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All Journal Dentino: Jurnal Kedokteran Gigi Pharmascience Berkala Kedokteran Journal of Dentomaxillofacial Science EnviroScienteae Acta Biochimica Indonesiana PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Community Empowerment Al Khidma: Jurnal Pengabdian Masyarakat Prosiding Konferensi Nasional PKM-CSR Jurnal Pengabdian Ilung (Inovasi Lahan Basah Unggul) Jurnal Pengabdian Masyarakat Bestari (JPMB) Asian Journal of Community Services (AJCS) Smart Society Empowerment Journal Homeostasis: Jurnal Mahasiswa Pendidikan Dokter
Lisda Hayatie, Lisda
Departemen Mikrobiologi Dan Parasitologi Divisi Parasitologi Fakultas Kedokteran Universitas Lambung Mangkurat, Banjarmasin
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Journal : Pharmascience

 1 
GC-MS Profiling and Inhibitory Effect on UV-C Exposure Induced Eryrhrocyte Damage of Sungkai Leaf: A Potential Novel Antioxidant Agent Mashuri, Mashuri; Suhartono, Eko; Muthmainah, Noor; Hayatie, Lisda; Assyfa, Nadia Salma Nazwa; Husna, Hanna Dwi Aprilia; Febrianti, Helma
Jurnal Pharmascience Vol 12, No 2 (2025): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v12i2.23081

Abstract

Daun sungkai (Peronema canescens Jack.) meruapakan tumbuhan yang dikenal memiliki berbagai manfaat farmakologis, termasuk sebagai antiinflamasi, antimikroba, dan antioksidan.  Tumbuhan ini mengandung senyawa fenolik, flavonoid, tanin, dan saponin yang dapat berperan seabagai antioksidan. Berkaitan dengan hal tersebut, penelitian ini bertujuan untuk menganalisis profil fitokimia dengan GC-MS. Selain itu, juga akan membuktikan aktivitas antioksidan ekstrak daun sungkai dalam menhambat kerusakan membran eritorit akibat pajanan sinar UV. Daun Sungkai diperoleh dari KHDTK Mandiangin diektrak dengan pelarut methanol dengan metode maserasi. Hasil ektrak dilakukan uji GC-MS dan uji penghambatan kerusakan eritrosit akibat sinar UV. Pengujian terdiri atas 2 kelompok, yani 2 kelompok control dan 3 kelompok perlakuan. Kelompok perlakuan menggunakan ektrak metanol daun sungkai masing-masing 10 ppm, 15 ppm, dan 25 ppm. Sementara itu, pemajanan eritrosit dilakukan selama 2 jam. Hasil penelitian ini dapat disimpulkan bahwa berdasarkan  analisis GC MS menunjukkan bahwa ekstrak metanol daun sungkai mengandung senyawa 4-Metoksi-3-trimetilsilil)metil-1-oktena, D-Limonen, Asam tridekanoat, 12-cis-oktadekanoat, asam 13-oktadesenoat, metil ester, asam oleat, dan Glisidil (Z) -9-heptadekanoat yang dapat mengurangi kerusakan eritrosit akibat paparan sinar UV. Selain itu, ektrak metanol daun sungkai dapat menghambat kerusakan membrane eritrosit yang ditandai oleh penurunan %Hb dan kadar MDA pada kelompok yang diberikan ekstrak methanol daun insulin. Kata Kunci: Pajaanan UV, antioksidan, Daun Sungkai, Membrane Eritrosit, Peroksidasi Lipid Sungkai leaf (Peronema canescens Jack.) is a plant known to have various pharmacological benefits, including as anti-inflammatory, antimicrobial, and antioxidant. This plant contains phenolic compounds, flavonoids, tannins, and saponins that can act as antioxidants. In this regard, this study aims to analyze the phytochemical profile by GC-MS. In addition, it will also prove the antioxidant activity of sungkai leaf extract in inhibiting erythrocyte membrane damage due to UV exposure. Sungkai leaves obtained from KHDTK Mandiangin were extracted with methanol solvent by maceration method. The extracts were subjected to GC-MS test and UV light-induced erythrocyte damage inhibition test. The test consisted of 2 groups, 2 control groups and 3 treatment groups. The treatment groups used methanol extract of sungkai leaves at 10 ppm, 15 ppm, and 25 ppm, respectively. Meanwhile, erythrocyte exposure was carried out for 2 hours. The results of this study can be concluded that based on GC MS analysis shows that the methanol extract of sungkai leaves contains compounds 4-Methoxy-3-trimethylsilyl)methyl-1-octene, D-Limonen, Tridecanoic acid, 12-cis-octadecanoic, 13-octadesenoic acid, methyl ester, oleic acid, and Glycidyl (Z)-9-heptadecanoic which can reduce erythrocyte damage due to UV exposure. In addition, sungkai leaf methanol extract can inhibit erythrocyte membrane damage characterized by a decrease in %Hb and MDA levels in the group given insulin leaf methanol extract.
Co-Authors Adma Hayani Dona Yanti Agatha Theodora Desvita Raharjo Alex Syamsuddin Alfina Hilma Anastasia Larasati Andi Azizah M Budiarman Ardi Siswanto Arifin Syamsul Asnawati Asnawati Asnawati Asnawati Assyfa, Nadia Salma Nazwa Aulia Azizaturridha Auryn Widyananda Sindunata Azizaturridha, Aulia Batosamma, Novatalia Darwis, Muhammad Wisnu Adi Dewi Indah Noviana Pratiwi Dewi Indah Noviana Pratiwi Dewi Indah Noviana Pratiwi, Dewi Indah Noviana Dewi Nurdiana Didik Dwi Sanyoto Djalalluddin Djalalluddin Dona Marisa, Dona Dwi Setyohadi, Dwi Edi Hartoyo Edyson Edyson Edyson Edyson Eko Suhartono Erida Wydiamala Erida Wydiamala Evorius Oriwarda Farida Heriyani Farida Heriyani Farida Heriyani Farida Heriyani Febrianti, Helma Fie Khaeriyah Fujiati ., Fujiati Gaida Akmila H. Sufiani Hana Najma Maulidya Harris, Muhammad Fathir Naman Hartina Fajar Damayanti Hendra Wana Nur'amin Hendra Wana Nur'amin Hesty Tri Wira Drana Wasistha Hilma Wardatina Husin, Gt Muhammad Irhamna Husna, Hanna Dwi Aprilia Ika Kustiyah Oktaviyanti Ika Novitasari Irawanto Ismi Aulia Isnaini Isnaini Isnaini Isnaini Istiana Istiana Istiana Istiana Joharman Joharman Joharman Joharman Kartika Veranisa Putri Krisma Aulia Lena Rosida Maisy Naqinie Mashuri Mashuri Mayang Rustia Anggraini Putri Meitria Syahadatina Noor Meitria Syahadatina Noor Melynda Lauren Muhammad Ali Riswandi Muhammad Ali Riswandi, Muhammad Ali Muhammad Fathir Naman Harris Muhammad Ihrammuf Tezar Muhammad Lazuardi Khalfi Muthmainah, Noor Muthmainah, Noor Nadiya Alifa Nur Istiqomah Nadya Hasna Aulia Nasywa Melanie Sugiyanto Nelly Al Audhah Nelly Al Audhah Nika Sterina Skripsiana Nisa Febiana Noer Komari Noor Muthmainah Novatalia Batosamma Nur Annisa Humaira Nur Qamariah Nur Qamariahi Nur Widy Wulandari Nurdiana Dewi Nuria Ra’yal Ain Nur’amin, Hendra Wana Panghiyangani, Roselina Patimah Patimah Putri Sri Hartini Rabbina Rahmah Rahmiati Rahmiati Rahmiati Rahmiati Rahmiati Rahmiati Rahmita Rahmita Reynaldo Gazali Rosihan Adhani, Rosihan Sandi Paufik Sari, Annida Permata Savitri Sita Nursanti Ali Silapurna, Endah Labati Silapurna, Endah Labaty Sinta Anisa Siti Juliati Sufiani Sufiani Syellin Ivasga Baylina Triawanti Triawanti Wahyuni Wahyuni Windy Yuliana Budianto, Windy Yuliana Wydiamala, Erida Zaitun, Nani Zulfa Emelda