Article Per Year (5 Year)
p-Index From 2021 - 2026
2.267
P-Index
This Author published in this journals
All Journal Journal of Robotics and Control (JRC) JURNAL KESEHATAN, SAINS, DAN TEKNOLOGI (JAKASAKTI) Sewagati Journal of Medicine and Health Technology
Indriani, Ratri Dwi
Unknown Affiliation
Aerospace Engineering Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Control & Systems Engineering Education Electrical & Electronics Engineering Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Mechanical Engineering Medicine & Pharmacology Neuroscience Public Health Social Sciences Other

Published : 14 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 14 Documents
Search

 1   2 
Exploring the Phytochemistry and Pharmacological Potentials of Annona squamosa L. : A Systematic Review of Traditional Uses and Modern Applications Rosyid Ridho, Muhammad Ainur; Indriani, Ratri Dwi; Wulansari, Arfiana Tanti; Purwani, Kristanti Indah; Nurhidayati, Tutik; Trisnawati, Indah; Aprilia, Veranita; Pradani, Anindhita Nabilah; Putra, Roy Ardiansyah; Lekatompessy, Vanela Chatrin
Journal of Medicine and Health Technology Vol. 2 No. 2 (2025)
Publisher : Direktorat Riset dan Pengabdian Kepada Masyarakat, Institut Teknologi Sepuluh Nopember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12962/j30466865.v2i2.4287

Abstract

Annona squamosa L. (Annonaceae) is a tropical evergreen fruit tree with a long history of traditional use across various cultures. Its fruit, known as srikayas, is commonly consumed fresh and used in candies, ice creams, and beverages. Different parts of A. squamosa have been widely applied in ethnomedicine as tonics, apophlegmatisants, coolants, abortifacients, and heart sedatives. Phytochemical studies have identified key bioactive compounds including annonaceous acetogenins (ACGs), diterpenes (DITs), alkaloids (ALKs), and cyclopeptides (CPs), with 33 diterpenes, 19 alkaloids, 88 acetogenins, and 13 cyclopeptides reported up to 2016. Extensive research reveals A. squamosa exhibits diverse pharmacological activities such as anticancer, antioxidant, antidiabetic, antihypertensive, hepatoprotective, antiparasitic, antimalarial, insecticidal, microbicidal, and molluscicidal effects. Notably, diterpenes and acetogenins contribute to its potent anticancer properties through apoptosis induction and cell cycle arrest. Leaf and seed extracts demonstrate significant antidiabetic, anti-inflammatory, and hepatoprotective actions, while seed peptides exhibit vasorelaxant and hypotensive effects via calcium channel inhibition. This review integrates phytochemical, ethnopharmacological, and bioactivity data, highlighting the therapeutic potential of A. squamosa and encouraging further clinical studies to validate its medicinal applications.
Peningkatan Literasi Kesehatan Masyarakat tentang Nyeri Punggung Bawah Melalui Edukasi Interaktif dengan Manekin Tiga Dimensi Tulang Belakang Abnormal Gumilar Fardhani; Indriani, Ratri Dwi; Eljatin, Dwinka Syafira; Njoto, Edwin Nugroho; Fadhlina, Afia Nuzila; Wirayuda, Anak Agung Bagus; Sari, Desiana Widityaning; Radiansyah, Riva Satya; Hedianto, Tri; Kuswanto, Djoko
Sewagati Vol 9 No 6 (2025)
Publisher : Pusat Publikasi ITS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12962/j26139960.v9i6.9133

Abstract

Nyeri punggung bawah merupakan penyakit muskuloskeletal dengan prevalensi tertinggi yang memerlukan upaya edukasi preventif kepada masyarakat. Kegiatan pengabdian masyarakat ini bertujuan meningkatkan pengetahuan masyarakat tentang nyeri punggung bawah melalui edukasi interaktif menggunakan manekin tulang belakang abnormal yang dikembangkan dari data MRI dan CT scan pasien nyeri punggung bawah, dimanufaktur menggunakan teknologi 3D printing dan cetakan silikon-lateks, serta dirangkai dengan wire khusus untuk memvisualisasikan mekanika nyeri punggung bawah. Metode pelaksanaan meliputi pelatihan kader mahasiswa sebagai fasilitator edukasi, penyuluhan masyarakat di Pendopo Kelurahan Medokan Semampir, serta skrining kesehatan gratis. Sebanyak 75 peserta menghadiri kegiatan, dengan 61 orang mengisi pretest-posttest lengkap. Hasil menunjukkan peningkatan pengetahuan yang signifikan (p<0,05) dari skor pretest (9,44 ± 0,96) ke posttest (9,79 ± 0,55), mengonfirmasi bahwa metode ini efektif dalam menstandarisasi pemahaman konsep biomekanika yang kompleks (ditunjukkan dengan penurunan standar deviasi). Skrining kesehatan gratis terbukti meningkatkan ketertarikan dan partisipasi masyarakat. Saran ke depan meliputi pembentukan kader kesehatan untuk menyebarluaskan edukasi secara berkelanjutan, monitoring dan evaluasi rutin, serta pengembangan media edukasi dalam berbagai format untuk memastikan program memberikan dampak jangka panjang terhadap literasi dan perilaku kesehatan masyarakat.
Phytochemical Constituents and Therapeutic Potential of Pine Bark and Needle Extracts in Cardiovascular and Metabolic Disorders Rosyid Ridho, Muhammad Ainur; Indriani, Ratri Dwi; Wulansari, Arfiana Tanti; Purwani, Kristanti Indah; Nurhidayati, Tutik; Aprilia, Veranita; Pradani, Anindhita Nabilah; Putra, Roy Ardiansyah; Farid, Ardiansyah
Journal of Medicine and Health Technology Vol. 3 No. 1 (2026)
Publisher : Direktorat Riset dan Pengabdian Kepada Masyarakat, Institut Teknologi Sepuluh Nopember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12962/j30466865.v3i1.4288

Abstract

Cardiovascular and metabolic diseases remain leading global health challenges, necessitating novel and complementary therapeutic strategies. Natural plant-derived compounds, particularly from pine bark and needles, have attracted attention for their potential health benefits. This study aims to comprehensively review the phytochemical composition of pine bark and needle extracts, focusing on their biological activities and potential roles in preventing and managing cardiovascular and metabolic disorders. A literature review was conducted using databases such as PubMed, ScienceDirect, and Google Scholar, focusing on studies published from 2000 to 2024. The selection criteria included in vitro, in vivo, and clinical research articles investigating the phytochemical profiles and pharmacological effects of pine bark and needle extracts on cardiovascular and metabolic health. Pine bark and needle extracts, especially from Pinus pinaster, are rich in proanthocyanidins, flavonoids, phenolic acids, stilbenes, and terpenoids. These bioactive compounds exhibit potent antioxidant, anti-inflammatory, and endothelial protective properties. Clinical and preclinical studies demonstrate improvements in blood pressure, lipid profiles, glucose metabolism, and vascular function. Emerging evidence also suggests a role in modulating gut microbiota, contributing to systemic metabolic benefits. Pine bark and needle extracts hold significant promise as adjunct therapies for cardiovascular and metabolic diseases through their multi-targeted mechanisms. Further well-designed clinical trials are necessary to validate their efficacy, optimize dosages, and ensure safety for broader therapeutic application.
Anesthetic Agents and Mitochondrial Function A Comprehensive Review of Cellular Bioenergetics and Clinical Implications Indriani, Ratri Dwi; Rosyid Ridho, Muhammad Ainur
Journal of Medicine and Health Technology Vol. 3 No. 1 (2026)
Publisher : Direktorat Riset dan Pengabdian Kepada Masyarakat, Institut Teknologi Sepuluh Nopember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12962/j30466865.v3i1.7987

Abstract

General anesthetic agents have traditionally been understood to function by modulating synaptic receptors. However, emerging evidence highlights mitochondria as a critical, non-canonical target. A comprehensive synthesis of these interactions and their clinical implications is essential for advancing perioperative safety. This narrative review aims to provide a comprehensive analysis of the molecular interactions between common anesthetic agents and mitochondrial function, bridging the mechanisms of cellular bioenergetics with relevant clinical outcomes. A literature search was conducted across major databases, including PubMed, Scopus, and Web of Science, to synthesize and interpret findings from in vitro, in vivo, and clinical studies published between January 2000 and August 2025. Our synthesis reveals that anesthetics directly modulate the electron transport chain, leading to a dual-edged production of reactive oxygen species (ROS) that can be either protective (preconditioning) or damaging (oxidative stress). We find that agents exhibit distinct mitochondrial profiles: sevoflurane often confers protection, propofol shows dose-dependent toxicity linked to bioenergetic failure, and dexmedetomidine acts as a mito-protective adjunct. These interactions disrupt mitochondrial dynamics and can culminate in a "bioenergetic crisis" at the synapse, where energy demand is increased while mitochondrial ATP supply is compromised. Viewing anesthetics as potent mitochondrial modulators is crucial for the evolution of anesthesiology. This perspective shifts the paradigm towards personalized anesthetic strategies based on a patient's underlying mitochondrial vulnerability. We conclude that future research should focus on developing non-invasive biomarkers of mitochondrial health and creating "mito-sparing" anesthetic protocols to improve patient safety and long-term outcomes.
Co-Authors Abdurahman Abdurrahman Adhi Dharma Wibawa, Adhi Dharma Aprilia, Veranita Dwinka Syafira Eljatin Fadhlina, Afia Nuzila Fadli, Sonny Farid, Ardiansyah Fitri, Wafa Sofia Fitriani, Fatimah Nur Gumilar Fardhani Haque, Sayidah Aulia Ul Haykal, Muhammad Nazhif Hedianto, Tri Hidayah, Rizka Nurul Hidayanti, Restu Imam Susilo Indriastuti, Endah Indriastuti, Endah Karimah, Rumman Khaidar, Reyfal Kristanti Indah Purwani Kuswanto, Djoko Lekatompessy, Vanela Chatrin Mahdi, Faizal Modjo, Annisa Afiyatushsholihah Njoto, Edwin Nugroho Nofiansyah, Rian Padma Nyoman Crisnapati Parlindungan, Putra Gelar Pradani, Anindhita Nabilah Prihatma Kriswidyatomo Putra, Gumilar Fardhani Ami Putra, Roy Ardiansyah Putri Alief Siswanto Putri, Atina Irani Wira Radiansyah, Riva Satya Rahman, Mafida Wida Rangkuti, Rahmah Yasinta Ridho, Muhammad Ainur Rosyid Ridhoi, Ahmad Rosyid Ridho, Muhammad Ainur Sakina Sania, Hen Sari, Desiana Widityaning Subiantoro, Andri Syulthoni, Zain Budi Thwe, Yamin Trisnawati, Indah Tutik Nurhidayati Wirayuda, Anak Agung Bagus Wulansari, Arfiana Tanti Yuri Pamungkas Zammara, Abdurrahman