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All Journal HAYATI Journal of Biosciences Jurnal Gizi dan Pangan Jurnal Ilmu Pertanian Indonesia ACTA VETERINARIA INDONESIANA Hemera Zoa Jurnal Sain Veteriner Medical Journal of Indonesia Indonesian Journal of Pharmaceutical Science and Technology Prosiding Seminar Biologi INDONESIAN JOURNAL OF PHARMACY Journal of Medicine and Health Journal of Dentomaxillofacial Science Argipa (Arsip gizi dan Pangan) ARSHI Veterinary Letters Jurnal Ilmu dan Teknologi Kayu Tropis JURNAL KAJIAN VETERINER Britain International of Exact Sciences Journal (BIoEx Journal) Jurnal Pusat Inovasi Masyarakat Jurnal Kedokteran Hewan Journal of Medicine and Health
Vetnizah Juniantito
Institut Pertanian Bogor
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Earth & Planetary Sciences Health Professions Immunology & microbiology Mathematics Medicine & Pharmacology Neuroscience Physics Public Health Social Sciences Veterinary

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Journal : INDONESIAN JOURNAL OF PHARMACY

 1 
Potential Deleterious Effects of L-Citrulline Supplementation in Isoproterenol-Induced Myocardial Infarction: Focus on Nitrosative Stress Gregorius Bhaskara Wikanendra; Wawaimuli Arozal; Kusmardi Kusmardi; Vetnizah Juniantito; Andrea Laurentius
Indonesian Journal of Pharmacy Vol 30 No 4, 2019
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjpharm30iss4pp269

Abstract

L-Citrulline shows potential activity as a supplement to prevent myocardial infarction through vasodilative and possible antioxidative effects but may be deleterious by causing nitrosative stress. This study determined the potentially deleterious effects of L-citrulline supplementation in isoproterenol-induced myocardial infarction with a focus on nitrosative stress. L-Citrulline supplementation was given orally at dosages of 300 or 600mg/kg body weight daily for 6 days. Myocardial infarction was induced in Wistar rats via subcutaneous injection of isoproterenol (85 mg/kg body weight (BW)) on day 4 and 5. Blood pressure was measured at the end of the study (day 6) and rats were sacrificed to collect heart tissue samples for a histopathological evaluation. The histopathological evaluation was done using hematoxylin and eosin staining for the myocardial damage evaluation and immunohistochemical (IHC) staining of arginase-2, inducible nitric oxide synthase (iNOS), and 3-nitrotyrosine to evaluate nitrosative stress. L-Citrulline supplementation failed to show a significant protective effect on blood pressure and exacerbated the decrease of diastolic blood pressure. Both low and high dose L-citrulline supplementation had a significant protective effect on myocardial damage compared to the isoproterenol group (p<0.01). L-Citrulline also caused increased nitrosative stress as shown by increased expression of arginase-2 and 3-nitrotyrosine on IHC staining but tended to show an ameliorative effect on iNOS expression. A significant increase in arginase-2 expression was detected between the high dose group and the other groups (p<0.01 vs. normal and isoproterenol groups; p<0.05 vs. low dose group). L-Citrulline supplementation increased 3-nitrotyrosine expression in a dose-dependent manner, which was significantly different compared to the normal group (low dose: p<0.013; high dose: p<0.003). L-Citrulline increased the production of nitrosative stress but resulted in less myocardial damage through its other effects.
Co-Authors . Jumari Abdullah Baharun Agatha Grace Agus Setiyono Agus Setyono Aisyah Aisyah Akhmad Endang Zainal Hasan Alfina Zalfa Suryono Ali Khomsan Andi Arus Victor Andrea Laurentius Annisa Rahmi Antonius Anre Sianturi Aria Kekalih Armando Balses Ishimora Azizah, Hanifah Nur Baharun, Rasyid Bambang Pontjo Priosoeryanto Bayu Febram Prasetyo Bustamam, Alhadi Cesilia M Dwiriani Chatarina Umbul Wahyuni D R Agungpriyono Deded Sarip Nawawi Dewi R Agungpriyono Dondhin Sajuthi Dondin Sajuthi Dwi Rofifah Putri Jania Endang Syamsudin Eva Harlina Evy Ayu Arida Evy Damayanthi Fajar Rezandaru Femmi Dwinda Agustini Fivi Melva Diana, Fivi Melva Gregorius Bhaskara Wikanendra I Nyoman Jaya Wistara IETJE WIENTARSIH Iis Ismawati Indra Hadikrishna Itje Wintarsih Kusmardi Kusmardi L N Sutardi Lukman Edwar Madyastuti, Rini Makhroja, Lalu Faris Naufal Mardianto, Umar Miranti Fardesiana Putri Mohamad Sadikin Mokhamad Fahrudin Monica Septiani Nafrialdi Nafrialdi Ni Wayan Kurniani Karja Nina Herlina Nopen Meisaroh Novianti, Titta Nugraha, Arifin Budiman Nur Indrawaty Lipoeto Prasandhya Astagiri Yusuf Purnamiharja, Tsulatsy Puspitasari Putri Ramadhanty Rafida Nisa Maghfiroh Ranady Perwira Nuruzzaman Rimbawan , Rita Kartika Sari Safitri, Debby Endayani Sajuthi, Dondhin Sharon Aurellia Silmi Hanifah Siti Magfiroh Soni Siswanto Sri Estuningsih Sri Wahyuni Salam Sri Widia A Jusman Subangkit, Mawar Syahruddin Said Tri Rahayu Umi Cahyaningsih Vici Eko Handayani Wahono Esthi Prasetyaningtyas Wawaimuli Arozal WoroWiranti, Rahayu Yenny Rakhmawati