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All Journal Saintika Medika: Jurnal Ilmu Kesehatan dan Kedokteran Keluarga. Majalah Kedokteran Bandung Research Journal of Life Science Jurnal Kebidanan Dan Kesehatan Tradisional MNJ (Malang Neurology Journal) Majalah Obstetri dan Ginekologi Biomedical Journal of Indonesia Medical Laboratory Technology Journal AcTion: Aceh Nutrition Journal Journal of Issues in Midwifery Asian Journal of Health Research
Wiyasa, I Wayan Arsana
Department Of Obstetrics And Gynaecology, Faculty Of Medicine, Universitas Brawijaya/ Saiful Anwar General Hospital, Malang, East Java, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Journal : Biomedical Journal of Indonesia

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Effect of Curcumin Nanoemulsion on Brain Cell Development, Locomotor Function, and Mortality of Zebrafish Larvae Model of Gestational Diabetes Mellitus Subandi, Subandi; Azahra, Mutiara Syifa; Ovinery, Amarsya; Akhmalia, Qorry' Afyu; Asih, Aliyah Tresna; Sulistomo, Hikmawan Wahyu; Nurdiana, Nurdiana; Wiyasa, I Wayan Arsana
Biomedical Journal of Indonesia Vol. 11 No. 3 (2025): Vol 11, No 3, 2025
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v11i3.270

Abstract

Introduction. Gestational diabetes mellitus (GDM) is glucose intolerance in pregnancy due to reduced ability of pancreatic beta cells to produce insulin, causing oxidative stress that triggers various complications such as brain apoptosis to locomotor disorders and decreased head size which has an impact on mortality rates. Pharmacological treatment of GDM has side effects that risk affecting fetal development. Therefore, curcumin as a herbal medicine can be an option for GDM treatment because it can increase insulin sensitivity by activating the peroxisome proliferator-activated receptor-gamma (PPAR-gamma) receptor. Methods. Post Test Only Control Group Design was used in this experimental study which was tested on each research variable consisting of 25 zebrafish embryos divided into 5 treatment groups consisting of a negative control, a positive control exposed to 3% glucose, and a diabetic group given curcumin nanoemulsion with three different doses (0.3125 μg/ml, 0.625 μg/ml, 1.25 μg/ml). One Way ANOVA and Post Hoc Tukey tests were used to analyze the data from this study. Results. P value from One Way ANOVA test p=0.024 for brain apoptosis, p=0.00 for locomotor ability, p=0.04 for head size, and p=0.006 for mortality rate. Turkey Post Hoc test showed significant differences in the control and 3% glucose + 0.625 µg/ml curcumin nanoemulsion groups (p<0.05). Conclusion. Curcumin nanoemulsion therapy has an effect on decreasing brain apoptosis, increasing locomotor, inhibiting the decrease in head size, and decreasing the mortality rate in zebrafish with gestational diabetes. The most effective dose of curcumin nanoemulsion is 0.625 µg/ml.
Co-Authors Achmad Hidayat Adriana, Kusuma Agus Hendra Al Rahmad Akhmalia, Qorry' Afyu Annissa Febriani Arianto, Onni Dwi Arifiandi, Maya Devi Asih, Aliyah Tresna Azahra, Mutiara Syifa Baihaqi, Irfani Bambang Rahardjo DAMAYANTI, ZUHRIA PUSPITA Darwitri, Darwitri Dewi Santosaningsih Dewi, Ratih Frastika Dian Kusumaningtyas, Dian Diani, Yuli Ayu Donny Wisnu Wardhana Dwi Yuni Nur Hidayati Edy Mustofa Een Nuraenah Effendi, Madina Paramitha Elisa Danik Kurniawati Evi Zahara Eviana Norahmawati Fahimma Fahimma Fajar Dwi Prastiwi Fikhy Rizky Hapsari Gandhari, Anak Agung Sagung Agung Ayuska Hariyati, Suheni Ninik Heni Pujiastuti Husnul Khotimah Husnul Khotimah Husnul Khotimah I Wayan Agung Indrawan I Wayang Agung Indrawan Irfani Baihaqi Kalsumy, Umi Kartika Agustina Kusuma Adriana Lamadi, Sutini Machlusil Husna Maharani Maharani Maria Antonia Barbara Batu Mali Mohammad Muljohadi Ali Nany Nita Noviana Ni Putu Sri Haryati Nina Rini Suprobo Nirwan Nugraha Noryanto, Mukhamad Nugrahanti Prasetyorini Nurdiana Nurdiana Nurlaili Ramli Ovinery, Amarsya Prastiwi, Fajar Dwi Puspita Handayani Qonita Prasta Agustia Raras, Tri Yudani M. Siskanita Nur Fitriana Sri Andarini Sri Winarsih Subandi Subandi Suheni Ninik Hariyati Sulistomo, Hikmawan Wahyu Sumarno Reto Prawiro Suseno, Daniel Alexander Sutini Lamadi Sutrisno Sutrisno Sutrisno Sutrisno Suwana, Febie Putra Syah Sembung Wasiso Tanti Tri Lestary Tatit Nurseta Teguh Wiyono Tri Yudani Mardining Raras Tri Yuliyani Wibisono, Hermawan Wino Vrieda Vierlia Yahya Irwanto Zahrani, Safira Astri Atika