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All Journal ODONTO Dental Journal Majalah Obat Tradisional Dentino: Jurnal Kedokteran Gigi Berkala Kedokteran Dental Journal (Majalah Kedokteran Gigi) Padjadjaran Journal of Dentistry Journal of Dentomaxillofacial Science Journal of Indonesian Dental Association E-Prodenta Journal of Dentistry Dentin Jurnal Pengabdian kepada Masyarakat Nusantara Jurnal Pengabdian Sumber Daya Manusia Odonto dental journal Jurnal Bioteknologi & Biosains Indonesia (JBBI) Jurnal Bioteknologi & Biosains Indonesia
Amy Nindia Carabelly
Department Of Oral And Maxillofacial Pathology, Faculty Of Dentistry, Lambung Mangkurat University, Banjarmasin, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Social Sciences Other

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THE EFFECT OF TOMAN FISH EXTRACT (Channa Micropeltes) ONNEUTROPHILIN DIABETES MELLITUSWOUND HEALING (In Vivo Study in the Back of Male Wistar Mice (Ratus Novergicus) Nuril Fajriani; Amy Nindia Carabelly; Maharani Laillyza Apriasari
Dentino : Jurnal Kedokteran Gigi Vol 3, No 1 (2018)
Publisher : FKG Unlam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v3i1.4613

Abstract

Background: Toman fishcontains albumin and unsaturated fatty acids which can be an alternative of diabetes mellitus wounds healing process. People with diabetes mellitus have their neutrophil decreased. Albumin increases the number of neutrophil. Unsaturated fatty acid decreases the number of neutrophil. Purpose: To prove the effect of toman fish extract of 16 ml/Kg BW mice orally on thenumber of neutrophil in day 2, 4, and 8 of male wistarmice with diabetic wound. Materials and Method: This research applied pure experimental research method with posttest only control design. This research took 36 wistarmice which weredivided into negative control group which is given BR2 feed, treatment group which is giventoman fish extract in 16 mL/Kg BW mice and positive control group which is given haruan fish extract in 13.54 mL/Kg BW mice. The Result: One-way ANOVAshowedthat there wassignificant differenceof all groups in day 2 (p=0.000), day 4 (p=0.000) and day 8 (p=0.000). Post-Hoc LSD test for the average of neutrophil number showedthat there was significant difference (p<0.05) between the negative control group, treatment group and the positive control group. Conclusion: Toman fish extract has an effect which increasesthe number ofneutrophil in day 2 and decreasesthe number of neutrophil in day 4 and 8 on the healing of diabetic wound in mice.
TOXICITY TEST OF THE MIXED MOUTHWASH OF MAULI BANANA STEM AND BASIL LEAF AGAINST FIBROBLAST CELL STUDY IN VITRO Martha Vania Saputri; Amy Nindia Carabelly; I Wayan Arya K. Firdaus
Dentino : Jurnal Kedokteran Gigi Vol 4, No 2 (2019)
Publisher : FKG Unlam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v4i2.7043

Abstract

Background: Mauli banana stem and basil leaf are herbal plants which can be used as an herbal mouthwash. People in South Kalimantan often use mauli banana stem to accelerate wound healing because of its antibacterial activity. Basil leaf are proven to inhibit bacterial growth. Mauli banana stem has a bitter taste, so to minimize that bitter taste, basil leaf can be used as a mixture. Basil leaf give fresh and aromatic effect. Extract of mauli banana stem is not toxic against fibroblast cell BHK-21 with 25% concentrate, but there is no research about the toxicity of a mixed mouthwash of mauli banana stem and basil leaf against fibroblast cell BHK-21 yet. Purpose: To analyze IC50 after treatment with a mixed mouthwash of mauli banana stem and basil leaf into the fibroblast cell BHK-21. Method: True experimental using the posttest only with control group design which consisted of 10 treatment groups with several concentrations. Those were 31,25 μg/mL, 62,5 μg/mL, 125 μg/mL, 250 μg/mL, 500 μg/mL, 1000 μg/mL, 2000 μg/mL and 4000 μg/mL. The toxicity test used MTT Assay as a method. This research was formed by 2 stages, which were preparation of fibroblast cell BHK-21 and the toxicity test. The cell viability counted with Freshney formula. Result: The result showed that the IC50 was 2183,43 μg/mL. Conclusion: The mixed mouthwash of mauli banana stem and basil leaf is not toxic against fibroblast cell BHK-21 because IC50 is 2183,43 μg/mL.
THE INFLUENCE OF TOMAN FISH (Channa micropeltes) EXTRACT ON THE NUMBER OF NEOVASCULAR IN DIABETES MELLITUS WOUND HEALING In Vivo Study on the Back of Male Wistar Rat (Rattus novergicus) Alya Royyana; Amy Nindia Carabelly; Didit Aspriyanto
Dentino : Jurnal Kedokteran Gigi Vol 3, No 2 (2018)
Publisher : FKG Unlam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v3i2.5362

Abstract

Background: Patients with diabetes mellitus (DM) have delayed wound healing. This happens becauseof the depletion of neovascular number. Neovascular plays an important role in wound healing by restoringblood flow to the wound area, so the new tissue gets enough oxygen and nutrition supply to proliferate. Tomanfish (Channamicropeltes) contains albumin that can increase and decrease the number of neovascular, so it’spotentially become an alternative medicine to accelerates wound healing in DM. Purpose: The aim of thisresearch to prove the effect of toman extract dose 16 ml/Kg BW rat orally on the number of neovascular inwound of diabetic wistar rats on the 4th,8th and 14th day. Materials and methods: This research used trueexperimental method with posttest only control group design. This research used 36 wistar rats which were thendivided into 9 groups, toman fish extract dose 16 ml/Kg BW of rat group, haruan fish extract dose 13,54 ml/KgBW of rat group and BR2 feed only group. Research result: The results of One Way-Anova and Post Hoc LeastSignificant Difference tests showed there was a significant difference between group of toman extract and groupof feed only, while on group of toman extract and group of haruan extract showed there was no significantdifference on 4th,8th and 14th day. The average value of toman extract-given group on 4th, 8thand 14th day were14,75. 7,5 and 6,75 respectively. Conclusion: Toman extract has effects which are increasing the number ofneovascular on 4th day and decreasing the number of neovascular on 8th and 14th day in wound healing withDM.
EFFECT OF CHANNA MICROPELTES IN THE GRANULATION, FIBROSIS AND NECROSIS OF DIABETIC WOUND HEALING Amy Nindia Carabelly; Juliyatin Putri Utami; Didit Aspriyanto; Muhammad Hasanu Reksi; Dewi Puspitasari; Priyawan Rachmadi
Dentino : Jurnal Kedokteran Gigi Vol 6, No 2 (2021)
Publisher : FKG Unlam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v6i2.12001

Abstract

Background: Diabetes mellitus (DM) is characterized by persistent hyperglycemia. The symptoms of DM is delayed wound healing. Delayed wound healing in diabetes will increase the risk of wound complications that will hinder the healing process, and lead to complications such as fibrosis and necrosis. The use of Channa Micropeltes (CM) extract at a dose of 16 mL/kg BW orally is proven to general optimal wound closure and wound contraction clinically in Wistar rats as diabetic model on day 14.However, the histopathological description of wound healing is yet to be known. Objective: To analyze the effect of 16 mL/kg BW dose of CM extract on histopathological changes of wound healing granulation tissue, fibrosis and necrosis in diabetic Wistar rats on day 14. Materials and Methods: This study was a true experimental design with a post-test only control group design. The samples were divided into two groups, namely the diabetic model group given CM extract at 16 mL/kg BW dose for 14 days, and the diabetic model group given BR2 feed only for 14 days. Results: The results of Mann-Whitney U test showed p = 0.003 for granulation tissue, p = 0.411 for fibrosis and p = 1 for necrosis, with the level of significance was p<0.05. Conclusion: The CM extract at 16 mL/kg BW dose affects the histopathological description of granulation tissue which presents a better result than those in the control group but did not affect the features of fibrosis and necrosis in diabetic Wistar rats on day 14. Keywords: Channa Micropeltes, Diabetic wound, Fibrosis, Granulation tissue, Necrosis.
THE EFFECT OF TOPICAL TOMAN (Channa micropeltes) FISH EXTRACT ON THE NUMBER OF NEUTROFIL CELLS IN DIABETES MELITUS WOUND HEALING (In Vivo Study on Male Wistar (Rattus novergicus) Rat’s Back) Annisa Vara Nurdianty; Maharani Laillyza Apriasari; Amy Nindia Carabelly
Dentino : Jurnal Kedokteran Gigi Vol 4, No 2 (2019)
Publisher : FKG Unlam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v4i2.7059

Abstract

Backgrounds: Diabetes mellitus forges the wound healing process to last longer. Toman fish which contains albumin and omega-6 fatty acid is proven to to enhance wound healing process in this systemic condition. Patients who suffer from diabetes mellitus retain high neutrophil number. Omega-6 fatty acids contained in Toman fish can decrease the number of  neutrophil cells. Objectives:  To prove the effect of Toman fish (Channa micropeltes) extract at 20% concentration topically on the number of neutrophil in diabetes mellitus-induced Wistar Rat (Rattus novergicus) injuries on day 4, 8 and 14.  Methods: This research was a true experimental study with posttest-only and control group with complete random design. Thirty six male Wistar rats (Rattus novergicus) was divided evenly for three treatments comprised of negative control given BR2 comfeed, positive control treated with Haruan fish (Channa striata) extraxt at 10% concentration topically and treatment group given with Toman fish (Channa micropeltes) extract at 20% concentration topically. Results: The data was analyzed using One Way ANOVA and was presenting the result of the 4th day (p=0.000), 8th day (p=0.001) and 14th day (p=0.000). Post-hoc Least Significant Difference (LSD) showed that p value was less than 0.05 which means that there was a significance difference in the mean of all treatment groups. Conclusion: Toman fish (Channa micropeltes) extract possesses the capacity in decreasing the number of neutrophil on 4th, 8th and 14th day in diabetic wound healing of Wistar Rat (Rattus novergicus).
PYTHOCHEMICAL SCREENING OF Musa acuminata STEM WATER EXTRACT Amy Nindia Carabelly; Didit Aspriyanto
Dentino : Jurnal Kedokteran Gigi Vol 5, No 1 (2020)
Publisher : FKG Unlam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v5i1.8127

Abstract

Background: Regenerative therapy has been progressing into the utilization of mesenchymal stem cell (MSC). Nevertheless, the limited number of MSC has put growth factor as an essential supplement for cell culture media yet relatively unaffordable because highly priced. Alternative compound which cost reasonably is required. Exogenous phytochemical material in herbal plant extract may increase the number of MSC, one of which is mauli banana stem. Purpose: To analyze secondary metabolites identified in mauli banana stem water extract. Method: Mauli banana stem was macerated using water solvent to be analyzed qualitatively for alkaloid, tannin, flavonoid, saponin, terpenoid, diterpen and steroid. Screening was followed by quantitative analysis to determine the total of alkaloid, flavonoid, condensed tannin and hydrolysable tannin. Result: Secondary metabolite compounds of mauli banana stem water extract were alkaloid (4.15%), hydrolysable tannin (1.055%), condensed tannin (0.42%) and flavonoid (0.31%). Conclusion: Mauli banana stem water extract has potential as alternative growth factor to increase the number of MSC in vitro.
THE EFFECT OF TOMAN (Channa micropeltes) FISH EXTRACT ON EPITHELIAL THICKNESS IN DIABETES MELLITUS WOUND HEALING (In Vivo Study on the back of male Wistar rat (Rattus novergicus)) Nina Audina; Amy Nindia Carabelly; Didit Aspriyanto
Dentino : Jurnal Kedokteran Gigi Vol 3, No 1 (2018)
Publisher : FKG Unlam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v3i1.4614

Abstract

Background: Re-epithelialization is the process of formation of new epithelium which is important in wound healing process, the faster the process then the sooner the process of wound healing. Toman fish (Channa micropeltes) is trusted as an alternative medicine to accelerate wound healing. Toman fish contains albumin which acts an antioxidant. Antioxidant can reduce Reactive Oxygen Species (ROS) which increased at state of hyperglicemia in people with diabetes mellitus (DM), Thus accelerating the process of Re epithelialization on diabetes wound. Purpose: The Purpose of this research was to prove that fish extract Toman dose 16 ml/Kg body weight effect on thickness of the epithelium of Wistar Rat Injuries Induced DM are seen on the 2, 4 and 8 day. Material and methods: This research was true experimental design with posttest-only with control design with complete random design. This research used 27 Wistar rats are divided into 9 treatment groups, Toman fish extract dose 16 mL/Kg BW, Haruan fish extract 13,54 mL/Kg BW, and BR2 feed only. The calculation of epithelial thickness was calculates using the ImageJ software application by measuring histopathological results. Research result: The result of Two way Anova test and Post Hoc LSD test showed that there was a significant difference of effect on group Toman fish extract 16 mL/Kg BW with Haruan fish extract 13,54 mL/Kg BW and BR2 feed only to increase the thickness of the wound of epithelium of Wistar rat Induced DM. Toman fish extract showed the highest mean of epithelial thickness with 2nd day (76,69 µm), 4th day (99,21 µm) and 8th day (124,23 µm). Conclusion: There was effect of Toman fish extract dose 16 mL/Kg BW on increased epithelial thickness of Wistar rats wound on induced diabetes mellitus are seen on the days 2, 4 and 8.
Angular cheilitis and oral pigmentation as early detection of Peutz-Jeghers syndrome Maharani Laillyza Apriasari; Amy Nindia Carabelly
Dental Journal (Majalah Kedokteran Gigi) Vol. 51 No. 1 (2018): March 2018
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (508.174 KB) | DOI: 10.20473/j.djmkg.v51.i1.p29-32

Abstract

Background: Peutz-Jeghers syndrome (PJS) is an inherited autosomal dominant disease determined by a mutation localized at 19p13.3 characterized by the occurrence of gastrointestinal hamartomatous polyps in association with mucocutaneous hyperpigmentation. The manifestation of PJS may first be encountered by a dentist during routine examination due to the presence of pigmented spots in the oral cavity. Purpose: To prevent a high risk of PJS, the dentist must establish its oral manifestation through early detection. Case: A 14-year-old male patient attended complaining of a week-long pain at the corners of the lips. An extra-oral exam revealed fissure lesions, redness, white crust and pain. The patient had experienced bleeding in his bowel movements, abdominal pain, nausea and vomiting since childhood. A number of black, painless, macular lesions, some 1-3 mm in diameter, were present on the upper lips, lower lips, fingers and palms. Case management: The patient was referred for a complete blood count check. The results obtained confirmed him to be suffering from severe anemia and he was, therefore, referred to an internist for treatment for PJS. Conclusion: It can be concluded that the early detection of PJS is crucial in order that the patient receives prompt treatment.
Ekstrak metanol batang pisang mauli (Musa sp.) dosis 125-1000 mg/kg bb tidak menimbulkan efek toksik pada hati mencit (Mus musculus) Mauli methanol extract of banana (Musa sp.) dosages of 125-1000 mg/kg bw is not cause toxic effects on the liver of mice (Mus musculus) Maharani Laillyza Apriasari; Amy Nindia Carabelly; Ghea Tri Andini
Journal of Dentomaxillofacial Science Vol. 12 No. 2 (2013): Formerly Jurnal Dentofasial ISSN 1412-8926
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15562/jdmfs.v12i2.355

Abstract

Musa sp. is one of Kalimantan Selatan original plant that empirically has benefit as herbal medicine for acceleration of wound healing. Banana contain many phytochemicals such us saponin, flavonoid, and tannin which can be used asantibiotic, pain relieving and anti inflamantory. This experiment was aimed to know the toxicity effect of methanolicextract of mauli banana stem inmice livers histopathological. The research is pure experimental study using post testonly with control design. Populations were 25 mices, divided into 5 groups. Group I as negative control group weregiven aquadest, and group II, III, IV, and V were given 125 mg, 250 mg, 500 mg, and 1000 mg methanolic extract ofMauli banana stem. They were given treatment daily as long as 21 days. All of the mice were necropsied at day 22, andthe livers were taken for to examine their histopatological changes. Each liver tissue was processed by paraffin blockembededdand hematoxylin eosin staining method. Histopathological changes were examined based on the present necrosis, degeneration, and megalohepathosit lesions. The results showed light necrosis, degeneration, andmegalohepathosit on the treatment group. The conclusion was methanolic extract of Mauli banana stem dosage 1251000mg/kgbwis not toxic significantly on the liver of mice.
Efektivitas ekstrak metanol batang pisang mauli 100%padapenyembuhan luka punggung mencit (Mus musculus)ditinjau dari jumlah sel radang (Effectiveness of 100%extract of Mauli Banana stem to healing process of mice’s (Mus musculus)back from the perspective of the number of inflamed cell) Maharani Laillyza Apriasari; Amy Nindia Carabelly; Gusti Febby Aprilia
Journal of Dentomaxillofacial Science Vol. 13 No. 1 (2014): Formerly Jurnal Dentofasial ISSN 1412-8926
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15562/jdmfs.v13i1.384

Abstract

Banana plant especially its trunk contains many kinds of fitokimia such as saponin, flavonoid, and tannin whichfunction as antibiotic and fasten the healing process. Mauli banana stem extract is often used by the people in HuluSungai Utara Banjarmasin Province to fasten healing skin injury. The purpose of this research is to histopathologicallyexamine the effectiveness of Mauli Banana stem extract to the healing process of the mice’s back (Mus musculus)onthe 3rd day. This purely true experimental research with post test only with control design used 27 mices which weredivided to 3 groups. Treatment group was given methanol extract of mauli banana stem whose average scores ofneutrofil and macrofag are representatively 2.333 and 1; negative control group was given aquadest with its averageneutrofil and macrofag scores are representatively 1.055 dan 1.678; and positive control group was given standardmedicine which contained Aloe veraextract with its average neutrofil and macrofag scores are representatively 1.066dan 1.667. The result of Kruskall-Wallis and Mann-Whiney showed a significant difference between treatment groupand negative control group. It can be concluded that the extract methanol of mauli banana stem on the healing processof injury to mancit’s back histopathologically influences the decreasing acute inflamed (neutrofil) cell and theincreasing chronic inflamed (macrophage) cell on the third day. In this case the extract of mauli banana stem ismedically potential to fasten the healing process of injury.
Co-Authors Agung Satria Wardhana Alexander Sitepu Alya Royyana Annisa Noviany Annisa Noviany Annisa Vara Nurdianty Apriasari, Maharani Lallyza Aprilyani, Nur Arifin, Rahmad Ariyati Retno Pratiwi, Ariyati Retno Ash-Shiddiq, Muhammad Hafizh Aspriyanto, Didit Audina, Nina Aulia, Shaula Nada Azizi, Fabillah Haikal Baitullah, Muhammad Akbar Bambang Setiawan Beta Widya Oktiani Dewi Nurdiana Dewi Puspitasari Dewi Puspitasari Dewi, Renie Kumala Dhya Aurellia Salsabila Karno Dian Masita Dewi Dwipura, Irnamanda Erika Norfitriyah Eriwati, Yosi Kusuma Erni Marlina Fajriani, Nuril Fitri Syahrina Ghea Tri Andini Gita Puspa Ningrum Gusti Febby Aprilia Hamdani, Riky Hutami, Wijayanti Diah Wasi I Wayan Arya K. Firdaus I Wayan Arya Krishnawan Firdaus Ichrom Nahzi, Muhammad Yanuar Ikhwan Faisal, Ikhwan Indah Listiana Kriswandini Jatmiko, Habibi Naufal Ketut Suardita, Ketut Khairunnida Khairunnida Kurniasari, Annisa Maharani Laillyza Apriasari Maharani Laillyza Apriasari Maharani Lailyza Apriasari Maman Diki Wahyudi MARIA BINTANG Maria Tanumihardja, Maria Marina Arum Syahadati Martha Vania Saputri Maulida, Novi Dwi Melissa Budipramana Milka Widya Sari Mira Hadistiana Mohd-Said, Shahida Muhammad Hasanu Reksi Muhammad Ikhlasul Amal Sangadji Muhammad Luthfi Nafisah, Riznasyarielia Nikmatun Nahzi, Yanuar Ichrom Nina Audina Norfitriyah, Erika Norhayati Norhayati Nurashfia Nurashfia Nuril Fajriani Nurul Ikhsani Umar Pramitha, Selviana Rizky Priyawan Rachmadi Puspitasati, Dewi Putra, Fedriko Gamaliel Rahman, Yajma Kamiila Ramadhaniyah, Nur Renie Kumala Dewi Rima Permata Sari Salsabila Karno, Dhya Aurellia Sari, Galuh Dwinta Sari, Milka Widya Sherli Diana Sinaga, Udur Siti Ujrumiah Suhartono Taat Putra Sutanti, Viranda Syahrina, Fitri Syifa Kamila Timothy Jogy Sotarduga Parhusip Tom Christian Tri Putri, Deby Kania Trianuanty, Aninditya Pimas Utami, Juliyatin Putri Wahyudi, Maman Diki Wydiamala, Erida Yusrinie Wasiaturrahmah