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All Journal Medika Tadulako The Indonesian Biomedical Journal GHIDZA: Jurnal Gizi dan Kesehatan Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Journal of Health and Nutrition Research
Gina Andyka Hutasoit
Department Of Anatomical Pathology, Faculty Of Medicine, Universitas Tadulako, Jl. Soekarno Hatta KM. 9, Palu 94118
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

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Pengaruh Sanitasi Dasar terhadap Status Gizi Wanita Prakonsepsi di Wilayah Kerja Puskesmas Kawatuna Kota Palu Miranti Miranti; Gina Andyka Hutasoit; Gabriella Bamba Ratih Lintin; Diah Mutiarasari; Abd. Farid Lewa
Ghidza: Jurnal Gizi dan Kesehatan Vol 6 No 2 (2022): December
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/ghidza.v6i2.579

Abstract

Salah satu periode status gizi yang paling menentukan adalah status gizi pada masa prakonsepsi. Permasalahan gizi di Indonesia dipengaruhi oleh beberapa faktor yaitu salah satunya sanitasi dasar, sehingga perlu memastikan sanitasi lingkungan untuk wanita prakonsepsi yang memiliki masalah gizi. Tujuan dari penelitian ini mengetahui pengaruh sanitasi dasar terhadap status gizi wanita prakonsepsi di wilayah kerja Puskesmas Kawatuna Kota Palu. Penelitian ini merupakan penelitian analitik observasional korelatif dengan pendekatan Cross Sectional dengan menggunakan kuisioner dan data antropometrik pemeriksaan panjang badan dan berat badan wanita prakonsepsi di Wilayah Kerja Puskesmas Kawatuna serta pengambilan sampel menggunakan metode purposive sampling. Jumlah sampel pada penelitian ini sebanyak 90 responden. Hasil analisis korelasi menunjukkan bahwa semua variabel sanitasi dasar memiliki hubungan signifikan terhadap status gizi wnita prakonsepsi, dengan nilai signifikansi p< 0,05 yang berarti bahwa terdapat korelasi signifikan antara variabel sanitasi dasar dengan status gizi. Peran sanitasi dasar menjadi hal krusial dalam status gizi Wanita prakonsepsi dalam mempersiapkan kehamilannya nanti.
KARAKTERISTIK PENDERITA DENGAN GAMBARAN HISTOPATOLOGI TUBERKULOSIS DI RSUD UNDATA Hutasoit, Gina Andyka; Rupawan, I Kadek; Sari, Puspita; Tutu, Arlin Rinni
Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Vol. 10 No. 2 (2024)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/htj.v10i2.1169

Abstract

Tuberkulosis merupakan penyakit penting sebagai penyebab morbiditas dan mortalitas. Penegakan diagnosis untuk tuberkulosis yang baik seharusnya dipadukan antara temuan klinik dan pemeriksaan histopatologi agar mendapatkan hasil diagnosis dan pengobatan yang baik. Tujuan penelitian ini untuk mengetahui karakteristik dari penderita dengan hasil pemeriksaan histopatologi yang disebabkan oleh tuberkulosis di RSUD Undata tahun 2016-2021. Metode penelitian yang digunakan dalam penelitian ini adalah metode deskriptif, yakni penelitian yang bertujuan untuk mendapatkan gambaran atau deskripsi suatu keadaan secara objektif. Berdasarkan hasil penelitian maka dapat disimpulkan bahwa penderita tuberkulosis terbanyak yaitu pada kelompok umur 19-25 tahun dan jenis kelamin laki-laki. Sampel pemeriksaan histopatologi terbanyak adalah sampel biopsy yang berukuran kecil. Lokasi terbanyak tuberkulosis ekstra paru adalah pada regio kelenjar getah bening colli/inguinal.
HUBUNGAN TUMOR BUDDING DENGAN KEJADIAN METASTASIS KELENJAR GETAH BENING PADA PENDERITA ADENOKARSINOMA KOLOREKTAL: HUBUNGAN TUMOR BUDDING DENGAN KEJADIAN METASTASIS KELENJAR GETAH BENING ADENOKARSINOMA KOLOREKTAL Hutasoit, Gina Andyka; Miskad, Upik Anderiani; Cangara, Muhammad Husni; Wahid, Syarifuddin; Achmad, Djumadi; Tawali, Suryani
Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Vol. 10 No. 3 (2024)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/htj.v10i3.1324

Abstract

ABSTRAK Adenokarsinoma kolorektal adalah karsinoma yang ditemukan pada kolon dan/atau rektum. Salah satu gambaran histopatologi yang penting pada adenokarsinoma kolorektal adalah tumor budding. Tumor budding adalah adanya sel tumor tunggal atau kelompok kecil hingga empat sel dalam stroma tumor. Keberadaan entitas tumor budding terkait dengan invasi limfovaskular dan metastasis pada kelenjar getah bening. Tujuan penelitian untuk mengetahui hubungan tumor budding dengan kejadian metastasis kelenjar getah bening pada penderita adenokarsinoma kolorektal di Makassar tahun 2021-2023. Metode penelitian adalah observasi analitik dengan desain cross sectional. Enam puluh empat sampel diperiksa menggunakan mikroskop cahaya Olympus CX-43 dan dianalisis statistik dengan uji Chi-square menggunakan SPSS 27. Dari 64 sampel, terdapat sampel low grade tumor budding tanpa metastasis kelenjar getah bening sebanyak 10 sampel (90,9%) dan dengan metastasis kelenjar getah bening sebanyak 1 sampel (9,1%). Sampel intermediate grade tumor budding tanpa metastasis kelenjar getah bening sebanyak 18 sampel (75,0%) dan dengan metastasis kelenjar getah bening sebanyak 6 sampel (25,0%). Sedangkan sampel high grade tumor budding tanpa metastasis kelenjar getah bening sebanyak 13 sampel (44,8%) dan positif metastasis kelenjar getah bening sebanyak 16 sampel (55,2%). Terdapat hubungan yang bermakna antara tumor budding dengan kejadian metastasis kelenjar getah bening pada adenokarsinoma kolorektal (p=0,009).
Snail Expression is Positively Correlated with Depth of Invasion in Colorectal Carcinoma Upik Anderiani Miskad; Fardah Akil; Muhammad Husni Cangara; Haslindah Dahlan; Gina Andyka Hutasoit; Muhammad Riza Ilyasa
The Indonesian Biomedical Journal Vol 16, No 6 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i6.3392

Abstract

BACKGROUND: Colorectal carcinoma ranks as the second deadliest and third most prevalent cancer globally. The depth of tumor invasion and the presence of tumor-infiltrating lymphocytes (TILs) are linked to survival rates in this disease. Meanwhile, Snail expression is positively correlated with tumor grade, recurrence, metastasis and poor prognosis in various tumors. However, not many studies discuss the correlation of Snail expression with invasion depth and TILs in Indonesia. Therefore, this study was conducted to investigate the correlation between Snail expression and both the depth of invasion and TIL scoring in colorectal carcinoma.METHODS: A cross-sectional study was conducted to evaluate 70 paraffin-embedded blocks of colorectal carcinoma patients. Snail expression was measured with immunohistochemistry using Snail rabbit polyclonal antibody. Stromal TILs were assessed on a single full-face hematoxylin and eosin (H&E) slide, and classified into high, intermediate, and low TILs.RESULTS: The results showed that the most invasion was to the muscularis propria (42.9%) and the least invasion was to the submucosa (4.3%). In scoring TILs, the most samples with intermediate TILs (58.6%) and the least samples with low TILs (4.3%). The analysis employing a Spearman Rank coefficient shows significant positive correlation between the expression of Snail with depth of invasion (r=0.273; p=0.022) but there was no significant correlation with TILs scoring (p=0.892).CONCLUSION: Even though, there is no significant correlation between Snail expression with TILs, there is, however, a significant positive correlation between Snail expression with depth of invasion in colorectal carcinoma. Therefore, Snail expression might be potentially used as a prognostic factor in colorectal carcinoma.KEYWORDS: Colorectal, carcinoma, Snail, depth of invasion and TILs
Comparison of Neutrophile-to-Lymphocyte Ratio Between Dengue Haemorrhagic Fever and Dengue Shock Syndrome in Pediatric Patients at Anutapura Hospital Amri, Imtihanah; Rahma, Rahma; Hutasoit, Gina Andyka; Putri, Ayu Sekarani Damana; Harun, Haerani; Rasyid, Riyadh
Journal of Health and Nutrition Research Vol. 4 No. 1 (2025)
Publisher : Media Publikasi Cendekia Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56303/jhnresearch.v4i1.360

Abstract

Dengue Hemorrhagic Fever (DHF) is an acute viral infectious disease that attacks the body. DHF is divided into 4 grades (I, II, III, IV), in which degrees 3 and 4 are also known as Dengue Shock Syndrome (DSS). When the disease severity is detected too late, it can be fatal. Therefore, a predictor or inflammatory marker is needed to detect and predict this. In this study, the inflammatory marker assessed is the NLR value. This study compares the neutrophil-lymphocyte ratio and the incidence of Dengue Hemorrhagic Fever and Dengue Shock Syndrome in pediatric patients at the Anutapura Regional Hospital, Central Sulawesi Province. This study uses an observational analytical method with a cross-sectional design using secondary data from medical records at the Anutapura Regional Hospital, Palu, in 2021-2023. The sample included is patients with a diagnosis of DHF, totaling 100 samples. The sampling technique used is random sampling. Based on the Mann-Whitney test, a significant difference (p = 0.001) was found in the NLR value between DHF and DSS. The mean NLR in DHF was lower (1.28 (±0.98 SD)) than in DSS (2.07 (±1.59 SD)). There was no significant relationship between age (p=0.217) and gender (p=0.597) in the DHF and DSS groups. It is then concluded that there is a significant difference in NLR values between DHF and DSS, where NLR values are lower in DHF and higher in DSS.
PD-1 and PDL-1 Immune Checkpoint Inhibitors: Emerging Hope for the Future of Lung Cancer Immunotherapy Ilyasa, Muhammad Riza; Ramadhani, Muhammad Zulmi; Santoso, Rex Jeremy; Hutasoit, Gina Andyka; Miskad, Upik Anderiani
Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Vol. 11 No. 3 (2025)
Publisher : Faculty of Medicine, Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/htj.v11i3.1723

Abstract

Background: Lung cancer is the leading cause of cancer-related deaths worldwide, with Non-Small Cell Lung Cancer (NSCLC) being the most common type. Despite advances in treatment, the prognosis remains poor. Immune checkpoint inhibitors targeting PD-1 and PD-L1 have emerged as a promising first-line treatment approach in combating cancer. Objectives: This literature review aims to evaluate the effectiveness of PD-1 and PD-L1 immune checkpoint inhibitors in the treatment of NSCLC. It also explores the potential of these inhibitors to improve patient survival rates compared to conventional therapies. Methods: A systematic literature search was conducted using databases such as PubMed, Google Scholar, ScienceDirect, and NCBI, with keywords including "PD-1," "PD-L1," "NSCLC," "lung cancer," and "immunotherapy." Results: All four inhibitors significantly improve survival rates compared to traditional chemotherapy. Atezolizumab and pembrolizumab show high effectiveness in patients with high PD-L1 expression. Durvalumab, when combined with chemotherapy, overcomes resistance mechanisms. Nivolumab, enhancing survival rates. Conclusion: PD-1 and PD-L1 inhibitors provide substantial benefits in the treatment of NSCLC, including increased survival rates and reduced need for aggressive therapies. Further research should focus on optimizing combination therapies to expand the therapeutic benefits of these inhibitors.
Co-Authors A Fahira Nur Abd Farid Lewa Achmad, Djumadi Adhar Arifuddin Asriadi Asriadi Cangara, Husni Diah Mutiarasari Fardah Akil Gabriella Bamba Ratih Lintin Gemilang, Anugrah Putra Haerani harun Haslindah Dahlan I Kadek Rupawan I Putu Fery Immanuel White Ilyasa, Muhammad Riza Imtihanah Amri Indah Puspasari Kiay Demak Irsan, Mohammad Irsan, Mohammad Mansur, Siti Rahma Mohammad Salman Muhammad Husni Cangara Muhammad Riza Ilyasa Munir, Muhammad Ardi Nyoman Widajadnja, I Puspita Sari Puspita Sari Putra Gemilang, Anugrah Putri, Ayu Sekarani Damana Rahma Rahma Ramadhani, Muhammad Zulmi Rasyid, Riyadh Rupawan, I Kadek Salman, Mohammad Santoso, Rex Jeremy Sulistiana, Ria Syarifuddin Wahid Tawali, Suryani Thaha, Rahma Thaha, Rahmah Thaha, Rahmah Trisnaini, Wira Tutu, Arlin Rinni Umar, Miranti Upik Anderiani Miskad UPIK ANDERIANI MISKAD, UPIK ANDERIANI Vidyanto, Vidyanto Widajadnja, I Nyoman Wulandari, Hanif Iga