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All Journal ODONTO Dental Journal Majalah Obat Tradisional Dentino: Jurnal Kedokteran Gigi Berkala Kedokteran Dental Journal (Majalah Kedokteran Gigi) Padjadjaran Journal of Dentistry Journal of Dentomaxillofacial Science Journal of Indonesian Dental Association E-Prodenta Journal of Dentistry Dentin Jurnal Pengabdian kepada Masyarakat Nusantara Jurnal Pengabdian Sumber Daya Manusia Odonto dental journal Jurnal Bioteknologi & Biosains Indonesia (JBBI) Jurnal Bioteknologi & Biosains Indonesia
Amy Nindia Carabelly
Department Of Oral And Maxillofacial Pathology, Faculty Of Dentistry, Lambung Mangkurat University, Banjarmasin, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Social Sciences Other

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Anti-inflammatory Effects of Channa micropeltes Extract through NF-κB and TNF-α in Diabetic Rat Carabelly, Amy Nindia; Aspriyanto, Didit; Sari, Milka Widya; Norfitriyah, Erika; Utami, Juliyatin Putri
Majalah Obat Tradisional Vol 29, No 1 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.87104

Abstract

Diabetes mellitus (DM) is a disorder of carbohydrate, fat, and protein metabolism caused by impaired insulin secretion, insulin action, or both characterized by hyperglycemia. Hyperglycemic condition is associated with inflammation process leading to complications. Food supplements play an important role in controlling protein metabolism and have anti-inflammatory properties such as Channa micropeltes (CM). This study aimed to analyze the effect of CM extract on the levels of molecular markers Nuclear factor kappa beta (NF-κB) and Tumor Necrosis Factor alfa (TNF-α) in normal and diabetic rats. The experimental design of this investigation was a post-test-only control group design and the samples were the diabetic model group given CM extract at 16 mL/kgBB dose, and negative control group for 14 days, respectively. Serum concentrations of    NF-κB and TNF-α were measured by ELISA. DM-CM group showed decreasing levels of NF-κB. TNF- α was detected with the lowest level in the N-CM group. The levels of TNF- α declined close to normal levels in the DM-CM group. Hence, the conclusion was the CM at a dose of 16 mL/kg BW for 14 days in Wistar rats can reduce Nf-κB and TNF-α in groups of normal and diabetic rats.
Correlation between presence of bacillus species and OHI-s in recurrent aphthous stomatitis patients Carabelly, Amy Nindia; Apriasari, Maharani Lallyza; Dwipura, Irnamanda; Pramitha, Selviana Rizky; Sutanti, Viranda; Kurniasari, Annisa; Nafisah, Riznasyarielia Nikmatun
Padjadjaran Journal of Dentistry Vol 34, No 3 (2022): November 2022
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol34no3.31901

Abstract

ABSTRACTIntroduction: The approximate prevalence of Recurrent Aphthous Stomatitis (RAS) was 45.42% at Gusti Hasan Aman Dental Hospital Banjarmasin. Bacillus sp. is a bacterium that can form spores that can be transmitted through air, dust, water and food. Poor oral conditions will increase the possibility of bacterial contamination, especially for ulcers found in RAS. This study aimed to analyzed correlation between the presence of Bacillus species and OHI-S in the oral ulceration of RAS patients. Methods: This was an analytical cross-sectional study conducted among Oral Medicine Department outpatients at Gusti Hasan Aman Dental Hospital, Banjarmasin, Indonesia. A total of 38 subjects were examined to assess Oral Hygiene Index Simplified and obtained bacteria samples using the swabs technique. Bacteria were then inoculated in blood agar base media and concurrently presented with gram staining. Bacteria were then identified using the catalase test, urease test, and oxidase test. Results: Bacillus species were predominantly identified in oral ulceration of RAS patients at Gusti Hasan Aman Dental Hospital Banjarmasin. Bacillus sp. (60,5%), Streptococcus sp. (34,2%), Neisseria sp. (2,6%), and Lactobacillus sp. (2,6%) were found in ulcerated RAS lesions. Spearman test resulted in p = 0.862 (p > 0.05), where no significant difference was obtained between presence of bacillus species and OHI-s in recurrent aphthous stomatitis patients. Conclusion: Bacillus species were predominantly identified in oral ulceration of RAS patients a. However, the presence of Bacillus sp. was not associated with OHI-S in RAS patients.Keywords: bacillus sp.; oral hygiene index simplified; recurrent aphthous stomatitis
Mauli Banana Stem Gel: A Potential Material for Dentin Remineralization Analyzed Using Fourier Transform Infrared Spectroscopy Carabelly, Amy Nindia; Rahman, Yajma Kamiila; Puspitasati, Dewi; Erlita, Isyana; Wydiamala, Erida
Majalah Obat Tradisional Vol 29, No 3 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.90537

Abstract

Dental caries requires remineralizing agents to restore the dentin. Mauli banana stem gel is predicted to be an alternative material for mineral deposition during the remineralization process. Fourier transform infrared spectroscopy (FTIR) can analyze substances that indicate dentin remineralization. This study aimed to conduct an FTIR analysis of Mauli banana stem gel as a potential substitute material for dentin remineralization. The study utilized dentin slices obtained from the first premolars of the maxilla, which were demineralized using EDTA. Subsequently, the dentin slices were treated with CPP-ACP, 50% MBSG, 62,5% MBSG, and artificial saliva. A test tube containing 15 ml of artificial saliva was placed inside the smeared material, which was applied twice a day. It was left for three minutes and then rinsed with deionized water before being incubated at 37 °C. Basting was carried out for 21 days, and FTIR observations were performed. The major absorbance peaks detected were O-H and N-H stretch; C-H stretch; SCN stretch; Amide I; CO32-(v3) and collagen; Amide II; CH2 scissoring; C-H deformation; C-H stretching; Amide III; and PO43-(V3). MBSG demonstrated superior retention of dentin collagen compared to the control group, but it could not maintain the mineral content level on day 21. MBSG demonstrated a decrease in crystallinity due to a rise in carbonate content in the hydroxyapatite lattice. The study's findings indicate that MBSG remains unsuitable for dentin remineralization. Additional additives are necessary to enhance the levels of collagen and minerals in remineralized dentin.
PHARMACOLOGICAL INVESTIGATION OF THE ORAL WOUND HEALING ACTIVITY OF Stachytarpheta jamaicensis ROOT EXTRACT GEL IN WISTAR RATS Utami, Juliyatin Putri; Wasiaturrahmah, Yusrinie; Carabelly, Amy Nindia; Aspriyanto, Didit; Nahzi, Yanuar Ichrom; Arifin, Rahmad; Ramadhaniyah, Nur; Jatmiko, Habibi Naufal
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 12 No. 1 (2025)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2025.9390

Abstract

The Stachytarpheta jamaicensis (L) Vahl root contains bioactive compounds like saponins, alkaloids, flavonoids, tannins, phenols, and terpenoids, which have antibacterial and anti-inflammatory properties. This study investigates the wound healing effects of Stachytarpheta jamaicensis (L) Vahl root extract gel in oral mucosa. The experiment involved 28 male Wistar rats, divided into four groups: a positive control treated with povidone iodine 10%, a negative control treated with gel base, and two experimental groups treated with 6% and 10% S. jamaicensis root extract gels. The gel was applied twice daily, and wound healing was assessed by epithelial thickness, inflammation cell and hydroxyproline content. Both concentrations of S. jamaicensis root extract gel significantly enhanced wound healing, as shown by increased epithelial thickness, inflammation cell and hydroxyproline content levels compared to the negative control. These findings suggest that S. jamaicensis root extract gel effectively promotes wound healing in the excision wound model.
Correlation between the socio-demographic characteristics and clinical profile with oral manifestations of HIV/AIDS patients Apriasari, Maharani Laillyza; Aprilyani, Nur; Carabelly, Amy Nindia; Utami, Juliyatin Putri
Padjadjaran Journal of Dentistry Vol 33, No 1 (2021): March 2021
Publisher : Faculty of Dentistry Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol33no1.26025

Abstract

Introduction: Human Immunodeficiency Virus (HIV) exhibits the capability to weaken human immune system. The infected subject will later be more susceptible to suffer from opportunistic diseases when the CD4 cell count is lesser than 200 cell/µL. Oral thrush, periodontal disease and xerostomia are common oral manifestations in AIDS patient which initially indicate the presence of HIV infection. This study was aimed to analyse the correlation between the socio-demographic characteristics and clinical profile with oral manifestations of HIV/AIDS patients. Methods: An analytic study with cross-sectional approach was conducted towards the clinical profile and oral manifestation data of HIV/AIDS patients, which obtained from secondary data in the form of medical record. The 55 samples were taken with total sampling technique. Results: The chi-square test found no significant correlation between HIV/AIDS patients socio-demographic and oral manifestations and several significant correlation of the HIV/AIDS patients' clinical profile with the oral manifestation as follows: the total number of CD4 and ARV therapy duration was significantly correlated with the HIV/AIDS patients with candidiasis and oral thrush (p=0.01); while in patients with periodontal disease was only significantly correlated  with the total number of CD4 (p=0.02); and no significant correlation found in HIV/AIDS patients with xerostomia. Conclusion: There is no correlation between HIV/AIDS patients socio-demographic and oral manifestations. There is a correlation between several HIV/AIDS patients clinical profile with the oral manifestation. The number of CD4 cells and the ARV therapy duration was correlated with patients with candidiasis and oral thrush, while in patients with periodontal disease on correlated with the number and CD4 cells. HIV/AIDS patients with xerostomia have no correlation with any of their clinical profile.
The Antibacterial Activity of Chitosan from Haruan (Channa striata) Fish Scales on the Growth of Streptococcus sanguinis Hutami, Wijayanti Diah Wasi; Tri Putri, Deby Kania; Carabelly, Amy Nindia; Kriswandini, Indah Listiana; Pratiwi, Ariyati Retno; Luthfi, Muhammad
Journal of Indonesian Dental Association Vol 3 No 2 (2020): October
Publisher : Indonesian Dental Association

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Introduction: Recurrent Aphthous Stomatitis (RAS) is the most common oral lesion in Banjarmasin, with a prevalence of 45.42%. Streptococcus sanguinis (S. sanguinis) is thought to be one of the factors causing RAS. One natural ingredient that is often used by the people of South Kalimantan is the Haruan fish. The high Haruan fish consumption will eventually leave fish scales that have the potential to pollute the environment if not addressed immediately. Fish scales contain chitin, which when deacetylated produces chitosan, which has antibacterial properties. Objectives: The purpose of this study was to determine the effectiveness of the chitosan from the scales of the Haruan fish (Channa striata) at inhibiting S. sanguinis growth. Methods: This study used a randomized pretest-posttest with control group design using five treatments. The five treatments were subjected to liquid dilution using the UV-Vis Spectrophotometer method to obtain minimum inhibitory concentration (MIC) and a solid dilution test using the Total Plate Count method to obtain minimum bactericidal concentration (MBC). Results: The results showed that Haruan scale chitosan proved to be effective as an antibacterial against S. sanguinis, with a MIC of 1.25% and a minimum lethal concentration of 2.5%. One-Way Anova test results showed significance for the MIC test (p = 0,000) and MBC test (p = 0.000; p < 0.05). Conclusion: Chitosan from Haruan fish scales is both inhibitory and lethal to S. sanguinis.
Upaya Preventif Tanggulangi Dbd Melalui Pelatihan Pembuatan Sabun Cair Serai Di Desa Guha Dewi, Dian Masita; Faisal, Ikhwan; Carabelly, Amy Nindia; Dewi, Renie Kumala
Jurnal Pengabdian kepada Masyarakat Nusantara Vol. 5 No. 4 (2024): Jurnal Pengabdian kepada Masyarakat Nusantara (JPkMN) Edisi September - Desembe
Publisher : Lembaga Dongan Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55338/jpkmn.v5i4.5004

Abstract

Desa Guha merupakan penghasil tanaman serai di Kabupaten HST, Provinsi kalimantan Selatan. Selama ini serai hanya digunakan sebagai bumbu dapur atau dijual dengan harga murah. Melalui kegiatan Program Dosen Wajib Pengabdian (PDWA), TIM pelaksana memberikan pelatihan pembuatan sabun cair serai kepada 25 orang ibu-ibu anggota PKK di Desa Guha sebagai peserta pelatihan. Program ini terdiri dari sosialisasi, praktek, dan evaluasi. Pelaksanaan Pelatihan pembuatan Sabun cair berbasis serai di desa Guha ini sukses dan berdampak positif dalam meningkatkan pengetahuan peserta pelatihan tentang manfaat serai sebagai tanaman yang dapat digunakan untuk mencegah gigitan nyamuk aedes aegypti sebagai vektor DBD dan meningkatkan skill peserta pelatihan dalam membuat sabun cair serai anti DBD. Pelaksanaan pelatihan ini diharapkan dapat dilanjutkan melalui program pengembangan produk sabun serai diantaranya pelatihan packaging, merek dan e commers
Demineralized dentin characteristics after application of Mauli banana stem gel Carabelly, Amy Nindia; Puspitasari, Dewi; Syahrina, Fitri; Wahyudi, Maman Diki; Salsabila Karno, Dhya Aurellia; Mohd-Said, Shahida
Dental Journal (Majalah Kedokteran Gigi) Vol. 57 No. 1 (2024): March
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v57.i1.p33-37

Abstract

Background: Demineralization of dentin is a condition of dissolving minerals in peritubular dentin due to exposure to acids that release hydroxyapatite ions. To prevent dentin demineralization, a therapeutic agent that can inhibit the dissolution ability of hydroxyapatite ions is needed. One therapeutic agent that can be used is the Mauli banana (MB) stem gel. Purpose: To observe the characteristics of dentin demineralization after the use of MB stem extract gel. Method: Mandibular incisor bovine teeth were demineralized with lactic acid pH 4.5 for 72 hours and then treated with 25%; 37.5%; 50%; and 62.5% MB gel and Chlorhexidine 2% for one minute. All samples were soaked in artificial saliva with 1 mg/ml saliva of collagenase enzyme for 24 hours. The characteristic of dentin demineralization was observed by using scanning electron microscope/electron dispersive X-ray spectroscopy (SEM-EDX). Results: The SEM image in the control, Chlorhexidine, 25%; 37.5%; 50%; and 62.5% MB gel groups showed dentinal tubules of about 3.67–4.94 µm; 3.55–4 µm; 4.18–5.6 µm; 2.28–2.86 µm; 3.29–3.81 µm; and 2.42–3.17 µm in size. The EDX test found carbon (C), nitrogen (N), oxygen (O), sodium (Na), phosphorous (P), chlorine (Cl), and calcium (Ca) in all groups. The one-way Analysis of Variance (ANOVA) test results showed significant differences in the levels of C, N, O, Cl, and Ca between all groups, while the Na showed no significant differences. Conclusion: The MB can inhibit the demineralization of bovine dentin based on the decrease in the size of the dentinal tubules and increasing the C, O, P, and Ca.
PHARMACOLOGICAL INVESTIGATION OF THE ORAL WOUND HEALING ACTIVITY OF Stachytarpheta jamaicensis ROOT EXTRACT GEL IN WISTAR RATS Utami, Juliyatin Putri; Wasiaturrahmah, Yusrinie; Carabelly, Amy Nindia; Aspriyanto, Didit; Nahzi, Yanuar Ichrom; Arifin, Rahmad; Ramadhaniyah, Nur; Jatmiko, Habibi Naufal
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 12 No. 1 (2025)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2025.9390

Abstract

The Stachytarpheta jamaicensis (L) Vahl root contains bioactive compounds like saponins, alkaloids, flavonoids, tannins, phenols, and terpenoids, which have antibacterial and anti-inflammatory properties. This study investigates the wound healing effects of Stachytarpheta jamaicensis (L) Vahl root extract gel in oral mucosa. The experiment involved 28 male Wistar rats, divided into four groups: a positive control treated with povidone iodine 10%, a negative control treated with gel base, and two experimental groups treated with 6% and 10% S. jamaicensis root extract gels. The gel was applied twice daily, and wound healing was assessed by epithelial thickness, inflammation cell and hydroxyproline content. Both concentrations of S. jamaicensis root extract gel significantly enhanced wound healing, as shown by increased epithelial thickness, inflammation cell and hydroxyproline content levels compared to the negative control. These findings suggest that S. jamaicensis root extract gel effectively promotes wound healing in the excision wound model.
Gene polymorphism in oral health condition associated with coal dust exposure: a systematic review Azizi, Fabillah Haikal; Aulia, Shaula Nada; Ash-Shiddiq, Muhammad Hafizh; Carabelly, Amy Nindia; Pramitha, Selviana Rizky
Padjadjaran Journal of Dentistry Vol 37, No 3 (2025): November 2025
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol37no3.59206

Abstract

Introduction: South Kalimantan, known as the second largest coal supplier in Indonesia, is associated with the presence of significant quantities of coal dust in the environment. Coal dust contains various substances that are carcinogenic and cytotoxic. Direct contact of coal dust to the oral cavity is at risk of gene polymorphism resulting in the manifestation of diseases in the mouth. The study aimed to explore the relationship between gene polymorphisms affecting oral health conditions and coal dust exposure through a systematic review. Methods: A systematic search of PubMed, Google Scholar, Crossref, Scopus, Web of Science, Lens, and Semantic Scholar databases was conducted for English peer-reviewed articles (1/1/2004–15/9/2024) on oral-related gene polymorphisms from coal dust exposure in humans, animals, and cells. The review followed PRISMA 2020 guidelines, with a narrative synthesis of the findings. Bias was assessed using the Newcastle-Ottawa Scale (NOS), SYstematic Review Centre for Laboratory animal Experimentation (SYRCLE) and Quality Assessment Tool for In Vitro Studies (QUIN). Result: Overall 17 studies were included. From all 6.703 case-control, 136 in vivo participants and 60 cell samples showed that gene polymorphisms were more frequent in the coal dust-exposed group compared to the non-exposed group and the healthy group. Predisposing factors such smoking, length of time, and age contribute to triggering oral gene polymorphisms. The limitation of this research was the limited number of studies discussing gene polymorphisms due to coal dust exposure directly to the oral cavity, which affected the representativeness of the articles. Conclusion: There are polymorphisms in 11 oral-related genes (AhR, CYP1A1, GSTM1, GSTT1, hOGG1, IL6, IL1B, NQO1, TNF, TP53, and XRCC1) after coal dust exposure, presenting genotoxic and mutagenic potential.
Co-Authors Agung Satria Wardhana Alexander Sitepu Alya Royyana Annisa Noviany Annisa Noviany Annisa Vara Nurdianty Apriasari, Maharani Lallyza Aprilyani, Nur Arifin, Rahmad Ariyati Retno Pratiwi, Ariyati Retno Ash-Shiddiq, Muhammad Hafizh Aspriyanto, Didit Audina, Nina Aulia, Shaula Nada Azizi, Fabillah Haikal Baitullah, Muhammad Akbar Bambang Setiawan Beta Widya Oktiani Dewi Nurdiana Dewi Puspitasari Dewi Puspitasari Dewi, Renie Kumala Dhya Aurellia Salsabila Karno Dian Masita Dewi Dwipura, Irnamanda Erika Norfitriyah Eriwati, Yosi Kusuma Erni Marlina Fajriani, Nuril Fitri Syahrina Ghea Tri Andini Gita Puspa Ningrum Gusti Febby Aprilia Hamdani, Riky Hutami, Wijayanti Diah Wasi I Wayan Arya K. Firdaus I Wayan Arya Krishnawan Firdaus Ichrom Nahzi, Muhammad Yanuar Ikhwan Faisal, Ikhwan Indah Listiana Kriswandini Jatmiko, Habibi Naufal Ketut Suardita, Ketut Khairunnida Khairunnida Kurniasari, Annisa Maharani Laillyza Apriasari Maharani Laillyza Apriasari Maharani Lailyza Apriasari Maman Diki Wahyudi MARIA BINTANG Maria Tanumihardja, Maria Marina Arum Syahadati Martha Vania Saputri Maulida, Novi Dwi Melissa Budipramana Milka Widya Sari Mira Hadistiana Mohd-Said, Shahida Muhammad Hasanu Reksi Muhammad Ikhlasul Amal Sangadji Muhammad Luthfi Nafisah, Riznasyarielia Nikmatun Nahzi, Yanuar Ichrom Nina Audina Norfitriyah, Erika Norhayati Norhayati Nurashfia Nurashfia Nuril Fajriani Nurul Ikhsani Umar Pramitha, Selviana Rizky Priyawan Rachmadi Puspitasati, Dewi Putra, Fedriko Gamaliel Rahman, Yajma Kamiila Ramadhaniyah, Nur Renie Kumala Dewi Rima Permata Sari Salsabila Karno, Dhya Aurellia Sari, Galuh Dwinta Sari, Milka Widya Sherli Diana Sinaga, Udur Siti Ujrumiah Suhartono Taat Putra Sutanti, Viranda Syahrina, Fitri Syifa Kamila Timothy Jogy Sotarduga Parhusip Tom Christian Tri Putri, Deby Kania Trianuanty, Aninditya Pimas Utami, Juliyatin Putri Wahyudi, Maman Diki Wydiamala, Erida Yusrinie Wasiaturrahmah