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All Journal Jurnal Anestesiologi Indonesia Jurnal Anestesi Perioperatif Sari Pediatri Abdimas Talenta : Jurnal Pengabdian Kepada Masyarakat Jurnal Biomedika dan Kesehatan Jurnal Prima Medika Sains Indonesian Journal of Anesthesiology and Reanimation (IJAR) Journal of Anaesthesia and Pain Indonesian Journal of Applied Research (IJAR) Journal SAGO Gizi dan Kesehatan Jurnal Neuroanestesi Indonesia Majalah Anestesia & Critical Care (MACC) Jurnal PADE: Pengabdian & Edukasi The Journal of Society Medicine (JSOCMED)
Lubis, Andriamuri Primaputra
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

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The Effect of Intrathecal 20 mg Ketamine on 0.5% 15 mg Bupivacaine in Spinal Anesthesia For Lower Extremity Surgery Chandra, Nopial Ade; Hamdi, Tasrif; Lubis, Andriamuri Primaputra
Journal of Anaesthesia and Pain Vol. 7 No. 1 (2026): January
Publisher : Faculty of Medicine, Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/

Abstract

Background: Regional anesthesia is widely used in orthopedic procedures to reduce complications such as nausea, vomiting, and pulmonary aspiration. Intrathecal ketamine is known to prolong analgesia duration, but evidence remains limited. This study aimed to compare the effectiveness and side effects of combining intrathecal ketamine 20 mg with 0.5% bupivacaine 15 mg versus bupivacaine alone in spinal anesthesia for lower extremity surgery. Methods: A randomized controlled trial (RCT) was conducted at RS Haji Medan and Rumkit Tk II Putri Hijau Medan, involving 30 patients undergoing spinal anesthesia. Subjects were divided into two groups: Group A (Ketamine + Bupivacaine) and Group B (Bupivacaine only). Variables observed included onset and duration of sensory and motor blockade, sedation level, hemodynamic responses, and adverse effects. Data were analyzed using SPSS v24.0. Results: No significant differences were found in baseline characteristics between the two groups. The addition of ketamine did not significantly affect the onset or duration of sensory and motor blockade. Hemodynamic parameters such as heart rate and blood pressure remained stable in both groups. However, sedation levels were lower and the incidence of adverse effects (such as nausea, shivering, and hallucinations) was higher in the ketamine group. Conclusion: The addition of intrathecal ketamine 20 mg to bupivacaine 0.5% 15 mg slightly prolonged spinal anesthesia but was associated with an increased risk of adverse effects and lower sedation. This combination should be used cautiously in clinical practice.
Hemodynamic Effects of Phenylephrine 100 µg versus Ephedrine 5 mg During Propofol-Induced General Anesthesia: A Randomized Study Sibarani, Nicholas Hamonangan; Lubis, Andriamuri Primaputra; Bangun, Chrismas Gideon; Yunanda, Yuki
Jurnal Anestesi Perioperatif Vol 13, No 3 (2025)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15851/jap.v13n3.4454

Abstract

Background: Propofol is widely used for induction of general anesthesia; however, it frequently associated hypotension due to vasodilation and myocardial depression. Vasopressors such as phenylephrine and ephedrine are commonly administered to counteract this effect, but evidence comparing their hemodynamic efficacy during induction remains limited.Methods: This randomized double-blind clinical trial included 80 patients undergoing elective surgery under general anesthesia. Patients were randomly allocated into two groups to receive either phenylephrine 100 µg or ephedrine 5 mg at the time of propofol induction. Demographic characteristics (sex, age, body mass index, and ASA physical status) were recorded. Hemodynamic parameters, including systolic blood pressure, diastolic blood pressure, mean arterial pressure, and heart rate, were measured after premedication and 30 seconds following propofol administration.Results: Baseline characteristics were comparable between the two groups. At 30 seconds after induction, there were no statistically significant differences in systolic blood pressure, diastolic blood pressure, mean arterial pressure, or heart rate between the phenylephrine and ephedrine groups. Both vasopressors effectively maintained hemodynamic stability during propofol induction.Discussion: The findings suggest that phenylephrine and ephedrine have similar hemodynamic profiles when administered during propofol induction. Despite their differing pharmacological mechanisms, both agents were equally effective in preventing early hypotension without significant differences in heart rate or blood pressure responses.Conclusion: Phenylephrine 100 µg and ephedrine 5 mg demonstrated comparable efficacy in maintaining hemodynamic stability during propofol-induced general anesthesia, with no significant difference in their ability to prevent hypotension.
Co-Authors Akbar, Hera Zein Annisa Syifanurhati Ansari, Aulia Kamal Ardinata, Dedi - Aulia, Miftah Furqon Bangun, Chrismas Gideon Bastian Lubis Chandra, Nopial Ade Elfazi, Tazzya Shailla Elmeida Effendy Etania, Cassandra Hamdi, Tasrif Hanafie, Achsanuddin Harahap, Dhiny Yolanda Harahap, Juliandi Hasibuan, Muhammad Ramadhan Hutagalung, Sunna Vyatra Irina, Rr Sinta Irina, Rr. Sinta Karim, T. Abdul Ketaren, Aga Shahri Putera Khairani, Mitra Lubis, Adhika Syaputra Mustafa Mahmud Amin Nadeak, Rommy Nadeak, Rommy Fransiscus Nasution, Afrida Aryani Panggabean, Mathilda Paramita, Deryne Anggia Pohan, Alfindy Maulana Putra, Muhammad Irvan Triono Rifani Masharto, Alegra Rina Amelia Rusda, Muhammad Sibarani, Nicholas Hamonangan Suherman, Jessen Syaputra, Adhika Tanjung, Ika Citra Dewi Tarigan, Randi Joel Oktavianus Taufik, Maulana Wahyuni, Arlinda Sari Wijaya, Dadik Wahyu Wijaya, Yudhi Yunanda, Yuki