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All Journal Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal Abdimasa Journal of Herbal, Clinical and Pharmaceutical Science (HERCLIPS) Science Midwifery Jurnal Promotif Preventif Jurnal Kesehatan Tambusai International Journal of Health, Economics, and Social Sciences (IJHESS) Jurnal EduHealth Jurnal Ilmiah Ilmu Terapan Universitas Jambi Journal of Pharmaceutical and Sciences. Jurnal Etnofarmasi Science: Indonesian Journal of Science Jurnal Ilmu Kesehatan Jurnal Etnofarmasi
Angga Bayu Budiyanto
Fakultas Sains Terapan Universitas Pendidikan Muhammadiyah Sorong
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary Other

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Anthocyanin Compounds from Ethanol Extract of Red Fruit (Pandanus conideus L.): A Functional Group Analysis Rizky, Indah Amelia; Budiyanto, Angga Bayu; Hardia, Lukman
Jurnal Penelitian Pendidikan IPA Vol 10 No 11 (2024): November
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i11.9321

Abstract

Red Fruit (Pandanus conoideus L.) is a typical Papuan plant that is rich in bioactive compounds such as anthocyanins, which have the potential to act as antioxidants. This research aims to analyze the chemical structure of anthocyanin compounds from red fruit ethanol extract using Fourier Transformed Infrared (FTIR) spectroscopy. FTIR is a spectroscopic tool widely used to characterize or detect functional groups and qualitatively identify compounds in samples. Anthocyanins act as antioxidants and have various biological activities such as preventing cancer, cardiovascular disease, and diabetes. Extraction was carried out using the maceration method using 70% ethanol solvent, and characterization was performed using FTIR in the wave range 4000-450 cm⁻¹. The results of the research that has been carried out show that the ethanol extract of red fruit contains secondary metabolites such as flavonoids, alkaloids, and saponins. The FTIR results of red fruit extract show the presence of functional groups characterized by the presence of the O-H, C-O-C, C-O, and C=C functional groups which are important indicators of the antioxidant properties of anthocyanins. This research confirms the potential of Red Fruit as a natural source of anthocyanins which are useful as antioxidants
Antioxidant Activity Test of Peel-off Mask of Ethanol Extract of Kitolod Leaves (Isotoma Longiflora L) Nur Indah Sari; Angga Bayu Budiyanto; Ratih Arum Astuti
Jurnal EduHealth Vol. 16 No. 04 (2025): Jurnal EduHealt, Edition October-December , 2025
Publisher : Sean Institute

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Abstract

Free radicals are one of the main causes of skin cell damage, resulting in premature aging. Antioxidants play an important role in neutralizing free radicals, thereby maintaining skin health. Kitolod leaves (Isotoma longiflora L.) are known to contain flavonoids, alkaloids, saponins, and polyphenols that have antioxidant potential. This study aims to formulate 70% ethanol extract of kitolod leaves into a peel-off gel mask preparation and evaluate its physical stability and antioxidant activity. The research method is experimental with variations in extract concentration of 5%, 10%, and 15%. Physical evaluation of the formulation included organoleptic testing, homogeneity, pH, viscosity, spreadability, adhesion, and drying time, while antioxidant activity was tested using the DPPH method. The results showed that all formulations met the characteristics of a good peel-off mask preparation and remained stable for 14 days of storage. The antioxidant activity test using the method showed that the IC50 value of kitolod leaf extract was 52.84 ppm, which is classified as strong. Thus, the peel-off gel mask containing kitolod leaf extract has the potential to be developed as a natural cosmetic product with good antioxidant activity.
Hubungan Faktor Sosiodemografis dengan Kepuasan Pasien terhadap Pelayanan Kefarmasian di RSUD Fakfak Salsabilah, Juliandani; Budiyanto, Angga Bayu; Irwandi, Irwandi
Jurnal Promotif Preventif Vol 8 No 6 (2025): Desember 2025: JURNAL PROMOTIF PREVENTIF
Publisher : Fakultas Kesehatan Masyarakat Universitas Pancasakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47650/jpp.v8i6.2360

Abstract

Kepuasan pasien merupakan indikator penting dalam menilai mutu pelayanan rumah sakit. Penelitian ini bertujuan mengetahui hubungan faktor sosiodemografis dengan kepuasan pasien serta membandingkan tingkat kepuasan antara pasien rawat jalan BPJS dan Non-BPJS di RSUD Fakfak. Penelitian menggunakan metode analitik kuantitatif dengan desain cross-sectional. Data dikumpulkan menggunakan kuesioner SERVQUAL dan dianalisis dengan uji Chi-Square serta Mann-Whitney. Jumlah responden sebanyak 376 orang melalui perhitungan OpenEpi. Hasil Chi-Square menunjukkan tidak ada hubungan signifikan antara jenis kelamin, usia, pendidikan, pekerjaan, dan pendapatan dengan kepuasan (p>0,05), namun jarak tempat tinggal dan jenis asuransi berhubungan signifikan (p<0,05). Uji Mann-Whitney menunjukkan perbedaan signifikan antara pasien BPJS dan Non-BPJS (p<0,05), di mana pasien Non-BPJS lebih puas terutama pada dimensi tangible dan empathy
Formulasi dan Uji Aktivitas Antioksidan Sediaan Lip Balm Ekstrak Etanol Biji Alpukat (Persea americana Mill.) dengan Metode DPPH Syahrani, Anggi; Astuti, Ratih Arum; Budiyanto, Angga Bayu
Jurnal Promotif Preventif Vol 8 No 6 (2025): Desember 2025: JURNAL PROMOTIF PREVENTIF
Publisher : Fakultas Kesehatan Masyarakat Universitas Pancasakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47650/jpp.v8i6.2430

Abstract

Antioksidan merupakan senyawa yang mampu menetralkan radikal bebas, yaitu molekul reaktif yang berpotensi menimbulkan kerusakan sel dan memicu stres oksidatif. Biji alpukat (Persea americana Mill.) diketahui mengandung flavonoid, tanin, dan polifenol yang berperan sebagai antioksidan. Penelitian ini bertujuan memformulasikan ekstrak etanol biji alpukat ke dalam sediaan lip balm serta mengkaji sifat fisik dan aktivitas antioksidannya. Ekstrak diperoleh melalui metode maserasi menggunakan etanol 70% dan diformulasikan dalam konsentrasi 2%, 4%, dan 6%. Evaluasi yang dilakukan meliputi uji organoleptik, homogenitas, pH, daya sebar, daya lekat, stabilitas, serta pengujian aktivitas antioksidan dengan metode DPPH pada panjang gelombang 517 nm. Hasil penelitian menunjukkan bahwa seluruh formula memiliki konsistensi semi-solid yang stabil, homogen, pH sekitar 6, serta memenuhi kriteria fisik lip balm tanpa perubahan warna, aroma, atau bentuk selama penyimpanan. Uji aktivitas antioksidan menunjukkan bahwa F1 memiliki aktivitas sangat lemah dengan nilai IC₅₀ (555,64 µg/mL), F2 memiliki aktivitas sedang dengan IC₅₀ (161,32 µg/mL), dan F3 menunjukkan aktivitas kuat dengan IC₅₀ (61,73 µg/mL). Penelitian ini menyimpulkan bahwa ekstrak etanol biji alpukat dapat diformulasikan dengan baik dalam lipbalm, namun aktivitas antioksidannya menurun pada konsentrasi ekstrak yang lebih kecil.
Antibacterial Effectiveness Test of Wrap Leaf Extract (Smilax rotundifolia) Against Escherichia coli and Propionibacterium acnes Bacteria Heti Aisyah; Irwandi Irwandi; Angga Bayu Budiyanto; A.M. Muslihin
Jurnal Penelitian Pendidikan IPA Vol 11 No 4 (2025): April
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i4.10699

Abstract

Diarrhea and acne, caused by the bacteria Escherichia coli and Propionibacterium acnes, are common illnesses in children and adults. Antibiotics can overcome bacterial infections, but cases of antibiotic resistance are increasing. This study aims to determine the effect of wrap leaf extract (Smilax rotundifolia) on the growth of P. acnes and E. coli. This research can support microbiology-based science learning that utilizes biodiversity for students. Phytochemical tests showed that the extract contained flavonoids, alkaloids and saponins. The results of antibacterial testing showed that wrap leaf extract was able to inhibit the growth of P. acnes bacteria from concentrations of 10% and 15% with an average inhibition of 5.31 mm and 6.42 mm, and the positive control (Amoxicillin) had an inhibition of 7.26 mm. However, E. coli did not show any inhibition zone. The Mann-Whitney test results showed that the wrapper leaf extract has antibacterial effectiveness by comparing the negative control with a concentration of 10% and 15% and the positive control with a concentration of 10%. There is a difference between the concentration comparison where the Sig.<0.05 value. Then, comparing the positive control with a concentration of 15% produces a Sig.>0.05 value, meaning there is no difference between the two.
Analgesic Activity Test of Carrot (Daucus carota L.) Peel Extract on White Mice Rahayu, Lintang Kumala; Ratih Arum Astuti; Angga Bayu Budiyanto
Jurnal EduHealth Vol. 16 No. 04 (2025): Jurnal EduHealt, Edition October-December , 2025
Publisher : Sean Institute

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Abstract

Pain is an unpleasant experience characterized by potential tissue damage. One plant that has the potential to inhibit pain through its chemical compounds, namely flavonoids and alkaloids, is carrot peel (Daucus carota L.). The purpose of this study was to determine the analgesic activity of carrot peel extract in male mice. Carrot peel was extracted using the maceration method with 96% solvent. This study used 15 mice as test animals, which were divided into 5 treatment groups, namely the negative control group (CMC-Na), the positive control group (Sodium Diclofenac), carrot peel extract 100 mg/kgBW, 150 mg/kgBW, and 200 mg/kgBW. The test was conducted using the tail flick method with an analgesia measuring device. The test was conducted using the tail flick method with an analgesia measuring device. The data obtained were then analyzed using a paired sample t-test. The results showed that the three doses of carrot peel ethanol extract, 100 mg/kgBW, 150 mg/kgBW, and 200 mg/kgBW, did not have analgesic activity in male mice.
Analgesic effectiveness test of kitolod leaf ethanol extract (isotoma longiflora l.) against male white mice (mus musculus) Yanti, Inda Dwi; Budiyanto, Angga Bayu; Hardia, Lukman
Science Midwifery Vol 13 No 6 (2026): February: Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v13i6.2227

Abstract

This study aims to evaluate the analgesic effectiveness of ethanol extract of Kitolod leaves (Isotoma longiflora L.) in male white mice (Mus musculus). Kitolod leaves are traditionally used as herbal remedies for pain, yet scientific evidence regarding their analgesic potential remains limited. This true experimental research employed a pre- and post-test with control group design, involving five groups: negative control (Na-CMC 1%), positive control (diclofenac sodium 50 mg), and three treatment groups administered Kitolod leaf extract at doses of 56 mg/kgBW, 112 mg/kgBW, and 224 mg/kgBW. Extract preparation was carried out using maceration with 96% ethanol, followed by phytochemical screening which confirmed the presence of flavonoids, alkaloids, tannins, and steroids. Analgesic activity was assessed using the tail flick method by measuring latency response to thermal stimuli at intervals of 30, 60, 90, 120, 150, and 180 minutes post-treatment. The results showed that Kitolod leaf extract increased pain response latency, with the 112 mg/kgBW and 224 mg/kgBW doses demonstrating the strongest analgesic effects comparable to diclofenac sodium. Statistical analysis using independent sample t-test and one-way ANOVA indicated significant differences (p < 0.05) between treatment and control groups. These findings suggest that Kitolod leaf ethanol extract possesses promising analgesic properties and may serve as a potential natural alternative for pain management.
EVALUASI POLA PERESEPAN OBAT ANTI HIPERTENSI Di PUSKESMAS Aulia Mifthakul Jannah; Lukman Hardia; Angga Bayu Budiyanto
JURNAL ETNOFARMASI Vol. 1 No. 01 (2023): JURNAL ETNOFARMASI
Publisher : Universitas Pendidikan Muhammadiyah Sorong

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36232/jurnalfarmasiunimuda.v1i01.1722

Abstract

Kriteria pemakaian obat secara rasional meliputi tepat diagnosa, tepat indikasi penyakit, tepat pemilihan obat, tepat pasien, tepat dosis, tepat cara pemakaian, tepat interval waktu pemberian, tepat lama pemberian, serta waspada terhadap efek samping. Evaluasi peresepan obat penting dilakukan untuk mengetahui dan memastikan bahwa pasien telah menerima pengobatan yang sesuai dengan kebutuhan klinisnya, dalam dosis dan jangka waktu yang sesuai, dan dengan biaya terendah. Ketidakrasionalan peresepan masih sering ditemukan terutama di Puskesmas yang merupakan pusat pelayanan kesehatan tingkat 1, dimana obat dan dosis yang diresepkan oleh tenaga medis kurang sesuai akibat ketersediaan obat yang terbatas, dan salah satunya adalah obat hipertensi. Sehingga perlu dilakukan evaluasi pola peresepan obat antihipertensi di Puskesmas Mariat Kabupaten Sorong periode Juli – September 2022. Penelitian ini bertujuan Untuk mengevaluasi pola peresepan obat anti-hipertensi di Puskesmas Mariat Kabupaten Sorong. Penelitian ini menggunakan rekam medis sebanyak 63 resep. Hasil penelitian Evaluasi Peresepan obat Antihipertensi Di Puskesmas Mariat Kabupaten Sorong Periode Juli-September 2022 bahwa tepat obat sebanyak 100% tepat pasien sebanyak 100% tepat dosis sebanyak 100%, tepat interval waktu pemberian sebanyak 88,46%. Obat Antihipertensi yang diberikan kepada pasien adalah terapi kombinasi golongan CCB+ACEI (amlodipin + captopril) dengan persentase yaitu 25% dan selanjutnya monoterapi amlodipin sebanyak 75%, dan captopril sebanyak 0%.
PENETAPAN KADAR SARI LARUT AIR, KADAR SARI LARUT ETANOL DAN IDENTIFIKASI ALKALOID PADA EKSTRAK ETANOL 96% DAUN KERSEN (Muntingia calabura L.) A.M. Muslihin; Angga Bayu Budiyanto
JURNAL ETNOFARMASI Vol. 1 No. 02 (2022): JURNAL ETNOFARMASI
Publisher : Universitas Pendidikan Muhammadiyah Sorong

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36232/jurnalfarmasiunimuda.v1i02.1725

Abstract

Kersen (Muntingia calabura L.) merupakan salah satu jenis tanaman yang tumbuh baik di daerah tropis seperti Indonesia. Pohon kersensangat mudah tumbuh tanpa penanaman khusus seperti tempat terbuka, perbukitan, hingga tepi-tepi jalan. Daun kersen juga memilikiberbagai kandungan seperti senyawa flavonoid, tannin, triterpene, saponin, polifenol yang menunjukkan adanya aktivitas antioksidan. Pada penelitian ini dilakukan penetapan kadar sari pada simplisia daun kersen menggunakan 2 jenis pelarut yaitu air dan etanol 96%dan simplisia sebanyak 5 gram pada masing masing pelarut. Berdasarkan hasil yang didapatkan kadar sari larut etanol mendapatkanhasil sebanyak 0,16% dan kadar sari larut air mendapatkan hasil sebanyak 0,96%. Penelitian ini juga dilakukan identifikasi alkaloid dan hasilnya menunjukkan bahwa Ekstrak Etanol daun Kersen (Muntingia calabura L.) positif mengandung Alkaloid.
PENETAPAN KADAR FENOLIK TOTAL EKSTRAK ETANOL 70% PELEPAH PISANG AMBON (Musa paradisiaca Var. Sapientum) DARI KABUPATEN SORONG, PAPUA BARAT Mohammad Usman Nur; Ratih Arum Astuti; Angga Bayu Budiyanto; Irwandi Irwandi
JURNAL ETNOFARMASI Vol. 1 No. 02 (2022): JURNAL ETNOFARMASI
Publisher : Universitas Pendidikan Muhammadiyah Sorong

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36232/jurnalfarmasiunimuda.v1i02.1727

Abstract

Penelitian terkait pemanfaatan limbah sudah banyak dilakukan, salah satunya pelepah pisang ambon. Ekstrak etanol pelepah pisang ambon terbukti memiliki efek farmakologi salah satunya sebagai penyembuh luka. Untuk mengetahui tingkat keamanan dan efektivitas sediaan ekstrak pelepah pisang ambon, maka perlu dilakukan beberapa uji spesifik dan non spesifik sebagai upaya untuk menjaga kualitas mutu. Penelitian ini bertujuan mengetahui parameter spesifik yaitu penetapan kadar total fenol ekstrak etanol pelepah pisang ambon dari Kabupaten Sorong, Papua Barat. Penelitian ini termasuk jenis penelitian non eksperimental. Metode ekstraksi yang digunakan adalah maserasi dengan pelarut etanol 70%. Uji parameter spesifik berupa kadar fenolik total dengan analisis kualitatif menggunakan uji tabung dan uji KLT serta analisis kuantitatif menggunakan Spektrofotometer UV-Vis masing-masing dengan pereaksi Folin-Ciocalteu. Hasil penelitian parameter spesifik ekstrak etanol pelepah pisang ambon dari kabupaten Sorong, Papua Barat adalah sebagai berikut: hasil uji tabung dan uji KLT menunjukkan bahwa ekstrak etanol pelepah pisang ambon mengandung senyawa fenolik, flavonoid, tanin, dan saponin ; hasil penetapan kadar berupa kadar fenolik total sebesar 15,42 ± 0,159 mg GAE/g ekstrak. Parameter standar umum ekstrak tanaman obat berupa parameter spesifik uji kandungan kimia ekstrak pada penelitian ini secara umum telah memenuhi ketentuan yang ditetapkan oleh Farmakope Herbal Indonesia.
Co-Authors A. M. Muslihin Achmad Noerkhaerin Putra Anggraini Palino Anisa, Meilinda Aponno, Alyssa Mileta Astuti, Ratih Arum Aulia Mifthakul Jannah Fabanyo, Syahrul H. Fajar Maulana . Heti Aisyah Heti Aisyah Indah Amelia Rizky Irwandi Irwandi Irwandi Irwandi Irwandi Irwandi Jannah, Aulia Mifthakul Lukman Hardia M. Yogi Riyantama Isjoni Maulana, Fajar MIFTAHUL JANNAH Mohammad Usman Nur Ngodihu, Muhammad Syafinuddin Almandari Nur Indah Sari Nur ‘Azah Nur, Mohammad Usman nurjanah, sartika wahyu Nurwahyuni Pasulu, Yusran Timang Pratama, Agus Sangka Rahayu, Lintang Kumala Rahayu, Mellawati Yuningtyas Rizky, Indah Amelia Rohmania, Siti Rossardy, Marzella Dea Salim, Fathiyah Salsabilah, Juliandani Siska Siska Syahrani, Anggi Tehuayo, Ona Bugis ulandari, clarista windi Utami, Hikmahtul Putri Wa Ode Suriani Wa Siti Arabiya Watora, Wahyuni Yanti, Inda Dwi Yuniatri, Nur Khusna yunus, sri ulan dari