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All Journal Journal of Robotics and Control (JRC) JURNAL KESEHATAN, SAINS, DAN TEKNOLOGI (JAKASAKTI) Sewagati Journal of Medicine and Health Technology
Indriani, Ratri Dwi
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Aerospace Engineering Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Control & Systems Engineering Education Electrical & Electronics Engineering Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Mechanical Engineering Medicine & Pharmacology Neuroscience Public Health Social Sciences Other

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Exploring the Phytochemistry and Pharmacological Potentials of Annona squamosa L. : A Systematic Review of Traditional Uses and Modern Applications Rosyid Ridho, Muhammad Ainur; Indriani, Ratri Dwi; Wulansari, Arfiana Tanti; Purwani, Kristanti Indah; Nurhidayati, Tutik; Trisnawati, Indah; Aprilia, Veranita; Pradani, Anindhita Nabilah; Putra, Roy Ardiansyah; Lekatompessy, Vanela Chatrin
Journal of Medicine and Health Technology Vol. 2 No. 2 (2025)
Publisher : Direktorat Riset dan Pengabdian Kepada Masyarakat, Institut Teknologi Sepuluh Nopember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12962/j30466865.v2i2.4287

Abstract

Annona squamosa L. (Annonaceae) is a tropical evergreen fruit tree with a long history of traditional use across various cultures. Its fruit, known as srikayas, is commonly consumed fresh and used in candies, ice creams, and beverages. Different parts of A. squamosa have been widely applied in ethnomedicine as tonics, apophlegmatisants, coolants, abortifacients, and heart sedatives. Phytochemical studies have identified key bioactive compounds including annonaceous acetogenins (ACGs), diterpenes (DITs), alkaloids (ALKs), and cyclopeptides (CPs), with 33 diterpenes, 19 alkaloids, 88 acetogenins, and 13 cyclopeptides reported up to 2016. Extensive research reveals A. squamosa exhibits diverse pharmacological activities such as anticancer, antioxidant, antidiabetic, antihypertensive, hepatoprotective, antiparasitic, antimalarial, insecticidal, microbicidal, and molluscicidal effects. Notably, diterpenes and acetogenins contribute to its potent anticancer properties through apoptosis induction and cell cycle arrest. Leaf and seed extracts demonstrate significant antidiabetic, anti-inflammatory, and hepatoprotective actions, while seed peptides exhibit vasorelaxant and hypotensive effects via calcium channel inhibition. This review integrates phytochemical, ethnopharmacological, and bioactivity data, highlighting the therapeutic potential of A. squamosa and encouraging further clinical studies to validate its medicinal applications.
Co-Authors Abdurahman Abdurrahman Adhi Dharma Wibawa, Adhi Dharma Aprilia, Veranita Dwinka Syafira Eljatin Fadhlina, Afia Nuzila Fadli, Sonny Fitri, Wafa Sofia Fitriani, Fatimah Nur Haque, Sayidah Aulia Ul Haykal, Muhammad Nazhif Hedianto, Tri Hidayah, Rizka Nurul Hidayanti, Restu Imam Susilo Indriastuti, Endah Indriastuti, Endah Karimah, Rumman Khaidar, Reyfal Kristanti Indah Purwani Lekatompessy, Vanela Chatrin Mahdi, Faizal Modjo, Annisa Afiyatushsholihah Njoto, Edwin Nugroho Nofiansyah, Rian Padma Nyoman Crisnapati Parlindungan, Putra Gelar Pradani, Anindhita Nabilah Prihatma Kriswidyatomo Putra, Gumilar Fardhani Ami Putra, Roy Ardiansyah Putri Alief Siswanto Putri, Atina Irani Wira Radiansyah, Riva Satya Rahman, Mafida Wida Rangkuti, Rahmah Yasinta Ridho, Muhammad Ainur Rosyid Ridhoi, Ahmad Rosyid Ridho, Muhammad Ainur Sakina Sania, Hen Sari, Desiana Widityaning Subiantoro, Andri Syulthoni, Zain Budi Thwe, Yamin Trisnawati, Indah Tutik Nurhidayati Wulansari, Arfiana Tanti Yuri Pamungkas Zammara, Abdurrahman