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Journal : The Indonesian Biomedical Journal

Ethanol Extract of Spondias pinnata Leaves Reduce Parasite Number and Increase Macrophage Phagocytosis Capacity of Mice Infected by Plasmodium berghei Dewa Ayu Agus Sri Laksemi; I Gusti Kamasan Arijana; I Made Sudarmaja; Ni Luh Ariwati; Ketut Tunas; Putu Ayu Asri Damayanti; Ni Luh Putu Eka Diarthini; I Kadek Swastika; Ida Ayu Dewi Wiryantini
The Indonesian Biomedical Journal Vol 13, No 1 (2021)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v13i1.1286

Abstract

BACKGROUND: Currently, there is no vaccine against malaria in humans, the development of resistance to anti-malarial drugs, causing the need to find new alternatives to overcome malaria infections. This study aimed to determine effect of Spondias pinnata in increasing cellular immunity, especially phagocytosis activity of peritoneal macrophages against Plasmodium berghei infection.METHODS: This was an experimental study with two stages of research, each stage requires 36 Balb/c mice, aged 2 months and weight 20-25 grams. After one week of acclimatization, the mice were put into 6 different groups, each group consisted of 6 mice. The negative control was a group of mice given distilled water for 14 days then infected by P. berghei in the 15th day. Meanwhile, T1, T2, T3, T4 and T5 groups were given S. pinnata leaves ethanol extract with dose of 25, 50, 100, 200 and 400 mg/kg body weight (BW)/day, respectively, and then infected by P. berghei in the 15th day.RESULTS: The results showed that the lowest parasitemia and the highest capacity of macrophage to phagocytose latex was found in treatment group T3 that received 50 mg/kg BW of S. pinnata leaves ethanol extract. Based on analysis of the Pearson correlation test, there was a significant correlation between percent phagocytosis and parasitemia (p<0.05).CONCLUSION: Ethanol extract of S. pinnata leaves lower the parasite number of P. berghei in Balb/c mice and increase the capacity of macrophage to phagocytose latex. However, the mechanisms of how S. pinnata leaves extract in activating phagocytosis capacity and reducing parasitemia still need further investigation.KEYWORDS: phagocytosis, Plasmodium berghei, parasite number, Spondias pinnata
Co-Authors ., Ni Putu Ayu Laksmini Anak A. A. W. P. Dewi Budiana, Nyoman Damayanti, Cokorda Istri Dewa Ayu Agus Sri Laksemi Dewa Ayu Agus Sri Laksmi Dewi Puspita Apsari Dewi, Anak A. A. W. P. Dewi, Ni Ketut Cintya Dhiancinantyan Windydaca Brata Putri Farmani, Putu Ika Karma Gayatri, Ni Kadek Weni Diah I Gusti Kamasan Arijana I Gusti NAWW Putra I Kadek Swastika I Ketut Suwiyoga I Made Sudarmaja I Made Sudarmaja I Nyoman Gede Budiana I Nyoman Mahayasa Adiputra I Nyoman Mangku Karmaya I Putu Darma Wijaya I Putu Prisa Jaya . I Putu Riska Ardinata I. Lesmana Ida Ayu Dewi Wiryantini Intan Puspa Kurniastuti, A.A. Ayu Komang Indah Luh Nela Andriani Luh Putu Ratna Sundari Made Ary Pradnyawati Made Karma Maha Wirajaya Manuaba, I.A. Ratih Wulansari Mulana, Victorinus Alfred Saptiono Mulana, Viktorinus Alfred Saptiono Ni Luh Ariwati Ni Luh Gde Ari Natalia Yudha Ni Luh Putu Eka Diarthini Ni Luh Rustini Ni Luh Rustini Ni Made Linawati Ni Made Sudiari Ni Putu Aryati Suryaningsih Ni Putu Widya Astuti Ni Wayan Mita Arisia Nurwiyanti, . Nyoman Titin Brimantari Nyoman Trisna Aryanata Oktayanti, Leny Prapti Wujani, Ni Luh Gede Puspa, Intan Putu Ayu Asri Damayanti Putu Ayu Asri Damayanti Putu Ayu Indrayathi Putu Ika Farmani Putu Indah Budi Apsari R. Niruri Rasmaya Niruri Rasmaya Niruri Rasmaya Niruri Rini Noviyani Sagun Chandra Yowani Sanjaya, I Putu Maheswara Dharma Septiari, I Gusti Ayu Agung Sri Laksemi, Dewa Ayu Agus Suadnyana, Ida Ayu Astiti Teri, Komang Triastawan, I Komang Agus Viktorinus Alfred Saptiono Mulana Vitalia Fina Carla Rettobjaan Widowati, I Gusti Ayu Rai - Widyani, Ni Made Wimpie I Pangkahila Wintariani, Ni Putu Wirajaya, Karma Maha Yudha, A.A. Ngurah Bagus Arista Yuniantari, Ni Wayan