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All Journal Jurnal Teknologi Dan Industri Pangan Jurnal Sains dan Teknologi Nuklir Indonesia (Indonesian Journal of Nuclear Science and Technology) Jurnal Matematika & Sains Journal of Mathematical and Fundamental Sciences INDONESIAN JOURNAL OF PHARMACY Acta Pharmaceutica Indonesia Indonesian Journal of Chemistry JSKK (Jurnal Sains Keolahragaan dan Kesehatan) Pharmacology and Clinical Pharmacy Research JFIOnline Jurnal Ilmu Kefarmasian Indonesia Narra J Pharmaceutical Sciences and Research (PSR) Journal of Scientific Insights Jurnal Kefarmasian Indonesia
Slamet Ibrahim -
Faculty Of Pharmacy, Universitas Jenderal Achmad Yani, Jl. Terusan Jenderal Sudirman, Cimahi 40633, Indonesia
Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Journal : INDONESIAN JOURNAL OF PHARMACY

 1 
Radioiodination of andrographolide and its biodistribution in mice for inflammatory tracer Jutti Levita; Cahya Nova A.; As’ari Nawawi; Slamet Ibrahim
Indonesian Journal of Pharmacy Vol 21 No 4, 2010
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (489.965 KB) | DOI: 10.14499/indonesianjpharm0iss0pp258-265

Abstract

Andrographolide,  a  bioactive  component  of  Andrographis  paniculata (Burm.F)  Nees,  is  the  major  lactone  diterpenoidal  bicyclic  constituent  in  this plant  which  has  proven  to  exert  anti-inflammatory  activity  in  vitro  which  was occurred via  several mechanism, e.g inhibition of inducible nitric oxide synthase (iNOS),  inhibition  of  radical  oxygen  species,  and  inhibition  of  NF-kappaB activation. The labeling with radionuclide is often used for therapy, detection and quantification of metabolites in the body. Even though the metabolites are very low  in  concentration  they  can  be  detected  by  the  energy  they  emitted. Radionuclide  can  be  used as  radiotracer  to  detect  whether  drug  really interacts with  its  target.  The  objective  of  this  research  is  to  synthesize 131I-labelled andrographolide  and  to  study  its  biodistribution  in  mice  to  understand  the location  of  its  organ  target.  Indirect  radioiodination  of  andrographolide  wascarried  out  by  using  bromine  as  the  leaving  group  and  followed  by  fast iodination  at  40oC,  yielded  72.6  %  purity  of  the  labeled  compound.  Iodination was occurred through proton substitution at C-12. Then the andrographolide-131I was  injected  into  lateral  vein  of  mice’s  tail  to  study  its  biodistribution.  The compound  was  distributed  in  all organs  with the  highest  accumulation  occurred in  the  stomach  (16.87  %/gram  organ).  The  result  showed  that  inducing  the animals  with  LPS  caused  inflammation  in  the  stomach  and  increased  the production  of  prostaglandin  as  proven  by  the  distribution  of  the  radioligand  in that organ.Key words: andrographolide, radioiodination, anti-inflammatory, biodistribution
FTIR Method for Peptide Content Estimation and Degradation Kinetic Study of Canarium Nut Protein Rozana Oktaviary; Ilma Nugrahani; Slamet Ibrahim Surantaatmadja; Tutus Gusdinar Kartawinata; Cintya Nurul Apsari
Indonesian Journal of Pharmacy Vol 31 No 2, 2020
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjpharm31iss2pp78

Abstract

Quantitative analysis of bioactive peptide mostly conducted by measuring the activity. While the determination of peptide content in natural sources has been conducted using various instruments, vibrational spectroscopy remains underutilized. Here, we attempted new developed method in peptide quantification and degradation kinetic analysis using Fourier-Transform Infrared Spectroscopy. Bovine Serum Albumin was used as standard protein in method development and validation. Peptide content was estimated by converting peak area to concentration. The method was used to estimate peptide content in Canarium nut protein and its hydrolysates, which potentially hold biological activity. Kinetic study was conducted with microwave as an accelerator for hydrolysis, an apparatus rarely used in peptide study. Amide I band on wavenumber range of 1724.05-1619.91 cm-1 was selected for analysis, considering its selectivity and linearity. The method also met other validation requirement, including accuracy and precision. When applied in quantitative analysis, the method was able to calculate peptide content decrease in Canarium nut protein after hydrolysis using papain (38.24%), pepsin (33.67%) and alkaline reagent (28.53%). In kinetic study, microwave-assisted peptide degradation exhibited logarithmic profile with the equation of y=-0.148ln(x)+0.9591 and R² value of 0.963. Based on these results, FTIR is useful in estimating peptide content and in analyzing degradation kinetic profile. 
Identification of physical interaction between levodopa–benzerazide hydrochloride Ilma Nugrahani; Sukmadjaja Asyarie; Sundani Noerono Soewandhi; Slamet Ibrahim
Indonesian Journal of Pharmacy Vol 18 No 2, 2007
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1353.355 KB) | DOI: 10.14499/indonesianjpharm0iss0pp96-104

Abstract

The aim of this research was to investigate the possibility physical interaction occurred between of levodopa and benzerazide hydrochloride, which known as compounds used in combination for the the antiparkinson. The “cold contact methods” was used which was developed from Kofler contact method’s (hot stage methods). Thermograms Differential Scanning Calorimetry and difractograms X-Ray indicated that levodopa – benzerazide hydrochloride tent to form a peritecticum-molecular compound physical interaction with eutectics point at 4:6 and 9:1 molar ratios.Key words: benzerazide hydrochloride, cold contact method, levodopa, physical interaction.
Co-Authors Aang Hanafiah WS Abdul Mutalib Abdul Mutalib Abdul Mutholib Ahmad Muhtadi Aiyi Asnawi Aliya Nur Hasanah Amir Mursadad As'ari Nawawi As'ari Nawawi As'ari Nawawi As’ari Nawawi Batari A. Larasati Bina Lohita Sari Cahya Nova A. Cintya Nurul Apsari Damayanti, Sophi Daryono H. Tjahjono Daryono Hadi Tjahjono Dea Dwi Puspita Eli Halimah Eli Halimah, Eli Elin Yulinah Elin Yulinah Sukandar Embit Kartadarma Enade P. Istyastono Engrid Juni Astuti Engrid Juni Astuti Entris Sutisna, Entris Fauzan Fikri Fikri, Fauzan Gumilar, Anggi H.Tjahjono, Daryono H.Tjahjono, Daryono Hidehiro Uekusa I Ketut Adnyana I Ketut Adnyana Ida Musfiroh, Ida Ika Ratna Hidayati Ilma Nugrahani Ilma Nugrahani Ilma Nugrahani Ilma Nugrahani Iwan J. P. de Esch Jutti Levita Kartasasmita, Rahmana E Kartasasmita, Rahmana E Kurnia Firman Leni Herliani Afrianti Leni Herliani Afrianti Lina Rahmawati Rizkuloh Mardiana Mardiana Mardiana, Mardiana Marlia Singgih Maula Eka Sriyani MEGANTARA, SANDRA Mira Andam Dewi, Mira Andam Muhammad Ali Zulfikar Muhammad Ali Zulfikar Mursadad, Amir Mutakin Mutakin N.S, Sundani Nawawi, Asari Nursalam Hamzah Nursamsiar Nursamsiar Nursyamsiah, Tresna Nursyamsiah, Tresna Nyi M. Saptarini Nyi M. Saptarini Okky Dwichandra Putra Pusparani Krisnamurthi Putri, Adinda Triani Rachmat Mauludin Rahmana Emran Kartasasmita Rahmana Emran Kartasasmita Rozana Oktaviary Saeful Amin Saeful Amin Saeful Amin, Saeful Saptarini, Nyi M. Sophi Damayanti Sophi Damayanti Sophi Damayanti Sophi Damayanti Sophi Damayanti Sri A. Sumiwi Sukmadjaja Asyarie Sukmadjaja Asyarie Sukmadjaja Asyarie Sukmadjaja Asyarie Sukmadjaja Asyarie Sumiwi, Sri A. Sundani N.S. Sundani Noerono Soewandhi Sundani Nurono Soewandhi Sundani Nurono Soewandhi Sundani Nurono Soewandhi Tutus Gusdinar Kartawinata Yogiyanto Yogiyanto