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Jasmiadi Jasmiadi
Program Studi Farmasi Fakultas MIPA Universitas Islam Makassar
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Education Energy Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics Public Health

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Pengaruh Pemberian Ekstrak Etanol Biji Kopi Robusta (Coffea chanefora L.) Pada Tikus Diabetes Melitus Hasanuddin, Rusman; pratama, Agus sangka; Irhas, Muhammad; Jasmiadi
Jurnal Novem Medika Farmasi Vol. 1 No. 2: volume 1 Issue 2
Publisher : Program Studi Farmasi, Universitas Islam Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59638/junomefar.v1i2.600

Abstract

Biji kopi robusta yang dapat menurunkan kadar glukosa darah adalah asam klorogenat. Tujuan penelitian untuk mengetahui pengaruh pemberian ekstrak etanol biji kopi robusta (Coffea chanefora L.) pada tikus (Rattus novegicus) diabetes mellitus tipe II yang di induksi oakan diet tinggi lemak. Metode penelitian dilakukan simplisia biji kopi robusta di maserasi dengan pelarut aquadest : etanol 96% (7:3). Penelitian menggunakan 25 ekor tikus wistar, 5 kelompok perlakuan glukosa darah awal, kemudian di induksi dengan pakan diet tinggi lemak selama 8 minggu. Kelompok I sebagai kontrol negatif (aquadest), kelompok II sebagai kontrol positif (Metformin), kelompok III, IV dan V diberikan perlakuan ekstrak etanol biji robusta 200 mg/kgBB, 300 mg/kgBB dan 400 mg/kgBB selama 7 hari. Kemudian diukur kadar glukosa darah dengan menggunakan glucometer hari ke 3 dan hari ke 7. Berdasarkan hasil penelitian, analisis data dan pembahasan maka dapat disimpulkan bahwa ekstrak etanol biji kopi robusta (Coffea chanefora L.) pada tikus (Rattus novergicus) diabetes mellitus tipe II, dengan dosis 200 mg/kgBB, 300 mg/kgBB dan 400 mg/kgBB mempengaruhi penurunan kadar glukosa darah puasa dan kadar glukosa darah sewaktu pada tikus yang telah diinduksi pakan tinggi lemak.
Aktivitas Antibakteri Ekstrak Etanol Umbi Rumput Teki (Cyperus rotundus L.) Terhadap Pertumbuhan bakteri Streptococcus mutans Sartini, Sartini; Jasmiadi; Nur zam zam, Andi; Irfayanti, Nur Alfiah; Nurdin, Fatmawati
Jurnal Novem Medika Farmasi Vol. 1 No. 2: volume 1 Issue 2
Publisher : Program Studi Farmasi, Universitas Islam Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59638/junomefar.v1i2.601

Abstract

Umbi rumput teki (Cyperus rotundus L.) mengandung senyawa polifenol (flavonoid, kumarin dan tannin) dan senyawa polifenol memiliki aktivitas antibakteri. Tujuan penelitian ini adalah untuk mengetahui ekstrak umbi rumput teki yang dapat menghambat pertumbuhan baktri Streptococcus mutant. Ekstraksi dilakukan dengan metode remaserasi menggunakan cairan penyari etanol 70% (1:5). ekstrak dibuat dengan konsentrasi 5% b/v, 10% b/v dan 20% b/v digunakan dalam uji aktivitas umbi rumput teki dengan menggunakan metode kirby bauer dengan difusi cakram (diameter 6 mm). Hasil penelitian menunjukkan bahwa ekstrak umbi rumput teki mempunyai aktivitas antibakteri terhadap Streptococcus mutans dengan konsentrasi 5% b/v, 10% b/v dan 20% b/v dengan masing-masing diameter zona hambat 6,61 mm; 7,71 mm; 8,13 mm;. diperoleh kesimpulan bahwa ekstrak umbi rumput teki dapat menghambat bakteri Streptococcus mutant.
Aktivitas Antipiretik Ekstrak Etanol Daun Beligo (Benincasa hispida (Thunb.) Cogn.) Pada Tikus Alim, Nur; Jasmiadi; sulastri, dewi; pratama, Agus sangka
Jurnal Novem Medika Farmasi Vol. 1 No. 2: volume 1 Issue 2
Publisher : Program Studi Farmasi, Universitas Islam Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59638/junomefar.v1i2.610

Abstract

Beligo merupakan tanaman yang dipercaya oleh masyarakat Indonesia sebagai obat demam. Penelitian tentang buah beligo sebagai obat demam telah banyak dilakukan. Namun, pada daun belum dilakukan sehingga pada penelitian ini dilakukan uji aktivitas antipiretik ekstrak etanol daun beligo (Benincasa hispida (Thunb.) Cogn.) pada tikus putih (Rattus norvegicus). Tujuan penelitian ini untuk mengetahui aktivitas antipiretik ekstrak etanol daun beligo pada tikus putih. Metode penelitian ini meliputi ekstraksi dan pengujian antipiretik dengan metode design pre post test with control group. Ekstraksi dilakukan secara maserasi dengan pelarut etanol 70%. Pengujian antipiretik yaitu tikus putih sebanyak 15 ekor dibagi menjadi 5 kelompok perlakuan. Kelompok I kontrol negatif diberi Na-CMC 1%, kelompok II kontrol positif diberi paracetamol, kelompok III, IV dan V diberi ekstak etanol daun beligo dosis 250 mg/kg BB, 500 mg/kg BB dan 750 mg/kg BB yang diinduksi pepton 5%, dilakukan pengukuran suhu awal, suhu setelah induksi dan suhu setelah perlakuan setiap 30 menit selama 180 menit. Hasil penelitian dianalisis secara statistik menggunakan Rancangan Acak Lengkap (RAL) dan uji Duncan yang menunjukkan bahwa ekstrak etanol daun beligo dosis 250 mg/kg BB, 500 mg/kg BB dan 750 mg/kg BB memiliki aktivitas antipiretik secara signifikan (p<0,05) yang tidak berbeda nyata dengan kontrol positif tablet paracetamol.
Aktivitas Antibakteri Ekstrak Etanol Daun Langsat (Lansium domesticum correa) Terhadap Staphylococcus aureus Dan Escherichia coli Pratama, Agus Sangka; jasmiadi, Jasmiadi; musdalifah; yusharumi
Jurnal Novem Medika Farmasi Vol. 1 No. 3: Volume 1 Issue 3
Publisher : Program Studi Farmasi, Universitas Islam Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59638/junomefar.v1i3.665

Abstract

Penelitian tentang uji aktivitas antibakteri ekstrak etanol daun Langsat (Lansium domesticum Correa) telah dilakukan. Tujuan penelitian ini adalah untuk mengetahui aktivitas antibakteri ekstrak etanol daun Langsat Lansium domesticum Correa) terhadap Bakteri Staphylococcus aureus dan Escherichia coli. Metode penelitian meliputi ekstraksi daun Langsat (Lansium domesticum Correa) secara maserasi menggunakan etanol 96%, pengujian aktivitas antibakteri terhadap bakteri Staphylococcus aureus dan Escherichia coli dengan metode difusi agar, dengan parameter zona hambatan yang terbentuk. Hasil penelitian menunjukkan konsentrasi 0,8%;1,6%;3,2; masing-masing memiliki diamenter hambatan sebesar 8,99 mm; 9,39 mm; 11,30 mm terhadap bakteri Staphylococcus aures dan 5,5%; 6%; 6,5% masing-masing memiliki diameter hambat sebesar 11,69 mm; 11,83 mm; 31,36 mm terhadap bakteri Escherichia coli. Daun Langsat (Lansium domesticum Correa) memiliki aktivitas antibakteri terhadap bakteri Staphylacoccus aureus dan Escherichia coli.
UJI AKTIVITAS ANTIOKSIDAN HASIL FRAKSINASI EKSTRAK METANOL DAUN ILALANG (Imperata cylindrica Linn.) DENGAN METODE DPPH Munadi, Rachmin; Jasmiadi; Ruslan, Ega Rossalinda
Cokroaminoto Journal of Chemical Science Vol. 6 No. 1 (2024)
Publisher : Universitas Cokroaminoto Palopo

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Research on the antioxidant activity of fractionated illalang (Imperata cylindrica Linn.) leaf extract using the DPPH method has been carried out. This research aims to determine the IC50 value of the n-Hexane fraction and the 70% ethanol fraction from the methanol extract of thatch leaves using the DPPH method. The research method was carried out by maceration extraction using methanol filter fluid. The methanol extract was fractionated using n-Hexane and 70% ethanol to produce n-Hexane and 70% ethanol fractions. The antioxidant activity test of methanol extract, n-Hexane fraction and 70% ethanol was carried out using the DPPH method. The results of the antioxidant activity test of the methanol extract of Illang leaves and the 70% ethanol fraction obtained an IC50 value of 14,786 μg/mL and 11,588 μg/mL respectively, classified as a very strong antioxidant, while the n-Hexane fraction obtained an IC50 value of 100,371 μg/mL and was classified as an antioxidant. strong.
Aphrodisiac Activity of Beligo (Benincasa hispida (Thunb.) Cogn.) Seeds of Ethanol Extract in Mice Alim, Nur; Jasmiadi, Jasmiadi; Nadillah, Nadia; Indrawaty Kadir , Ira; Afirah, Nur
Jurnal Kedokteran Brawijaya Vol. 33 No. 2 (2024)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2024.033.02.1

Abstract

Beligo (Benincasa hispida (Thunb.) Cogn.), is empirically used by the people of South Sulawesi-Indonesia as an aphrodisiac. Beligo seeds contain alkaloids, phenolics, flavonoids, and unsaturated fatty acids, which have the potential to act as aphrodisiacs. The primary objective of this research is to determine the aphrodisiac activity of an ethanol extract from beligo seeds in mice.  The procedure entails extraction and aphrodisiac evaluation using introduction, climbing, and coitus test parameters. Aphrodisiac testing was carried out for seven days using 25 mice as experimental animals, divided into five groups. Each group consists of four males and one female. Group I was given Sod. CMC 1% as a negative control; II, III, and IV were given ethanol extracts of beligo seeds at doses of 350mg/kg, 700mg/kg, 1400mg/kg BW, and group V, as a positive control, was given Yohimbine. The results showed that the ethanol extract of beligo seeds at doses of 350mg/kg BW, 700mg/kg BW, and 1400mg/kg BW had aphrodisiac activity (p=0.0001) compared to Sod. CMC 1% based on data on the amount of introduction and climbing. However, based on data on the number of coitus, it showed that the ethanol extract of beligo seeds at doses of 350mg/kg BW (p=0.072) had no aphrodisiac activity, 700mg/kg BW (p=0.007), 1400mg/kg BW (p=0.0001) had aphrodisiac activity compared to Na-CMC 1% and only a dose of 1400 mg/kg BW had the same aphrodisiac activity compared with Yohimbine (p=0.967). It is concluded that the ethanol extract of beligo seeds had aphrodisiac activity.
Effect of Giving Ethanol Extract of Robusta Coffee Beans (Coffea canephora Pierre ex A. Froehner) Based on Immunohistochemical Examination of GLUT-4 Protein Expression in White Rats (Rattus norvegicus) Model of Diabetes Mellitus Jasmiadi; Rusman; Nur Alim; Tarisa Jabal Rahma
Jurnal Penelitian Pendidikan IPA Vol 11 No 8 (2025): August
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i8.12044

Abstract

Metabolic disorders are characterized by an increase in blood sugar due to a decrease in insulin secretion by pancreatic beta cells. Cells are unable to stimulate glucose absorption in muscle and fat tissue. The presence of GLUT-4 can increase the rate of glucose entry into insulin target tissues. The chlorogenic acid compound in robusta coffee beans is believed to lower blood glucose levels by activating GLUT-4. The aim of the research was to determine the effect of administering ethanol extract of robusta coffee beans (Coffea canephora Pierre ex A. Froehner) based on immunohistochemical examination of GLUT-4 protein expression in mice (Rattus norvegicus) with Type 2 Diabetes Mellitus. The research method included extraction by maceration with 96% ethanol: distilled water (3:7) solvent and immunohistochemical testing of the effect of ethanol extraction of Robusta coffee beans on mice. Rats were divided into 5 treatment groups, namely, Na-CMC 1%, metformin, 150 mg/kg BB, 300 mg/kg BB and 450 mg/kg BB and fed a high-fat diet for 6 months and immunohistochemical examination of skeletal muscle tissue was carried out. The results of immunohistochemical examination found that protein expression occurred in the positive control of coffee bean ethanol extract at doses of 150 mg/kg BB, 300 mg/kg BB and 450 mg/kg BB. The statistical test results show that the ethanol extract of robusta coffee beans at doses of 150 mg/kg BB, 300 mg/kg BB and 450 mg/kg BB is significant with the negative control      Na-CMC 1% but with the positive control metformin the three doses of ethanol extract of robusta coffee beans are not significant. From the discussion above, it can be concluded that the ethanol extract of robusta coffee beans has an effect at doses of 300 mg/kg BB and 450 mg/kg BB
Co-Authors A. Ihdinal Hagg A. Suparlan Isya Syamsu Abdillah, Nurliana Afirah, Nur Ahmad Fauzan Alda Ta.ri Alim, Nur andi nur zam zam aprianti, ayu Hasanuddin, Rusman Indrawaty Kadir , Ira Irfayanti, Nur Alfiah Muhammad Irhas, Muhammad Munadi, Rachmin Musdalifah Musdalifah Nadillah, Nadia Nur Alfiah Irfayanti Nur Alim Nur Alim Nur Linda Nurdin, Fatmawati Nurliana Abdillah Pratama, Agus Sangka Ruslan, Ega Rossalinda Rusman sangka pratama, agus Sartini Sartini Sri Wahyuni Gaffar Sulastri, Dewi Tahirah Hasan Tarisa Jabal Rahma yusharumi Zhafirah, Nur Zhafirah Zulfitri Zulfitri