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All Journal Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal Abdimasa Jurnal Ners Journal of Herbal, Clinical and Pharmaceutical Science (HERCLIPS) Science Midwifery Jurnal Promotif Preventif Jurnal Kesehatan Tambusai Jurnal EduHealth Midwinerslion : Jurnal Kesehatan STIKes Buleleng Jurnal Ilmiah Ilmu Terapan Universitas Jambi Journal of Pharmaceutical and Sciences. Jurnal Etnofarmasi Science: Indonesian Journal of Science Jurnal Ilmu Kesehatan Jurnal Etnofarmasi
Angga Bayu Budiyanto
Universitas Pendidikan Muhammadiyah Sorong
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Veterinary Other

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Analgesic Activity Test of Carrot (Daucus carota L.) Peel Extract on White Mice Lintang Kumala Rahayu; Ratih Arum Astuti; Angga Bayu Budiyanto
Jurnal EduHealth Vol. 16 No. 04 (2025): Jurnal EduHealt, Edition October-December , 2025
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Pain is an unpleasant experience characterized by potential tissue damage. One plant that has the potential to inhibit pain through its chemical compounds, namely flavonoids and alkaloids, is carrot peel (Daucus carota L.). The purpose of this study was to determine the analgesic activity of carrot peel extract in male mice. Carrot peel was extracted using the maceration method with 96% solvent. This study used 15 mice as test animals, which were divided into 5 treatment groups, namely the negative control group (CMC-Na), the positive control group (Sodium Diclofenac), carrot peel extract 100 mg/kgBW, 150 mg/kgBW, and 200 mg/kgBW. The test was conducted using the tail flick method with an analgesia measuring device. The test was conducted using the tail flick method with an analgesia measuring device. The data obtained were then analyzed using a paired sample t-test. The results showed that the three doses of carrot peel ethanol extract, 100 mg/kgBW, 150 mg/kgBW, and 200 mg/kgBW, did not have analgesic activity in male mice.
Pengaruh Perbedaan Metode Ekstraksi Terhadap Kadar Total Flavonoid dan Alkaloid Bonggol Buah Merah (Pandanus conoideus L.) Innal Saitis; A.M. Muslihin; Lukman Hardia; Angga Bayu Budiyanto; Irwandi Irwandi; Marzella Dea Rossardy; Wahyuni Watora; Justitia Cahyani Fadli; Wiwit Ayu Fitrianti
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1666

Abstract

Background: Red fruit (Pandanus conoideus L.) is an endemic plant of Papua that has been traditionally used to treat various diseases. Its biological activities are associated with the presence of secondary metabolites, particularly flavonoids and alkaloids. Objective: This study aimed to identify the secondary metabolites and evaluate the effect of different extraction methods on the total flavonoid and alkaloid contents of ethanolic extracts of red fruit (Pandanus conoideus L.) stem core. Methods: Extraction was performed using three different methods, namely maceration, Soxhlet extraction, and reflux extraction with ethanol as the solvent. Secondary metabolites were identified qualitatively, while total flavonoid and alkaloid contents were determined spectrophotometrically. Results: Phytochemical screening revealed the presence of alkaloids, flavonoids, terpenoids, steroids, and tannins in the ethanolic extract of red fruit stem core. The total flavonoid contents obtained by maceration, Soxhlet extraction, and reflux extraction were 218.966 mgQE/g (21.89%), 104.023 mgQE/g (10.40%), and 247.701 mgQE/g (24.77%), respectively. The total alkaloid contents obtained by maceration, Soxhlet extraction, and reflux extraction were 145.770 mgAE/g (14.58%), 65.767 mgAE/g (6.58%), and 76.433 mgAE/g (7.64%), respectively. Conclusion: The extraction method affected the total flavonoid and alkaloid contents obtained from the sample. Reflux extraction produced the highest total flavonoid content (247.701 mgQE/g), whereas maceration produced the highest total alkaloid content (145.770 mgAE/g). Therefore, reflux was the most effective method for flavonoid extraction, while maceration was the most effective method for alkaloid extraction from the stem core of red fruit (Pandanus conoideus L.).
Potensi Antiinflamasi Daun Dollu (Dodonaea Viscosa L.): Studi In Vivo Pada Model Edema Karagenan Tikus Putih (Rattus Norvegicus) Azzahra Vivin Mahdiya Afandy; Angga Bayu Budiyanto; Lukman Hardia
Jurnal Ners Vol. 10 No. 4 (2026)
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i4.62070

Abstract

potential plant is dollu leaf (Dodonaea viscosa L.), which reportedly contains a variety of secondary metabolites, such as flavonoids, alkaloids, tannins, saponins, and phenolic compounds that are thought to play a role in inhibiting the inflammatory response. Objective to assess the anti-inflammatory activity of dollu leaf ethanol extract (D. viscosa L.) in male white rats with carrageenan-induced inflammation. Methods the study was conducted using a laboratory experimental design with a model of foot edema induced by a 1% carrageenan solution. The experimental animals were divided into five groups, namely negative control, positive control, and three treatment groups that received dollu leaf ethanol extract with doses of 125, 250, and 500 mg/kg body weight. Observation of edema volume was carried out every one hour for six hours using a plethysmometer. All data were statistically analyzed using the One-Way ANOVA test followed by the Least Significant Difference follow-up test at the significance level of p < 0.05. Results dollu leaf ethanol extract showed increased anti-inflammatory activity over observation time. Compared to negative controls, doses of 125 and 250 mg/kgBB showed significant differences from the first hour (p=0.024 and p=0.006), while all doses showed very significant edema inhibition from the third hour to the sixth hour (p<0.001). Against positive controls, the dose of 250 mg/kgBB still showed a difference in the first to fourth hours (p=0.010–0.045), but at the fifth and sixth hours the entire dose did not differ significantly (p>0.05), showing an efficacy of the extract comparable to standard drugs in the advanced inflammatory phase. The dose of 250 mg/kg BB provides the most consistent anti-inflammatory response compared to other doses. Conclusion dollu leaf ethanol extract (D.  viscose L.) It has been proven to provide a significant anti-inflammatory effect in suppressing the formation of edema due to carrageenan induction in male white rats. This activity is mainly seen in the advanced inflammatory phase and the dose of 250 mg/kg BB is the dose that shows the most optimal effectiveness, so this extract has the potential to be developed as an anti-inflammatory phytopharmaceutical candidate.
Analisis Potensi Interaksi Obat Pada Resep Pasien Hipertensi Lansia di Puskesmas Dabatan Misool Selatan, Raja Ampat Nurul Maghfirah1; Lukman Hardia; Angga Bayu Budiyanto
Jurnal Ners Vol. 10 No. 4 (2026)
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i4.62242

Abstract

Elderly people with hypertension generally receive combination therapy to control blood pressure and manage comorbidities, so they are at risk of experiencing potential drug interactions. This study aims to analyze the potential for drug interactions in the prescriptions of elderly hypertension patients at the South Dabatan Misool Health Center, Raja Ampat Regency. Methods this study was a non-experimental observational study with a retrospective descriptive approach. The research sample used a total sampling technique of 130 prescriptions of elderly hypertension patients who met the inclusion criteria. Data were obtained from prescriptions and medical records, then analyzed descriptively based on the type of interaction, mechanism, and severity. Results the majority of patients were aged 60–65 years (53.85%) and were female (80.00%). Of the 130 prescriptions, 47 cases of potential drug interactions were found. The most common combination was amlodipine–simvastatin in 14 cases (29.79%), followed by amlodipine–mefenamic acid in 11 cases (23.40%). Most interactions were pharmacodynamic interactions of moderate severity, while major interactions were found in amlodipine–simvastatin and captopril–allopurinol combinations. Conclusion the potential for drug interactions in elderly hypertensive patients at the South Dabatan Misool Health Center is quite high, so it is necessary to screen drug interactions and evaluate therapy regularly to improve the safety and effectiveness of treatment.
Studi Fitokimia Senyawa Aktif Ekstrak Batang Nelambo suon (Rubiaceae) Marzella Dea Rossardy; A.M. Muslihin; Wahyuni Watora; Angga Bayu Budiyanto; Lukman Hardia; Irwandi Irwandi; Alyssa Mileta Aponno; Hikmahtul Putri Utami
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1333

Abstract

Background: Papua has high biodiversity with significant potential as a source of traditional medicinal plants, including Nelambo suon (Rubiaceae), which has been empirically used by local communities. However, scientific information regarding the active compounds in its stem bark remains limited. Objective: This study aimed to identify the secondary metabolite groups present in the ethanol extract of Nelambo suon stem bark through phytochemical screening. Methods: The research was conducted experimentally using the maceration method with 80% ethanol as the solvent. The stem bark simplicia was extracted and qualitatively screened for alkaloids, flavonoids, tannins, and saponins using specific reagents. Results: The results showed that the ethanol extract of Nelambo suon stem bark contained alkaloids, flavonoids, tannins, and saponins, indicated by characteristic color changes, precipitate formation, and foam production. Conclusion: These findings suggest that Nelambo suon stem bark is a potential source of bioactive compounds and may be further developed as a herbal medicinal material based on local wisdom.
UJI AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL TALI KUNING (Anamirta Cocculus) : Array Rohmi Masitoh; A M Muslihin; Angga Bayu Budiyanto
Midwinerslion : Jurnal Kesehatan STIKes Buleleng Vol 9 No 2 (2024): MIDWINERSLION Jurnal Kesehatan STIKes Buleleng
Publisher : LPPM STIKes Buleleng

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52073/mjksb.v9i2.433

Abstract

Antioksidan adalah senyawa yang penting dalam mengatasi radikal bebas pada tubuh. Antioksidan alami lebih banyak digunakan dari pada antioksidan sintetik karna efek sampingnya yang lebih minim. Tali kuning (Anamirta cocculus) merupakan jenis tanaman merambat yang biasa digunakan oleh masyarakat papua sebagai obat tradisional untuk mengobati malaria. Penelitian ini bertujuan untuk mengetahui kandungan metabolit sekunder dan aktivitas antioksidan dari ekstrak etanol tali kuning. Metode: Pengujian skrining fitokimia dilakukan secara kualitatif menggunakan reagen uji sedangkan pengujian aktivitas antioksidan menggunakan metode DPPH. Hasil: Skrining fitokimia menunjukkan bahwa tali kuning mengandung senyawa golongan flavonoid, alkaloid, terpenoid dan tanin. aktivitas antioksidan ekstrak etanol tali kuning dengan konsentrasi 10, 20, 30, 40, 50 ppm menunjukkan aktivitas antioksidan dengan nilai IC50 20,12 μg/mL sedangkan pada larutan pembanding Vitamin C dengan konsentrasi 0,1, 0,2, 0,3, 0,4, 0,5 ppm menunjukkan aktivitas antioksidan dengan nilai IC50 0,34 μg/mL. Simpulan: Hasil skrining fitokimia menunjukkan bahwa tali kuning mengandung senyawa flavonoid, alkaloid, terpenoid dan tanin sedangkan aktivitas antioksidan dari ekstrak etanol tali kuning tergolong dalam antioksidan yang sangat kuat dengan nilai IC50 kurang dari 50 μg/mL.
Literature Review : Aktivitas Antioksidan Ekstrak Tongkol Jagung (Zea mays L.) Meilinda Anisa; Lukman Hardia; Angga Bayu Budiyanto
JIKES : Jurnal Ilmu Kesehatan Vol. 2 No. 1 (2023): Juli-Desember 2023
Publisher : Yayasan Pendidikan Tanggui Baimbaian

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71456/jik.v2i1.601

Abstract

Tongkol jagung (Zea mays L.) adalah salah satu limbah tanaman jagung yang berfungsi sebagai antioksidan. Aktivitas antioksidan tongkol jagung telah banyak diteliti. Oleh karena itu, perlu dilakukan literature review untuk mengumpulkan penelitian terbaru agar dapat dijadikan sebagai panduan bagi para peneliti dalam mempelajari lebih lanjut tentang antioksidan dari tongkol jagung atau untuk menghasilkan konsep baru. Tujuan dari penelitian literature review ini yaitu untuk mengetahui aktivitas antioksidan ekstrak tongkol jagung dan mengetahui kandungan senyawa pada tongkol jagung yang memiliki aktivitas antioksidan sehingga dapat dimanfaatkan menjadi antioksidan alami. Metode yang digunakan dalam penelitian ini yaitu literature review dengan pendekatan sistematis. Oleh karena itu, pedoman PRISMA digunakan dalam pengambilan data. Database yang digunakan dalam penelitian ini yaitu Scopus dan ditemukan 19 artikel yang sesuai setelah disaring. Temuan analisis menunjukkan bahwa tongkol jagung memiliki aktivitas sebagai antioksidan, kandungan senyawa pada tongkol jagung yang memiliki aktivitas antioksidan antara lain karotenoid, tanin, asam fenolik seperti asam hidroksisinamat dan asam hidroksibenzoat serta flavonoid seperti flavonol dan berbagai jenis antosianin.
Co-Authors A M Muslihin A. M. Muslihin Achmad Noerkhaerin Putra Alyssa Mileta Aponno Anisa, Meilinda Astuti, Ratih Arum Aulia Mifthakul Jannah Azzahra Vivin Mahdiya Afandy Carmel Josuhua Paulus Diah Wulandari Fabanyo, Syahrul H. Heti Aisyah Hikmahtul Putri Utami Inda Dwi Yanti Indah Amelia Rizky Innal Saitis Irwandi Irwandi Irwandi Irwandi Irwandi Irwandi Irwandi Irwandi Jannah, Aulia Mifthakul Justitia Cahyani Fadli Lintang Kumala Rahayu Lukman Hardia M. Yogi Riyantama Isjoni Marzella Dea Rossardy Meilinda Anisa Mohammad Usman Nur Ngodihu, Muhammad Syafinuddin Almandari Nur Indah Sari Nur ‘Azah Nur, Mohammad Usman nurjanah, sartika wahyu Nurul Maghfirah1 Ona Bugis Tehuayo Pasulu, Yusran Timang Pratama, Agus Sangka Rahayu, Mellawati Yuningtyas Ratih Arum Astuti Rohmania, Siti Rohmi Masitoh Salim, Fathiyah Salsabilah, Juliandani Siska Siska ulandari, clarista windi Wa Siti Arabiya Wahyuni Watora WaOde Suriani Wiwit Ayu Fitrianti Yuniatri, Nur Khusna yunus, sri ulan dari