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All Journal Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal Abdimasa Jurnal Ners Journal of Herbal, Clinical and Pharmaceutical Science (HERCLIPS) Science Midwifery Jurnal Promotif Preventif Jurnal Kesehatan Tambusai Jurnal EduHealth Midwinerslion : Jurnal Kesehatan STIKes Buleleng Jurnal Ilmiah Ilmu Terapan Universitas Jambi Journal of Pharmaceutical and Sciences. Jurnal Etnofarmasi Science: Indonesian Journal of Science Jurnal Ilmu Kesehatan Jurnal Etnofarmasi
Angga Bayu Budiyanto
Universitas Pendidikan Muhammadiyah Sorong
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Veterinary Other

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PENETAPAN KADAR FENOLIK TOTAL EKSTRAK ETANOL 70% PELEPAH PISANG AMBON (Musa paradisiaca Var. Sapientum) DARI KABUPATEN SORONG, PAPUA BARAT Mohammad Usman Nur; Ratih Arum Astuti; Angga Bayu Budiyanto; Irwandi Irwandi
JURNAL ETNOFARMASI Vol. 1 No. 02 (2022): JURNAL ETNOFARMASI
Publisher : Universitas Pendidikan Muhammadiyah Sorong

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36232/jurnalfarmasiunimuda.v1i02.1727

Abstract

Penelitian terkait pemanfaatan limbah sudah banyak dilakukan, salah satunya pelepah pisang ambon. Ekstrak etanol pelepah pisang ambon terbukti memiliki efek farmakologi salah satunya sebagai penyembuh luka. Untuk mengetahui tingkat keamanan dan efektivitas sediaan ekstrak pelepah pisang ambon, maka perlu dilakukan beberapa uji spesifik dan non spesifik sebagai upaya untuk menjaga kualitas mutu. Penelitian ini bertujuan mengetahui parameter spesifik yaitu penetapan kadar total fenol ekstrak etanol pelepah pisang ambon dari Kabupaten Sorong, Papua Barat. Penelitian ini termasuk jenis penelitian non eksperimental. Metode ekstraksi yang digunakan adalah maserasi dengan pelarut etanol 70%. Uji parameter spesifik berupa kadar fenolik total dengan analisis kualitatif menggunakan uji tabung dan uji KLT serta analisis kuantitatif menggunakan Spektrofotometer UV-Vis masing-masing dengan pereaksi Folin-Ciocalteu. Hasil penelitian parameter spesifik ekstrak etanol pelepah pisang ambon dari kabupaten Sorong, Papua Barat adalah sebagai berikut: hasil uji tabung dan uji KLT menunjukkan bahwa ekstrak etanol pelepah pisang ambon mengandung senyawa fenolik, flavonoid, tanin, dan saponin ; hasil penetapan kadar berupa kadar fenolik total sebesar 15,42 ± 0,159 mg GAE/g ekstrak. Parameter standar umum ekstrak tanaman obat berupa parameter spesifik uji kandungan kimia ekstrak pada penelitian ini secara umum telah memenuhi ketentuan yang ditetapkan oleh Farmakope Herbal Indonesia.
ANALISIS GUGUS FUNGSI SERTA PENETAPAN KADAR TOTAL FLAVONOID DAN ALKALOID PADA EKSTRAK PAKIS MERAH (Stenochlaena palutris) Angga Bayu Budiyanto; Wa Siti Arabiya
JURNAL ETNOFARMASI Vol. 3 No. 01 (2025): JURNAL ETNOFARMASI
Publisher : Universitas Pendidikan Muhammadiyah Sorong

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36232/jurnalfarmasiunimuda.v3i01.1987

Abstract

This study aimed to evaluate the effectiveness of three extraction methods (maceration, soxhletation, and reflux) in obtaining bioactive compounds from Red Fern (Stenochlaena palutris), which is known to have therapeutic potential. The methods used included cold extraction (maceration) and hot extraction (soxhletation, reflux) with ethanol solvent, which was chosen because of its ability to dissolve polar and nonpolar compounds. The maceration method produced the highest yield of 15.4002% with extraction for 72 hours without heating, which maintained the stability of the active compounds. In contrast, the soxhletation and reflux methods produced yields of 2% and 10%, respectively, possibly due to degradation of the active compounds due to heating. Phytochemical screening showed the presence of alkaloids, flavonoids, tannins, saponins, steroids, and terpenoids in the resulting extracts. FTIR assay identified various important functional groups such as hydroxyl (-OH), alkanes, and C-O in all extraction methods. and the determination of the total alkaloid content obtained was 1.066335% while the total flavonoid content obtained was 4.652425%. So from the data it can be seen that the total Flavonoid compound is greater than the Alkaloid compound
AKTIVITAS SPF LOTION KOMBINASI EKSTRAK RUMPUT LAUT (EUCHEUMA COTTONI) DAN EKSTRAK LIDAH BUAYA (ALOE VERA) yunus, sri ulan dari; Budiyanto, Angga Bayu; Astuti, Ratih Arum
Jurnal Kesehatan Tambusai Vol. 7 No. 1 (2026): MARET 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v7i1.56520

Abstract

Paparan sinar ultraviolet (UV) yang berlebihan dapat meneyebabkan kerusakan kulit sehingga diperlukan sediaan tabir surya yang aman dan efektif. Rumput laut (Eucheuma cottoni) dan lidah buaya (Aloe vera) memiliki zat bioaktif alami yang bisa melindungi kulit dari sinar matahari. Penelitian ini membuat lotion tabir surya dari campuran ekstrak etanol 95% rumput laut dan 96% lidah buaya. Tujuannya adalah merancang lotion, memeriksa sifat fisik dan ketahanannya, serta mengukur nilai Sun Protection Factor (SPF) secara in vitro. Lotion diformulasikan menjadi tiga formula dengan kadar ekstrak berbeda. Pemeriksaan fisik meliputi uji organoleptik, homogenitas, pH, daya sebar, daya lekat, dan viskositas sebelum serta sesudah uji stabilitas dengan metode cycling test. Analisis statistikmenggunakan uji paired t-test menunjukkan tidak terdapat perbedaan yang signifikan (p > 0,05) pada seluruh parameter fisik, sehingga sediaan dinyatakn stabil. Penentuan nilai SPF dilakukan dengan metode spektrofotometer UV-Vis pada panjang gelombang 290-320 nm dan dianalisis secara deskriptif. Nilai SPF pada formula I 3,1 formula II 4,5 dan formula III 6,21. Hasil menunjukkan Formula III memiliki nilai SPF tertinggi.
Anti-inflammatory Activity Test of Red Pucuk Leaf Extract Against (Syzygium myrtifolium Walp) White Rats (Rattus norvegicus) Ona Bugis Tehuayo; Angga Bayu Budiyanto; Irwandi Irwandi
Jurnal EduHealth Vol. 17 No. 01 (2026): Jurnal EduHealt, January-March 2026
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The plant S. myrtifolium Walp, also known as red shoots, is an ornamental plant with characteristic red easy leaves and green old leaves. This plant is known to contain active compounds that have potential as pharmacological agents, especially anti-inflammatory. The purpose of this study was to identify the anti-inflammatory activity of ethanol extract of red shoot leaves (S. myrtifolium Walp) against white rats (Rattus norvegicus) using several dose variations. The population in this study was the red shoots leaf plant (Syzygium myrtifolium Walp) obtained from Mariat Pantai Village, Sorong Regency. While the samples used in this study were red shoot leaves (Syzygium myrtifolium Walp) which were taken fresh green leaves. The results of phytochemical analysis identified the presence of alkaloid, flavonoid, tannin, saponin and phenol compounds. The test data were analyzed using ANOVA method followed by Paired Sample T test and LSD test to determine the presence and absence of differences from before treatment and after treatment. The test results showed that red shoot leaf extract has anti-inflammatory activity against white rats significantly at doses of 200 mg / kg BW, 300 mg / kgBB and 450 mg / kgBB.
Analis Kualitatif Senyawa Formalin pada Mie Basah Diwarung Bakso Kabupaten Sorong WaOde Suriani; Ratih Arum Astuti; Angga Bayu Budiyanto
Science: Indonesian Journal of Science Vol. 2 No. 1 (2025)
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/science.v2i1.263

Abstract

Mie basah merupakan produk makanan yang cukup banyak dikonsumsi oleh masyarakat. Mie basah mengandung kadar air sekitar 52-60%, yang cukup tinggi, sehingga menyebabkan mie tidak bertahan lama dalam penyimpanannya. Hal ini mendorong produsen yang tidak bertanggung jawab untuk menambahkan zat pengawet berbahaya, yaitu formalin, agar mie memiliki masa simpan yang lebih lama.Penelitian ini bertujuan untuk mengetahui ada tidaknya senyawa formalin pada mie basah di wilayah Aimas dan Mariat. Metode yang digunakan dalam penelitian ini adalah analisis kualitatif dengan pereaksi nash. Pengambilan sampel dilakukan dengan metode sampling jenuh karena sampel kurang dari 30. Penelitian ini dilaksanakan di Laboratorium Terpadu Universitas Pendidikan Muhammadiyah Sorong.Hasil penelitian yang dilakukan pada 27 sampel mie basah yang beredar di wilayah Kabupaten Sorong menunjukkan tidak terjadinya perubahan warna pada filtrat sampel yang telah ditambahkan pereaksi nash. Oleh karena itu, dapat ditarik kesimpulan bahwa mie basah yang beredar di wilayah Kabupaten Sorong tidak mengandung formalin. Hal ini menunjukkan bahwa mie basah telah memenuhi syarat mutu SNI 2987:2015.
Efficacy of Akway (Drymis sp.) Bark Extract in Restoring Hemoglobin Levels: A Preclinical Study in a Sodium Nitrite-Induced Anemia Mice Model Lukman Hardia; Fabanyo, Syahrul H.; Budiyanto, Angga Bayu; Muslihin, A. M.; Rossardy, Marzella Dea; Irwandi, Irwandi; Watora, Wahyuni
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 11 No. 1 (2026)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v11i1.44062

Abstract

The high prevalence of anemia prompted us to explore the potential of local herbs in Papua, Indonesia, which is known for its rich natural resources. In this study, we aim to conduct preclinical tests on anemia model test animals to validate the effectiveness of akway bark extract (ABE) as the basis for the development of effective and safe herbal antianemia drugs in the future. This study employs a quantitative analytical approach, utilizing an experimental design with a pre-posttest with a control group design. The research sample used 20 mice test animals, divided into 5 groups consisting of 4 animals each, namely: the control group (positive and negative), and the intervention group using ABE doses of 10, 30, and 50mg/kg. This study was approved by the Health Research Ethics Committee of STIFAR Makassar (Number: 299/EC.1.1.B/III/KEPK/2024). Data analysis showed that a 14-day intervention using ABE was able to increase Hb levels (D% = 52.00±27.13 [ABE dose 10mg/kg]; 49.72±7.86 [ABE dose 50mg/kg] and 42.82±12.75 [ABE dose 30mg/kg]) significantly (p<0.05) when compared with the negative control (D% = 4.54±5.14), but when compared with the positive control (D% = 52.57±10.85) the average increase in Hb levels was not significant (p>0.05). In conclusion, our study showed that mice of the anemia model, intervened using ABE at doses of 10, 30, and 50mg/kg once daily for 14 days, experienced increased Hb levels.
Anthocyanin Compounds from Ethanol Extract of Red Fruit (Pandanus conideus L.): A Functional Group Analysis Indah Amelia Rizky; Angga Bayu Budiyanto; Lukman Hardia
Jurnal Penelitian Pendidikan IPA Vol 10 No 11 (2024): November
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i11.9321

Abstract

Red Fruit (Pandanus conoideus L.) is a typical Papuan plant that is rich in bioactive compounds such as anthocyanins, which have the potential to act as antioxidants. This research aims to analyze the chemical structure of anthocyanin compounds from red fruit ethanol extract using Fourier Transformed Infrared (FTIR) spectroscopy. FTIR is a spectroscopic tool widely used to characterize or detect functional groups and qualitatively identify compounds in samples. Anthocyanins act as antioxidants and have various biological activities such as preventing cancer, cardiovascular disease, and diabetes. Extraction was carried out using the maceration method using 70% ethanol solvent, and characterization was performed using FTIR in the wave range 4000-450 cm⁻¹. The results of the research that has been carried out show that the ethanol extract of red fruit contains secondary metabolites such as flavonoids, alkaloids, and saponins. The FTIR results of red fruit extract show the presence of functional groups characterized by the presence of the O-H, C-O-C, C-O, and C=C functional groups which are important indicators of the antioxidant properties of anthocyanins. This research confirms the potential of Red Fruit as a natural source of anthocyanins which are useful as antioxidants
Analysis of administrative-pharmaceutical completeness on patient prescriptions at Puskesmas X, Sorong City Carmel Josuhua Paulus; Lukman Hardia; Angga Bayu Budiyanto
Science Midwifery Vol 14 No 2 (2026): June: Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v14i2.2374

Abstract

Prescription completeness is an important indicator in pharmaceutical services because it is related to therapeutic accuracy and patient safety. Incomplete prescriptions may increase the risk of medication errors during drug preparation and administration. This study aimed to determine the level of administrative and pharmaceutical completeness of patient prescriptions at Puskesmas X, Sorong City. This research used a descriptive observational method with a retrospective approach involving 1,572 patient prescriptions selected using a total sampling technique. The assessment was conducted based on the standards of the Indonesian Ministry of Health Regulation Number 73 of 2016 and Number 58 of 2014. The results showed that all prescriptions (100%) were categorized as incomplete. In the administrative aspect, patient name and prescription date reached 100% completeness, while patient height, doctor’s practice license number, and doctor’s phone number showed 0% completeness. Doctor’s initials/signature were found in 60.8% of prescriptions. In the pharmaceutical aspect, drug name, stability, and compatibility reached 100% completeness, while dosage form and drug strength reached 70.6% and 69.3%, respectively. The study concluded that pharmaceutical completeness was better than administrative completeness; however, prescription writing at Puskesmas X, Sorong Citis still, did not meet pharmaceutical service standards.
Analgesic effectiveness test of kitolod leaf ethanol extract (isotoma longiflora l.) against male white mice (mus musculus) Inda Dwi Yanti; Angga Bayu Budiyanto; Lukman Hardia
Science Midwifery Vol 13 No 6 (2026): February: Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v13i6.2227

Abstract

This study aims to evaluate the analgesic effectiveness of ethanol extract of Kitolod leaves (Isotoma longiflora L.) in male white mice (Mus musculus). Kitolod leaves are traditionally used as herbal remedies for pain, yet scientific evidence regarding their analgesic potential remains limited. This true experimental research employed a pre- and post-test with control group design, involving five groups: negative control (Na-CMC 1%), positive control (diclofenac sodium 50 mg), and three treatment groups administered Kitolod leaf extract at doses of 56 mg/kgBW, 112 mg/kgBW, and 224 mg/kgBW. Extract preparation was carried out using maceration with 96% ethanol, followed by phytochemical screening which confirmed the presence of flavonoids, alkaloids, tannins, and steroids. Analgesic activity was assessed using the tail flick method by measuring latency response to thermal stimuli at intervals of 30, 60, 90, 120, 150, and 180 minutes post-treatment. The results showed that Kitolod leaf extract increased pain response latency, with the 112 mg/kgBW and 224 mg/kgBW doses demonstrating the strongest analgesic effects comparable to diclofenac sodium. Statistical analysis using independent sample t-test and one-way ANOVA indicated significant differences (p < 0.05) between treatment and control groups. These findings suggest that Kitolod leaf ethanol extract possesses promising analgesic properties and may serve as a potential natural alternative for pain management.
Antioxidant Activity Test of Peel-off Mask of Ethanol Extract of Kitolod Leaves (Isotoma Longiflora L) Nur Indah Sari; Angga Bayu Budiyanto; Ratih Arum Astuti
Jurnal EduHealth Vol. 16 No. 04 (2025): Jurnal EduHealt, Edition October-December , 2025
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Free radicals are one of the main causes of skin cell damage, resulting in premature aging. Antioxidants play an important role in neutralizing free radicals, thereby maintaining skin health. Kitolod leaves (Isotoma longiflora L.) are known to contain flavonoids, alkaloids, saponins, and polyphenols that have antioxidant potential. This study aims to formulate 70% ethanol extract of kitolod leaves into a peel-off gel mask preparation and evaluate its physical stability and antioxidant activity. The research method is experimental with variations in extract concentration of 5%, 10%, and 15%. Physical evaluation of the formulation included organoleptic testing, homogeneity, pH, viscosity, spreadability, adhesion, and drying time, while antioxidant activity was tested using the DPPH method. The results showed that all formulations met the characteristics of a good peel-off mask preparation and remained stable for 14 days of storage. The antioxidant activity test using the method showed that the IC50 value of kitolod leaf extract was 52.84 ppm, which is classified as strong. Thus, the peel-off gel mask containing kitolod leaf extract has the potential to be developed as a natural cosmetic product with good antioxidant activity.
Co-Authors A M Muslihin A. M. Muslihin Achmad Noerkhaerin Putra Alyssa Mileta Aponno Anisa, Meilinda Astuti, Ratih Arum Aulia Mifthakul Jannah Azzahra Vivin Mahdiya Afandy Carmel Josuhua Paulus Diah Wulandari Fabanyo, Syahrul H. Heti Aisyah Hikmahtul Putri Utami Inda Dwi Yanti Indah Amelia Rizky Innal Saitis Irwandi Irwandi Irwandi Irwandi Irwandi Irwandi Irwandi Irwandi Jannah, Aulia Mifthakul Justitia Cahyani Fadli Lintang Kumala Rahayu Lukman Hardia M. Yogi Riyantama Isjoni Marzella Dea Rossardy Meilinda Anisa Mohammad Usman Nur Ngodihu, Muhammad Syafinuddin Almandari Nur Indah Sari Nur ‘Azah Nur, Mohammad Usman nurjanah, sartika wahyu Nurul Maghfirah1 Ona Bugis Tehuayo Pasulu, Yusran Timang Pratama, Agus Sangka Rahayu, Mellawati Yuningtyas Ratih Arum Astuti Rohmania, Siti Rohmi Masitoh Salim, Fathiyah Salsabilah, Juliandani Siska Siska ulandari, clarista windi Wa Siti Arabiya Wahyuni Watora WaOde Suriani Wiwit Ayu Fitrianti Yuniatri, Nur Khusna yunus, sri ulan dari