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All Journal Saintika Medika: Jurnal Ilmu Kesehatan dan Kedokteran Keluarga. Majalah Kedokteran Bandung Research Journal of Life Science MNJ (Malang Neurology Journal) Majalah Obstetri dan Ginekologi Biomedical Journal of Indonesia Medical Laboratory Technology Journal AcTion: Aceh Nutrition Journal Journal of Issues in Midwifery Asian Journal of Health Research
Wiyasa, I Wayan Arsana
Department Of Obstetrics And Gynaecology, Faculty Of Medicine, Universitas Brawijaya/ Saiful Anwar General Hospital, Malang, East Java, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Journal : Research Journal of Life Science

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Turmeric (Curcuma longa) Decoctum Had no Effect on Vascular Endothelial Growth Factor (VEGF) and Vascular Endothelial Cadherin (VE-cadherin) Expression in the Chick Embryo Sri Winarsih; I Wayan Arsana Wiyasa; Sri Andarini; Sumarno Reto Prawiro
Research Journal of Life Science Vol 5, No 2 (2018)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat, Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (362.581 KB) | DOI: 10.21776/ub.rjls.2018.005.02.3

Abstract

Turmeric (Curcuma longa) as a medicinal plant has widely consumed by pregnant women. The absence of dose standardization and the regulation of turmeric consumption in pregnancy raise concerns, especially if taken in early pregnancy. Angiogenesis is the process of new blood vessel formation from previously existing blood vessels, and plays an important role in embryogenesis and placentation during pregnancy. Angiogenesis is regulated by angiogenic molecules, such as VEGF and VE-cadherin. Turmeric has antiangiogenic effects in which the crude extract is pharmacologically more potent compared to the pure curcumin form. This study aimed to determine whether a turmeric decoctum affects the expression of VEGF and VE-cadherin in chick embryos. Turmeric was extracted by the decoction and freeze dried methods to obtain turmeric decoctum powder. This was tested on embryonated chicken eggs, which were divided into four groups; control group (2% DMSO) and treatment groups receiving various doses of the turmeric decoctum (200 ppm, 300 ppm and 400 ppm). The eggs used were less than 7 days after oviposition and incubated for 16 hours prior to injection of the treatment solution in ovo to the center of the yolk, followed by reincubation for up to 48 hours. Intraembryonic VEGF and VE-cadherin expression were assessed by whole-mount immunohistochemistry and quantified using image analysis techniques. This study showed administration of turmeric decoctum up to 400 ppm had no effect on the expression of VEGF and VE-cadherin in chick embryos.
Co-Authors Achmad Hidayat Adriana, Kusuma Agus Hendra Al Rahmad Akhmalia, Qorry' Afyu Annissa Febriani Arianto, Onni Dwi Arifiandi, Maya Devi Asih, Aliyah Tresna Azahra, Mutiara Syifa Baihaqi, Irfani Bambang Rahardjo DAMAYANTI, ZUHRIA PUSPITA Darwitri, Darwitri Dewi Santosaningsih Dewi, Ratih Frastika Diani, Yuli Ayu Donny Wisnu Wardhana Dwi Yuni Nur Hidayati Edy Mustofa Een Nuraenah Effendi, Madina Paramitha Elisa Danik Kurniawati Evi Zahara Eviana Norahmawati Fahimma Fahimma Fajar Dwi Prastiwi Fikhy Rizky Hapsari Gandhari, Anak Agung Sagung Agung Ayuska Hariyati, Suheni Ninik Heni Pujiastuti Husnul Khotimah Husnul Khotimah Husnul Khotimah I Wayan Agung Indrawan I Wayang Agung Indrawan Irfani Baihaqi Kalsumy, Umi Kartika Agustina Kusuma Adriana Lamadi, Sutini Machlusil Husna Maharani Maharani Maria Antonia Barbara Batu Mali Mohammad Muljohadi Ali Nany Nita Noviana Ni Putu Sri Haryati Nina Rini Suprobo Nirwan Nugraha Noryanto, Mukhamad Nugrahanti Prasetyorini Nurdiana Nurdiana Nurlaili Ramli Ovinery, Amarsya Prastiwi, Fajar Dwi Puspita Handayani Qonita Prasta Agustia Raras, Tri Yudani M. Siskanita Nur Fitriana Sri Andarini Sri Winarsih Subandi Subandi Suheni Ninik Hariyati Sulistomo, Hikmawan Wahyu Sumarno Reto Prawiro Suseno, Daniel Alexander Sutini Lamadi Sutrisno Sutrisno Sutrisno Sutrisno Suwana, Febie Putra Syah Sembung Wasiso Tanti Tri Lestary Tatit Nurseta Teguh Wiyono Tri Yudani Mardining Raras Tri Yuliyani Wibisono, Hermawan Wino Vrieda Vierlia Yahya Irwanto