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All Journal JURNAL ILMIAH PLATAX Saintek Perikanan : Indonesian Journal of Fisheries Science and Technology Bioma : Berkala Ilmiah Biologi Pharmaciana: Jurnal Kefarmasian Jurnal Kelautan : Indonesian Journal of Marine Science and Technology Jurnal Perikanan dan Kelautan Agrokreatif Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal FishtecH Omni-Akuatika Wikrama Parahita : Jurnal Pengabdian Masyarakat Jurnal Penelitian Pendidikan IPA (JPPIPA) EnviroScienteae Squalen Bulletin of Marine and Fisheries Postharvest and Biotechnology JCES (Journal of Character Education Society) Jurnal Kelautan dan Perikanan Terapan (JKPT) Jurnal Kelautan Nasional Abditani : Jurnal Pengabdian Masyarakat Jurnal Pascapanen dan Bioteknologi Kelautan dan Perikanan Jurnal Ilmiah Tatengkorang Jurnal Ilmiah Sesebanua Advances in Food Science, Sustainable Agriculture and Agroindustrial Engineering (AFSSAAE) JURNAL PERIKANAN TROPIS KAUDERNI PELAGICUS: Jurnal IPTEK Terapan Perikanan dan Kelautan Jurnal Empathy Pengabdian Kepada Masyarakat Juvenil: Jurnal Ilmiah Kelautan dan Perikanan Jurnal Pengabdian Kepada Masyarakat Pengmasku Batara Wisnu : Indonesian Journal of Community Services Jurnal Sains dan Teknologi Abdimas Indonesian Journal JURNAL PENGABDIAN PENDIDIKAN MASYARAKAT (JPPM) Jurnal Ilmiah Pengabdian Kepada Masyarakat Jurnal Penelitian Chanos Chanos Depik Jurnal Ilmu-Ilmu Perairan, Pesisir dan Perikanan Amal Ilmiah: Jurnal Pengabdian Kepada Masyarakat Depik Jurnal Ilmu-Ilmu Perairan, Pesisir, dan Perikanan Jurnal Perikanan
Wendy Alexander Tanod
Aquatic Product Processing And Storage, Department Of Fisheries And Marine, Politeknik Negeri Nusa Utara, Tahuna, Sangihe Islands, North Sulawesi 95812, Indonesia
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Journal : JURNAL ILMIAH PLATAX

 1 
Antifungal Potential Of The Sponge Styllisa Flabelliformis Against The Pathogenic And Resistant Aspergillus Fungi Tomasoa, Aprelia Martina; Rieuwpassa, Frets Jonas; Azhari, Deidy; Ijong, Frans Gruber; Mege, Revolson Alexius; Tanod, Wendy Alexander; Balansa, Walter
Jurnal Ilmiah Platax Vol. 11 No. 1 (2023): ISSUE JANUARY-JUNE 2023
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35800/jip.v11i1.48603

Abstract

Together with bacterial and viral infection, fungal infection represents the world's top ten killer diseases, desperately requiring new antifungal drugs. This research aimed to evaluate the antifungal activity of the sponge Styllisa flabelliformis against the pathogenic fungi Aspergillus flavus and Aspergillus parasiticus by the standard agar diffusion technique. Three concentrations (1, 10, and 10 mg/mL) for the extract and 0.5 mg/mL for ketoconazole and fluconazole were prepared and evaluated in triplicate against the tested fungi. Whereas ketoconazole poorly inhibited A. parasiticus and fluconazole weakly inhibited A. flavus, the extract of S. flabelliformis exerted antifungal activity against A. parasiticus (6.8 ± 1.8; 8.3 ± 3.2; and 9.5 ± 2.1) mm and A. flavus (6.8 ± 1.1; 11.5 ± 1.4; and 14.3 ± 1.1) mm 1, 10 and 100 mg/mL respectively. PASS analysis showed jasplakinolide as a promising antifungal agent with potential activity (Pa) of 0.736. STITCH analysis further confirmed that jasplakinolide worked by inhibiting the expression of cytoskeleton genes that prevented fungi from synthesizing chitin and inhibiting the formation of the fungi’s cell walls and hyphae, different from the ergosterol synthesis inhibition in ketoconazole and fluconazole, implying the potential of jasplakinolide as an antifungal agent.
Co-Authors AA Sudharmawan, AA Abigail Mary Moore Adel, Yeldi S Agus Turambi Alismi M Salanggon Alismi M Salanggon Amelia, Resky Anggraini Barlian Anita Treisya Aristawati Anita Treisya Aristawati Aprelia M. Tomasoa Aprelia M. Tomasoa Aprelia Martina Tomasoa, Aprelia Martina Asriani Hasanuddin Astri Juwita Mahihody Azhari, Deidy Balansa, Walter Biahimo, Syahputra Bilqis, Dewi Shofya Cahyono, Eko Christian A. Manansang Deddy Wahyudi Deddy Wahyudi Deddy Wahyudi Deddy Wahyudi Deddy Wahyudi Destu Ayu Hapsari Destu Ayu Hasari Dewanto, Didit Kustantio Dewanto, Didit Kustantio Dewanto, Didit Kustantio Didit Kustantio Dewanto Didit Kustantio Dewanto Didit Kustantio Dewanto Didit Kustantio Dewanto Didit Kustantio Dewanto Didit Kustantio Dewanto Didit Kustantio Dewanto Edward Irsan L. Ferre EKO CAHYONO Eko Cahyono Eko Cahyono, Eko Ely John Karimela Eunike Irene Kumaseh Finarti Finarti Finarti Finarti Finarti, Finarti Firman Farid Muhsoni Fitria F. Lungary Frans Gruber Ijong Frets Jonas Rieuwpassa Frets Jonas Rieuwpassa Gansalangi Ferdinand hanifah hanifah Herjumes Aatjin Indra Wibowo Jaka F.P. Palawe Jaka Frianto Putra Palawe Janis, Ronaldo Ferdinan Jefri Antonius Mandeno Jimi Palawe Kasaluhe, Meityn Kendek, Tasya Jenifel Kris Handoko Kundiman, Gita Artika Putri Lawendatu, Angryani Enjel Lawendatu, Angryani Enjela Livana Dethris Rawung Maalua, Sheyla Magie Kapojos Mahihody, Astri Mahihody, Astri Juwita Makisake, Nadia Arlina Manampiring, Nonny Mandalika, Ervina Dian Mandeno, Jefri Anthonius Mandiangan, Meyrijean Marnens Ch. Karaeng Masteria Yunovilsa putra Meityn Disye Kasaluhe Moh. Yasir Mohamad Akbar Muliadin Muliadin Muliadin Muliadin Muliadin Muliadin Muliadin Muliadin Muliadin, Muliadin Musdalifah Musdalifah Novalina M. Ansar Novalina Maya Sari Ansar Novelia Tatinting Obyn I. Pumpente Obyn Imhart Pumpente Pramardika, Dhito Dwi Putra, Masteria Yunovilsa Putut Har Riyadi Putut Har Riyadi Remy E. P Mangindaan Renol Renol Renol, Renol Revolson Mege Roni Hermawan Roni Hermawan Roni Hermawan Roni Hermawan Roni Hermawan Roni Hermawan, Roni Rorong, Miranda Salanggon, Alismi M Samliok Ndobe Sari Aswani Septania Takasiaheng Siegfried Berhimpon Siti Aisiah Somba, Vira Valentine Stevy I. M. Wodi Stevy Imelda Murniati Wodi Steward I. Makawekes Takasihaeng, Septania Tampany, Ighen Tampi, Regina Romalya Meilan Tengkue, Fiorenza Puspa Indah Tengkue, Florenza Puspa Indah Tinungki, Maria Notosari Tinungki, Maria Notosori Trivonia Kerol Talete Usy N. Manurung Walter Balansa Wodi, Stevy Imelda Murniati Yana Sambeka Yana Sambeka Yeldi S Adel Yeldi S Adel Yulina Irawati Zakinah A Alhaddad