOGI NUKLEUS Vol 10, No 3: Jurnal Pembelajaran Dan Biologi Nukleus November 2024
Publisher : Universitas Labuhanbatu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36987/jpbn.v10i3.6041

Abstract

Beauty and healthy skin as well as skin problems such as acne are challenges for the pharmaceutical sector in innovating to produce clay mask cosmetic products made from coconut dregs. Apart from maintaining healthy skin, coconut dregs clay mask products also maintain environmental health. Galactomannan contained in coconut dregs acts as a thickener, stabilizer, emulsifier and additive. The lauric acid contained in VCO acts as an antibacterial, antiviral and antiprotozoal. The combination of coconut dregs and VCO in a clay mask is more optimal as a cosmetic product. The aim of the research is to utilize coconut dregs waste into pharmaceutical products, produce a clay mask made from coconut dregs with a combination of VCO which has the potential to act as an antibacterial and produce a clay mask product that is effective as an anti-acne. The method was carried out by preparing coconut dregs flour, making various clay mask formulations: F0, F1, F2, F3 and F4, testing the stability of the clay mask product and testing the antibacterial properties of the clay mask against P. acnes using the well diffusion method. The results show that the organoleptic formulas are semi-solid, the colors are white, cream, brownish cream and light brown, while the odor ranges from odorless to vanilla, all formulas are homogeneous, pH 7, spreadability and dryness are stable and antibacterial is in the medium to strong category. The conclusion shows that F4 is more effective as an antibacterial against Propionibacterium acnes with an inhibition zone of 16.21 ± 0.85 mm and the clay mask preparation has the potential as an anti-acne
Co-Authors Amanzino, Regina Asmara Apri Yoci Ro Berlina Br. Sembiring, Heylen Sebryna Cander Pasaribu Chalis Fajri Hasibuan Daeli, Mestika Clemesiya Yulianti Dame Meldaria sipahutar Defacto Firmawai Zega Defacto Firmawati Zega Defacto Firmawati Zega Defacto Firmawati Zega Deswita Asriani Tanjung Dini Pratiwi Elseria Saragih Elseria Saragih Elya Cytra Bonaparti Silaban Ester Angelina Manurung Fadilla, Zahira Ferdinand Susilo Fransiska Riati Nova Simbolon Ginting, Junius Gian Hayyu Nisa Abdillah Herlina Simanjuntak Herlina Simanjuntak Herlina Simanjuntak Herlina Simanjuntak Hermawan Purba Iksen, Iksen Indah Sari Jamilah Nasution Junita Br Manullang Junita Br. Manullang Junita Manullang Karnina, Sisca Kasih, Indah Kasmara, Dwi Pratiwi Kasta Gurning Kembaren, Gita Br. Ketrin Evelia Pinondang Sitanggang Lydia Br Barus Lydia Br Barus Lydia Br. Barus Lydia Br. Barus Mahral Effendi Sembiring Manihuruk, Fani Nuryana Megawati Butar - Butar Megawati Butar-butar Nahampun, Laura Yunita Ningsih Prastika Zega Nora Yanti Lumbangaol Nurbaiti Br. Singarimbun Nurbaiti Br. Singarimbun Nurbaiti Br. Singarimbun Parsaoran Pardede Pasaribu, Selli M Pasaribu, Sudana Fatahillah PURBA, FRANSISKA Purba, Hermawan Purwandari, Vivi Rahmi Hayati Rahmiati Rahmiati Rahmiati Rahmiati Rahmiati Rahmiati Ratna A.K Marpaung, Dwi Reni Yusman Rini Febrianti RINI FEBRIANTI Risanti Situmorang Riska Amelia Putri Royani Purba, Sanna Kamisna Sahat Sinaga Sahat Sinaga Sahat Sinaga Sanna Kamisna Royani Purba Sapitri, Alfi Sari, Mesi Puspita Selli M Pasaribu Sembiring, Mahral Effendi Sesilia Sri Susandri Br. Gultom Sianturi, Ayu Enjelina Sihotang, Santyria Simanjuntak, Herlina Sinaga, Florenita Sinaga, Fnesia Sinaga, Sahat Sinaga, Suharni Pintamas Sinaga, Verawati Br. Singarimbun, Nurbaiti Br Siti Maimunah Siti Maimunah Suharni Pintamas Sinaga Suharni Pintamas Sinaga Suharni Sinaga Susi Amenta Br. Perangin Angin Toberni S Situmorang Toberni S Situmorang Toberni S Situmorang Toberni S Situmorang Vera Novita Manalu Wahyuni, Sri Wan Yuli Anjani Wanda Lestari, Wanda Wulan Anggreni Br. Manurung Yanti Yanti Yanti Yanti Yelni, Afrida Zega, Defcato Firmawati Zuhairiah Nasution, Zuhairiah