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Faktor risiko diabetes melitus tipe 2 pada wanita usia subur di Kota Bekasi Safitri, Debby Endayani; Rimbawan, Rimbawan; Dwiriani, Cesilia Meti; Khomsan, Ali; Juniantito, Vetnizah
ARGIPA (Arsip Gizi dan Pangan) Vol 9 No 2 (2024)
Publisher : UHAMKA PRESS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/argipa.v9i2.18050

Abstract

Diabetes mellitus has a significant impact on health and, in the long term, can lead to complications. Women are at a higher risk of developing type 2 diabetes mellitus compared to men. For women of reproductive age, diabetes mellitus can affect reproductive health and pregnancy quality, which may influence the next generation. The study aimed to determine risk factors for type 2 diabetes mellitus in women of reproductive age in Bekasi City. This was matched case control study, involving 72 subjects selected by purposive sampling. The study was conducted at community health centre in Bekasi. Results: There were no significant differences in nutritional status (p=0.083) and age at menarche (p=0.234) of women of reproductive age with T2DM and non-T2DM. Long menstrual cycles increase the risk of type 2 diabetes mellitus by 6.2 times higher than normal menstrual cycles (p=0.005). A history of gestational diabetes in women of reproductive age increases the risk 2.2 times higher for women of reproductive age to experience T2DM in the future (p=0.027). Long menstrual cycles and gestational diabetes are important factors contributing to the increased risk of T2DM in women of reproductive age.
Efek Andrographolide Oral Terhadap Biomarker Jantung pada Tikus yang Diinduksi Doxorubicin Silmi Hanifah; Wawaimuli Arozal; Vetnizah Juniantito
Journal of Medicine and Health Vol 5 No 2 (2023)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28932/jmh.v5i2.5026

Abstract

Doxorubicin remains the most prescribed anticancer agent despite its unintended side effects on non-target organs. A limiting-dose strategy is used to lower incidence of cardiotoxicity. Andrographolide has therapeutic effects including antioxidant and anti-inflammatory. This study aimed to assess cardioprotective effects of andrographolide oral on lactate dehydrogenase (LDH), creatine kinase-myocardial band (CK-MB), and relative cardiac weight in doxorubicin-induced rats. Sixteen male rats Sprague Dawley randomized into four groups: receives saline i.p and vehicle orally (Normal), doxorubicin 16 mg/kgBW i.p and vehicle orally (Dox), doxorubicin 16 mg/kgBW i.p+andrographolide 30 mg/kgBW orally (Dox+And30), doxorubicin 16 mg/kgBW i.p+andrographolide 60 mg/kgBW orally (Dox+And60). Blood was collected via cardiac puncture and cardiac organs were weighed after four-weeks administration. Total LDH and CK-MB measured spectrophotometrically. LDH and CK-MB levels significantly elevated, and signs of acute toxicity in Dox group compared with Normal group. Co-treatment with andrographolide at 30 mg/kgBW and 60 mg/kgBW reduced signs of toxicity and significantly attenuated LDH and CK-MB levels compared with Dox group (P<0.05 and P<0.01). However, body weight and relative cardiac weight were not significantly different in all groups after co-treatment with andrographolide. In conclusion, andrographolide lowered LDH and CK-MB levels, therefore has a protective potency in alleviating toxic effects of doxorubicin.
-TOCOPHEROL IMPROVED THE QUALITY OF BEAGLE DOG BREED CHILLED SEMEN STORAGE AT 4 C IN TRIS-SKIM MILK EXTENDER Makhroja, Lalu Faris Naufal; Juniantito, Vetnizah; Fahrudin, Mokhamad; Prasetyaningtyas, Wahono Esthi; Karja, Ni Wayan Kurniani
Jurnal Kedokteran Hewan Vol 19, No 3 (2025): September
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v19i3.44561

Abstract

Improvement of canine reproduction has been developed by artificial insemination (AI) for effective breeding. -tocopherol widely recognized as an antioxidant that has been used to improve the quality of the spermatozoa. This study evaluated the effect of -tocopherol supplementation in dog chilled semen quality. Beagle dog breed semen samples were obtained from male Beagles using massage technique. The semen was then diluted with tris-skim milk extender supplemented with -tocopherol of various concentration, 0% as control group (T-0), 0.1% (T-0.1), 0.2% (T-0.2), and 0.3% (T-0.3), then were stored at 4 C and evaluated daily for four days, particularly for variables namely sperm motility, sperm viability, and plasma membrane integrity. Results showed that the quality of spermatozoa was higher when spermatozoa preserved in extender containing of 0.1% or 0.2% -tocopherol compared to those of control and 0.3% -tocopherol group (P0.05). The highest quality found in group with 0.2% -tocopherol. In conclusion, supplementation -tocopherol 0.2% in dog chilled semen extender is effective for improving and maintaining chilled dog sperm quality for 4 days of storage.
MOLECULAR DETECTION OF Coxiella burnetii THE CAUSE OF ZOONOSIS Q FEVER IN VARIOUS ORGANS OF CATTLE IN BANDUNG REGENCY Purnamiharja, Tsulatsy Puspitasari; Juniantito, Vetnizah; WoroWiranti, Rahayu; Setiyono, Agus
Jurnal Kedokteran Hewan Vol 17, No 3 (2023): September
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v17i3.32716

Abstract

Primary objective of this study was to ascertain the presence of Coxiella burnetii (C. burnetii) as the causative of Q fever in cattle within Bandung Regency. Tissue samples were procured from 240 slaughtered cattles in abattoirs across Bandung Regency. Each breed of cattle consists of Brahman cross (BX), Simmental, Limousin, Friesien Holstein crossbreed, and Friesien Holstein (FH) with total of 192, 3, 13, 29, and 3, respectively. Detection method employed was nested-Polymerase Chain Reaction (PCR) to identify the presence of C. burnetii Deoxyribonucleic Acid (DNA) within tissue samples. Positive samples underwent further examination employing hematoxylin-eosin (HE) staining to identify lesions attributed to C. burnetii. Five BX cattle were identified as positive for C. burnetii in lungs and heart. However, histopathological analysis of both organs did not reveal any notable changes. These findings suggest the occurrence of C. burnetii infection in cattle within Bandung Regency, without specific histopathological changes indicative of Q fever lesions. In conclusion, presence of asymptomatic C. burnetii infections should be regarded as a significant threat to human health.
Effect of Biscuits Enriched with Bilih Fish (Mystacoleucus padangensis) on Growth of Experimental Rats Diana, Fivi Melva; Rimbawan, Rimbawan; Damayanthi, Evy; Dewi, Mira; Juniantito, Vetnizah; Lipoeto, Nur Indrawaty
Jurnal Gizi dan Pangan Vol. 15 No. 1 (2020)
Publisher : The Food and Nutrition Society of Indonesia in collaboration with the Department of Community Nutrition, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (311.198 KB) | DOI: 10.25182/jgp.2020.15.1.11-18

Abstract

The research aimed to produce biscuits formulated with Bilih fish and to analyse the effect of Bilih-fish-based biscuits on the growth of experimental rats. Six biscuit formulas were developed using three different amounts of Bilih fish flour (0 g, 20 g, and 30 g added to one formula dough) and two flavors (chocolate and vanilla). One biscuit formula was selected based on the best organoleptic test. Four treatments were applied to 24 male growing rats (21 day olds of the Spraque Dawley strain) for 28 days using a completely randomized design study. The treatments used were P1 (standard feed), P2 (standard feed + standard biscuits), P3 (standard feed + standard biscuits + pure omega-3 oil) and P4 (standard feed + the best formula biscuit). The parameters measured on rats were weight and tail length. The best formula biscuit based on the organoleptic test was the chocolate-flavor biscuits prepared with 20 g Bilih fish flour. The longest tail length was found in the P4 treatment (2,257±0.52 cm), which was significantly longer than the P2 (1.46±0.34 cm) and P1 (1.34±0.29 cm) treatments. No significant weight differences were found among the rats in all treatments. Hence, the chocolate-flavor biscuits formulated with the addition of 20 g Bilih fish flour increased the linear growth in experimental rats as shown by the significant difference in the tail lengths found in the treatment group.